Junru Yang
YOU?
Author Swipe
View article: Noninvasive elastography-based assessment of liver fibrosis in primary biliary cholangitis
Noninvasive elastography-based assessment of liver fibrosis in primary biliary cholangitis Open
The Model A and Model B were the efficient noninvasive models with high accuracy in predicting the histological stages of PBC.
View article: FAM172A deletion aggravates high fat diet-induced MASLD via the eIF2α-ATF4-FGF21 loop
FAM172A deletion aggravates high fat diet-induced MASLD via the eIF2α-ATF4-FGF21 loop Open
Fam172a gene deletion can promote HFD-induced MASLD via the eIF2α-ATF4 pathway. The expression of Fgf21, up-regulated by the eIF2α-ATF4 pathway, partially inhibit the effects of Fam172a gene deletion via negative feedback loop. Thus, FAM17…
View article: PD-L2 act as an independent immune checkpoint in colorectal cancer beyond PD-L1
PD-L2 act as an independent immune checkpoint in colorectal cancer beyond PD-L1 Open
Introduction Immunotherapy, especially immune checkpoint blockade (ICB), holds promise as a therapeutic strategy in colorectal cancer (CRC) by harnessing the patient’s immune system to target malignant cells. Particularly, the PD-1/PD-L1 a…
View article: Prevalence and risk factors of significant fibrosis in chronic hepatitis B patients with concurrent metabolic dysfunction-associated steatotic liver disease
Prevalence and risk factors of significant fibrosis in chronic hepatitis B patients with concurrent metabolic dysfunction-associated steatotic liver disease Open
MASLD was associated with higher fibrosis stage in patients with CHB. Early detection and intervention are crucial to patients with three or more cardiometabolic risk factors.
View article: First-principles study of V-doped TiAlN and TiN coating materials
First-principles study of V-doped TiAlN and TiN coating materials Open
In this paper, the unit cell model of V-doped TiN and TiAlN is constructed, and the formation enthalpy of the unit cell and lattice parameters of the doped models are calculated by first principles. The results show that the lattice parame…
View article: An Analysis of the Static and Dynamic Behavior of the Hydraulic Compensation System of a Multichannel Valve
An Analysis of the Static and Dynamic Behavior of the Hydraulic Compensation System of a Multichannel Valve Open
Electro-hydraulic proportional valve is the core control valve in many hydraulic systems used in agricultural and engineering machinery. To address the problem related to the large throttling losses and poor stability typically associated …
View article: Upregulation of GLT25D1 in Hepatic Stellate Cells Promotes Liver Fibrosis via the TGF-β1/SMAD3 Pathway <i>In Vivo</i> and <i>In vitro</i>
Upregulation of GLT25D1 in Hepatic Stellate Cells Promotes Liver Fibrosis via the TGF-β1/SMAD3 Pathway <i>In Vivo</i> and <i>In vitro</i> Open
Collectively, the upregulation of GLT25D1 in HSCs promoted the progression of liver fibrosis by affecting HSCs activation and collagen stability.
View article: EOGT Correlated With Immune Infiltration: A Candidate Prognostic Biomarker for Hepatocellular Carcinoma
EOGT Correlated With Immune Infiltration: A Candidate Prognostic Biomarker for Hepatocellular Carcinoma Open
Background A preliminary study by our group revealed that the deficiency of EGF domain-specific O-linked N-acetylglucosamine transferase (EOGT) impaired regulatory T-cell differentiation in autoimmune hepatitis. Nevertheless, the prognosti…
View article: Altered N-/O-Glycosylation Sites On The Receptor-Binding Domain (RBD) in COVID-19 Are Related To Coronavirus Infection And Pathogenesis.
