Junping Liu
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View article: 5-Hydroxytryptamine receptor 1D overexpression exacerbates gastric cancer proliferation, invasion, and angiogenesis by activating the Wnt/β-catenin signaling
5-Hydroxytryptamine receptor 1D overexpression exacerbates gastric cancer proliferation, invasion, and angiogenesis by activating the Wnt/β-catenin signaling Open
Dysregulation of 5-Hydroxytryptamine and its receptors play important roles in the development and progression of malignant tumors. However, the biological role and underlying molecular mechanism of 5-Hydroxytryptamine Receptor 1D (HTR1D) …
View article: Development of edible nanocomposite films incorporating cinnamaldehyde-carvacrol for extending the shelf life of ready-to-eat steaks
Development of edible nanocomposite films incorporating cinnamaldehyde-carvacrol for extending the shelf life of ready-to-eat steaks Open
View article: ATP13A2 restrains macrophage NLRP3 activation to repress neurodegeneration via modulating mitochondrial homeostasis 9349
ATP13A2 restrains macrophage NLRP3 activation to repress neurodegeneration via modulating mitochondrial homeostasis 9349 Open
Description Neuro-immune crosstalk has become increasingly recognized in Parkinson’s disease (PD). ATP13A2, a key genetic factor associated with PD, is well-known for its critical neuroprotective role. However, it remains unclear whether m…
View article: DCC-2036 induces repolarization of TAMs to M1 type and enhances CD8+ T cell immunity in TNBC
DCC-2036 induces repolarization of TAMs to M1 type and enhances CD8+ T cell immunity in TNBC Open
Therapies for triple-negative breast cancer (TNBC) still need innovative approaches, while repolarizing tumor-associated macrophages (TAMs) may offer a breakthrough in the targeted therapy and immunotherapy of TNBC. In this study, our grou…
View article: The Clinical Efficacy of Self-Designed Nuangong Zhitong Ling in Primary Dysmenorrhea of Cold Coagulation Syndrome
The Clinical Efficacy of Self-Designed Nuangong Zhitong Ling in Primary Dysmenorrhea of Cold Coagulation Syndrome Open
Objective: To investigate the clinical efficacy of the self-designed Nuangong Zhitong Ling in primary dysmenorrhea (PD) of cold coagulation syndrome. Methods: Forty patients with PD of cold coagulation syndrome who were treated with the se…
View article: Exposure to Nanoplastics and Co-Contaminants in Foods and Environment: Threats to Human Health
Exposure to Nanoplastics and Co-Contaminants in Foods and Environment: Threats to Human Health Open
Nanoplastics have emerged as significant global pollutants, drawing worldwide concern. Due to their small particle size, large specific surface area, and high surface activity, nanoplastics can combine with other environmental contaminants…
View article: Implications of the c.1201C > G (p.Arg401Gly) mutation in FGG gene on fibrinogen stability and function
Implications of the c.1201C > G (p.Arg401Gly) mutation in FGG gene on fibrinogen stability and function Open
Congenital dysfibrinogenemia, a rare coagulation disorder characterized by decreased fibrinogen activity while antigen level is usually normal. We conducted a study on a three-generation family comprising 15 members, among whom three indiv…
View article: Trends and forecasts of vitamin A deficiency burden in China, 1990–2035
Trends and forecasts of vitamin A deficiency burden in China, 1990–2035 Open
Objective The purpose of this study was to analyze changes in the disease burden caused by vitamin A deficiency (VAD) in China from 1990 to 2021, based on the Global Burden of Disease (GBD) Database, and to predict the disease burden trend…
View article: Global and Chinese epidemiologic study of polycystic ovary syndrome in women of childbearing age, 1990–2021, and projections to 2035: Based on the Global Burden of Disease 2021 study
Global and Chinese epidemiologic study of polycystic ovary syndrome in women of childbearing age, 1990–2021, and projections to 2035: Based on the Global Burden of Disease 2021 study Open
Objective The aim of this study was to synthesize and analyze the burden of disease of polycystic ovary syndrome (PCOS) in women of reproductive age globally and in China from 1990 to 2021. Methods The study utilized data from the Global B…
View article: Terpine-4-ol alleviates lipopolysaccharide-induced intestinal injury in weaned piglets by regulating intestinal epithelial cell homeostasis via the Wnt/β-catenin signaling pathway
