Junning Pu
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View article: Betaine alleviates hepatic lipid metabolism disorder in finishing pigs fed a low-energy diet through regulating m6A RNA methylation
Betaine alleviates hepatic lipid metabolism disorder in finishing pigs fed a low-energy diet through regulating m6A RNA methylation Open
Background Low dietary energy levels can disrupt energy balance, causing metabolic disorders, particularly those involving in hepatic lipid metabolism. Betaine (BET), an important methyl donor, has demonstrated protective effects against l…
View article: Dietary xylooligosaccharides modulate oxidative stress and pathogen resistance in growing rabbits
Dietary xylooligosaccharides modulate oxidative stress and pathogen resistance in growing rabbits Open
Background Given the high incidence of gastrointestinal disorders in intensive rabbit production, we assessed the effects of graded levels of xylooligosaccharides (XOS) on growth performance, nutrient digestibility and intestinal health in…
View article: Effect of maternal and post-weaning dietary chitosan oligosaccharide supplementation on reproductive performance of sow and gut growth and development in offspring
Effect of maternal and post-weaning dietary chitosan oligosaccharide supplementation on reproductive performance of sow and gut growth and development in offspring Open
This study investigated the effects of dietary chitosan oligosaccharide (COS) in sows on the reproductive performance and milk composition of sows, as well as the intestinal growth and development of piglets. A total of forty pregnant sows…
View article: Effects of Different Net Energy Levels in Low-Protein Diversified Diets on Growth Performance, Nutrient Digestibility, Carcass Characteristics, Meat Quality, and Colonic Microbiota in Finishing Pigs
Effects of Different Net Energy Levels in Low-Protein Diversified Diets on Growth Performance, Nutrient Digestibility, Carcass Characteristics, Meat Quality, and Colonic Microbiota in Finishing Pigs Open
In China, the application of low-protein, low-soybean meal diversified feeding strategies exhibits significant importance for reducing the dependence on soybean meal imports, lowering livestock and poultry feed costs, and decreasing nitrog…
View article: Evaluation of the nutritional value of corn contaminated with deoxynivalenol and irradiated with electron beam and its effects on growth performance, nutrient digestibility, serum parameters, and intestinal permeability in piglets
Evaluation of the nutritional value of corn contaminated with deoxynivalenol and irradiated with electron beam and its effects on growth performance, nutrient digestibility, serum parameters, and intestinal permeability in piglets Open
Deoxynivalenol (DON) negatively affects the growth of piglets. Electron beam irradiation (EBI) has the potential to reduce the DON content in feeds. However, the quantitative effects of DON contamination and EBI on the nutritional value of…
View article: Emergence of <i>Staphylococcus aureus</i> Resistance to Antimicrobial Peptides Nisin, NZ2114 and Bacitracin Involves Multiple Phenotypic Changes
Emergence of <i>Staphylococcus aureus</i> Resistance to Antimicrobial Peptides Nisin, NZ2114 and Bacitracin Involves Multiple Phenotypic Changes Open
The rise of antibiotic‐resistant bacteria has intensified global interest in antimicrobial peptides (AMPs) as promising feed additives. Although AMPs were initially considered less prone to resistance due to their broad‐spectrum activity, …
View article: Effects of Dietary Pretreatment with All-trans Lycopene on Lipopolysaccharide-Induced Jejunal Inflammation: A Multi-Pathway Phenomenon
Effects of Dietary Pretreatment with All-trans Lycopene on Lipopolysaccharide-Induced Jejunal Inflammation: A Multi-Pathway Phenomenon Open
This study was conducted to investigate the effects and mechanisms of all-trans lycopene on intestinal health by establishing lipopolysaccharide-induced (LPS-induced) jejunal inflammation model. Dietary lycopene supplementation enhanced se…
View article: Gut Metabolome in Companion Animal Nutrition—Linking Diets to Health
Gut Metabolome in Companion Animal Nutrition—Linking Diets to Health Open
Tailoring diet to support a healthy gut microbiome is key for animal well-being. The gut metabolome, including all small molecules in the gut, is central to diet–microbiome–health interactions. While comprehension of the gut metabolome in …
View article: Current Evidence on Raw Meat Diets in Pets: A Natural Symbol, but a Nutritional Controversy
Current Evidence on Raw Meat Diets in Pets: A Natural Symbol, but a Nutritional Controversy Open
Feeding raw meat to cats and dogs has become a common practice in Western countries. Many pet owners cite their pets’ wild carnivore ancestry and believe raw meat diets are healthier, citing higher nutritional value, a lack of processing, …
View article: All-trans retinoic acid protects piglets from TGEV-induced diarrhea and intestinal epithelial apoptosis by modulating redox status and endoplasmic reticulum stress pathways
All-trans retinoic acid protects piglets from TGEV-induced diarrhea and intestinal epithelial apoptosis by modulating redox status and endoplasmic reticulum stress pathways Open
Transmissible gastroenteritis virus (TGEV) is a significant pathogen responsible for diarrhea in piglets, with its pathogenesis intricately associated with apoptosis. As a bioactive vitamin A derivative, all-trans retinoic acid (ATRA) poss…
View article: Absence of gut microbiota alleviates iron overload-induced colitis by modulating ferroptosis in mice
Absence of gut microbiota alleviates iron overload-induced colitis by modulating ferroptosis in mice Open
Iron overload activates ferroptosis in colonic cells, increases the relative abundance of harmful bacteria, and exacerbates DSS-induced colitis in mice. Iron overload exacerbates DSS-induced ferroptosis and colitis in a microbiota-dependen…
View article: Mulberry leaf benefits the intestinal epithelial barrier via direct anti-oxidation and indirect modulation of microbiota in pigs
Mulberry leaf benefits the intestinal epithelial barrier via direct anti-oxidation and indirect modulation of microbiota in pigs Open
Mulberry leaf in diet improved epithelial barrier via the direct anti-oxidation through the activation of Keap1-Nrf2 signaling pathway and the indirect modulation of gut microbiota in weaned pigs.
