Jun Tang
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View article: Clinical Values of serum carcinoembryonic antigen (CEA), glycoprotein antigen (CA) 50, CA19-9, and CA72-4, and the soluble fragment of cytokeratin 19 (CYFRA21-1) in early screening and prognosis prediction of colon cancer
Clinical Values of serum carcinoembryonic antigen (CEA), glycoprotein antigen (CA) 50, CA19-9, and CA72-4, and the soluble fragment of cytokeratin 19 (CYFRA21-1) in early screening and prognosis prediction of colon cancer Open
aim: To investigate the clinical values of serum tumor markers carcinoembryonic antigen (CEA), glycoprotein antigen (CA) 50, CA19-9, and CA72-4, and the soluble fragment of cytokeratin 19 (CYFRA21-1) in early screening and prognosis predic…
View article: Early human albumin infusion was associated with 28-day mortality in patients with acute respiratory failure and hypoalbuminaemia in the intensive care unit: a retrospective study of the MIMIC-IV database
Early human albumin infusion was associated with 28-day mortality in patients with acute respiratory failure and hypoalbuminaemia in the intensive care unit: a retrospective study of the MIMIC-IV database Open
View article: Promising Response to Neoadjuvant Chemotherapy Plus Immunotherapy in Metaplastic Breast Carcinoma
Promising Response to Neoadjuvant Chemotherapy Plus Immunotherapy in Metaplastic Breast Carcinoma Open
We observed a promising response on addition of immunotherapy to NAC among patients with MpBC, suggesting that immunotherapy may have great potential in the treatment of metaplastic breast carcinoma.
View article: Oncogene Silencing via ecDNA Micronucleation
Oncogene Silencing via ecDNA Micronucleation Open
Extrachromosomal DNA (ecDNA) is a common source of oncogene amplification across many types of cancer. The non-Mendelian inheritance of ecDNA contributes to heterogeneous tumour genomes that rapidly evolve to resist treatment. Here, using …
View article: Targeting site-specific N-glycosylated B7H3 induces potent antitumor immunity
Targeting site-specific N-glycosylated B7H3 induces potent antitumor immunity Open
View article: Antibody-drug conjugates in breast cancer: current evidence and future directions
Antibody-drug conjugates in breast cancer: current evidence and future directions Open
View article: Chinese Position Paper on Biologic Therapy for Chronic Rhinosinusitis With Nasal Polyps
Chinese Position Paper on Biologic Therapy for Chronic Rhinosinusitis With Nasal Polyps Open
Emerging biologics that selectively target key cytokines present a promising therapeutic alternative for patients suffering from severe, uncontrollable chronic rhinosinusitis with nasal polyps (CRSwNP). Despite the limited availability of …
View article: Gut microbial characteristics of the damp-heat constitution: a population-based multicenter cross-sectional study.
Gut microbial characteristics of the damp-heat constitution: a population-based multicenter cross-sectional study. Open
The gut microbiota of the DHC population exhibits significantly reduced diversity and is closely related to inflammation, metabolic disorders, and liver steatosis, which is consistent with clinical observations, thus serving as a potential…
View article: The Effect of Incorporating 3D-Printed Newborn Phantom Heads with Cleft Lip and Palate into Undergraduate Orthodontic Education: Comparing Learning Outcomes and Student Feedback
The Effect of Incorporating 3D-Printed Newborn Phantom Heads with Cleft Lip and Palate into Undergraduate Orthodontic Education: Comparing Learning Outcomes and Student Feedback Open
View article: “A Mother Makes a Better Nurse”: A Phenomenological Study of Neonatal Nurses’ Readiness Recalibration Following Postpartum Return to Work
“A Mother Makes a Better Nurse”: A Phenomenological Study of Neonatal Nurses’ Readiness Recalibration Following Postpartum Return to Work Open
Aim To explore the lived experience of neonatal nurses returning to work postpartum, focusing on their adaptation processes and the recalibration of professional readiness under the influence of motherhood. Background The transition back t…
View article: IL-8 Downregulation Mediates the Beneficial Effects of Infection-Induced Fever on Breast Cancer Prognosis
IL-8 Downregulation Mediates the Beneficial Effects of Infection-Induced Fever on Breast Cancer Prognosis Open
