Junmei Cairns
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View article: Plasma interleukin-22 concentration and disease activity in inflammatory bowel disease
Plasma interleukin-22 concentration and disease activity in inflammatory bowel disease Open
The relationship between interleukin-22 and clinical characteristics of patients with inflammatory bowel disease is uncertain. We sought to determine whether plasma interleukin-22 concentrations are associated with disease activity in a la…
View article: Lessons learned from a candidate gene study investigating aromatase inhibitor treatment outcome in breast cancer
Lessons learned from a candidate gene study investigating aromatase inhibitor treatment outcome in breast cancer Open
The role of germline genetics in adjuvant aromatase inhibitor (AI) treatment efficacy in ER-positive breast cancer is poorly understood. We employed a two-stage candidate gene approach to examine associations between survival endpoints and…
View article: Table S3 from Anastrozole Regulates Fatty Acid Synthase in Breast Cancer
Table S3 from Anastrozole Regulates Fatty Acid Synthase in Breast Cancer Open
Table S3 shows Overlapped genes (highlighted) between ERα CHIPseq in the presence of anastrozole and RNAseq in the presence of anastrozole.
View article: Table S3 from Anastrozole Regulates Fatty Acid Synthase in Breast Cancer
Table S3 from Anastrozole Regulates Fatty Acid Synthase in Breast Cancer Open
Table S3 shows Overlapped genes (highlighted) between ERα CHIPseq in the presence of anastrozole and RNAseq in the presence of anastrozole.
View article: Table S2 from Anastrozole Regulates Fatty Acid Synthase in Breast Cancer
Table S2 from Anastrozole Regulates Fatty Acid Synthase in Breast Cancer Open
Table S2 shows ERα binding partners in the presence of anastrozole or E2
View article: Table S1 from Anastrozole Regulates Fatty Acid Synthase in Breast Cancer
Table S1 from Anastrozole Regulates Fatty Acid Synthase in Breast Cancer Open
Table S1 shows FASN CHIP primers
View article: Supplementary Information and Figures from Anastrozole Regulates Fatty Acid Synthase in Breast Cancer
Supplementary Information and Figures from Anastrozole Regulates Fatty Acid Synthase in Breast Cancer Open
Supplementary information and Figures S1-S6
View article: Data from Anastrozole Regulates Fatty Acid Synthase in Breast Cancer
Data from Anastrozole Regulates Fatty Acid Synthase in Breast Cancer Open
Our previous matched case–control study of postmenopausal women with resected early-stage breast cancer revealed that only anastrozole, but not exemestane or letrozole, showed a significant association between the 6-month estrogen concentr…
View article: Table S1 from Anastrozole Regulates Fatty Acid Synthase in Breast Cancer
Table S1 from Anastrozole Regulates Fatty Acid Synthase in Breast Cancer Open
Table S1 shows FASN CHIP primers
View article: Supplementary Information and Figures from Anastrozole Regulates Fatty Acid Synthase in Breast Cancer
Supplementary Information and Figures from Anastrozole Regulates Fatty Acid Synthase in Breast Cancer Open
Supplementary information and Figures S1-S6
View article: Table S2 from Anastrozole Regulates Fatty Acid Synthase in Breast Cancer
Table S2 from Anastrozole Regulates Fatty Acid Synthase in Breast Cancer Open
Table S2 shows ERα binding partners in the presence of anastrozole or E2
View article: Data from Anastrozole Regulates Fatty Acid Synthase in Breast Cancer
Data from Anastrozole Regulates Fatty Acid Synthase in Breast Cancer Open
Our previous matched case–control study of postmenopausal women with resected early-stage breast cancer revealed that only anastrozole, but not exemestane or letrozole, showed a significant association between the 6-month estrogen concentr…
View article: Data from Anastrozole has an Association between Degree of Estrogen Suppression and Outcomes in Early Breast Cancer and is a Ligand for Estrogen Receptor α
Data from Anastrozole has an Association between Degree of Estrogen Suppression and Outcomes in Early Breast Cancer and is a Ligand for Estrogen Receptor α Open
