Jinghua Ren
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View article: [Retracted] Downregulation of Bmi‑1 is associated with suppressed tumorigenesis and induced apoptosis in CD44 <sup>+</sup> nasopharyngeal carcinoma cancer stem‑like cells
[Retracted] Downregulation of Bmi‑1 is associated with suppressed tumorigenesis and induced apoptosis in CD44 <sup>+</sup> nasopharyngeal carcinoma cancer stem‑like cells Open
Following the publication of the above article, a concerned reader drew to the Editor's attention that one set of the tumor data comparing between the 'CD44+' experiments in Fig. 4A and the 'CON' experiments in Fig. 4B on p. 428 had appare…
View article: Analysis of the application of 3D‐printed personalized positioning fixation in nasopharyngeal carcinoma radiotherapy
Analysis of the application of 3D‐printed personalized positioning fixation in nasopharyngeal carcinoma radiotherapy Open
Objective This study aims to evaluate the impact of personalized 3D‐printed headrest devices on setup errors and dosimetry in nasopharyngeal carcinoma radiotherapy. Methods A total of 50 nasopharyngeal carcinoma patients (28 male, 22 femal…
View article: Association between the platelet-albumin-bilirubin score and all-cause mortality in ICU-admitted heart failure patients: a retrospective cohort analysis and machine learning-based prognostic modeling
Association between the platelet-albumin-bilirubin score and all-cause mortality in ICU-admitted heart failure patients: a retrospective cohort analysis and machine learning-based prognostic modeling Open
Background The platelet-albumin-bilirubin (PALBI) score has shown prognostic value across multiple medical conditions; nevertheless, its effectiveness in forecasting prognoses among severely ill heart failure (HF) patients treated in Inten…
View article: Peptide Coacervates with Metal–Phenolic Membranes Modulate Glucose Metabolism and Enhance Cancer Immunotherapy
Peptide Coacervates with Metal–Phenolic Membranes Modulate Glucose Metabolism and Enhance Cancer Immunotherapy Open
Glucose consumption by tumors induces metabolic restriction of T cells, which results in immune evasion and tumor progression. Regulating cellular metabolism represents a promising strategy to enhance cancer immunotherapy; however, redirec…
View article: Elevated ERβ expression driven by low ASB8-mediated ubiquitination in lung adenocarcinoma promotes lymph node metastasis via tumor-associated neutrophils
Elevated ERβ expression driven by low ASB8-mediated ubiquitination in lung adenocarcinoma promotes lymph node metastasis via tumor-associated neutrophils Open
This study investigated the role of estrogen receptor beta (ERβ) in the lymph node metastasis of lung adenocarcinoma (LUAD), focusing on its interaction with tumor-associated neutrophils (TANs) and its regulation of lymphangiogenesis. Clin…
View article: Cadmium accumulation in wheat grain: Accumulation models and soil thresholds for safe production
Cadmium accumulation in wheat grain: Accumulation models and soil thresholds for safe production Open
The high cadmium (Cd) accumulation ability of wheat has garnered significant attention in China. It is crucial to identify the key factors affecting Cd accumulation in wheat and to develop predictive models to derive the threshold concentr…
View article: TGF-β1 induces autophagy and mediates the effect on macrophages differentiation in primary liver cancer
TGF-β1 induces autophagy and mediates the effect on macrophages differentiation in primary liver cancer Open
This integrated transcriptome compendium and experimental validation offer both mechanistic insights and a resource for understanding TAM heterogeneity in primary liver cancers.
View article: Oleanolic Acid Restores Drug Sensitivity in Sorafenib-resistant Hepatocellular Carcinoma: Evidence from <i>In Vitro</i> and <i>In Vivo</i> Studies
Oleanolic Acid Restores Drug Sensitivity in Sorafenib-resistant Hepatocellular Carcinoma: Evidence from <i>In Vitro</i> and <i>In Vivo</i> Studies Open
Oleanolic acid shows promise as an adjunct therapy for overcoming sorafenib resistance in HCC. By reducing cell aggressiveness and restoring drug sensitivity, OA may enhance the therapeutic efficacy of current treatments for advanced HCC.
