Jinyi Ren
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View article: Total syntheses of <i>ent</i> -aogacillin A and aogacillin B
Total syntheses of <i>ent</i> -aogacillin A and aogacillin B Open
The first asymmetric total syntheses of aogacillin B and ent -aogacillin A and were reported in 7 steps, featuring a one-pot aldol/lactonization reaction.
View article: DRP1 downregulation impairs mitophagy, driving mitochondrial ROS and SASP production in rheumatoid arthritis CD4+PD-1+T cells
DRP1 downregulation impairs mitophagy, driving mitochondrial ROS and SASP production in rheumatoid arthritis CD4+PD-1+T cells Open
View article: Exploring the differential functions of circulating follicular helper T and peripheral helper T cells in rheumatoid arthritis based on metabolism patterns
Exploring the differential functions of circulating follicular helper T and peripheral helper T cells in rheumatoid arthritis based on metabolism patterns Open
Introduction The number of circulating follicular helper T (cTfh) and peripheral helper T (Tph) cells is elevated in rheumatoid arthritis (RA), yet the molecular mechanisms mediating their specific contributions to RA pathology remain uncl…
View article: Novel Aerogel Structure of β-Eucryptite: Featuring Low Density, High Specific Surface Area, and Negative Thermal Expansion Coefficient
Novel Aerogel Structure of β-Eucryptite: Featuring Low Density, High Specific Surface Area, and Negative Thermal Expansion Coefficient Open
Traditional β-eucryptite (LiAlSiO4) is renowned for its unique characteristics of low thermal expansion and high temperature thermal stability, making it an ideal material for precision instruments and aerospace applications. In this study…
View article: Mitochondrial dynamics in autoimmune diseases
Mitochondrial dynamics in autoimmune diseases Open
Mitochondria, as the “energy factories” of cells, are vital for maintaining cell life and function. Mitochondria are highly mobile organelles within cells, constantly changing their morphology through fusion and fission processes to achiev…
View article: Activation of eIF2α-ATF4 by endoplasmic reticulum-mitochondria coupling stress enhances COX2 expression and MSC-based therapeutic efficacy for rheumatoid arthritis
Activation of eIF2α-ATF4 by endoplasmic reticulum-mitochondria coupling stress enhances COX2 expression and MSC-based therapeutic efficacy for rheumatoid arthritis Open
Compared with unmodified MSCs, ERS-MSCs exhibited enhanced immunosuppressive potency, primarily through COX2 overexpression, which was regulated by ATF4 activation. Moreover, ERS and mitochondrial stress jointly regulated ATF4 expression. …
View article: Resistin upregulates fatty acid oxidation in synoviocytes of metabolic syndrome-associated knee osteoarthritis via CAP1/PKA/CREB to promote inflammation and catabolism
Resistin upregulates fatty acid oxidation in synoviocytes of metabolic syndrome-associated knee osteoarthritis via CAP1/PKA/CREB to promote inflammation and catabolism Open
This study clarifies the mechanism by which MetS causes synovitis from a metabolic perspective and provides new ideas for further research and treatment of MetS-KOA.
View article: Associations of magnesium depletion score with the incidence and mortality of osteoarthritis: a nationwide study
Associations of magnesium depletion score with the incidence and mortality of osteoarthritis: a nationwide study Open
Background Magnesium is an essential immune nutrient for the body, and recent studies have found that it plays an important role in osteoarthritis (OA). Magnesium depletion score(MDS) is a new method for evaluating the magnesium status of …
View article: Association between pan-immune-inflammation value and coronary heart disease in elderly population: a cross-sectional study
Association between pan-immune-inflammation value and coronary heart disease in elderly population: a cross-sectional study Open
Background Systemic inflammation, immune and nutrition status are closely linked to the occurrence and development of coronary heart disease (CHD). Pan-immune-inflammation value (PIV) is a new method for evaluating systemic inflammation an…
View article: MSCs with upregulated lipid metabolism block hematopoietic stem cell differentiation via exosomal CTP-1A in MDS
MSCs with upregulated lipid metabolism block hematopoietic stem cell differentiation via exosomal CTP-1A in MDS Open
View article: Activation of eIF2α-ATF4 by endoplasmic reticulum-mitochondria coupling stress enhances COX2 expression and MSC-based therapy for rheumatoid arthritis
Activation of eIF2α-ATF4 by endoplasmic reticulum-mitochondria coupling stress enhances COX2 expression and MSC-based therapy for rheumatoid arthritis Open
Background Mesenchymal stem/stromal cell (MSCs) therapy represents a potential therapeutic tool to treat RA, but loss of secretory property post delivery restricted clinical application. It has been verified that endoplasmic reticulum stre…
View article: Novel Aerogel Structure of Β-Eucryptite: Featuring Low Density, High Specific Surface Area and Negative Thermal Expansion Coefficient
Novel Aerogel Structure of Β-Eucryptite: Featuring Low Density, High Specific Surface Area and Negative Thermal Expansion Coefficient Open
View article: Resistin Upregulates Fatty Acid Oxidation in Synoviocytes of Metabolic Syndrome-Associated Knee Osteoarthritis via CAP1/PKA/CREB to Promote Inflammation and Catabolism
Resistin Upregulates Fatty Acid Oxidation in Synoviocytes of Metabolic Syndrome-Associated Knee Osteoarthritis via CAP1/PKA/CREB to Promote Inflammation and Catabolism Open
Background: To explore whether there were metabolism disorder which promote inflammatory and catabolic phenotype in fibroblast-like synoviocytes (FLS) from KOA patients with MetS (MetS-KOA-FLS), and the roles and mechanisim of resistin in …
View article: Dynamin-Related Protein 1 Binding Partners MiD49 and MiD51 Increased Mitochondrial Fission In Vitro and Atherosclerosis in High-Fat-Diet-Fed ApoE-/- Mice
Dynamin-Related Protein 1 Binding Partners MiD49 and MiD51 Increased Mitochondrial Fission In Vitro and Atherosclerosis in High-Fat-Diet-Fed ApoE-/- Mice Open
Novel components of the mitochondrial fission machinery, mitochondrial dynamics proteins of 49 kDa (MiD49) and 51 kDa (MiD51), have been recently described, and their potential therapeutic targets for treating cardiovascular disease have b…
View article: The Effect of Aging on Precipitates, Mechanical and Magnetic Properties of Fe-21Cr-15Ni-6Mn-Nb Low Magnetic Stainless Steel
The Effect of Aging on Precipitates, Mechanical and Magnetic Properties of Fe-21Cr-15Ni-6Mn-Nb Low Magnetic Stainless Steel Open
The effect of aging on the precipitates, mechanical and magnetic properties of Fe-21Cr-15Ni-6Mn-Nb low magnetic stainless steel were investigated. The steel was aged at 550–750 °C for 2 h after solution heat treatment at 1100 °C for 1 h. D…
View article: Evaluation of microstructure and mechanical properties of Fe–1.2Mn–0.3Cr–1.4Ni–0.4Mo–C steel welded joints
Evaluation of microstructure and mechanical properties of Fe–1.2Mn–0.3Cr–1.4Ni–0.4Mo–C steel welded joints Open
View article: Dendrite Segregation Changes in High Temperature Homogenization Process of As-cast H13 Steel
Dendrite Segregation Changes in High Temperature Homogenization Process of As-cast H13 Steel Open
The microstructural evolution and microhardness changes of the H13 ingot during homogenization process were investigated to characterize the dendrite segregation changes by optical microscopy (OM), scanning electron microscopy (SEM), elect…