Terpine-4-ol alleviates lipopolysaccharide-induced intestinal injury in weaned piglets by regulating intestinal epithelial cell homeostasis via the Wnt/β-catenin signaling pathway Open
View article: Unmasking the rising global burden of depression: A 32-year GBD analysis of gender disparities and regional hotspots in Sub-Saharan Africa
Unmasking the rising global burden of depression: A 32-year GBD analysis of gender disparities and regional hotspots in Sub-Saharan Africa Open
Aims Depression, a leading contributor to the global disease burden, exhibits alarming increases in incidence and prevalence, with pronounced disparities across regions and genders. This study provides the first comprehensive analysis of d…
View article: Protective effects of matrine on cardiomyocytes infected with coxsackievirus B₃via modulation of the calpain-2/caspase-12 signaling pathway
Protective effects of matrine on cardiomyocytes infected with coxsackievirus B₃via modulation of the calpain-2/caspase-12 signaling pathway Open
Viral myocarditis (VMC) presents a substantial threat, especially for children, often leading to cardiogenic shock and fulminant myocarditis. Our study aimed to evaluate the role of calpain-2 and caspase-12, which were involved in the endo…
View article: MRPL21-PARP1 axis promotes cisplatin resistance in head and neck squamous cell carcinoma by inhibiting autophagy through the PI3K/AKT/mTOR signaling pathway
MRPL21-PARP1 axis promotes cisplatin resistance in head and neck squamous cell carcinoma by inhibiting autophagy through the PI3K/AKT/mTOR signaling pathway Open
Background Head and neck squamous cell carcinoma (HNSCC) constitutes a major clinical challenge that severely affects patient survival. Mitochondrial ribosomal protein (MRP) family plays an important role in energy metabolism by participat…
View article: Two cases of Amyloid-Related Imaging Abnormalities (ARIA) following lecanemab treatment for alzheimer’s disease and a literature review
Two cases of Amyloid-Related Imaging Abnormalities (ARIA) following lecanemab treatment for alzheimer’s disease and a literature review Open
During lecanemab treatment for AD, it is essential to fully understand the mechanisms, imaging characteristics, and management strategies of ARIA. Close monitoring of clinical symptoms and imaging changes is crucial for the timely detectio…
View article: Experimental investigation of flat fan nozzle V-cut depths and its impact on spray characteristics
Experimental investigation of flat fan nozzle V-cut depths and its impact on spray characteristics Open
View article: Global burden of tuberculosis among adults aged 60 years and older, 1990-2021: Findings from the global burden of disease study 2021
Global burden of tuberculosis among adults aged 60 years and older, 1990-2021: Findings from the global burden of disease study 2021 Open
The increasing MDR-TB and XDR-TB burden in older individuals underscores the need for tailored interventions to combat TB burden, such as implementing active case finding among adults aged 60 years and older.
View article: Preclinical and clinical evaluation of intratumoral injection of an IL-12 expressing SKV-012 oncolytic virus for advanced solid tumors
Preclinical and clinical evaluation of intratumoral injection of an IL-12 expressing SKV-012 oncolytic virus for advanced solid tumors Open
Background SKV-012 is a novel engineered oncolytic virus (containing the viral neurovirulence ICP34.5 gene transcribed by the Survivin promoter with an upstream genetic component of interleukin-12 (IL-12) driven by the cytomegalovirus prom…
View article: Single-cell profiling of bone metastasis ecosystems from multiple cancer types reveals convergent and divergent mechanisms of bone colonization
Single-cell profiling of bone metastasis ecosystems from multiple cancer types reveals convergent and divergent mechanisms of bone colonization Open
Bone is a common site for metastasis of solid cancers. The diversity of histological and molecular characteristics of bone metastases (BMs) remains poorly studied. Here, we performed single-cell RNA sequencing on 42 BMs from eight cancer t…
View article: Thyroid function and hepatic fibrosis/cirrhosis: a two-sample Mendelian randomization study
Thyroid function and hepatic fibrosis/cirrhosis: a two-sample Mendelian randomization study Open
Background Evidence on the relationship between thyroid function and hepatic fibrosis/cirrhosis are still unclear, with inconsistent conclusions. This Mendelian randomization (MR) study aimed to investigate the potential causal association…
