Junmi Lu
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View article: Association between microsatellite instability status, clinicopathological features and mitochondrial DNA amplification in patients with colorectal cancer
Association between microsatellite instability status, clinicopathological features and mitochondrial DNA amplification in patients with colorectal cancer Open
The relationship between BRAF-V600E mutations, mitochondrial DNA amplification and microsatellite instability-high (MSI-H) in colorectal cancer (CRC) has yet to be fully elucidated. The aim of the present study was to assess the associatio…
View article: CD4+ T-Cell Legumain Deficiency Attenuates Hypertensive Damage via Preservation of TRAF6
CD4+ T-Cell Legumain Deficiency Attenuates Hypertensive Damage via Preservation of TRAF6 Open
BACKGROUND: T cells are central to the immune responses contributing to hypertension. LGMN (legumain) is highly expressed in T cells; however, its role in the pathogenesis of hypertension remains unclear. METHODS: Peripheral blood samples …
View article: Improving fusion call confidence and reliability through an optimized process in low quality RNA from formalin-fixed, paraffin-embedded samples
Improving fusion call confidence and reliability through an optimized process in low quality RNA from formalin-fixed, paraffin-embedded samples Open
Identifying fusion genes in solid tumors is crucial for precision diagnosis and treatment of cancer patients. However, poor RNA quality may pose a major challenge to the reliability of fusion detection. In this study, an optimized RNA fusi…
View article: HMGB family proteins: Potential biomarkers and mechanistic factors in cardiovascular diseases
HMGB family proteins: Potential biomarkers and mechanistic factors in cardiovascular diseases Open
Cardiovascular disease (CVD) is the most fatal disease that causes sudden death, and inflammation contributes substantially to its occurrence and progression. The prevalence of CVD increases as the population ages, and the pathophysiology …
Overexpression of p-Akt, p-mTOR and p-eIF4E proteins associates with metastasis and unfavorable prognosis in non-small cell lung cancer Open
The Akt (protein kinase B)/mammalian target of rapamycin (mTOR) pathway, which is dysregulated in various cancers, controls the assembly of eukaryotic translation initiation factor 4F (eIF4E) complex. However, whether aberrant expression o…
View article: Expression of DR5 and c‑FLIP proteins as novel prognostic biomarkers for non‑small cell lung cancer patients treated with surgical resection and chemotherapy
Expression of DR5 and c‑FLIP proteins as novel prognostic biomarkers for non‑small cell lung cancer patients treated with surgical resection and chemotherapy Open
TRAIL‑R2 (DR5), one of the death receptors, can activate the extrinsic apoptosis pathway, while cellular FLICE‑inhibitory protein (c‑FLIP) can inhibit this pathway. Both of them play important roles in the occurrence and development of mos…
View article: Elevated expression of G3BP1 associates with YB1 and p‐AKT and predicts poor prognosis in nonsmall cell lung cancer patients after surgical resection
Elevated expression of G3BP1 associates with YB1 and p‐AKT and predicts poor prognosis in nonsmall cell lung cancer patients after surgical resection Open
Purpose G3BP1 is an RNA‐binding protein and plays roles in regulating signaling pathway. YB‐1 is a DNA/RNA binding protein encoded by YBX1 gene. Phosphorylated AKT (p‐AKT) acts as a pivotal molecule in PI3K/AKT pathway. YB‐1 drives stress …
View article: <p>Prognostic analysis of patients with mutant and wild-type <em>EGFR</em> gene lung adenocarcinoma</p>
Prognostic analysis of patients with mutant and wild-type <em>EGFR</em> gene lung adenocarcinoma Open
The OS time of patients with mutation of exon 18 was lower than those of exon 19 and exon 21. EGFR-TKI treatment was an independent positive predictor in patients with EGFR gene mutation. Surgery treatment, age, clinical stages, and pathol…
View article: Detection and application of circulating tumor cell and circulating tumor DNA in the non-small cell lung cancer.
Detection and application of circulating tumor cell and circulating tumor DNA in the non-small cell lung cancer. Open
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death in both men and women. The ability of cancer cells to break-off from the primary tumor and spread to distant organs is the main cause of death of cancer patien…
View article: MicroRNAs associated with therapy of non-small cell lung cancer
MicroRNAs associated with therapy of non-small cell lung cancer Open
The incidence of non-small cell lung cancer (NSCLC) has been rising over the past several decades. Despite various therapeutic regimens and modern diagnostic techniques are developed, NSCLC still have an extremely poor prognosis due to dru…
View article: Long non-coding RNAs associated with non-small cell lung cancer
Long non-coding RNAs associated with non-small cell lung cancer Open
Lung cancer, with 80-85% being non-small cell lung cancer (NSCLC), is the leading cause of cancer-related death in both men and women. Long non-coding RNAs (lncRNAs), always defined as non-protein-coding RNA molecules longer than 200 nucle…
View article: Primary synovial sarcoma of the larynx in a 14-year-old boy diagnosed by immunohistochemistry and fluorescence in situ hybridization: a rare case report.
Primary synovial sarcoma of the larynx in a 14-year-old boy diagnosed by immunohistochemistry and fluorescence in situ hybridization: a rare case report. Open
Synovial sarcoma (SS) is an aggressive soft tissue tumor, which occurs predominantly in young adults. The SS can arise in almost any part of the body, especially in the lower extremity. The SS of head and neck accounts for 1.9-3.5% of all …
View article: High expression of heat shock protein 10 (Hsp10) is associated with poor prognosis in oral squamous cell carcinoma.
High expression of heat shock protein 10 (Hsp10) is associated with poor prognosis in oral squamous cell carcinoma. Open
Heat shock protein 10 (Hsp10), located in mitochondria, is a co-chaperone involved in the protein folding and aggregation with Hsp60. Besides, a wide range of other extramitochondrial and extracellular activities, such a mammalian mitochon…