Purpose:To determine if the degree of estrogen suppression with aromatase inhibitors (AI: anastrozole, exemestane, letrozole) is associated with efficacy in early-stage breast cancer, and to examine for differences in the mechanism of acti…
View article: Data from Anastrozole has an Association between Degree of Estrogen Suppression and Outcomes in Early Breast Cancer and is a Ligand for Estrogen Receptor α
Data from Anastrozole has an Association between Degree of Estrogen Suppression and Outcomes in Early Breast Cancer and is a Ligand for Estrogen Receptor α Open
Purpose:To determine if the degree of estrogen suppression with aromatase inhibitors (AI: anastrozole, exemestane, letrozole) is associated with efficacy in early-stage breast cancer, and to examine for differences in the mechanism of acti…
View article: Supplementary Data Clean from Anastrozole has an Association between Degree of Estrogen Suppression and Outcomes in Early Breast Cancer and is a Ligand for Estrogen Receptor α
Supplementary Data Clean from Anastrozole has an Association between Degree of Estrogen Suppression and Outcomes in Early Breast Cancer and is a Ligand for Estrogen Receptor α Open
This file is the revised clean Supplementary Data
View article: Supplementary Data Clean from Anastrozole has an Association between Degree of Estrogen Suppression and Outcomes in Early Breast Cancer and is a Ligand for Estrogen Receptor α
Supplementary Data Clean from Anastrozole has an Association between Degree of Estrogen Suppression and Outcomes in Early Breast Cancer and is a Ligand for Estrogen Receptor α Open
This file is the revised clean Supplementary Data
View article: Interpretable histopathology-based prediction of disease relevant features in Inflammatory Bowel Disease biopsies using weakly-supervised deep learning
Interpretable histopathology-based prediction of disease relevant features in Inflammatory Bowel Disease biopsies using weakly-supervised deep learning Open
Crohn's Disease (CD) and Ulcerative Colitis (UC) are the two main Inflammatory Bowel Disease (IBD) types. We developed deep learning models to identify histological disease features for both CD and UC using only endoscopic labels. We explo…
View article: Preclinical-to-Clinical Anti-Cancer Drug Response Prediction and Biomarker Identification Using TINDL
Preclinical-to-Clinical Anti-Cancer Drug Response Prediction and Biomarker Identification Using TINDL Open
Prediction of the response of cancer patients to different treatments and identification of biomarkers of drug response are two major goals of individualized medicine. Here, we developed a deep learning framework called TINDL, completely t…
View article: Testis- specific Y-encoded- like protein 1 and cholesterol metabolism: Regulation of CYP1B1 expression through Wnt signaling
Testis- specific Y-encoded- like protein 1 and cholesterol metabolism: Regulation of CYP1B1 expression through Wnt signaling Open
The cytochromes P450 (CYPs) represent a large gene superfamily that plays an important role in the metabolism of both exogenous and endogenous compounds. We have reported that the testis-specific Y-encoded-like proteins (TSPYLs) are novel …
View article: Anastrozole Regulates Fatty Acid Synthase in Breast Cancer
Anastrozole Regulates Fatty Acid Synthase in Breast Cancer Open
Our previous matched case–control study of postmenopausal women with resected early-stage breast cancer revealed that only anastrozole, but not exemestane or letrozole, showed a significant association between the 6-month estrogen concentr…
View article: A Deep Learning Framework for Prediction of Clinical Drug Response of Cancer Patients and Identification of Drug Sensitivity Biomarkers using Preclinical Samples
A Deep Learning Framework for Prediction of Clinical Drug Response of Cancer Patients and Identification of Drug Sensitivity Biomarkers using Preclinical Samples Open
Background Prediction of the response of cancer patients to different treatments and identification of biomarkers of drug sensitivity are two major goals of individualized medicine. In this study, we developed a deep learning framework cal…