View article: Maternal chitosan oligosaccharide supplementation during late gestation and lactation optimizes placental function in sows and intestinal function in 21-day-old IUGR suckling piglets
Maternal chitosan oligosaccharide supplementation during late gestation and lactation optimizes placental function in sows and intestinal function in 21-day-old IUGR suckling piglets Open
Maternal dietary supplementation with chitosan oligosaccharide (COS) has been considered as a potential intervention to mitigate the occurrence of intrauterine growth restriction (IUGR) and improve postnatal growth. The present study inves…
View article: Spray-dried plasma protects against rotavirus-induced gastroenteritis via regulating macrophage and T cells divergence in weanling pigs
Spray-dried plasma protects against rotavirus-induced gastroenteritis via regulating macrophage and T cells divergence in weanling pigs Open
Infectious gastroenteritis is the major cause for diarrhea in piglets. The protection of spray-dried plasma (SDP) on viral gastroenteritis during the progression of rotavirus (RV) infection remain unclear. In this study, 64 weanling piglet…
View article: The influence of iron nutrition on the development of intestine and immune cell divergency in neonatal pigs
The influence of iron nutrition on the development of intestine and immune cell divergency in neonatal pigs Open
Background Appropriate iron supplementation is essential for neonatal growth and development. However, there are few reports on the effects of iron overload on neonatal growth and immune homeostasis. Thus, the aim of this study was to inve…
View article: Betaine addition to the diet alleviates intestinal injury in growing rabbits during the summer heat through the AAT/mTOR pathway
Betaine addition to the diet alleviates intestinal injury in growing rabbits during the summer heat through the AAT/mTOR pathway Open
Background The aim of this experiment was to investigate the effect of different levels of betaine (Bet) inclusion in the diet on the intestinal health of growing rabbits under summer heat. A total of 100 weaned Qixing meat rabbits aged 35…
View article: All-trans retinoic acid alleviates transmissible gastroenteritis virus-induced intestinal inflammation and barrier dysfunction in weaned piglets
All-trans retinoic acid alleviates transmissible gastroenteritis virus-induced intestinal inflammation and barrier dysfunction in weaned piglets Open
Background Transmissible gastroenteritis virus (TGEV) is one of the main pathogens causing severe diarrhea of piglets. The pathogenesis of TGEV is closely related to intestinal inflammation. All- trans retinoic acid (ATRA) is the main acti…
View article: Purine Metabolism and Hexosamine Biosynthetic Pathway Abnormalities in Diarrheal Weaned Piglets Identified Using Metabolomics
Purine Metabolism and Hexosamine Biosynthetic Pathway Abnormalities in Diarrheal Weaned Piglets Identified Using Metabolomics Open
Post-weaning diarrhea significantly contributes to the high mortality in pig production, but the metabolic changes in weaned piglets with diarrhea remain unclear. This study aimed to identify the differential metabolites in the urine of di…
View article: Effects of betaine on growth performance and intestinal health of rabbits fed different digestible energy diets
Effects of betaine on growth performance and intestinal health of rabbits fed different digestible energy diets Open
An experiment was conducted to determine the effects of betaine on growth performance and intestinal health in rabbits fed diets with different levels of digestible energy. During a 36-d experiment, a total of 144 healthy 35-d-old weaned N…
View article: Synbiotics improve growth performance and nutrient digestibility, inhibit PEDV infection, and prevent intestinal barrier dysfunction by mediating innate antivirus immune response in weaned piglets
Synbiotics improve growth performance and nutrient digestibility, inhibit PEDV infection, and prevent intestinal barrier dysfunction by mediating innate antivirus immune response in weaned piglets Open
This experiment was conducted to explore the effects of dietary synbiotics (SYB) supplementation on growth performance, immune function, and intestinal barrier function in piglets challenged with porcine epidemic diarrhea virus (PEDV). For…
View article: Effect of<i>Saccharomyces cerevisiae</i>Postbiotics and Essential Oil on Growth Performance and Intestinal Health of Weanling Pigs During K88 ETEC Infection
Effect of<i>Saccharomyces cerevisiae</i>Postbiotics and Essential Oil on Growth Performance and Intestinal Health of Weanling Pigs During K88 ETEC Infection Open
Enterotoxigenic Escherichia coli (ETEC) is one of the major bacterial infections, causing substantial economic losses globally in the swine industry. This study aimed to investigate the impact of low Saccharomyces cerevisiae fermentation p…
View article: Betaine addition to dietary can alleviate intestinal injury to growing meat rabbits in summer heat through the AAT/mTOR pathway
Betaine addition to dietary can alleviate intestinal injury to growing meat rabbits in summer heat through the AAT/mTOR pathway Open
Background The aim of this experiment was to investigate the effect of different levels of betaine (Bet) inclusion in the diet on the intestinal health of growing meat rabbits under summer heat. A total of 100 weaned Qixing meat rabbits ag…
View article: Betaine affects abdominal flare fat metabolism via regulating m6A RNA methylation in finishing pigs fed a low-energy diet
Betaine affects abdominal flare fat metabolism via regulating m6A RNA methylation in finishing pigs fed a low-energy diet Open
This study was conducted to investigate the effects of betaine on lipid metabolism and m6A RNA methylation in finishing pigs fed a low-energy diet. The results showed that betaine significantly enhanced serum concentration of triglyceride …