Junli Xue
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View article: Yin Yang 1 Promotes Antiprogrammed Cell Death‐1 Resistance in Hepatocellular Carcinoma through Polypeptide N‐Acetylgalactosaminyltransferase 16‐Mediated Glycosylation of Programmed Death Ligand‐1
Yin Yang 1 Promotes Antiprogrammed Cell Death‐1 Resistance in Hepatocellular Carcinoma through Polypeptide N‐Acetylgalactosaminyltransferase 16‐Mediated Glycosylation of Programmed Death Ligand‐1 Open
Immune checkpoint inhibitors (ICIs) are widely used for treating hepatocellular carcinoma (HCC), yet their efficacy remains limited, with suboptimal response rates. The predictive power of the current biomarker, programmed death ligand‐1 (…
View article: The gut-brain axis in the context of colorectal cancer
The gut-brain axis in the context of colorectal cancer Open
The gut-brain axis (GBA) plays a pivotal role in the pathophysiology of colorectal cancer (CRC), influencing tumor progression, immune responses, and therapeutic outcomes. Bidirectional communication between the gut and the brain, mediated…
View article: MAGEA6 Engages a YY1‐Dependent Transcription to Dictate Perineural Invasion in Colorectal Cancer
MAGEA6 Engages a YY1‐Dependent Transcription to Dictate Perineural Invasion in Colorectal Cancer Open
Perineural invasion (PNI), characterized by tumor cells surrounding and invading nerves, is associated with poor prognosis in colorectal cancer (CRC). Understanding the mechanisms of PNI is crucial for developing targeted therapies to impe…
View article: Transcription factor ONECUT3 regulates HDAC6/HIF-1α activity to promote the Warburg effect and tumor growth in colorectal cancer
Transcription factor ONECUT3 regulates HDAC6/HIF-1α activity to promote the Warburg effect and tumor growth in colorectal cancer Open
The Warburg effect, also known as aerobic glycolysis, plays a crucial role in the onset and progression of colorectal cancer (CRC), although its mechanism remains unclear. In this study, bioinformatics analysis of public databases combined…
View article: Phase Ib study of the oral PI3Kδ inhibitor linperlisib in patients with advanced solid tumors
Phase Ib study of the oral PI3Kδ inhibitor linperlisib in patients with advanced solid tumors Open
Background Patients with advanced solid tumors have a suboptimal prognosis. This study investigated the safety and feasibility of linperlisib, a selective phosphatidylinositol 3-kinase delta isoform (PI3Kδ) inhibitor, for treating patients…
View article: Comprehensive characterization of tumor innervation in colorectal cancer
Comprehensive characterization of tumor innervation in colorectal cancer Open
Purpose Complex innervation occurs at colorectal cancer (CRC) sites, and these nerves play a certain role in the occurrence and development of tumors. This study aimed to reveal the morphological changes in the nervous system in CRC and th…
View article: Transcription factor ONECUT3 regulates HDAC6/HIF-1α activity to promote the Warburg effect and tumor growth in colorectal cancer
Transcription factor ONECUT3 regulates HDAC6/HIF-1α activity to promote the Warburg effect and tumor growth in colorectal cancer Open
The Warburg effect, also known as aerobic glycolysis, plays a crucial role in the onset and progression of colorectal cancer, although its mechanism remains unclear. Bioinformatics analysis of public databases and verification of clinical …
View article: First-in-human study of GFH018, a small molecule inhibitor of transforming growth factor-β receptor I inhibitor, in patients with advanced solid tumors
First-in-human study of GFH018, a small molecule inhibitor of transforming growth factor-β receptor I inhibitor, in patients with advanced solid tumors Open
Background Transforming growth factor-β (TGF-β) is a cytokine with multiple functions, including cell growth regulation, extracellular matrix production, angiogenesis homeostasis adjustment and et al. TGF-β pathway activation promotes tumo…
View article: Mechanical cues of extracellular matrix determine tumor innervation
Mechanical cues of extracellular matrix determine tumor innervation Open
Peripheral tumors can establish local autonomic and sensory nerve networks, termed as tumor innervation (TIN), to support tumorigenesis and metastasis. While nerve dependence in cancers is well-established, the mechanisms governing TIN rem…
View article: PYGL-mediated glucose metabolism reprogramming promotes EMT phenotype and metastasis of pancreatic cancer
PYGL-mediated glucose metabolism reprogramming promotes EMT phenotype and metastasis of pancreatic cancer Open
Epithelial-mesenchymal transition (EMT) is closely associated with tumor invasion and metastasis. However, key regulators of EMT in pancreatic ductal adenocarcinoma (PDAC) need to be further studied. Bioinformatics analyses of pancreatic c…
View article: Expert consensus on the diagnosis and treatment of <scp><i>NTRK</i></scp> gene fusion solid tumors in China
Expert consensus on the diagnosis and treatment of <span><i>NTRK</i></span> gene fusion solid tumors in China Open
Gene fusions can drive tumor development for multiple types of cancer. Currently, many drugs targeting gene fusions are being approved for clinical application. At present, tyrosine receptor kinase (TRK) inhibitors targeting neurotrophic t…
