Junseong Park
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View article: Large Language Model Assistant for Emergency Department Discharge Documentation
Large Language Model Assistant for Emergency Department Discharge Documentation Open
Importance Emergency department (ED) discharge documentation is time-consuming and often incomplete. Objective To develop a large language model (LLM) assistant that generates ED discharge notes and to evaluate its effectiveness on documen…
View article: Tumor microenvironment-preserving gliosarcoma organoids as an in vitro preclinical platform: a comparative analysis with glioblastoma models
Tumor microenvironment-preserving gliosarcoma organoids as an in vitro preclinical platform: a comparative analysis with glioblastoma models Open
Background Gliosarcoma (GS) is a rare variant of glioblastoma (GBM), characterized by biphasic glial and sarcomatous histology and poor prognosis. Despite its distinct clinical features, GS remains underrepresented in glioma research due t…
View article: Correction: Intravesical instillation-based mTOR-STAT3 dual targeting for bladder cancer treatment
Correction: Intravesical instillation-based mTOR-STAT3 dual targeting for bladder cancer treatment Open
View article: Author Correction: A lignan from Alnus japonica inhibits glioblastoma tumorspheres by suppression of FOXM1
Author Correction: A lignan from Alnus japonica inhibits glioblastoma tumorspheres by suppression of FOXM1 Open
View article: N-phenylmaleimide induces bioenergetic switch and suppresses tumor growth in glioblastoma tumorspheres by inhibiting SLC25A11
N-phenylmaleimide induces bioenergetic switch and suppresses tumor growth in glioblastoma tumorspheres by inhibiting SLC25A11 Open
View article: Improved Subseasonal Prediction of Atmospheric Energy Transport over the Northwest Pacific Using an Atmosphere–Ocean Coupled Model
Improved Subseasonal Prediction of Atmospheric Energy Transport over the Northwest Pacific Using an Atmosphere–Ocean Coupled Model Open
Poleward transport of energy is essential for reducing Earth’s energy imbalance. During boreal summer, equatorward dry static energy transport (DSET) and poleward latent heat transport (LHT) are located in the upper and lower tropical atmo…
View article: First-pass success rate and predictive factors for stylet use in videolaryngoscopic intubations with a Macintosh blade: a prospective observational study
First-pass success rate and predictive factors for stylet use in videolaryngoscopic intubations with a Macintosh blade: a prospective observational study Open
Routine stylet preparation for elective videolaryngoscopic intubations with a Macintosh blade may not be necessary, as only a small percentage of patients required it.
View article: Single-Cell RNA Sequencing of Baseline Immune Profiles After Third Vaccination Associated with Subsequent SARS-CoV-2 Infection in Naïve Individuals
Single-Cell RNA Sequencing of Baseline Immune Profiles After Third Vaccination Associated with Subsequent SARS-CoV-2 Infection in Naïve Individuals Open
Even though vaccines protected many from infection, not all were protected, and vaccinated individuals displayed a wide range of clinical outcomes, from complete protection against infection to multiple breakthrough infections. This study …
View article: Arcyriaflavin A, a cyclin D1/CDK4 inhibitor, suppresses tumor growth, migration, and invasion of metastatic melanoma cells
Arcyriaflavin A, a cyclin D1/CDK4 inhibitor, suppresses tumor growth, migration, and invasion of metastatic melanoma cells Open
Background Despite advancements in targeted therapy and immunotherapy, cutaneous melanoma continues to have a high mortality rate and poor prognosis, with therapies having limited efficacy in advanced melanoma. Therefore, it is crucial to …
View article: Disruption of bioenergetics enhances the radio-sensitivity of patient-derived glioblastoma tumorspheres
Disruption of bioenergetics enhances the radio-sensitivity of patient-derived glioblastoma tumorspheres Open
View article: Evaluating the Dermatological Benefits of Snowberry (Symphoricarpos albus): A Comparative Analysis of Extracts and Fermented Products from Different Plant Parts
Evaluating the Dermatological Benefits of Snowberry (Symphoricarpos albus): A Comparative Analysis of Extracts and Fermented Products from Different Plant Parts Open
Skin ageing is influenced by both intrinsic and extrinsic factors, with excessive ultraviolet (UV) exposure being a significant contributor. Such exposure can lead to moisture loss, sagging, increased wrinkling, and decreased skin elastici…
View article: Intravesical instillation-based mTOR-STAT3 dual targeting for bladder cancer treatment
Intravesical instillation-based mTOR-STAT3 dual targeting for bladder cancer treatment Open
View article: Comparison of Glioblastoma Cell Culture Platforms Based on Transcriptional Similarity with Paired Tissue
Comparison of Glioblastoma Cell Culture Platforms Based on Transcriptional Similarity with Paired Tissue Open
No standardized in vitro cell culture models for glioblastoma (GBM) have yet been established, excluding the traditional two-dimensional culture. GBM tumorspheres (TSs) have been highlighted as a good model platform for testing drug effect…
View article: Intratumoral IL-12 delivery via mesenchymal stem cells combined with PD-1 blockade leads to long-term antitumor immunity in a mouse glioblastoma model
Intratumoral IL-12 delivery via mesenchymal stem cells combined with PD-1 blockade leads to long-term antitumor immunity in a mouse glioblastoma model Open
Anti-PD-1 and MSC_IL-12 monotherapies show long-term therapeutic responses, and their combination further enhances antitumor efficacy against glioblastoma via inducing immune-favorable tumor microenvironment.
