Junqiang Lv
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View article: A galactoarabinan-containing glycoprotein isolated from the fruits of Lycium barbarum reverses the tumor-associated macrophage phenotype
A galactoarabinan-containing glycoprotein isolated from the fruits of Lycium barbarum reverses the tumor-associated macrophage phenotype Open
Lycium barbarum fruits possess a well-established history of use in traditional Chinese medicine due to their potent immunomodulatory properties, extending to cancer immunity. In this study, a purified galactoarabinan-containing glycoprote…
View article: C19orf12 inhibits mitochondrial function and enhances the antitumor effects of metformin in non-small cell lung cancer
C19orf12 inhibits mitochondrial function and enhances the antitumor effects of metformin in non-small cell lung cancer Open
Glucose metabolic reprogramming from oxidative phosphorylation to glycolysis is a hallmark of cancer, yet the mechanisms driving aerobic glycolysis are unclear. In this study, we identified chromosome 19 open reading frame 12 (C19orf12), a…
View article: PIM1–HDAC2 axis modulates intestinal homeostasis through epigenetic modification
PIM1–HDAC2 axis modulates intestinal homeostasis through epigenetic modification Open
View article: Folic acid prevents interferon-induced iron accumulation and ferroptosis and improves liver health in children with biliary atresia
Folic acid prevents interferon-induced iron accumulation and ferroptosis and improves liver health in children with biliary atresia Open
Background & Aims Biliary atresia (BA) is an obstructive newborn jaundice disease that leads to liver failure in the majority of affected infants. Viral infection is an important environmental trigger of BA. The aim of the study is to esta…
View article: Bacterial indole-3-lactic acid affects epithelium–macrophage crosstalk to regulate intestinal homeostasis
Bacterial indole-3-lactic acid affects epithelium–macrophage crosstalk to regulate intestinal homeostasis Open
Tryptophan and its derivatives perform a variety of biological functions; however, the role and specific mechanism of many tryptophan derivatives in intestinal inflammation remain largely unclear. Here, we identified that an Escherichia co…
View article: Aberrant metabolic processes promote the immunosuppressive microenvironment in multiple myeloma
Aberrant metabolic processes promote the immunosuppressive microenvironment in multiple myeloma Open
Introduction Multiple myeloma (MM) is still an incurable plasma cell malignancy. The efficacy of immunotherapy on MM remains unsatisfactory, and the underlying molecular mechanisms still are not fully understood. Methods In this study, we …
View article: Enterobacter ludwigii protects DSS-induced colitis through choline-mediated immune tolerance
Enterobacter ludwigii protects DSS-induced colitis through choline-mediated immune tolerance Open
Commensal intestinal bacteria play key roles in regulating host immune tolerance; however, bacterial strains and related metabolites directly involved in this regulation are largely unknown. Here, using a mouse model of dextran sulfate sod…
View article: Interactions of Bacterial Toxin CNF1 and Host JAK1/2 Driven by Liquid-Liquid Phase Separation Enhance Macrophage Polarization
Interactions of Bacterial Toxin CNF1 and Host JAK1/2 Driven by Liquid-Liquid Phase Separation Enhance Macrophage Polarization Open
CNF1 is a key toxin secreted by UPEC, which induces inflammation during UPEC infections. CNF1 is well known to activate Rho GTPases to disturb host cell signaling pathways.
View article: An infection-induced RhoB-Beclin 1-Hsp90 complex enhances clearance of uropathogenic Escherichia coli
An infection-induced RhoB-Beclin 1-Hsp90 complex enhances clearance of uropathogenic Escherichia coli Open
Host cells use several anti-bacterial pathways to defend against pathogens. Here, using a uropathogenic Escherichia coli (UPEC) infection model, we demonstrate that bacterial infection upregulates RhoB, which subsequently promotes intracel…
View article: Multiple myeloma hinders erythropoiesis and causes anaemia owing to high levels of CCL3 in the bone marrow microenvironment
Multiple myeloma hinders erythropoiesis and causes anaemia owing to high levels of CCL3 in the bone marrow microenvironment Open
View article: Enterobacter Ludwigii Protects Experimental Colitis Through CD103+DC and Treg Cells
Enterobacter Ludwigii Protects Experimental Colitis Through CD103+DC and Treg Cells Open
Background: Intestinal bacteria are closely related with inflammatory bowel disease (IBD), and regulatory cell-mediated immune tolerance is important to inhibit IBD. Commensal intestinal bacteria play key roles in regulating immune toleran…
View article: Cytotoxic necrotizing factor 1 promotes bladder cancer angiogenesis through activating RhoC
Cytotoxic necrotizing factor 1 promotes bladder cancer angiogenesis through activating RhoC Open
Uropathogenic Escherichia coli (UPEC), a leading cause of urinary tract infections, is associated with prostate and bladder cancers. Cytotoxic necrotizing factor 1 (CNF1) is a key UPEC toxin; however, its role in bladder cancer is unknown.…
View article: Alpha-hemolysin of uropathogenic Escherichia coli induces GM-CSF-mediated acute kidney injury
Alpha-hemolysin of uropathogenic Escherichia coli induces GM-CSF-mediated acute kidney injury Open
View article: Cytotoxic Necrotizing Factor 1 Downregulates CD36 Transcription in Macrophages to Induce Inflammation During Acute Urinary Tract Infections
Cytotoxic Necrotizing Factor 1 Downregulates CD36 Transcription in Macrophages to Induce Inflammation During Acute Urinary Tract Infections Open
Urinary tract infections (UTIs) caused by uropathogenic Escherichia coli (UPEC) induce cystitis, pyelonephritis, and can cause kidney scarring and failure if inflammation is not under control. The detailed effects of cytotoxic necro…
View article: FBXL10 contributes to the development of diffuse large B-cell lymphoma by epigenetically enhancing ERK1/2 signaling pathway
FBXL10 contributes to the development of diffuse large B-cell lymphoma by epigenetically enhancing ERK1/2 signaling pathway Open
Epigenetic modifiers have emerged as critical factors governing the biology of different cancers. Herein we show that FBXL10 (also called KDM2B or JHDM1B), an important member of Polycomb repressive complexes, is overexpressed in human dif…
View article: Cytotoxic necrotizing factor 1 promotes prostate cancer progression through activating the Cdc42–PAK1 axis
Cytotoxic necrotizing factor 1 promotes prostate cancer progression through activating the Cdc42–PAK1 axis Open
Uropathogenic Escherichia coli (UPEC) is the leading cause of urinary tract infections and plays a role in prostatic carcinogenesis and prostate cancer (PCa) progression. However, the mechanisms through which UPEC promotes PCa development …