Junling Shi
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View article: Integrative computational-experimental discovery of α-hederin as a multi-mechanistic, low-toxicity antifungal agent targeting Candida albicans CYP51
Integrative computational-experimental discovery of α-hederin as a multi-mechanistic, low-toxicity antifungal agent targeting Candida albicans CYP51 Open
This study advances antifungal drug discovery by validating CYP51 as a high-value target for structure-guided screening, identifying α-hederin as a low-toxicity, multi-mechanistic antifungal agent and establishing a computational-experimen…
View article: Reactive oxygen species in polycystic ovary syndrome: Mechanistic insights into pathogenesis and therapeutic opportunities
Reactive oxygen species in polycystic ovary syndrome: Mechanistic insights into pathogenesis and therapeutic opportunities Open
View article: Bovine Collagen Peptide Improves Hypoxia Tolerance and Anti‐Fatigue Capacity in Hypobaric Hypoxic Environments: A Combined Animal and Human Study
Bovine Collagen Peptide Improves Hypoxia Tolerance and Anti‐Fatigue Capacity in Hypobaric Hypoxic Environments: A Combined Animal and Human Study Open
Peptides are recognized in functional foods for their biological activities. This study investigated the amino acid composition, physicochemical properties, in vitro antioxidant activity, and physiological effects in vivo of bovine collage…
View article: Computational biology predicts metabolic engineering targets for increased production of 103 valuable chemicals in yeast
Computational biology predicts metabolic engineering targets for increased production of 103 valuable chemicals in yeast Open
Development of efficient cell factories that can compete with traditional chemical production processes is complex and generally driven by case-specific strategies, based on the product and microbial host of interest. Despite major advance…
View article: SERS-lateral flow immunoassay based on AuNR@Ag@SiO2-AuNP assembly for ultra-sensitive detection of deoxynivalenol in grain
SERS-lateral flow immunoassay based on AuNR@Ag@SiO2-AuNP assembly for ultra-sensitive detection of deoxynivalenol in grain Open
View article: Effects of derivatization and probiotic transformation on the antioxidative activity of fruit polyphenols
Effects of derivatization and probiotic transformation on the antioxidative activity of fruit polyphenols Open
View article: Sers-Lateral Flow Immunoassay Based on Aunr@Ag@Sio2-Aunp Assembly for Ultra-Sensitive Detection of Deoxynivalenol in Grain
Sers-Lateral Flow Immunoassay Based on Aunr@Ag@Sio2-Aunp Assembly for Ultra-Sensitive Detection of Deoxynivalenol in Grain Open
View article: Therapeutic effect of iturin A on <i>Candida albicans</i> oral infection and its pathogenic factors
Therapeutic effect of iturin A on <i>Candida albicans</i> oral infection and its pathogenic factors Open
Candida albicans is responsible for conditions ranging from superficial infections such as oral or vaginal candidiasis to potentially fatal systemic infections. It produces pathogenic factors contributing to its virulence. Iturin A, a lipo…
View article: tRNA-derived small RNAs are embedded in the gene regulatory network instructing<i>Drosophila</i>metamorphosis
tRNA-derived small RNAs are embedded in the gene regulatory network instructing<i>Drosophila</i>metamorphosis Open
A class of noncoding RNAs, referred to as tsRNAs, is emerging with a potential to exert a new layer in gene regulation. These RNAs are breakdown products of tRNAs, either through active processing or passive cleavage or both. Since tRNAs a…
View article: Editorial: Reviews in the impact of gut microbiota in health and disease
Editorial: Reviews in the impact of gut microbiota in health and disease Open
EDITORIAL article Front. Microbiol., 11 August 2023Sec. Microorganisms in Vertebrate Digestive Systems Volume 14 - 2023 | https://doi.org/10.3389/fmicb.2023.1230925
View article: Crystal Structure Analysis and Characterization of NADP-Dependent Glutamate Dehydrogenase with Alcohols Activity from Geotrichum candidum
Crystal Structure Analysis and Characterization of NADP-Dependent Glutamate Dehydrogenase with Alcohols Activity from Geotrichum candidum Open