Infection-induced fever may improve breast cancer prognosis through IL-8 downregulation and the mediation mechanisms may be involved in neutrophil degranulation, extracellular matrix organization and asparagine N-linked glycosylation. Such…
View article: Interfacial Gradation Via W50v Alloy Suppresses High-Temperature Cracking in Tungsten-Steel Joints
Interfacial Gradation Via W50v Alloy Suppresses High-Temperature Cracking in Tungsten-Steel Joints Open
View article: Enhancing transcription–replication conflict targets ecDNA-positive cancers
Enhancing transcription–replication conflict targets ecDNA-positive cancers Open
View article: Inactivated cGAS‐STING Signaling Facilitates Endocrine Resistance by Forming a Positive Feedback Loop with AKT Kinase in ER+HER2– Breast Cancer
Inactivated cGAS‐STING Signaling Facilitates Endocrine Resistance by Forming a Positive Feedback Loop with AKT Kinase in ER+HER2– Breast Cancer Open
Endocrine‐resistant ER+HER2– breast cancer (BC) is particularly aggressive and leads to poor clinical outcomes. Effective therapeutic strategies against endocrine‐resistant BC remain elusive. Here, analysis of the RNA‐sequencing data from …
View article: Comprehensive pan‐cancer analysis of mitochondrial outer membrane permeabilisation activity reveals positive immunomodulation and assists in identifying potential therapeutic targets for immunotherapy resistance
Comprehensive pan‐cancer analysis of mitochondrial outer membrane permeabilisation activity reveals positive immunomodulation and assists in identifying potential therapeutic targets for immunotherapy resistance Open
Background Mitochondrial outer membrane permeabilisation (MOMP) plays a pivotal role in cellular death and immune activation. A deeper understanding of the impact of tumour MOMP on immunity will aid in guiding more effective immunotherapeu…
View article: Characterization of gene regulatory networks underlying key properties in human hematopoietic stem cell ontogeny
Characterization of gene regulatory networks underlying key properties in human hematopoietic stem cell ontogeny Open
Human hematopoiesis starts at early yolk sac and undergoes site- and stage-specific changes over development. The intrinsic mechanism underlying property changes in hematopoiesis ontogeny remains poorly understood. Here, we analyzed single…
View article: Does the Dose of Standard Adjuvant Chemotherapy Affect the Triple-negative Breast Cancer Benefit from Extended Capecitabine Metronomic Therapy? An Exploratory Analysis of the SYSUCC-001 Trial
Does the Dose of Standard Adjuvant Chemotherapy Affect the Triple-negative Breast Cancer Benefit from Extended Capecitabine Metronomic Therapy? An Exploratory Analysis of the SYSUCC-001 Trial Open
This study found the dose reduction of adjuvant taxane might negatively impact the efficacy of capecitabine. Therefore, the reduction of anthracycline dose over paclitaxel should be given priority during conventional adjuvant chemotherapy,…
View article: Adverse independent prognostic effect of initial lung cancer on female patients with second primary breast cancer: a propensity score-matched study based on the SEER database
Adverse independent prognostic effect of initial lung cancer on female patients with second primary breast cancer: a propensity score-matched study based on the SEER database Open
Objective To investigate the prognostic impact of initial lung cancer (LC) on second primary breast cancer after LC (LC-BC) and further develop a nomogram for predicting the survival of patients. Methods All patients diagnosed with LC-BC a…
View article: Practical Application and Students' Abilities Assessment of Blended Teaching in Breast Oncology Department Clinical Internship
Practical Application and Students' Abilities Assessment of Blended Teaching in Breast Oncology Department Clinical Internship Open
Objective Blended teaching has become the hot spot and advanced direction of educational reform, but there is little experience of blended teaching in clinical medicine internship courses. Besides, there is a lack of student ability assess…
View article: Promising Response to Neoadjuvant Chemotherapy Plus Immunotherapy in Metaplastic Breast Carcinoma
Promising Response to Neoadjuvant Chemotherapy Plus Immunotherapy in Metaplastic Breast Carcinoma Open
View article: Dysbiosis of lower respiratory tract microbiome are associated with proinflammatory states in non‐small cell lung cancer patients