View article: Establishment of tumor microenvironment-preserving organoid model from patients with intracranial meningioma
Establishment of tumor microenvironment-preserving organoid model from patients with intracranial meningioma Open
Background Although meningioma is the most common primary brain tumor, treatments rely on surgery and radiotherapy, and recurrent meningiomas have no standard therapeutic options due to a lack of clinically relevant research models. Curren…
View article: Anti-Inflammatory Activity of Vacuum Distillate from <i>Panax ginseng</i> Root on LPS-Induced RAW264.7 Cells
Anti-Inflammatory Activity of Vacuum Distillate from <i>Panax ginseng</i> Root on LPS-Induced RAW264.7 Cells Open
Panax ginseng has been widely applied as an important herb in traditional medicine to treat numerous human disorders. However, the inflammatory regulation effect of P. ginseng distillate (GSD) has not yet been fully assessed.…
View article: P758 Effectiveness and tolerability of methotrexate monotherapy in Crohn’s disease patients: A multicenter observational study
P758 Effectiveness and tolerability of methotrexate monotherapy in Crohn’s disease patients: A multicenter observational study Open
Background Methotrexate monotherapy is recommended as a maintenance therapy for Crohn’s disease (CD). However, long-term follow-up data are scarce. We aimed to examine the effectiveness and tolerability of methotrexate monotherapy in 94 CD…
View article: P843 Effectiveness and tolerability of methotrexate combined with biologics in patients with Crohn’s disease: A multicenter observational study
P843 Effectiveness and tolerability of methotrexate combined with biologics in patients with Crohn’s disease: A multicenter observational study Open
Background Methotrexate (MTX) combination therapy with biological agents has gained increasing interest. Here, we assessed the efficacy and tolerability of the MTX combination therapy in patients with Crohn’s disease (CD). Methods We perfo…
View article: RADT-28. DISRUPTION OF BIOENERGETICS ENHANCES RADIO-SENSITIVITY OF PATIENT-DERIVED GLIOBLASTOMA TUMORSPHERES
RADT-28. DISRUPTION OF BIOENERGETICS ENHANCES RADIO-SENSITIVITY OF PATIENT-DERIVED GLIOBLASTOMA TUMORSPHERES Open
INTRODUCTION Glioblastoma (GBM), the most common primary brain tumor, has been associated with poor prognosis despite various treatment modalities, the surgical resection accompanied by chemotherapy and radiotherapy. Although the importanc…
View article: STEM-19. POTENTIAL THERAPEUTIC EFFECTS OF NOVEL HISTONE DEACETYLASE INHIBITORS ON HUMAN-DERIVED GLIOBLASTOMA TUMORSPHERES
STEM-19. POTENTIAL THERAPEUTIC EFFECTS OF NOVEL HISTONE DEACETYLASE INHIBITORS ON HUMAN-DERIVED GLIOBLASTOMA TUMORSPHERES Open
BACKGROUND Histone deacetylase (HDAC) inhibitor is a promising anticancer drug targeting epigenetic alterations on tumor cells, however, failed to prove its feasibility on glioblastoma (GBM) in several trials. We developed new HDAC inhibit…
View article: P07.06.A PATIENT-DERIVED GLIOBLASTOMA MINIATURE AND CANCER STEM CELL SUICIDE-INDUCING NANO-AWAKENER BASED ON IT
P07.06.A PATIENT-DERIVED GLIOBLASTOMA MINIATURE AND CANCER STEM CELL SUICIDE-INDUCING NANO-AWAKENER BASED ON IT Open
BACKGROUND Patient-specific anti-tumor therapies can evolve by vitalizing the mother tissue-like cancer niche, cellular profile, genetic signature, and drug responsiveness. This evolution elucidated a key mechanism along with the developme…
View article: Classification of IDH wild-type glioblastoma tumorspheres into low- and high-invasion groups based on their transcriptional program
Classification of IDH wild-type glioblastoma tumorspheres into low- and high-invasion groups based on their transcriptional program Open