View article: Targeting pyroptosis reverses KIAA1199-mediated immunotherapy resistance in colorectal cancer
Targeting pyroptosis reverses KIAA1199-mediated immunotherapy resistance in colorectal cancer Open
Background Despite advancements in treatment modalities, several patients with colorectal cancer (CRC) remain unresponsive to immune checkpoint inhibitor therapy. Pyroptosis, an inflammatory programmed cell death process, holds substantial…
View article: Fn14-targeting, NIR-II responsive nanomaterials for enhanced radiotherapy against glioblastomas
Fn14-targeting, NIR-II responsive nanomaterials for enhanced radiotherapy against glioblastomas Open
Diagram illustrating the preparation of Fn14-targeting, NIR-II responsive nanomaterials Fn14-AuNPs, and the proposed mechanism to overcome glioma radioresistance through localized mild heat, which may provide a therapeutic advantage for gl…
View article: ESG's Global Dissemination and Impact: A Cross-Cultural Perspective
ESG's Global Dissemination and Impact: A Cross-Cultural Perspective Open
This study explores the global dissemination and impact of ESG (Environmental, Social, and Governance) from a cross-cultural perspective. By comparing practices and feedback across different cultural backgrounds, the study reveals the simi…
View article: Occurrence characteristics, source analysis and ecological risk of PFASs in different cultivated soil at an urban scale in Yangtze River Basin
Occurrence characteristics, source analysis and ecological risk of PFASs in different cultivated soil at an urban scale in Yangtze River Basin Open
Per- and polyfluorinated substances (PFASs) contaminates the arable soil through multiple paths, and poses a threat to both farmland ecosystems and human health. In this study, the potential sources and distribution characteristics of 12 l…
View article: Neutrophil extracellular traps in cancer
Neutrophil extracellular traps in cancer Open
Neutrophil extracellular traps (NETs), which consist of chromatin DNA studded with granule proteins, are released by neutrophils in response to both infectious and sterile inflammation. Beyond the canonical role in defense against pathogen…
View article: Efficacy and safety of ciprofol for sedation in outpatient gynecological procedures: a phase III multicenter randomized trial
Efficacy and safety of ciprofol for sedation in outpatient gynecological procedures: a phase III multicenter randomized trial Open
Objective Ciprofol (also known as cipepofol and HSK3486), is a compound similar to propofol in chemical structure and hypnotic effect. Herein we evaluated the efficacy and safety of ciprofol for sedation in outpatient gynecological procedu…
View article: Intratumoral Delivery of Interleukin 9 via Oncolytic Vaccinia Virus Elicits Potent Antitumor Effects in Tumor Models
Intratumoral Delivery of Interleukin 9 via Oncolytic Vaccinia Virus Elicits Potent Antitumor Effects in Tumor Models Open
The success of cancer immunotherapy is largely associated with immunologically hot tumors. Approaches that promote the infiltration of immune cells into tumor beds are urgently needed to transform cold tumors into hot tumors. Oncolytic vir…
View article: Efficacy and safety of radiotherapy combined with anti‐angiogenic therapy and immune checkpoint inhibitors in <scp>MSS</scp>/<scp>pMMR</scp> metastatic colorectal cancer
Efficacy and safety of radiotherapy combined with anti‐angiogenic therapy and immune checkpoint inhibitors in <span>MSS</span>/<span>pMMR</span> metastatic colorectal cancer Open
Purpose Several studies have demonstrated the effectiveness of anti‐angiogenic drugs in combination with immune checkpoint inhibitors (ICIs) in patients with microsatellite stable (MSS) or mismatch repair proficient (pMMR) metastatic color…
View article: Medium distribution, source characteristics and ecological risk of bisphenol compounds in agricultural environment
Medium distribution, source characteristics and ecological risk of bisphenol compounds in agricultural environment Open
Bisphenol compounds (BPs) are commonly used in industry and agriculture. However, BPs pollution has already raised global concerns due to their ecological risks. This study investigated nine types of BPs in agricultural soil and irrigation…
View article: Hepatic regulatory T-cells promote colorectal liver metastasis in NASH
Hepatic regulatory T-cells promote colorectal liver metastasis in NASH Open