Dysbiosis of lower respiratory tract microbiome are associated with proinflammatory states in non‐small cell lung cancer patients Open
Background The lung has a sophisticated microbiome, and respiratory illnesses are greatly influenced by the lung microbiota. Despite the fact that numerous studies have shown that lung cancer patients have a dysbiosis as compared to health…
View article: Cone Density Distribution and Related Factors in Patients Receiving Hydroxychloroquine Treatment
Cone Density Distribution and Related Factors in Patients Receiving Hydroxychloroquine Treatment Open
Hydroxychloroquine reduces retinal cone cell density in the vertical axis. Cone density loss in the horizontal axis increases with age; further, hydroxychloroquine dosage is negatively correlated with cone density in the vertical axis and …
View article: Recent progress in biomimetic nanomedicines based on versatile targeting strategy for atherosclerosis therapy
Recent progress in biomimetic nanomedicines based on versatile targeting strategy for atherosclerosis therapy Open
Atherosclerosis (AS) is considered to be one of the major causes of cardiovascular disease. Its pathological microenvironment is characterized by increased production of reactive oxygen species, lipid oxides, and excessive inflammatory fac…
View article: Intra-cervical lymphatic immunotherapy for dust mite-induced allergic rhinoconjunctivitis in children: a 3-year prospective randomized controlled trial
Intra-cervical lymphatic immunotherapy for dust mite-induced allergic rhinoconjunctivitis in children: a 3-year prospective randomized controlled trial Open
Background Pediatric allergic rhinoconjunctivitis has become a public concern with an increasing incidence year by year. Conventional subcutaneous immunotherapy (SCIT) has long treatment time, high cost and poor compliance. The novel immun…
View article: Comprehensive analysis of angiogenesis pattern and related immune landscape for individual treatment in osteosarcoma
Comprehensive analysis of angiogenesis pattern and related immune landscape for individual treatment in osteosarcoma Open
View article: What is the appropriate genetic testing criteria for breast cancer in the Chinese population?—Analysis of genetic and clinical features from a single cancer center database
What is the appropriate genetic testing criteria for breast cancer in the Chinese population?—Analysis of genetic and clinical features from a single cancer center database Open
Background Genetic testing plays an important role in guiding screening, diagnosis, and precision treatment of breast cancer (BC). However, the appropriate genetic testing criteria remain controversial. The current study aims to facilitate…
View article: TMT-Based Comparative Proteomic Analysis of the Spermatozoa of Buck (Capra hircus) and Ram (Ovis aries)
TMT-Based Comparative Proteomic Analysis of the Spermatozoa of Buck (Capra hircus) and Ram (Ovis aries) Open
Spermatozoa are unique cells that carry a library of proteins that regulate the functions of molecules to achieve functional capabilities. Currently, large amounts of protein have been identified in spermatozoa from different species using…
View article: Evolutionary route of nasopharyngeal carcinoma metastasis and its clinical significance
Evolutionary route of nasopharyngeal carcinoma metastasis and its clinical significance Open
View article: Icaritin (SNG162) promotes apoptosis and inhibits proliferation by regulating IL-6/STAT3 signals in a novel preliminarily identified canine malignant melanoma cell line
Icaritin (SNG162) promotes apoptosis and inhibits proliferation by regulating IL-6/STAT3 signals in a novel preliminarily identified canine malignant melanoma cell line Open
Background Malignant melanoma is one of the most common tumors in canines. Although there are radiotherapy and chemotherapy treatments, clinical outcomes for most patients remain poor. To change this situation, novel study models are neede…
View article: Nuclear export signal mutation of epidermal growth factor receptor enhances malignant phenotypes of cancer cells.
Nuclear export signal mutation of epidermal growth factor receptor enhances malignant phenotypes of cancer cells. Open
Nuclear epidermal growth factor receptor (EGFR) has been shown to be correlated with drug resistance and a poor prognosis in patients with cancer. Previously, we have identified a tripartite nuclear localization signal (NLS) within EGFR. T…