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View article: Gingival mesenchymal stem cells derived from patients with rheumatoid arthritis treat experimental arthritis
Gingival mesenchymal stem cells derived from patients with rheumatoid arthritis treat experimental arthritis Open
A therapeutic strategy using mesenchymal stem cells (MSCs) has been accepted as a novel therapy for treating rheumatoid arthritis (RA). Human gingiva‐derived MSCs (GMSCs) are superior in regulating immune responses. Autologous MSCs are the…
View article: miRNA-148a–containing GMSC-derived EVs modulate Treg/Th17 balance via IKKB/NF-κB pathway and treat a rheumatoid arthritis model
miRNA-148a–containing GMSC-derived EVs modulate Treg/Th17 balance via IKKB/NF-κB pathway and treat a rheumatoid arthritis model Open
Mesenchymal stem cells (MSCs) have demonstrated potent immunomodulatory properties that have shown promise in the treatment of autoimmune diseases, including rheumatoid arthritis (RA). However, the inherent heterogeneity of MSCs triggered …
View article: Targeting kinase ITK treats autoimmune arthritis via orchestrating T cell differentiation and function
Targeting kinase ITK treats autoimmune arthritis via orchestrating T cell differentiation and function Open
IL-2 inducible T cell kinase (ITK) is critical in T helper subset differentiation and its inhibition has been suggested for the treatment of T cell-mediated inflammatory diseases. T follicular helper (Tfh), Th17 and regulatory T cells (Tre…
View article: RA Fibroblast-Like Synoviocytes Derived Extracellular Vesicles Promote Angiogenesis by miRNA-1972 Targeting p53/mTOR Signaling in Vascular Endotheliocyte
RA Fibroblast-Like Synoviocytes Derived Extracellular Vesicles Promote Angiogenesis by miRNA-1972 Targeting p53/mTOR Signaling in Vascular Endotheliocyte Open
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammatory in joints. Invasive pannus is a characteristic pathological feature of RA. RA fibroblast-like synoviocytes (FLSs) are showed tumor-like biological cha…
View article: Construction of CII-Specific CAR-T to Explore the Cytokine Cascades Between Cartilage-Reactive T Cells and Chondrocytes
Construction of CII-Specific CAR-T to Explore the Cytokine Cascades Between Cartilage-Reactive T Cells and Chondrocytes Open
Cytokine cascades exist in many autoimmune disorders which amplify and sustain the autoimmune process and lead to chronic inflammatory injury to the host tissues. Increasing evidence indicates that chondrocytes can interact with T cells, w…
View article: Induced, but not natural, regulatory T cells retain phenotype and function following exposure to inflamed synovial fibroblasts
Induced, but not natural, regulatory T cells retain phenotype and function following exposure to inflamed synovial fibroblasts Open
Induced regulatory T cells are phenotypic and functionally stable when encountering inflamed synovial fibroblast.
View article: Sonic Hedgehog Regulates Proliferation, Migration and Invasion of Synoviocytes in Rheumatoid Arthritis via JNK Signaling
Sonic Hedgehog Regulates Proliferation, Migration and Invasion of Synoviocytes in Rheumatoid Arthritis via JNK Signaling Open
Activated fibroblast-like synoviocytes (FLSs) play a central role in the formation of synovial pannus and joint destruction in rheumatoid arthritis (RA). Targeting FLSs could be a potential therapeutic strategy. The objective of this study…
View article: Human gingival tissue-derived MSC suppress osteoclastogenesis and bone erosion via CD39-adenosine signal pathway in autoimmune arthritis
Human gingival tissue-derived MSC suppress osteoclastogenesis and bone erosion via CD39-adenosine signal pathway in autoimmune arthritis Open
GMSC inhibit osteoclast formation in vitro and in vivo partially via CD39-CD73-adenosine signals. Manipulation of GMSC may have a therapeutic implication on rheumatoid arthritis and other bone erosion related diseases. FUND: This study was…
View article: Negligible Effect of Sodium Chloride on the Development and Function of TGF-β-Induced CD4+ Foxp3+ Regulatory T Cells
Negligible Effect of Sodium Chloride on the Development and Function of TGF-β-Induced CD4+ Foxp3+ Regulatory T Cells Open
High-salt diets inhibit the suppressive function of thymus-derived natural regulatory T cells (tTreg). Transforming growth factor β (TGF-β)-induced ex vivo regulatory T cells (iTreg) comprise another Treg subset that exhibits similarities …
View article: Additional file 3: of A preclinical study—systemic evaluation of safety on mesenchymal stem cells derived from human gingiva tissue
Additional file 3: of A preclinical study—systemic evaluation of safety on mesenchymal stem cells derived from human gingiva tissue Open
Table S2. Electrocardiogram of rhesus by intravenous injection of GMSCs in short-term toxicity test (n = 4, x ¯ $$ \overline{x} $$ ± S). (XLS 29 kb)
View article: Additional file 2: of A preclinical studyâ systemic evaluation of safety on mesenchymal stem cells derived from human gingiva tissue
Additional file 2: of A preclinical studyâ systemic evaluation of safety on mesenchymal stem cells derived from human gingiva tissue Open
Table S1. Rating criteria of abnormal behavior. (XLS 26 kb)
View article: A protocol for humanized synovitis mice model.
A protocol for humanized synovitis mice model. Open
Rheumatoid arthritis (RA) is a debilitating autoimmune disease that causes progressive chronic inflammation of the joints and destruction of articular cartilage and bone erosion. Cartilage destruction is a key characteristic in patients wi…
View article: Additional file 5: of A preclinical study—systemic evaluation of safety on mesenchymal stem cells derived from human gingiva tissue
Additional file 5: of A preclinical study—systemic evaluation of safety on mesenchymal stem cells derived from human gingiva tissue Open
Table S4. Bone marrow count of rhesus by intravenous injection of GMSCs in long-term toxicity test (n = 4, x ¯ $$ \overline{x} $$ ± S). (XLS 31 kb)
View article: Additional file 4: of A preclinical study—systemic evaluation of safety on mesenchymal stem cells derived from human gingiva tissue
Additional file 4: of A preclinical study—systemic evaluation of safety on mesenchymal stem cells derived from human gingiva tissue Open
Table S3. Electrocardiogram of rhesus by intravenous injection of GMSCs in long-term toxicity test (n = 4, x ¯ $$ \overline{x} $$ ± S). (XLS 29 kb)
View article: Human Gingiva-Derived Mesenchymal Stem Cells Ameliorate Streptozoticin-induced T1DM in mice via Suppression of T effector cells and Up-regulating Treg Subsets
Human Gingiva-Derived Mesenchymal Stem Cells Ameliorate Streptozoticin-induced T1DM in mice via Suppression of T effector cells and Up-regulating Treg Subsets Open
There is yet no cure for type 1 diabetes (T1DM) so far. A significant body of evidence has demonstrated that bone marrow-derived mesenchymal stem cells (BMSCs) showed great potential in controlling T1DM. But there exists much difficulty in…
View article: Human Gingiva-Derived Mesenchymal Stem Cells Inhibit Xeno-Graft-versus-Host Disease via CD39–CD73–Adenosine and IDO Signals
Human Gingiva-Derived Mesenchymal Stem Cells Inhibit Xeno-Graft-versus-Host Disease via CD39–CD73–Adenosine and IDO Signals Open
Mesenchymal stem cells have the capacity to maintain immune homeostasis and prevent autoimmunity. We recently reported that human-derived gingival mesenchymal stem cells (GMSCs) have strong capacity to suppress immune responses and T cell-…