Background Non-alcoholic steatohepatitis (NASH), a progressive inflammatory form of NAFLD, underlies an extremely versatile and dynamic inflammatory microenvironment along with aberrant metabolism and ongoing liver regeneration. Regulatory…
View article: Supplementary Figure 1 from Rho Kinase Inhibitor Fasudil Suppresses the Vasculogenic Mimicry of B16 Mouse Melanoma Cells Both <i>In Vitro</i> and <i>In Vivo</i>
Supplementary Figure 1 from Rho Kinase Inhibitor Fasudil Suppresses the Vasculogenic Mimicry of B16 Mouse Melanoma Cells Both <i>In Vitro</i> and <i>In Vivo</i> Open
B16 cells were seeded in 96-well plates and incubated with various concentrations of fasudil for 24h. The cell inhibitory rate was measured using an MTT assay. Fasudil inhibited B16 cell proliferation in a dose-dependent manner, and the IC…
View article: Data from Rho Kinase Inhibitor Fasudil Suppresses the Vasculogenic Mimicry of B16 Mouse Melanoma Cells Both <i>In Vitro</i> and <i>In Vivo</i>
Data from Rho Kinase Inhibitor Fasudil Suppresses the Vasculogenic Mimicry of B16 Mouse Melanoma Cells Both <i>In Vitro</i> and <i>In Vivo</i> Open
The aim of this study was to investigate the biologic role of the Rho kinase inhibitor fasudil in the vasculogenic mimicry (VM) of B16 mouse melanoma cells. It was previously reported that RhoA plays a critical role in angiogenesis by coor…
View article: Supplementary Figure 2 from Rho Kinase Inhibitor Fasudil Suppresses the Vasculogenic Mimicry of B16 Mouse Melanoma Cells Both <i>In Vitro</i> and <i>In Vivo</i>
Supplementary Figure 2 from Rho Kinase Inhibitor Fasudil Suppresses the Vasculogenic Mimicry of B16 Mouse Melanoma Cells Both <i>In Vitro</i> and <i>In Vivo</i> Open
(A) HE staining of tissue section. A vessel formed with elongated endothelial cells was showed by a red arrow, moreover, the vessel lack of endothelial cells nearby was pointed out by a yellow arrow. Original magnification, ×400. (B) Plen…
View article: Data from Rho Kinase Inhibitor Fasudil Suppresses the Vasculogenic Mimicry of B16 Mouse Melanoma Cells Both <i>In Vitro</i> and <i>In Vivo</i>
Data from Rho Kinase Inhibitor Fasudil Suppresses the Vasculogenic Mimicry of B16 Mouse Melanoma Cells Both <i>In Vitro</i> and <i>In Vivo</i> Open
The aim of this study was to investigate the biologic role of the Rho kinase inhibitor fasudil in the vasculogenic mimicry (VM) of B16 mouse melanoma cells. It was previously reported that RhoA plays a critical role in angiogenesis by coor…
View article: Supplementary Figure 2 from Rho Kinase Inhibitor Fasudil Suppresses the Vasculogenic Mimicry of B16 Mouse Melanoma Cells Both <i>In Vitro</i> and <i>In Vivo</i>
Supplementary Figure 2 from Rho Kinase Inhibitor Fasudil Suppresses the Vasculogenic Mimicry of B16 Mouse Melanoma Cells Both <i>In Vitro</i> and <i>In Vivo</i> Open
(A) HE staining of tissue section. A vessel formed with elongated endothelial cells was showed by a red arrow, moreover, the vessel lack of endothelial cells nearby was pointed out by a yellow arrow. Original magnification, ×400. (B) Plen…
View article: Supplementary Figure 1 from Rho Kinase Inhibitor Fasudil Suppresses the Vasculogenic Mimicry of B16 Mouse Melanoma Cells Both <i>In Vitro</i> and <i>In Vivo</i>
Supplementary Figure 1 from Rho Kinase Inhibitor Fasudil Suppresses the Vasculogenic Mimicry of B16 Mouse Melanoma Cells Both <i>In Vitro</i> and <i>In Vivo</i> Open
B16 cells were seeded in 96-well plates and incubated with various concentrations of fasudil for 24h. The cell inhibitory rate was measured using an MTT assay. Fasudil inhibited B16 cell proliferation in a dose-dependent manner, and the IC…
View article: Supplementary Figure 1 from Platelet TLR4-ERK5 Axis Facilitates NET-Mediated Capturing of Circulating Tumor Cells and Distant Metastasis after Surgical Stress
Supplementary Figure 1 from Platelet TLR4-ERK5 Axis Facilitates NET-Mediated Capturing of Circulating Tumor Cells and Distant Metastasis after Surgical Stress Open
Hepatic I/R promotes aggregation of platelets with CT26 tumor cells and facilitates NET-mediated tumor cell entrapment.
View article: Supplementary Movie A from Platelet TLR4-ERK5 Axis Facilitates NET-Mediated Capturing of Circulating Tumor Cells and Distant Metastasis after Surgical Stress
Supplementary Movie A from Platelet TLR4-ERK5 Axis Facilitates NET-Mediated Capturing of Circulating Tumor Cells and Distant Metastasis after Surgical Stress Open
Supplementary Movie A