Junting Fan
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View article: A study on numerical simulation method of Cs2LiYCl6:Ce3+ detection response in neutron well logging
A study on numerical simulation method of Cs2LiYCl6:Ce3+ detection response in neutron well logging Open
View article: Cognitive Function After Stopping Folic Acid and DHA Intervention: An Extended Follow-Up Results from the Randomized, Double Blind, Placebo-Controlled Trial in Older Adults with Mild Cognitive Impairment
Cognitive Function After Stopping Folic Acid and DHA Intervention: An Extended Follow-Up Results from the Randomized, Double Blind, Placebo-Controlled Trial in Older Adults with Mild Cognitive Impairment Open
Background: Our previously randomized controlled trial (RCT) showed daily oral folic acid (FA), docosahexaenoic acid (DHA) and their combined treatment for 6 months could significantly improve cognitive function in mild cognitive impairmen…
View article: A novel bellidifolin intervention mitigates nonalcoholic fatty liver disease-like changes induced by bisphenol F
A novel bellidifolin intervention mitigates nonalcoholic fatty liver disease-like changes induced by bisphenol F Open
As a potential endocrine-disrupting chemical, bisphenol F (BPF) may cause nonalcoholic fatty liver disease (NAFLD)-like changes, but the mechanisms under its pathogenesis as well as the intervention strategies remain unclear. Using the ele…
View article: Cyclopeptide moroidin inhibits vasculogenic mimicry formed by glioblastoma cells <i>via</i> regulating β-catenin activation and EMT pathways
Cyclopeptide moroidin inhibits vasculogenic mimicry formed by glioblastoma cells <i>via</i> regulating β-catenin activation and EMT pathways Open
Glioblastoma (GBM) is a highly vascularized malignant brain tumor with poor clinical outcomes. Vasculogenic mimicry (VM) formed by aggressive GBM cells is an alternative approach for tumor blood supply and contributes to the failure of ant…
View article: Selective biosynthesis of a rhamnosyl nosiheptide by a novel bacterial rhamnosyltransferase
Selective biosynthesis of a rhamnosyl nosiheptide by a novel bacterial rhamnosyltransferase Open
Nosiheptide (NOS) is a thiopeptide antibiotic produced by the bacterium Streptomyces actuosus . The hydroxyl group of 3‐hydroxypyridine in NOS has been identified as a promising site for modification, which we therefore aimed to rhamnosyla…
View article: Folate Deficiency Increased Microglial Amyloid-β Phagocytosis via the RAGE Receptor in Chronic Unpredictable Mild-Stress Rat and BV2 Cells
Folate Deficiency Increased Microglial Amyloid-β Phagocytosis via the RAGE Receptor in Chronic Unpredictable Mild-Stress Rat and BV2 Cells Open
Depression is often considered one of the prevalent neuropsychiatric symptoms of Alzheimer’s disease (AD). β-amyloid (Aβ) metabolism disorders and impaired microglia phagocytosis are potential pathological mechanisms between depression and…
View article: Swertia bimaculata moderated liver damage in mice by regulating intestine microbiota
Swertia bimaculata moderated liver damage in mice by regulating intestine microbiota Open
Swertia bimaculata (SB) is a medicinal herb in China having an array of therapeutic and biological properties. This study aimed to explore the attenuating effect of SB on carbon tetrachloride (CCl4) induced hepato-toxicity by re…
View article: Correction to: Chemical Composition and Cytotoxic Activity of Lindera pulcherrima VAR. Hemsleyana
Correction to: Chemical Composition and Cytotoxic Activity of Lindera pulcherrima VAR. Hemsleyana Open
View article: Combined probiotics attenuate chronic unpredictable mild stress-induced depressive-like and anxiety-like behaviors in rats
Combined probiotics attenuate chronic unpredictable mild stress-induced depressive-like and anxiety-like behaviors in rats Open
Increasing evidence indicated that probiotics can be effective in improving behaviors similar to depression and anxiety disorders. However, the underlying mechanisms remain unclear, as is the effects of single vs. combined probiotics on de…