Altered N-/O-Glycosylation Sites On The Receptor-Binding Domain (RBD) in COVID-19 Are Related To Coronavirus Infection And Pathogenesis. Open
Objective: To discuss the possible significances of N-Linked and O-Linked glycosylation on the RBD of COVID-19 Methods: Amino acid sequences multiple alignments of RBD used Clustal Omega (v.1.2.4) using default parameters. Prediction of po…
View article: Environmental impact correction for resistivity logging in CBM horizontal well
Environmental impact correction for resistivity logging in CBM horizontal well Open
The resistivity logging in CBM horizontal well is under the influence of factors such as borehole, mud invasion and anisotropy. The environmental impact correction can improve the interpretation accuracy of CBM the horizontal well. This pa…
View article: Identifying coal structure using logging data
Identifying coal structure using logging data Open
Coal structure, which is important for the mining of CBM, is closely related to the coal reservoir fracture characteristics. This paper calculates the integrity coefficient, stability coefficient and fracture coefficient of coal, and const…
View article: Selecting fracturing interval for the exploitation of tight oil reservoirs from logs: a case study
Selecting fracturing interval for the exploitation of tight oil reservoirs from logs: a case study Open
The optimal selection of fracturing interval for the exploitation of tight oil reservoirs is very important for formulating a development program. In this study, the reservoir quality and the reservoir fracability are evaluated, and the cr…
View article: <p>Diammonium Glycyrrhizinate Mitigates Liver Injury Via Inhibiting Proliferation Of NKT Cells And Promoting Proliferation Of Tregs</p>
Diammonium Glycyrrhizinate Mitigates Liver Injury Via Inhibiting Proliferation Of NKT Cells And Promoting Proliferation Of Tregs Open
We believe that the potential protective effect of DG against Con A-induced hepatitis may be partially attributed to its inhibitory activities on inflammatory cytokines in the livers, lymphocyte apoptosis in the thymus, NKT cells prolifera…
View article: Deficient O-GlcNAc Glycosylation Impairs Regulatory T Cell Differentiation and Notch Signaling in Autoimmune Hepatitis
Deficient O-GlcNAc Glycosylation Impairs Regulatory T Cell Differentiation and Notch Signaling in Autoimmune Hepatitis Open
Post-translational modifications such as glycosylation play an important role in the functions of homeostatic proteins, and are critical driving factors of several diseases; however, the role of glycosylation in autoimmune hepatitis is poo…
View article: Downregulation of Glt25d1 aggravates carbon tetrachloride‑induced acute hepatic injury through activation of the TGF‑β1/Smad2 signaling pathway
Downregulation of Glt25d1 aggravates carbon tetrachloride‑induced acute hepatic injury through activation of the TGF‑β1/Smad2 signaling pathway Open
Collagen β (1‑O) galactosyltransferase 1 (GLT25D1) has been reported to transfer galactose to hydroxylysine residues via β (1‑O) linkages in collagen. The present study investigated the function of the collagen galactosyltransferase activi…
View article: raw data.xls
raw data.xls Open
We retrospectively analyzed 659 patients with chronic hepatitis B virus(HBV) infection and 410 patients in our medical center, from October, 2015 to December, 2017. We set 659 CHB patients as training set, and 410 patients with other chron…
View article: New algorithm for predicting gastroesophageal varices
New algorithm for predicting gastroesophageal varices Open
We retrospectively analyzed 659 patients with chronic hepatitis B virus(HBV) infection and 410 patients in our medical center, from October, 2015 to December, 2017. We set 659 CHB patients as training set, and 410 patients with other chron…
View article: CCDC 1501938: Experimental Crystal Structure Determination
CCDC 1501938: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Molecular Dynamics Study on the Interface Properties of the Ternary Boride Cladding Materials with Atomic Vacancy Defects
Molecular Dynamics Study on the Interface Properties of the Ternary Boride Cladding Materials with Atomic Vacancy Defects Open
In the paper, the interface models of Mo2FeB2 (100)/α-Fe (001) with different atomic vacancy defects are constructed. The formation energies of different atomic vacancy defects and the interface binding energies of the models are studied.…