Jae‐Hwan Nam
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View article: Design and immunogenicity of a quadrivalent mRNA vaccine targeting HSV-2 with comparative evaluation of co-formulated and admixed formulations
Design and immunogenicity of a quadrivalent mRNA vaccine targeting HSV-2 with comparative evaluation of co-formulated and admixed formulations Open
Introduction The globally prevalent herpes simplex virus 2 (HSV-2) establishes lifelong latent infections in sensory neurons and causes recurrent genital disease. However, no vaccine is available to prevent HSV-2 infection. The mRNA vaccin…
View article: A20 mRNA therapeutics ameliorate systemic sclerosis by suppressing TRAF-6/NF-KB signaling and DREAM expression and exerting antifibrotic effects
A20 mRNA therapeutics ameliorate systemic sclerosis by suppressing TRAF-6/NF-KB signaling and DREAM expression and exerting antifibrotic effects Open
Introduction Systemic sclerosis (SSc) is a chronic autoimmune disorder characterized by progressive fibrosis, vascular abnormalities, and immune dysregulation. Decreased expression of A20 ( TNFAIP3 ), a key negative regulator of inflammati…
View article: Rapid‐Turnaround Co‐Administration of mRNA‐Based MHC‐I and MHC‐II‐Restricted Neoantigens Enhances Immune Responses of Antigen‐Specific CD8 <sup>+</sup> T Cells and Anti‐Cancer Efficacy in Colorectal Cancer
Rapid‐Turnaround Co‐Administration of mRNA‐Based MHC‐I and MHC‐II‐Restricted Neoantigens Enhances Immune Responses of Antigen‐Specific CD8 <sup>+</sup> T Cells and Anti‐Cancer Efficacy in Colorectal Cancer Open
Personalized cancer vaccines (PCVs) represent a promising frontier in cancer immunotherapy; however, challenges in neoantigen prediction and treatment optimization persist. This study aims to introduce an innovative mRNA‐based PCV platform…
View article: Comparative immunologic profiling of mRNA and protein-conjugated vaccines: acute inflammatory responses and anti-PEG antibody production
Comparative immunologic profiling of mRNA and protein-conjugated vaccines: acute inflammatory responses and anti-PEG antibody production Open
Messenger ribonucleic acid (mRNA) vaccines have become a prevalent immunization method, even as the coronavirus disease 2019 (COVID-19) pandemic recedes. However, the potential adverse effects using mRNA vaccines need to be explored in thi…
View article: Impact of administration routes and dose frequency on the toxicology of SARS-CoV-2 mRNA vaccines in mice model
Impact of administration routes and dose frequency on the toxicology of SARS-CoV-2 mRNA vaccines in mice model Open
The increasing use of SARS-CoV-2 mRNA vaccines has raised concerns about their potential toxicological effects, necessitating further investigation to ensure their safety. To address this issue, we aimed to evaluate the toxicological effec…
View article: Immunogenicity and protection of a triple repeat domain III mRNA vaccine against Zika virus
Immunogenicity and protection of a triple repeat domain III mRNA vaccine against Zika virus Open
Zika virus (ZIKV) infection is primarily transmitted by mosquitoes and often asymptomatic in most individuals. Infection during pregnancy can lead to severe birth defects such as congenital microcephaly, and currently, there is no approved…
View article: Novel Less Toxic, Lymphoid Tissue‐Targeted Lipid Nanoparticles Containing a Vitamin B5‐Derived Ionizable Lipid for mRNA Vaccine Delivery
Novel Less Toxic, Lymphoid Tissue‐Targeted Lipid Nanoparticles Containing a Vitamin B5‐Derived Ionizable Lipid for mRNA Vaccine Delivery Open
Following their approval by the Food and Drug Administration, lipid nanoparticles (LNPs) have emerged as promising tools for delivering mRNA vaccines and therapeutics. Ionizable lipids are among the essential components of LNPs, as they pl…
View article: SARS-CoV2 mRNA vaccine intravenous administration induces myocarditis in chronic inflammation
SARS-CoV2 mRNA vaccine intravenous administration induces myocarditis in chronic inflammation Open
The current COVID-19 mRNA vaccines were developed and applied for pandemic-emergent conditions. These vaccines use a small piece of the virus’s genetic material (mRNA) to stimulate an immune response against COVID-19. However, their potent…
View article: Rational Design of Lipid Nanoparticles for Enhanced mRNA Vaccine Delivery via Machine Learning
Rational Design of Lipid Nanoparticles for Enhanced mRNA Vaccine Delivery via Machine Learning Open
Since the coronavirus pandemic, mRNA vaccines have revolutionized the field of vaccinology. Lipid nanoparticles (LNPs) are proposed to enhance mRNA delivery efficiency; however, their design is suboptimal. Here, a rational method for desig…
View article: Accurate antibody loop structure prediction enables zero-shot design of target-specific antibodies
Accurate antibody loop structure prediction enables zero-shot design of target-specific antibodies Open
Protein loops, characterized by their versatile structures with varying sizes and shapes, can recognize a wide range of targets with high specificity and affinity. The variable loops of the antibody complementarity-determining region (CDR)…
View article: Single Oral Dose Toxicity Study of Cheongmokpye in Mice
Single Oral Dose Toxicity Study of Cheongmokpye in Mice Open
