Junqi Kuang
YOU?
Author Swipe
View article: Breaking the link between morphology and potency for mESCs
Breaking the link between morphology and potency for mESCs Open
View article: Specnuezhenide and ecliptasaponin A from Ligustrum lucidum Ait and Ecliptae Herba improved premature ovarian failure by targeting the ESR1
Specnuezhenide and ecliptasaponin A from Ligustrum lucidum Ait and Ecliptae Herba improved premature ovarian failure by targeting the ESR1 Open
This study was designed to investigate the role of Ligustrum lucidum Ait and Ecliptae Herba on premature ovarian failure (POF) and the underlying mechanisms. In the POF mouse model constructed using cyclophosphamide (CTX), Ligustrum lucidu…
View article: Cpt1a Drives primed-to-naïve pluripotency transition through lipid remodeling
Cpt1a Drives primed-to-naïve pluripotency transition through lipid remodeling Open
Metabolism has been implicated in cell fate determination, particularly through epigenetic modifications. Similarly, lipid remodeling also plays a role in regulating cell fate. Here, we present comprehensive lipidomics analysis during BMP4…
View article: ALKBH5 governs human endoderm fate by regulating the DKK1/4-mediated Wnt/β-catenin activation
ALKBH5 governs human endoderm fate by regulating the DKK1/4-mediated Wnt/β-catenin activation Open
N6-methyladenonsine (m6A) is ubiquitously distributed in mammalian mRNA. However, the precise involvement of m6A in early development has yet to be fully elucidated. Here, we report that deletion of the m6A demethylase ALKBH5 in human embr…
View article: Cell fate decision by a morphogen-transcription factor-chromatin modifier axis
Cell fate decision by a morphogen-transcription factor-chromatin modifier axis Open
View article: Engineering mouse cell fate controller by rational design
Engineering mouse cell fate controller by rational design Open
View article: Generation of musculoskeletal cells from human urine epithelium-derived presomitic mesoderm cells
Generation of musculoskeletal cells from human urine epithelium-derived presomitic mesoderm cells Open
View article: Exclusion of HDAC1/2 complexes by oncogenic nuclear condensates
Exclusion of HDAC1/2 complexes by oncogenic nuclear condensates Open
View article: c-Jun as a one-way valve at the naive to primed interface
c-Jun as a one-way valve at the naive to primed interface Open
View article: Cell fate decision by a morphogen-transcription factor-chromatin modifier axis
Cell fate decision by a morphogen-transcription factor-chromatin modifier axis Open
Cell fate decision remains poorly understood at the molecular level. Embryogenesis provides a unique opportunity to analyse molecular details associated cell fate decisions. Works based on model organisms have provided a conceptual framewo…
View article: c-JUN is a barrier in hESC to cardiomyocyte transition
c-JUN is a barrier in hESC to cardiomyocyte transition Open
Loss of c-JUN leads to early mouse embryonic death, possibly because of a failure to develop a normal cardiac system. How c-JUN regulates human cardiomyocyte cell fate remains unknown. Here, we used the in vitro differentiation of human pl…
View article: The NuRD complex cooperates with SALL4 to orchestrate reprogramming
The NuRD complex cooperates with SALL4 to orchestrate reprogramming Open
Cell fate decision involves rewiring of the genome, but remains poorly understood at the chromatin level. Here, we report that chromatin remodeling complex NuRD participates in closing open chromatin in the early phase of somatic reprogram…
View article: Sin3a and CDX2 Target TBX15 to Dissociate HES7 Oscillation From Anterior-Posterior Elongation in vitro
Sin3a and CDX2 Target TBX15 to Dissociate HES7 Oscillation From Anterior-Posterior Elongation in vitro Open
View article: Hierarchical deployment of Tbx3 dictates the identity of hypothalamic KNDy neurons to control puberty onset
Hierarchical deployment of Tbx3 dictates the identity of hypothalamic KNDy neurons to control puberty onset Open
The neuroendocrine system consists of a heterogeneous collection of neuropeptidergic neurons in the brain, among which hypothalamic KNDy neurons represent an indispensable cell subtype controlling puberty onset. Although neural progenitors…
View article: Regeneration of the human segmentation clock in somitoids <i>in vitro</i>
Regeneration of the human segmentation clock in somitoids <i>in vitro</i> Open
View article: The Art of Reprogramming for Regenerative Medicine
The Art of Reprogramming for Regenerative Medicine Open
Traditional pharmaceuticals in the forms of small chemical compounds or macromolecules such as proteins or RNAs have provided lifesaving solutions to many acute and chronic conditions to date. However, there are still many unmet medical ne…
View article: H3K27ac mediated SS18/BAFs relocation regulates JUN induced pluripotent-somatic transition
H3K27ac mediated SS18/BAFs relocation regulates JUN induced pluripotent-somatic transition Open
Background The exit from pluripotency or pluripotent-somatic transition (PST) landmarks an event of early mammalian embryonic development, representing a model for cell fate transition. Results In this study, using a robust JUN-induced PST…
View article: Additional file 12 of H3K27ac mediated SS18/BAFs relocation regulates JUN induced pluripotent-somatic transition
Additional file 12 of H3K27ac mediated SS18/BAFs relocation regulates JUN induced pluripotent-somatic transition Open
Additional file 12. ATAC-seq TSS binding sites data in this study.
