Junqing Liang
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View article: Sodium valproate drives propionylation-mediated epigenetic reprogramming to enhance mesothelin CAR-T cell therapy in solid tumors
Sodium valproate drives propionylation-mediated epigenetic reprogramming to enhance mesothelin CAR-T cell therapy in solid tumors Open
Chimeric antigen receptor (CAR)-T cell therapy has shown success in hematologic malignancies but remains limited in solid tumors due to poor persistence, migration, and TME-induced exhaustion. In an investigator-initiated trial in relapsed…
View article: Prediction of lymphovascular invasion in non-mass enhancement breast cancer using DCE-MRI and clinical-pathological features
Prediction of lymphovascular invasion in non-mass enhancement breast cancer using DCE-MRI and clinical-pathological features Open
Objective The present study explores the relationship between the distribution patterns of non-mass enhancement (NME) type invasive breast cancer in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and lymphovascular invasion…
View article: Assessment of ultra-pulse CO2 laser therapy in comparison to sequential laser and drug treatments for scar reduction
Assessment of ultra-pulse CO2 laser therapy in comparison to sequential laser and drug treatments for scar reduction Open
Scar management, particularly for early proliferative burn scars, remains a clinical challenge. This study assesses the efficacy of ultra-pulse carbon dioxide (CO 2 ) laser therapy in comparison to sequential laser therapy and pharmacologi…
View article: Melatonin lessens the susceptibility to atrial fibrillation in sleep deprivation by ameliorating Ca2+ mishandling in response to mitochondrial oxidative stress
Melatonin lessens the susceptibility to atrial fibrillation in sleep deprivation by ameliorating Ca2+ mishandling in response to mitochondrial oxidative stress Open
MLT significantly decreases the susceptibility to SD-induced AF by ameliorating mitochondrial oxidative stress and Ca2+ mishandling. These findings suggest a potential therapeutic application of MLT as an antiarrhythmic intervention for SD…
View article: <i>Peganum harmala</i> Polysaccharide Mitigates <scp>LPS</scp>‐Induced Inflammatory Response in Macrophages by Activating Autophagy Pathway
<i>Peganum harmala</i> Polysaccharide Mitigates <span>LPS</span>‐Induced Inflammatory Response in Macrophages by Activating Autophagy Pathway Open
Peganum harmala, a member of the Zygophyllaceae family, is known for its diverse biological activities, including anti‐inflammatory properties. The mechanisms through which P. harmala polysaccharide (LTP) induces autophagy, however, remain…
View article: Precision Medicine Unveiled: Deciphering the Molecular Tapestry of Endotoxin-Induced Acute Lung Injury through microRNA Modulation and Exploring the Therapeutic Nexus with Ligustrazine in the Sun-Luo Microvascular System
Precision Medicine Unveiled: Deciphering the Molecular Tapestry of Endotoxin-Induced Acute Lung Injury through microRNA Modulation and Exploring the Therapeutic Nexus with Ligustrazine in the Sun-Luo Microvascular System Open
Endotoxin-induced acute lung injury (ALI) poses a severe challenge to critical care medicine, necessitating a profound understanding of its underlying molecular mechanisms for targeted therapeutic interventions. This comprehensive review e…
View article: Qili Qiangxin (QLQX) capsule as a multi-functional traditional Chinese medicine in treating chronic heart failure (CHF): A review of ingredients, molecular, cellular, and pharmacological mechanisms
Qili Qiangxin (QLQX) capsule as a multi-functional traditional Chinese medicine in treating chronic heart failure (CHF): A review of ingredients, molecular, cellular, and pharmacological mechanisms Open
Chronic heart failure (CHF) is a key part of cardiovascular continuum. Under the guidance of the theory of vessel-collateral doctrine, the present study proposes therapeutic benefits of Qili Qiangxin (QLQX) capsules, an innovative Chinese …
View article: Tongxinluo enhances the effect of atorvastatin on the treatment of atherosclerosis with chronic obstructive pulmonary disease by maintaining the pulmonary microvascular barrier
Tongxinluo enhances the effect of atorvastatin on the treatment of atherosclerosis with chronic obstructive pulmonary disease by maintaining the pulmonary microvascular barrier Open
Atherosclerosis (AS) is a common comorbidity of chronic obstructive pulmonary disease (COPD), and systemic inflammation is an important mechanism of COPD with AS. Tongxinluo (TXL) improves the function of vascular endothelial cells. We aim…
View article: [Retracted] miRNA‑429 suppresses osteogenic differentiation of human adipose‑derived mesenchymal stem cells under oxidative stress via targeting SCD‑1
[Retracted] miRNA‑429 suppresses osteogenic differentiation of human adipose‑derived mesenchymal stem cells under oxidative stress via targeting SCD‑1 Open
[This retracts the article DOI: 10.3892/etm.2019.8246.].