Pharmacognosy Research,2024,16,3,616-625.DOI:10.5530/pres.16.3.73Published:June 2024Type:Original ArticleAuthors:Do-Hyung Kim, Jin Won Park, Dong-Keon Lee, Hyeong-Jun Park, Hye Won Kwak, Daegeun Kim, Yongkwan Kim, Ho Park, Jae-Hwan Nam, Wa…
View article: A lipid nanoparticle platform incorporating trehalose glycolipid for exceptional mRNA vaccine safety
A lipid nanoparticle platform incorporating trehalose glycolipid for exceptional mRNA vaccine safety Open
The rapid development of messenger RNA (mRNA) vaccines formulated with lipid nanoparticles (LNPs) has contributed to control of the COVID-19 pandemic. However, mRNA vaccines have raised concerns about their potential toxicity and clinical …
View article: Analysis of the Immunostimulatory Effects of Cytokine-Expressing Internal Ribosome Entry Site–Based RNA Adjuvants and Their Applications
Analysis of the Immunostimulatory Effects of Cytokine-Expressing Internal Ribosome Entry Site–Based RNA Adjuvants and Their Applications Open
Developing new adjuvants that can effectively induce humoral and cellular immune responses while broadening the immune response is of great value. In this study, we aimed to develop single-stranded RNA adjuvants expressing (1) granulocyte …
View article: The Adenylyl Cyclase Activator Forskolin Increases Influenza Virus Propagation in MDCK Cells by Regulating ERK1/2 Activity
The Adenylyl Cyclase Activator Forskolin Increases Influenza Virus Propagation in MDCK Cells by Regulating ERK1/2 Activity Open
Vaccination is the most effective method for preventing the spread of the influenza virus. Cell-based influenza vaccines have been developed to overcome the disadvantages of egg-based vaccines and their production efficiency has been previ…
View article: Knife’s edge: Balancing immunogenicity and reactogenicity in mRNA vaccines
Knife’s edge: Balancing immunogenicity and reactogenicity in mRNA vaccines Open
Since the discovery of messenger RNA (mRNA), there have been tremendous efforts to wield them in the development of therapeutics and vaccines. During the COVID-19 pandemic, two mRNA vaccines were developed and approved in record-breaking t…
View article: mRNA vaccine encoding Gn Provides Protection Against Severe Fever with Thrombocytopenia Syndrome Virus in mice
mRNA vaccine encoding Gn Provides Protection Against Severe Fever with Thrombocytopenia Syndrome Virus in mice Open
We developed a promising mRNA vaccine against Severe Fever with Thrombocytopenia Syndrome (SFTS), an infectious disease caused by the SFTS virus that is primarily transmitted through tick bites. Administration of lipid nanoparticle-encapsu…
View article: Trehalose-based lipid improves mRNA vaccine safety
Trehalose-based lipid improves mRNA vaccine safety Open
The rapid development of lipid nanoparticle (LNP)-formulated mRNA vaccines strongly contributed to overcoming the COVID-19 pandemic. However, in parallel with this success, the toxicity of ionizable cationic lipids has emerged as a potenti…
View article: mRNA-HPV Therapeutic Vaccine Encoding E6 and E7 Improves Therapeutic Potential in HPV-mediated Cancer
mRNA-HPV Therapeutic Vaccine Encoding E6 and E7 Improves Therapeutic Potential in HPV-mediated Cancer Open
The viral E6 and E7 oncoproteins of human papillomavirus (HPV) are strongly associated with cervical cancer. We developed and assessed the efficacy of an mRNA-HPV therapeutic vaccine (mHTV), containing the E6 and E7 proteins, in C57BL/J mi…
View article: Heterologous prime-boost regimen elicits potent humoral and cell-mediated immune responses and provides complete protection against SFTSV
Heterologous prime-boost regimen elicits potent humoral and cell-mediated immune responses and provides complete protection against SFTSV Open
Severe Fever with Thrombocytopenia Syndrome Virus(SFTSV) was first discovered in 2009 as the causative agent of severe fever with thrombocytopenia syndrome. Despite its potential threat to public health, no prophylactic vaccine is yet avai…
View article: Analysis of vaccine-induced immune responses according to the immunization sequences of mRNA and protein vaccines
Analysis of vaccine-induced immune responses according to the immunization sequences of mRNA and protein vaccines Open
In response to the COVID-19 pandemic, different types of vaccines, such as inactive, live-attenuated, messenger RNA, and protein subunit, have been developed against SARS-CoV2. This circumstance has unintentionally led to heterologous prim…
View article: Immune Responses to Varicella Zoster Virus and Effective Vaccines
Immune Responses to Varicella Zoster Virus and Effective Vaccines Open
Varicella zoster virus (VZV) causes two distinct diseases, varicella (chickenpox) during primary infection, and herpes zoster (shingles) resulting from reactivation. The purpose of this review is to summarize the present understanding of V…
View article: Next‐generation sequencing for typing human papillomaviruses and predicting multi‐infections and their clinical symptoms
Next‐generation sequencing for typing human papillomaviruses and predicting multi‐infections and their clinical symptoms Open
Human papillomavirus (HPV) has more than 100 different types, some of which are associated with cancer. The most common example is that of cervical cancer, which is associated with HPV16 and HPV18. Here, we performed next‐generation sequen…