Explanipedia

Enhanced Clonality and Autoantibody Production by Antibody-Secreting Cells in CRSwNP 3002 Open

Junqin Bai, Atsushi Kato, Bruce Tan · 2025

Description Background Nasal polyps (NP) in chronic rhinosinusitis with NP (CRSwNP) contain increased extrafollicularly activated antibody-secreting cells (ASCs) that produce autoantibodies, including anti-dsDNA IgG, which predict NP recur…

Factor Analysis‐Based Quantitative Endotyping Improves Associations With CRS Cross‐Sectional and Longitudinal Outcomes Open

Brooke N. Gleason, Zhidi Luo, Aditi Agarwal, Siyuan Dong, Regan L. Harmon , et al. · 2025

Background Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory disease characterized by persistent sinonasal inflammation. There is increasing interest in endotype‐based classification, which categorizes CRS based on underlying in…

Expression of <span>IL</span>‐4 Receptor Alpha in Ectopic Lymphoid Tissue in Chronic Rhinosinusitis Open

Kengo Kanai, Hiroyuki Kusano, Aiko Oka, Marie Yamada, Ryou Takagi , et al. · 2025

Executive Summary of the Clinical Practice Guideline on the Surgical Management of Chronic Rhinosinusitis Open

Jennifer J. Shin, Meghan Wilson, Margo McKenna, Richard M. Rosenfeld, K von Ammon , et al. · 2025

Objective The purpose of this specialty‐specific clinical practice guideline is to identify quality improvement opportunities and provide clinicians with trustworthy, evidence‐based recommendations for the surgical management of chronic rh…

Clinical Practice Guideline: Surgical Management of Chronic Rhinosinusitis Open

Jennifer J. Shin, Meghan Wilson, Margo McKenna, Richard M. Rosenfeld, K von Ammon , et al. · 2025

Objective The purpose of this specialty‐specific clinical practice guideline is to identify quality improvement opportunities and provide clinicians with trustworthy, evidence‐based recommendations for the surgical management of chronic rh…

Long‐Term Implications of Short‐Term Symptom and Radiographic Severity Outcomes After ESS in CRS Patients Open

Aditi Agarwal, Zhidi Luo, Siyuan Dong, Caroline P.E. Price, Regan L. Harmon , et al. · 2025

Increased autoreactivity and maturity of EBI2+ antibody-secreting cells from nasal polyps Open

Junqin Bai, Atsushi Kato, Kathryn E. Hulse, Joshua B. Wechsler, Vikramsingh Gujar , et al. · 2024

Elevated numbers of antibody-secreting cells (ASCs) and anti-double-stranded DNA (anti-dsDNA) antibodies are found in nasal polyp (NP) tissue. The presence of anti-dsDNA IgG in tissue prospectively predicts recurrent NP but the characteris…

ScRNA-seq Reveals Iso/Subtype Specific Differences in Maturity and Signaling Pathways Utilized by Plasma cells in CRSwNP Open

Junqin Bai, Atsushi Kato, Whitney W. Stevens, Robert P. Schleimer, Bruce K. Tan · 2024

IL-13 and IL-13–induced periostin levels are specifically decreased in patients following endoscopic sinus surgery for chronic rhinosinusitis Open

Regan Harmon, Alexander L. Schneider, Junqin Bai, Samuel D. Racette, Abhita Reddy , et al. · 2023

Endotypic heterogeneity and pathogenesis in chronic rhinosinusitis Open

Junqin Bai, Bruce K. Tan, Atsushi Kato · 2023

Purpose of review This review aims to provide updates in realms of endotypic heterogeneity, pathogenesis at the molecular level, potential of biomarkers, and cutting-edge scope of biologics in CRS. Recent findings High-dimensional analyses…

B Lineage Cells and IgE in Allergic Rhinitis and CRSwNP and the Role of Omalizumab Treatment Open

Junqin Bai, Bruce K. Tan · 2023

Background Allergic rhinitis (AR) and chronic rhinosinusitis (CRS) are two prevalent nasal diseases where both type 2 inflammation and immunoglobulin E (IgE) may play important roles. Although they can exist independently or comorbidly, su…

Nasal polyp antibody secreting cells have features of long-lived plasma cells and frequently produce autoantibodies and IgE Open

Junqin Bai · 2023

Evidence that oncostatin M synergizes with IL-4 signaling to induce TSLP expression in chronic rhinosinusitis with nasal polyps Open

Baofeng Wang, Ping‐Ping Cao, James E. Norton, Julie A. Poposki, Aiko I. Klingler , et al. · 2023

Prognostic factors for polyp recurrence in chronic rhinosinusitis with nasal polyps Open

Junqin Bai, Julia Huang, Caroline P.E. Price, Jacob M. Schauer, Lydia Suh , et al. · 2022

Anti‐phospholipid antibodies are elevated and functionally active in chronic rhinosinusitis with nasal polyps Open

Jacob G. Eide, Jeffanie Wu, Whitney W. Stevens, Junqin Bai, Songwang Hou , et al. · 2022

Background Polyps from patients with chronic rhinosinusitis with nasal polyps (CRSwNP) contain increased levels of autoreactive antibodies, B cells and fibrin deposition. Anti‐phospholipid antibodies (APA) are autoantibodies known to cause…

18-Year Follow-Up After Coronary Stenting for Left Main Coronary Artery Lesions Open

Junqin Bai, Zhichao Dong, Li‐Fei Pan, Xunlong Xia, Bo Zhang · 2020

The current treatment of radiation-induced coronary artery disease (RCAD) is comparable to that of generic coronary artery disease (CAD); however, the outcomes of these treatment measures have not been fully examined in RCAD. A 33-year-old…

Roles of ComW, HPF and YhaM in Competence Regulation in Streptococcus pneumoniae Open

Junqin Bai · 2018

This dissertation concentrates on determining how three competence-specific proteins—ComW, HPF, and YhaM—regulate competence development induced by competence-stimulating peptides in Streptococcus pneumoniae. The first dissertation study o…

Competence for Genetic Transformation in Streptococcus pneumoniae: Mutations in σ <sup>A</sup> Bypass the ComW Requirement for Late Gene Expression Open

Yanina Tovpeko, Junqin Bai, Donald A. Morrison · 2016

Streptococcus pneumoniae is able to integrate exogenous DNA into its genome by natural genetic transformation. Transient accumulation of high levels of the only S. pneumoniae alternative σ factor is insufficient for development of full com…

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