View article: Targeting type Iγ phosphatidylinositol phosphate kinase overcomes oxaliplatin resistance in colorectal cancer
Targeting type Iγ phosphatidylinositol phosphate kinase overcomes oxaliplatin resistance in colorectal cancer Open
Rationale: Oxaliplatin is a widely used chemotherapy drug for advanced colorectal cancer (CRC) and its resistance is a major challenge for disease treatment. However, the molecular mechanism underlying oxaliplatin resistance remains largel…
View article: Development of an Autophagy-Based and Stemness-Correlated Prognostic Model for Hepatocellular Carcinoma Using Bulk and Single-Cell RNA-Sequencing
Development of an Autophagy-Based and Stemness-Correlated Prognostic Model for Hepatocellular Carcinoma Using Bulk and Single-Cell RNA-Sequencing Open
Accumulating evidence has proved that autophagy serves as a tumor promoter in formed malignancies, and the autophagy-related prognostic signatures have been constructed as clinical tools to predict prognosis in many high-mortality cancers.…
View article: [Corrigendum] Silencing of type Iγ phosphatidylinositol phosphate kinase suppresses ovarian cancer cell proliferation, migration and invasion
[Corrigendum] Silencing of type Iγ phosphatidylinositol phosphate kinase suppresses ovarian cancer cell proliferation, migration and invasion Open
Subsequently to the publication of the above paper, the authors have drawn to our attention that the middle panel in Fig. 3B, representing the migration of PIPKIγ‑depleted cells (PIPKIγ‑1), was inadvertently mixed up with the left panel of…
View article: m6A methyltransferase RBM15 promotes cardiomyocytes survival under hypoxia by increasing Thbs4 RNA methylation and mediating PI3K/Akt signaling
m6A methyltransferase RBM15 promotes cardiomyocytes survival under hypoxia by increasing Thbs4 RNA methylation and mediating PI3K/Akt signaling Open
Background mRNA modifications constitute ancient mechanisms in regulating gene expression after transcription. N6-methyladenosis (m6A), which is the most prevalent internal RNA modification, is not only installed by m6A methyltransferases,…
View article: Knockdown of lncRNA PVT1 alleviates high glucose-induced proliferation and fibrosis in human mesangial cells by miR-23b-3p/WT1 axis
Knockdown of lncRNA PVT1 alleviates high glucose-induced proliferation and fibrosis in human mesangial cells by miR-23b-3p/WT1 axis Open
Background Diabetic nephropathy (DN) is a severe complication of diabetes with type 1 and 2. Long non-coding RNAs (lncRNAs) are being found to be involved in the DN pathogenesis. In this study, we aimed to further explore the effect and un…
View article: Corrigendum to “PIPKI <i>γ</i> Regulates CCL2 Expression in Colorectal Cancer by Activating AKT‐STAT3 Signaling”
Corrigendum to “PIPKI <i>γ</i> Regulates CCL2 Expression in Colorectal Cancer by Activating AKT‐STAT3 Signaling” Open
[This corrects the article DOI: 10.1155/2019/3690561.].
View article: PIPKI<i>γ</i> Regulates CCL2 Expression in Colorectal Cancer by Activating AKT-STAT3 Signaling
PIPKI<i>γ</i> Regulates CCL2 Expression in Colorectal Cancer by Activating AKT-STAT3 Signaling Open
Colorectal cancer (CRC) remains the third most commonly diagnosed cancer, ranking second among the most common causes of cancer-related mortality. Immune checkpoint therapy has recently been shown to have great potential. However, only som…
View article: Type Iγ phosphatidylinositol phosphate kinase promotes tumor growth by facilitating Warburg effect in colorectal cancer
Type Iγ phosphatidylinositol phosphate kinase promotes tumor growth by facilitating Warburg effect in colorectal cancer Open
Our findings reveal a new regulatory role of PIPKIγ in Warburg effect and provide a key contributor in colorectal cancer metabolism with potential therapeutic potentials. FUND: National Key Research and Development Program of China, Outsta…
View article: MicroRNA‑152 regulates insulin secretion and pancreatic β cell proliferation by targeting PI3Kα
MicroRNA‑152 regulates insulin secretion and pancreatic β cell proliferation by targeting PI3Kα Open
An increasing number of microRNAs (miRNAs/miRs) are reported to have important roles in diabetes. Glucose‑stimulated insulin secretion and pancreatic β cell proliferation are essential in the control of metabolic disorder, however, the und…
View article: EGFR-induced phosphorylation of type Iγ phosphatidylinositol phosphate kinase promotes pancreatic cancer progression
EGFR-induced phosphorylation of type Iγ phosphatidylinositol phosphate kinase promotes pancreatic cancer progression Open
Pancreatic cancer is one of the deadliest malignancies and effective treatment has always been lacking. In current study, we investigated how the type Iγ phosphatidylinositol phosphate kinase (PIPKIγ) participates in the progression of pan…
View article: Silencing of type Iγ phosphatidylinositol phosphate kinase suppresses ovarian cancer cell proliferation, migration and invasion
Silencing of type Iγ phosphatidylinositol phosphate kinase suppresses ovarian cancer cell proliferation, migration and invasion Open
Metastasis is the major cause of death in ovarian cancer patients. Given that the molecular mechanism underlying metastasis formation is critical for improving therapeutic development and clinical treatment, it must be fully understood. Re…