To better understand its mechanism of activity towards higher alcohols, we overexpressed and purified new Geotrichum candidum GDH (GcGDH). The purified GcGDH (50.27 kDa) was then crystallized, and the crystal diffracted to a resolution of …
View article: Computational biology predicts metabolic engineering targets for increased production of 102 valuable chemicals in yeast
Computational biology predicts metabolic engineering targets for increased production of 102 valuable chemicals in yeast Open
Development of efficient cell factories that can compete with traditional chemical production processes is complex and generally driven by case-specific strategies, based on the product and microbial host of interest. Despite major advance…
View article: Computational biology predicts metabolic engineering targets for increased production of 102 valuable chemicals in yeast
Computational biology predicts metabolic engineering targets for increased production of 102 valuable chemicals in yeast Open
Development of efficient cell factories that can compete with traditional chemical production processes is complex and generally driven by case-specific strategies, based on the product and microbial host of interest. Despite major advance…
View article: Microgravity and immune cells
Microgravity and immune cells Open
The microgravity environment experienced during spaceflight severely impaired immune system, making astronauts vulnerable to various diseases that seriously threaten the health of astronauts. Immune cells are exceptionally sensitive to cha…
View article: Multiplicative and Additive Interactions of Hyperuricemia and Hypertension on the Risk of Chronic Kidney Disease: Evidence from a Prospective Population-Based Cohort Study
Multiplicative and Additive Interactions of Hyperuricemia and Hypertension on the Risk of Chronic Kidney Disease: Evidence from a Prospective Population-Based Cohort Study Open
View article: Effect of Ketogenic Diets on Body Composition and Metabolic Parameters of Cancer Patients: A Systematic Review and Meta-Analysis
Effect of Ketogenic Diets on Body Composition and Metabolic Parameters of Cancer Patients: A Systematic Review and Meta-Analysis Open
A ketogenic diet characterized by high fat and low carbohydrate can drive the body to produce a large number of ketone bodies, altering human metabolism. Unlike normal cells, tumor cells have difficulty in consuming ketone bodies. Therefor…
View article: Simulated Microgravity Accelerates Alloy Corrosion by Aspergillus sp. via the Enhanced Production of Organic Acids
Simulated Microgravity Accelerates Alloy Corrosion by Aspergillus sp. via the Enhanced Production of Organic Acids Open
The space station and other long-term manned spacecrafts will experience the risk of microbial corrosion, especially mold, which will be harmful to the platform system and astronauts. Aspergillus sp. has been widely reported to produce org…
View article: Effects of Walnut Pulp on the Cultivation Characteristics and Anti-hypoxia Potential of Lactobacillus rhamnosus Enriched with Selenium
Effects of Walnut Pulp on the Cultivation Characteristics and Anti-hypoxia Potential of Lactobacillus rhamnosus Enriched with Selenium Open
In order to develop a cheap and efficient culture system of Lactobacillus rhamnosus, walnut pulp was used to replace the nitrogen source in MRS medium. Taking cell growth as the indicator, the cultivation system was optimized in aspects of…
View article: Improvement of the Biosynthesis of Resveratrol in Endophytic Fungus (Alternaria sp. MG1) by the Synergistic Effect of UV Light and Oligomeric Proanthocyanidins
Improvement of the Biosynthesis of Resveratrol in Endophytic Fungus (Alternaria sp. MG1) by the Synergistic Effect of UV Light and Oligomeric Proanthocyanidins Open
Resveratrol, a natural polyphenol compound with multiple bioactivities, is widely used in food and pharmaceutical industry. Endophytic fungus Alternaria sp. MG1, as a native producer of resveratrol, shows increasing potential application. …
View article: Effects of Bacillus subtilis iturin A on HepG2 cells in vitro and vivo
Effects of Bacillus subtilis iturin A on HepG2 cells in vitro and vivo Open
View article: A Review of ULK1-Mediated Autophagy in Drug Resistance of Cancer
A Review of ULK1-Mediated Autophagy in Drug Resistance of Cancer Open
