Junlong Xue
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View article: Host angiogenic reprogramming by Echinococcus multilocularis protoscoleces protein via PDGFR/PI3K/AKT cascade
Host angiogenic reprogramming by Echinococcus multilocularis protoscoleces protein via PDGFR/PI3K/AKT cascade Open
Background Alveolar echinococcosis (AE) is a globally present zoonotic disease caused by Echinococcus multilocularis ( E. multilocularis ) infection, characterized by the formation of tumor-like growths primarily in the liver, with the pot…
View article: CD155 as a therapeutic target in alveolar echinococcosis: insights from an Echinococcus multilocularis infection mouse model
CD155 as a therapeutic target in alveolar echinococcosis: insights from an Echinococcus multilocularis infection mouse model Open
Introduction Alveolar echinococcosis (AE) is a life-threatening zoonotic parasitic disease caused by the metacestode stage of Echinococcus multilocularis , characterized by granulomatous lesions and liver fibrosis. Immune exhaustion is the…
View article: ADSCs attenuate Liver fibrosis via inducing HSC senescence: validation in dual-etiology models
ADSCs attenuate Liver fibrosis via inducing HSC senescence: validation in dual-etiology models Open
Background Liver fibrosis (LF) results from various causes, which require finding conserved mechanisms to help treat related diseases. Although adipose-derived stem cells (ADSCs) transplantation can alleviate hepatic fibrosis, their mechan…
View article: The paradigm shifts of periodontal regeneration strategy: From reparative manipulation to developmental engineering
The paradigm shifts of periodontal regeneration strategy: From reparative manipulation to developmental engineering Open
View article: Identifying KLF14 as a potential regulatory factor in liver regeneration trough transcriptomic and metabolomic
Identifying KLF14 as a potential regulatory factor in liver regeneration trough transcriptomic and metabolomic Open
Liver regeneration is a complex process crucial for recovery after partial hepatectomy (PH) or ex-vivo liver resection and autotransplantation (ELRA). This study aimed to explore the molecular mechanisms involved in liver regeneration by a…
View article: Enhancing Mesenchymal Stem Cell Functionality Through Nestin Overexpression: A Novel Approach for Treating End-Stage Liver Disease
Enhancing Mesenchymal Stem Cell Functionality Through Nestin Overexpression: A Novel Approach for Treating End-Stage Liver Disease Open
Transplantation of mesenchymal stem cells (MSCs) represents a novel therapeutic strategy for end-stage liver disease. However, the clinical application of MSCs is limited by challenges in their proliferation and procurement. In this study,…
View article: Evolution of Biological Hydroxyapatite Modification Strategy: Anti-Inflammation Approach Rescues the Calcium–NOD-Like Receptor–Inflammation Axis-Mediated Periodontal Redevelopment Failure
Evolution of Biological Hydroxyapatite Modification Strategy: Anti-Inflammation Approach Rescues the Calcium–NOD-Like Receptor–Inflammation Axis-Mediated Periodontal Redevelopment Failure Open
Periodontal regenerative medicine is currently undergoing a paradigm shift from dissecting the healing process toward utilization of the developmental program. Biological hydroxyapatite (BHA), a major component of guided tissue regeneratio…
View article: Nature Knows Best: Extracellular Matrix‐Gelatin Hydrogel Masking Bioauthentic Bone Scaffold Locking Blood Clot to Induce M2 Macrophage‐Mediated Bone Regeneration via Activating an Endocytosis‐Macroautophagy‐Inflammation Axis
Nature Knows Best: Extracellular Matrix‐Gelatin Hydrogel Masking Bioauthentic Bone Scaffold Locking Blood Clot to Induce M2 Macrophage‐Mediated Bone Regeneration via Activating an Endocytosis‐Macroautophagy‐Inflammation Axis Open
Individualized biological hydroxyapatite (BHA) scaffolds are essential for repairing critical craniomaxillofacial bone defects. Additive manufacturing relies on synthetic hydroxyapatite and biomimetic structures, making the resulting scaff…
View article: Inducing the “re-development state” of periodontal ligament cells via tuning macrophage mediated immune microenvironment
Inducing the “re-development state” of periodontal ligament cells via tuning macrophage mediated immune microenvironment Open
The results of this study could provide some favorable theoretical bases for applying periodontal development engineering strategy in resolving the difficulties in periodontal multi-tissue regeneration.
View article: Cell-free immunomodulatory biomaterials mediated in situ periodontal multi-tissue regeneration and their immunopathophysiological processes
Cell-free immunomodulatory biomaterials mediated in situ periodontal multi-tissue regeneration and their immunopathophysiological processes Open