View article: Synthesis and Bioactivities of Marine Pyran-Isoindolone Derivatives as Potential Antithrombotic Agents
Synthesis and Bioactivities of Marine Pyran-Isoindolone Derivatives as Potential Antithrombotic Agents Open
2,5-Bis-[8-(4,8-dimethyl-nona-3,7-dienyl)-5,7-dihydroxy-8-methyl-3-keto-1,2,7,8-teraahydro-6H-pyran[a]isoindol-2-yl]-pentanoic acid (FGFC1) is a marine pyran-isoindolone derivative isolated from a rare marine microorganism Stachybotrys lon…
View article: Dysiarenone from Marine Sponge Dysidea arenaria Attenuates ROS and Inflammation via Inhibition of 5-LOX/NF-κB/MAPKs and Upregulation of Nrf-2/OH-1 in RAW 264.7 Macrophages
Dysiarenone from Marine Sponge Dysidea arenaria Attenuates ROS and Inflammation via Inhibition of 5-LOX/NF-κB/MAPKs and Upregulation of Nrf-2/OH-1 in RAW 264.7 Macrophages Open
In conclusion, we demonstrated that dysiarenone possesses anti-inflammation and anti-oxidation activity via inhibiting 5-LOX/NF-κB/MAPK and Nrf2/HO-1 signaling pathway. Dysiarenone might be a promising lead compound for inflammatory diseas…
View article: Improved anticancer activity of betulinic acid on breast cancer through a grafted copolymer-based micelles system
Improved anticancer activity of betulinic acid on breast cancer through a grafted copolymer-based micelles system Open
Betulinic acid (3β-Hydroxy-20(29)-lupaene-28-oic acid, BA) has excellent anti-cancer activity but poor solubility and low bioavailability. To improve the antitumor activity of BA, a polyvinyl caprolactam-polyvinyl acetate-polyethylene glyc…
View article: Four new triterpene glucosides from <i>Salacia cochinchinensis</i> Lour
Four new triterpene glucosides from <i>Salacia cochinchinensis</i> Lour Open
Four new triterpene glucosides (1–4) were isolated from the 90% ethanol extract of Salacia cochinchinensis, together with five known compounds (5–9). The structures of the new compounds were elucidated by comprehensive…
View article: Chemical Composition, Antioxidant and Antimicrobial Activities of Essential Oil from the Leaves of Lindera fragrans Oliv.
Chemical Composition, Antioxidant and Antimicrobial Activities of Essential Oil from the Leaves of Lindera fragrans Oliv. Open
The chemical composition of the essential oil obtained by hydrodistillation from the leaves of Lindera fragrans Oliv.was determined by gas chromatography (GC) and gas chromatography coupled with mass spectrometry (GC-MS).Sixty two compound…
View article: Yan-Hou-Qing formula attenuates ammonia-induced acute pharyngitis in rats via inhibition of NF-κB and COX-2
Yan-Hou-Qing formula attenuates ammonia-induced acute pharyngitis in rats via inhibition of NF-κB and COX-2 Open
View article: <p>Targeted Prodrug-Based Self-Assembled Nanoparticles for Cancer Therapy</p>
Targeted Prodrug-Based Self-Assembled Nanoparticles for Cancer Therapy Open
This work demonstrates a new combination of nanomaterials for chemotherapy and may promote prodrug-based DDS clinical applications in the future.
View article: Application of Soluplus to Improve the Flowability and Dissolution of Baicalein Phospholipid Complex
Application of Soluplus to Improve the Flowability and Dissolution of Baicalein Phospholipid Complex Open
In this study, a novel ternary complex system (TCS) composed of baicalein, phospholipids, and Soluplus was prepared to improve the flowability and dissolution for baicalein phospholipid complex (BPC). TCS was characterized using differenti…
View article: Dalbergioidin Ameliorates Doxorubicin-Induced Renal Fibrosis by Suppressing the TGF-<i>β</i>Signal Pathway
Dalbergioidin Ameliorates Doxorubicin-Induced Renal Fibrosis by Suppressing the TGF-<i>β</i>Signal Pathway Open
We investigated the effect of Dalbergioidin (DAL), a well-known natural product extracted from Uraria crinita , on doxorubicin- (DXR-) induced renal fibrosis in mice. The mice were pretreated for 7 days with DAL followed by a single inject…