View article: Single‐cell <scp>RNA</scp> sequencing of a poorly metastatic melanoma cell line and its subclones with high lung and brain metastasis potential reveals gene expression signature of metastasis with prognostic implication
Single‐cell <span>RNA</span> sequencing of a poorly metastatic melanoma cell line and its subclones with high lung and brain metastasis potential reveals gene expression signature of metastasis with prognostic implication Open
The molecular mechanisms underlying melanoma metastasis remain poorly understood. In this study, we aimed to delineate the mechanisms underlying gene expression alterations during metastatic potential acquisition and characterize the metas…
View article: Suppression of Metastatic Ovarian Cancer Cells by Bepridil, a Calcium Channel Blocker
Suppression of Metastatic Ovarian Cancer Cells by Bepridil, a Calcium Channel Blocker Open
Although surgery followed by platinum-based therapy is effective as a standard treatment in the early stages of ovarian cancer, the majority of cases are diagnosed at advanced stages, leading to poor prognosis. Thus, the identification of …
View article: Impact of flux type variable exchange method in the atmosphere-ocean coupled version of the Korean Integrated Model (KIM) system for extended medium-range weather forecast
Impact of flux type variable exchange method in the atmosphere-ocean coupled version of the Korean Integrated Model (KIM) system for extended medium-range weather forecast Open
Extended medium-range prediction targets a period of up to 30 days, which is a longer period than medium-range (up to 15 days) and shorter than seasonal (up to 3 months) forecast. The atmospheric response to the initial condition significa…
View article: Mesenchymal Stem-Like Cells Derived from the Ventricle More Effectively Enhance Invasiveness of Glioblastoma Than Those Derived from the Tumor
Mesenchymal Stem-Like Cells Derived from the Ventricle More Effectively Enhance Invasiveness of Glioblastoma Than Those Derived from the Tumor Open
Although vMSLCs are non-tumorigenic, this study adds to our understanding of how GBM cells acquire infiltrative features by vMSLCs, which are present in the region where GBM genesis originates.
View article: Assessing Spatial Distribution of Multicellular Self-Assembly Enables the Prediction of Phenotypic Heterogeneity in Glioblastoma
Assessing Spatial Distribution of Multicellular Self-Assembly Enables the Prediction of Phenotypic Heterogeneity in Glioblastoma Open
Phenotypic heterogeneity of glioblastomas is a leading determinant of therapeutic resistance and treatment failure. However, functional assessment of the heterogeneity of glioblastomas is lacking. We developed a self-assembly-based assessm…
View article: Dual inhibition of CPT1A and G6PD suppresses glioblastoma tumorspheres
Dual inhibition of CPT1A and G6PD suppresses glioblastoma tumorspheres Open
View article: EXTH-66. BIOENERGETIC SWITCH AND BIOLOGIC RESPONSE WITH SLC25A11 INHIBITION TARGETING MALATE-ASPARTATE SHUTTLE (MAS) ON GLIOBLASTOMA TUMORSPHERE
EXTH-66. BIOENERGETIC SWITCH AND BIOLOGIC RESPONSE WITH SLC25A11 INHIBITION TARGETING MALATE-ASPARTATE SHUTTLE (MAS) ON GLIOBLASTOMA TUMORSPHERE Open
BACKGROUND: Cancer cells depended on cytosolic nicotinamide adenine dinucleotide (NADH) transported into mitochondria via the malate-aspartate shuttle (MAS) for ATP production. KN612 (N-phenylmaleimide), a MAS inhibitor, is known to interf…
View article: Human allogenic γδ T cells kill patient-derived glioblastoma cells expressing high levels of DNAM-1 ligands
Human allogenic γδ T cells kill patient-derived glioblastoma cells expressing high levels of DNAM-1 ligands Open
Adoptive transfer of γδ T cells is a novel immunotherapeutic approach to glioblastoma. Few recent studies have shown the efficacy of γδ T cells against glioblastoma, but no previous studies have identified the ligand-receptor interactions …