View article: Factors associated with exposure to tuberculosis education among internal migrants with diabetes in China: a multilevel regression analysis of cross-sectional data from the 2017 China Migrants Dynamic Survey
Factors associated with exposure to tuberculosis education among internal migrants with diabetes in China: a multilevel regression analysis of cross-sectional data from the 2017 China Migrants Dynamic Survey Open
Objective Individuals with diabetes are at high risk for tuberculosis (TB) infection. This study aimed to identify the barriers to access to TB education among internal migrants with diabetes in China. Design Cross-sectional study. Setting…
View article: Neurodegenerative disorders reversed by ATP13A2 flipping sphingomyelin across lysosome
Neurodegenerative disorders reversed by ATP13A2 flipping sphingomyelin across lysosome Open
Neurodegenerative disorders involve ATP13A2 gene mutations in Parkinson’s disease (PD), Kufor-Rakeb syndrome (KRS), spastic paraplegia (SPG), neuronal ceroid lipofuscinosis (NCL), and amyotrophic lateral sclerosis (ALS). Here, we report th…
View article: Associations between exposure to brominated flame retardants and hyperlipidemia risk in U.S. Adults
Associations between exposure to brominated flame retardants and hyperlipidemia risk in U.S. Adults Open
View article: Evaluating the hydraulic performance of rotating spray plate sprinklers
Evaluating the hydraulic performance of rotating spray plate sprinklers Open
The current study was design to evaluate the performance of rotating spray plate sprinklers, R3000 with three nozzle sizes i.e., #16-N1, #24-N2 and #32-N3 corresponding to 3.18, 4.76 and 6.35 mm diameters, respectively using various combin…
View article: Peanut Skin Procyanidins Regulate Insulin Signaling and Hepatic Metabolism in Diabetic Mice
Peanut Skin Procyanidins Regulate Insulin Signaling and Hepatic Metabolism in Diabetic Mice Open
View article: NADPH Oxidase 4 in Prostate Cancer: Expression and Potential Role in Ferroptosis
NADPH Oxidase 4 in Prostate Cancer: Expression and Potential Role in Ferroptosis Open
Prostate cancer (PCa), the most common male malignant tumor worldwide, is associated with high morbidity and mortality, particularly when it progresses to metastatic disease. Ferroptosis, an iron-dependent form of cell death, has been impl…
View article: Effects of music therapy on physiological response and anxiety in perioperative ophthalmic patients: a systematic review
Effects of music therapy on physiological response and anxiety in perioperative ophthalmic patients: a systematic review Open
View article: Social participation and exposure to tuberculosis education: a cross-sectional study of older (≥ 60 years) domestic migrants in China
Social participation and exposure to tuberculosis education: a cross-sectional study of older (≥ 60 years) domestic migrants in China Open
Low levels of exposure to tuberculosis education in older migrants are evident in China. Social participation is associated with higher exposure to tuberculosis education.
View article: Unraveling the mechanisms underlying air pollution-induced dysfunction of the oral–gut–brain axis: implications for human health and well-being
Unraveling the mechanisms underlying air pollution-induced dysfunction of the oral–gut–brain axis: implications for human health and well-being Open
Air pollution exposure has become an international health issue that poses many risks to life and health. The bidirectional regulatory network, known as the oral–gut–brain axis connects the oral cavity, intestine, and central nervous syste…
View article: Melatonin Ameliorates Age‐Related Sarcopenia via the Gut–Muscle Axis Mediated by Serum Lipopolysaccharide and Metabolites
Melatonin Ameliorates Age‐Related Sarcopenia via the Gut–Muscle Axis Mediated by Serum Lipopolysaccharide and Metabolites Open
Background Sarcopenia affects the quality of life and increases adverse outcomes in the elderly. However, as a potential safe and effective remedy to many age‐related disorders, little is known about the protective effect of melatonin agai…
View article: Protective effect of L-lysine on silver carp surimi during freezing storage: Gel quality improvement and physicochemical properties
Protective effect of L-lysine on silver carp surimi during freezing storage: Gel quality improvement and physicochemical properties Open