Junming Yie
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View article: A protective human antibody against respiratory syncytial virus by targeting a prefusion epitope across sites IV and V of the viral fusion glycoprotein
A protective human antibody against respiratory syncytial virus by targeting a prefusion epitope across sites IV and V of the viral fusion glycoprotein Open
Respiratory syncytial virus (RSV) is one of the leading pathogens that cause lower respiratory tract infections in infants and the elderly. Passive immunoprophylaxis with monoclonal antibody (mAb) has been approved to prevent morbidity and…
View article: Molecular mechanism of an antagonistic antibody against glucose-dependent insulinotropic polypeptide receptor
Molecular mechanism of an antagonistic antibody against glucose-dependent insulinotropic polypeptide receptor Open
Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone involved in regulating glucose and lipid metabolism. GIP receptor (GIPR) antagonism is believed to offer therapeutic potential for various metabolic diseases. Pharma…
View article: Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models
Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models Open
Antibody antagonists of the insulinotropic receptor GIPR prevent weight gain in obese animal models, and the effect is enhanced by GLP-1R agonists.
View article: Erratum: Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15
Erratum: Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15 Open
View article: A Novel Fc-FGF21 With Improved Resistance to Proteolysis, Increased Affinity Toward β-Klotho, and Enhanced Efficacy in Mice and Cynomolgus Monkeys
A Novel Fc-FGF21 With Improved Resistance to Proteolysis, Increased Affinity Toward β-Klotho, and Enhanced Efficacy in Mice and Cynomolgus Monkeys Open
Fibroblast growth factor (FGF) 21 is a natural hormone that modulates glucose, lipid, and energy metabolism. Previously, we engineered an Fc fusion FGF21 variant with two mutations, Fc-FGF21(RG), to extend the half-life and reduce aggregat…