View article: Constructing a competing endogenous RNA network for osteoarthritis
Constructing a competing endogenous RNA network for osteoarthritis Open
The dual-specificity phosphatase 1-specific ceRNA network can be used as a diagnostic tool to assess the progression of OA patients.
View article: Corrigendum: Bazi Bushen Capsule Alleviates Post-Menopausal Atherosclerosis via GPER1-Dependent Anti-Inflammatory and Anti-Apoptotic Effects
Corrigendum: Bazi Bushen Capsule Alleviates Post-Menopausal Atherosclerosis via GPER1-Dependent Anti-Inflammatory and Anti-Apoptotic Effects Open
[This corrects the article DOI: 10.3389/fphar.2021.658998.].
View article: Bazi Bushen Capsule Alleviates Post-Menopausal Atherosclerosis via GPER1-Dependent Anti-Inflammatory and Anti-Apoptotic Effects
Bazi Bushen Capsule Alleviates Post-Menopausal Atherosclerosis via GPER1-Dependent Anti-Inflammatory and Anti-Apoptotic Effects Open
Bazi Bushen capsule (BZBS), as a Chinese medicine used to relieve fatigue, has been proven effective for the treatment of atherogenesis through antilipid effects. To investigate the potential mechanism of BZBS in the anti-atherosclerotic e…
View article: Chinese medicine Bazi Bushen capsule improves lipid metabolism in ovariectomized female ApoE−/− mice
Chinese medicine Bazi Bushen capsule improves lipid metabolism in ovariectomized female ApoE−/− mice Open
BZBS treatment reduced serum lipid levels and improved fatty acid metabolism in high-fat diet-fed, surgically induced menopausal ApoE-/- mice.
View article: miRNA‑429 suppresses osteogenic differentiation of human adipose‑derived mesenchymal stem cells under oxidative stress via targeting SCD‑1
miRNA‑429 suppresses osteogenic differentiation of human adipose‑derived mesenchymal stem cells under oxidative stress via targeting SCD‑1 Open
Role of microRNA-429 (miRNA-429) in osteogenic differentiation of hADMSCs was elucidated to explore the potential mechanism. Serum level of miRNA-429 in osteoporosis patients and controls was determined by quantitative real-time polymerase…
View article: Tongxinluo Attenuates Myocardiac Fibrosis after Acute Myocardial Infarction in Rats via Inhibition of Endothelial-to-Mesenchymal Transition
Tongxinluo Attenuates Myocardiac Fibrosis after Acute Myocardial Infarction in Rats via Inhibition of Endothelial-to-Mesenchymal Transition Open
Endothelial-to-mesenchymal transition (EndMT) is an essential mechanism in myocardial fibrosis (MF). Tongxinluo (TXL) has been confirmed to protect the endothelium against reperfusion injury after acute myocardial infarction (AMI). However…
View article: Qiliqiangxin Attenuates Oxidative Stress-Induced Mitochondrion-Dependent Apoptosis in Cardiomyocytes <i>via</i> PI3K/AKT/GSK3β Signaling Pathway
Qiliqiangxin Attenuates Oxidative Stress-Induced Mitochondrion-Dependent Apoptosis in Cardiomyocytes <i>via</i> PI3K/AKT/GSK3β Signaling Pathway Open
Qiliqiangxin capsule (QLQX) is a well-known traditional Chinese medicine that exhibits cardioprotective effects in heart failure patients. However, it remains unclear whether and by which mechanism QLQX attenuates oxidative stress-induced …
View article: Tongxinluo Regulates Expression of Tight Junction Proteins and Alleviates Endothelial Cell Monolayer Hyperpermeability via ERK‐1/2 Signaling Pathway in Oxidized Low‐Density Lipoprotein‐Induced Human Umbilical Vein Endothelial Cells
Tongxinluo Regulates Expression of Tight Junction Proteins and Alleviates Endothelial Cell Monolayer Hyperpermeability via ERK‐1/2 Signaling Pathway in Oxidized Low‐Density Lipoprotein‐Induced Human Umbilical Vein Endothelial Cells Open
Vascular hyperpermeability resulting from distortion of endothelial junctions is associated with a number of cardiovascular diseases. Endothelial tight junction regulates the paracellular permeability of macromolecules, a function of Human…