View article: Interaction Between SNP Genotype and Efficacy of Anastrozole and Exemestane in Early‐Stage Breast Cancer
Interaction Between SNP Genotype and Efficacy of Anastrozole and Exemestane in Early‐Stage Breast Cancer Open
Aromatase inhibitors (AIs) are the treatment of choice for hormone receptor–positive early breast cancer in postmenopausal women. None of the third‐generation AIs are superior to the others in terms of efficacy. We attempted to identify ge…
View article: CDC25B partners with PP2A to induce AMPK activation and tumor suppression in triple negative breast cancer
CDC25B partners with PP2A to induce AMPK activation and tumor suppression in triple negative breast cancer Open
Cell division cycle 25 (CDC25) dual specificity phosphatases positively regulate the cell cycle by activating cyclin-dependent kinase/cyclin complexes. Here, we demonstrate that in addition to its role in cell cycle regulation, CDC25B func…
View article: Pharmacogenomics of aromatase inhibitors in postmenopausal breast cancer and additional mechanisms of anastrozole action
Pharmacogenomics of aromatase inhibitors in postmenopausal breast cancer and additional mechanisms of anastrozole action Open
Aromatase inhibitors (AIs) reduce breast cancer recurrence and prolong survival, but up to 30% of patients exhibit recurrence. Using a genome-wide association study of patients entered on MA.27, a phase III randomized trial of anastrozole …
View article: Single-nucleotide polymorphism biomarkers of adjuvant anastrozole-induced estrogen suppression in early breast cancer
Single-nucleotide polymorphism biomarkers of adjuvant anastrozole-induced estrogen suppression in early breast cancer Open
Objectives Based on our previous findings that postmenopausal women with estrone (E1) and estradiol (E2) concentrations at or above 1.3 pg/ml and 0.5 pg/ml, respectively, after 6 months of adjuvant anastrozole therapy had a three-fold risk…
View article: Anastrozole has an Association between Degree of Estrogen Suppression and Outcomes in Early Breast Cancer and is a Ligand for Estrogen Receptor α
Anastrozole has an Association between Degree of Estrogen Suppression and Outcomes in Early Breast Cancer and is a Ligand for Estrogen Receptor α Open
Purpose: To determine if the degree of estrogen suppression with aromatase inhibitors (AI: anastrozole, exemestane, letrozole) is associated with efficacy in early-stage breast cancer, and to examine for differences in the mechanism of act…
View article: Deep sequencing across germline genome-wide association study signals relating to breast cancer events in women receiving aromatase inhibitors for adjuvant therapy of early breast cancer
Deep sequencing across germline genome-wide association study signals relating to breast cancer events in women receiving aromatase inhibitors for adjuvant therapy of early breast cancer Open
We were unable to identify common or rare variant regions that added value to the findings from our previous GWAS. We did find two haplotypes that were significant after adjusting for our top GWAS SNP but these were considered to be of mar…
View article: Identification of pathways associated with chemosensitivity through network embedding
Identification of pathways associated with chemosensitivity through network embedding Open
Basal gene expression levels have been shown to be predictive of cellular response to cytotoxic treatments. However, such analyses do not fully reveal complex genotype- phenotype relationships, which are partly encoded in highly interconne…
View article: Anastrozole Aromatase Inhibitor Plasma Drug Concentration Genome‐Wide Association Study: Functional Epistatic Interaction Between <i><scp>SLC</scp>38A7</i> and <i><scp>ALPPL</scp>2</i>
Anastrozole Aromatase Inhibitor Plasma Drug Concentration Genome‐Wide Association Study: Functional Epistatic Interaction Between <i><span>SLC</span>38A7</i> and <i><span>ALPPL</span>2</i> Open
Anastrozole is a widely prescribed aromatase inhibitor for the therapy of estrogen receptor positive ( ER +) breast cancer. We performed a genome‐wide association study ( GWAS ) for plasma anastrozole concentrations in 687 postmenopausal w…