Explanipedia

A Novel Relationship between Corticotropin-Releasing Hormone Level and High-Altitude Hypoxia in Human and Rat Model Open

Feng‐Ming Kong, Gang Xu, Ping Ping Wang, Songchao Chen, Ke Hao , et al. · 2025

Background: Acute mountain sickness (AMS) strikes people who travel too quickly to high altitude, outstripping their ability to acclimatize. Individual susceptibility to AMS remains unpredictable. The aim of study was to investigate the ne…

Comparison of the microbiome of sputum from HIV/AIDS patients using PacBio 16S rRNA sequencing and ddPCR Open

Yu‐Ming Lai, Wenqian Jiang, Tianzhu Zhu, Jun Lin, Xiaoling Yu · 2025

Multiplex detection of respiratory RNA viruses without amplification based on CRISPR-Cas13a immunochromatographic test strips Open

Quan Wang, Wenqian Jiang, Zhiqing Huang, Zhitao Yuan, Zhiwei Chen , et al. · 2025

Acute respiratory infections, caused by RNA viruses like respiratory syncytial virus, influenza, rhinovirus, and coronavirus, are major global health threats. Real-time quantitative reverse transcription polymerase chain reaction (RT-qPCR)…

A Stable Cell Line-Based Genomic DNA Reference Material for Accurate Hpv 45 Detection Open

Shujun Zhou, Hongbo Hu, Yuping Li, Wenjun Dai, Yi‐Hsin Yang , et al. · 2025

Discovery of fecal microbial signatures in patients with ankylosing spondylitis Open

Yuquan You, Wei Zhang, Meimei Cai, Qingxin Guo, Jiawen Wang , et al. · 2023

Objectives: This study aimed to investigate the characteristics of the gut microbiota in Chinese patients with ankylosing spondylitis (AS) and healthy controls in Quanzhou aiming to explore the correlation between microbiome changes and AS…

Study on Thermal Conductivity of P-Phenylenediamine Modified Graphene/Epoxy Composites Open

Jun Lin, Jiancheng Zhou, Mengyao Guo, Danqing Chen, Guohua Chen · 2022

Thermal management has become an important requirement for many types of electrical equipment due to the development of integrated circuits. In this study, modified and reduced graphene fillers were synthesized in two steps, and then epoxy…

Current status of cancer starvation therapy Open

Jianyi Li, Dandan Tong, Jun Lin · 2022

Conventional therapies for malignant tumors have limitations and disadvantages. In recent years, the cancer starvation therapy has emerged which intends to deprive cancer cells of nutritional supply. There are several approaches to"starve"…

Pain characteristics and countermeasures to improve intraoperative pain for patients with temporomandibular joint disorder during treatment of orthodontics Open

Jun Lin, Wei Zhang, Renfa Lai · 2021

To explore and analyze the pain characteristics and countermeasures to improve intraoperative pain for patients with temporomandibular joint disorder during treatment of orthodontics. The patients were randomly divided into control group a…

Efficacy of needle-knife combined with etanercept treatment regarding disease activity and hip joint function in ankylosing spondylitis patients with hip joint involvement Open

Yuquan You, Meimei Cai, Jun Lin, Lianqun Liu, Chen Chang-xian , et al. · 2020

This study aimed to assess the efficacy of needle-knife (NK) combined with etanercept (NKCE) in attenuating pain, inflammation, disease activity, and improving hip joint function in ankylosing spondylitis (AS) patients with hip joint invol…

Preparation and Characterization of Aptamers Against O,p’-DDT Open

Wei Zhang, Danyang Li, Jianguang Zhang, Lingli Jiang, Zhaofa Li , et al. · 2020

The compound 1,1,1-trichloro-2-(p-chlorophenyl)-2-(o-chlorophenyl) ethane (o,p’-DDT) has been identified as one of the endocrine-disrupting chemicals causing adverse effects on wildlife and even humans through bioaccumulation. Its detectio…

SELEX tool: a novel and convenient gel-based diffusion method for monitoring of aptamer-target binding Open

Qingxiu Liu, Wei Zhang, Siying Chen, Zhenjing Zhuang, Yi Zhang , et al. · 2020

Dynamic spatiotemporal expression pattern of limbal stem cell putative biomarkers during mouse development Open

Zhi Hou Guo, Yiming Zeng, Jun Lin · 2020

Limbal stem cells (LSCs), a subpopulation of limbal epithelial basal cells, are crucial to the homeostasis and wound healing of corneal epithelium. The identification and isolation of LSCs remains a challenge due to lack of specific LSCs b…

miR‐106b‐5p promotes aggressive progression of hepatocellular carcinoma via targeting RUNX3 Open