View article: Additional file 11 of H3K27ac mediated SS18/BAFs relocation regulates JUN induced pluripotent-somatic transition
Additional file 11 of H3K27ac mediated SS18/BAFs relocation regulates JUN induced pluripotent-somatic transition Open
Additional file 11. RNA-seq data in this study.
View article: Additional file 8 of H3K27ac mediated SS18/BAFs relocation regulates JUN induced pluripotent-somatic transition
Additional file 8 of H3K27ac mediated SS18/BAFs relocation regulates JUN induced pluripotent-somatic transition Open
Additional file 8. shRNA target sequences used in this study.
View article: Additional file 10 of H3K27ac mediated SS18/BAFs relocation regulates JUN induced pluripotent-somatic transition
Additional file 10 of H3K27ac mediated SS18/BAFs relocation regulates JUN induced pluripotent-somatic transition Open
Additional file 10. IP-MS data in this study.
View article: Additional file 13 of H3K27ac mediated SS18/BAFs relocation regulates JUN induced pluripotent-somatic transition
Additional file 13 of H3K27ac mediated SS18/BAFs relocation regulates JUN induced pluripotent-somatic transition Open
Additional file 13. Antibody used in this study.
View article: Additional file 9 of H3K27ac mediated SS18/BAFs relocation regulates JUN induced pluripotent-somatic transition
Additional file 9 of H3K27ac mediated SS18/BAFs relocation regulates JUN induced pluripotent-somatic transition Open
Additional file 9. RT-qPCR primers used in this study.
View article: SS18 regulates pluripotent-somatic transition through phase separation
SS18 regulates pluripotent-somatic transition through phase separation Open
View article: Rapid generation of ACE2 humanized inbred mouse model for COVID-19 with tetraploid complementation
Rapid generation of ACE2 humanized inbred mouse model for COVID-19 with tetraploid complementation Open
The research can be used to generate animal models of severe disease based on the hACE2 mice for development of treatment against severe COVID-19 and also quickly establish specific mouse models in response to other emergency situations in…
View article: The nuclear factor CECR2 promotes somatic cell reprogramming by reorganizing the chromatin structure
The nuclear factor CECR2 promotes somatic cell reprogramming by reorganizing the chromatin structure Open
View article: Screening Genes Promoting Exit from Naive Pluripotency Based on Genome-Scale CRISPR-Cas9 Knockout
Screening Genes Promoting Exit from Naive Pluripotency Based on Genome-Scale CRISPR-Cas9 Knockout Open
Two of the main problems of stem cell and regenerative medicine are the exit of pluripotency and differentiation to functional cells or tissues. The answer to these two problems holds great value in the clinical translation of stem cell as…
View article: SETDB1-Mediated Cell Fate Transition between 2C-Like and Pluripotent States
SETDB1-Mediated Cell Fate Transition between 2C-Like and Pluripotent States Open
Known as a histone H3K9 methyltransferase, SETDB1 is essential for embryonic development and pluripotent inner cell mass (ICM) establishment. However, its function in pluripotency regulation remains elusive. In this study, we find that und…
View article: Induction of Pluripotent Stem Cells from Mouse Embryonic Fibroblasts by Jdp2-Jhdm1b-Mkk6-Glis1-Nanog-Essrb-Sall4
Induction of Pluripotent Stem Cells from Mouse Embryonic Fibroblasts by Jdp2-Jhdm1b-Mkk6-Glis1-Nanog-Essrb-Sall4 Open
View article: Resolving Cell Fate Decisions during Somatic Cell Reprogramming by Single-Cell RNA-Seq
Resolving Cell Fate Decisions during Somatic Cell Reprogramming by Single-Cell RNA-Seq Open