The difficulty of early diagnosis and the development of drug resistance are two major barriers to the successful treatment of cancer. Autophagy plays a crucial role in several cellular functions, and its dysregulation is associated with b…
View article: Tracing the mass flow from glucose and phenylalanine to pinoresinol and its glycosides in Phomopsis sp. XP-8 using stable isotope assisted TOF-MS
Tracing the mass flow from glucose and phenylalanine to pinoresinol and its glycosides in Phomopsis sp. XP-8 using stable isotope assisted TOF-MS Open
Phomopsis sp. XP-8, an endophytic fungus from the bark of Tu-Chung ( Eucommia ulmoides Oliv) showed capability to biosynthesize pinoresinol (Pin) and pinoresinol diglucoside (PDG) from glucose (glu) and phenylalanine (Phe). To verify the m…
View article: Hydrogen Sulfide From Cysteine Desulfurase, Not 3-Mercaptopyruvate Sulfurtransferase, Contributes to Sustaining Cell Growth and Bioenergetics in E. coli Under Anaerobic Conditions
Hydrogen Sulfide From Cysteine Desulfurase, Not 3-Mercaptopyruvate Sulfurtransferase, Contributes to Sustaining Cell Growth and Bioenergetics in E. coli Under Anaerobic Conditions Open
Endogenous hydrogen sulfide (H2S), which is primarily generated by 3-mercaptopyruvate sulfurtransferase (3-MST) in Escherichia coli (E. coli) under aerobic conditions, renders bacteria highly resistant to oxidative…
View article: Clinostat Rotation Affects Metabolite Transportation and Increases Organic Acid Production by <i>Aspergillus carbonarius</i> , as Revealed by Differential Metabolomic Analysis
Clinostat Rotation Affects Metabolite Transportation and Increases Organic Acid Production by <i>Aspergillus carbonarius</i> , as Revealed by Differential Metabolomic Analysis Open
Fungi are ubiquitous in nature and have the ability to corrode various materials by producing metabolites. Research on how the space station environment, especially microgravity, affects fungal metabolism is helpful to understand the role …
View article: Anti-tumor potential of cell free culture supernatant of Lactobacillus rhamnosus strains isolated from human breast milk
Anti-tumor potential of cell free culture supernatant of Lactobacillus rhamnosus strains isolated from human breast milk Open
View article: Genomic sequencing, genome-scale metabolic network reconstruction, and in silico flux analysis of the grape endophytic fungus Alternaria sp. MG1
Genomic sequencing, genome-scale metabolic network reconstruction, and in silico flux analysis of the grape endophytic fungus Alternaria sp. MG1 Open
This study details the diverse capability and key genes of Alternaria sp. MG1 to produce multiple secondary metabolites. The first model of the species Alternaria was constructed, providing an overall understanding of the physiological beh…
View article: Correction to: Characterization, the Antioxidant and Antimicrobial Activity of Exopolysaccharide Isolated from Poultry Origin Lactobacilli
Correction to: Characterization, the Antioxidant and Antimicrobial Activity of Exopolysaccharide Isolated from Poultry Origin Lactobacilli Open
View article: MOESM7 of Genomic sequencing, genome-scale metabolic network reconstruction, and in silico flux analysis of the grape endophytic fungus Alternaria sp. MG1
MOESM7 of Genomic sequencing, genome-scale metabolic network reconstruction, and in silico flux analysis of the grape endophytic fungus Alternaria sp. MG1 Open
Additional file 7. Dataset S6. Flux distribution involved in resveratrol synthesis with the ethanol uptake rate perturbed from 0 to 0.05Â mmol/gDW/h.
View article: MOESM6 of Genomic sequencing, genome-scale metabolic network reconstruction, and in silico flux analysis of the grape endophytic fungus Alternaria sp. MG1
MOESM6 of Genomic sequencing, genome-scale metabolic network reconstruction, and in silico flux analysis of the grape endophytic fungus Alternaria sp. MG1 Open
Additional file 6. Dataset S5. Flux distribution with the resveratrol production rate increased from 0.0073 to 0.02Â mmol/gDW/h.
View article: MOESM5 of Genomic sequencing, genome-scale metabolic network reconstruction, and in silico flux analysis of the grape endophytic fungus Alternaria sp. MG1
MOESM5 of Genomic sequencing, genome-scale metabolic network reconstruction, and in silico flux analysis of the grape endophytic fungus Alternaria sp. MG1 Open
Additional file 5. Dataset S4. Result of essential genes identified by FBA using PDB medium.