Hao Gu, Shensen Gu, Xinlong Zhang, Song-Jiang Zhang, Dongming Zhang , et al. · 2019

Background and Objectives The roles of microRNA(miR)‐106b‐5p in hepatocellular carcinoma (HCC) remain unclear. We aimed here to investigate the clinical significance of miR‐106b‐5p expression in HCC and its underlying mechanisms. Methods E…

An Insight into the Difficulties in the Discovery of Specific Biomarkers of Limbal Stem Cells Open

Zhi Hou Guo, Wei Zhang, Yang Yan Sheng Jia, Q. Liu, Zhao Fa Li , et al. · 2018

Keeping the integrity and transparency of the cornea is the most important issue to ensure normal vision. There are more than 10 million patients going blind due to the cornea diseases worldwide. One of the effective ways to cure corneal d…

Synthesis and biological evaluation of clovamide analogues as potent anti-neuroinflammatory agents in vitro and in vivo Open

Xiaolong Hu, Jun Lin, Xian-Yu Lv, Jiahao Feng, Xiao‐Qi Zhang , et al. · 2018

Practical Application of Aptamer-Based Biosensors in Detection of Low Molecular Weight Pollutants in Water Sources Open

Wei Zhang, Qing Liu, Zhi Guo, Jun Lin · 2018

Water pollution has become one of the leading causes of human health problems. Low molecular weight pollutants, even at trace concentrations in water sources, have aroused global attention due to their toxicity after long-time exposure. Th…

β-Elemene inhibits the proliferation of primary human airway granulation fibroblasts by down-regulating canonical Wnt/β-catenin pathway Open

Cheng Xue, Lingling Hong, Jun Lin, Xiangyang Yao, Dinghui Wu , et al. · 2018

Benign airway stenosis is a clinical challenge because of recurrent granulation tissues. Our previous study proved that a Chinese drug, β-elemene, could effectively inhibit the growth of fibroblasts cultured from hyperplastic human airway …

Cell surface expression of nucleolin mediates the antiangiogenic and antitumor activities of kallistatin Open

Huang Xiao-ping, Xiao Wang, Xiaolan Xie, Gao-Ping Zhang, Feng-Jiao Lv , et al. · 2017

Kallistatin is a unique serine proteinase inhibitor and heparin-binding protein. A previous study conducted by our group indicated that kallistatin has antiangiogenic and antitumoral activities. In the present study, we report that kallist…

Kallistatin protects against bleomycin-induced idiopathic pulmonary fibrosis by inhibiting angiogenesis and inflammation. Open

Huang Xiao-ping, Xiao Wang, Xiaolan Xie, Shulan Zeng, Zhaofa Li , et al. · 2017

Aberrant angiogenesis and vascular remodeling are the main features of idiopathic pulmonary fibrosis. Kallistatin is an anti-angiogenic peptide with known effects on endothelial cells. This study aimed to demonstrate that kallistatin has b…

Inhibition of integrin β3, a binding partner of kallistatin, leads to reduced viability, invasion and proliferation in NCI-H446 cells Open

Guoquan Wang, Xiao Wang, Huang Xiao-ping, Huiyong Yang, Su-Qiu Pang , et al. · 2016

These findings reveal a novel role for kallistatin in preventing small cell lung cancer growth and mobility, by direct interaction with integrin β3, leading to blockade of the related signaling pathway.

Bubbles in graphene - a computational study Open

Mikkel Settnes, Stephen R. Power, Jun Lin, Dirch Hjorth Petersen, Antti‐Pekka Jauho · 2015

Strain-induced deformations in graphene are predicted to give rise to large\npseudomagnetic fields. We examine theoretically the case of gas-inflated\nbubbles to determine whether signatures of such fields are present in the local\ndensity…

165. Theophylline-Dependent Aptazyme as a Novel Tool for Transgene Expression Regulation in Mammalian Cells Open

Jingxian Feng, Jiawen Wang, Jun Lin, Yong Diao · 2015

Successful and safe gene therapy approaches rely on regulatory tools ensuring both specific and controlled expression of the therapeutic gene. To ensure safety, timing or dosing in patients, external control of therapeutic gene expression …

Patched Green's function techniques for two-dimensional systems: Electronic behavior of bubbles and perforations in graphene Open

Mikkel Settnes, Stephen R. Power, Jun Lin, Dirch Hjorth Petersen, Antti‐Pekka Jauho · 2015

We present a numerically efficient technique to evaluate the Green's function\nfor extended two dimensional systems without relying on periodic boundary\nconditions. Different regions of interest, or `patches', are connected using\nself en…

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