Junwen He
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View article: Integrated Multi‐Omics Analysis and Cross‐Model Validation Reveal Mitochondrial Signatures in Alzheimer's Disease
Integrated Multi‐Omics Analysis and Cross‐Model Validation Reveal Mitochondrial Signatures in Alzheimer's Disease Open
Aims Alzheimer's disease (AD) is a devastating neurodegenerative disorder where mitochondrial dysfunction is increasingly recognized as pivotal, yet its comprehensive molecular underpinnings remain incompletely understood. This study aimed…
View article: Genetic and pathway complexity in Alzheimer’s disease: Insights from multi-omic data about the immune response and mitochondrial function
Genetic and pathway complexity in Alzheimer’s disease: Insights from multi-omic data about the immune response and mitochondrial function Open
Despite recent developments, the genetics and biology of Alzheimer’s disease remain insufficiently characterized. As an important first step toward developing effective treatment strategies to slow or prevent Alzheimer’s disease onset, the…
View article: Convergent and Divergent Mitochondrial Pathways as Causal Drivers and Therapeutic Targets in Neurological Disorders
Convergent and Divergent Mitochondrial Pathways as Causal Drivers and Therapeutic Targets in Neurological Disorders Open
Mitochondrial dysfunction is implicated across a spectrum of neurological diseases, yet its causal role and mechanistic specificity remain unclear. This study employed a multi-modal integrative analysis of mitochondrial gene expression in …
View article: Integration Methods for Co-Packaged Optics using Sin-to-Polymer Waveguide Coupling
Integration Methods for Co-Packaged Optics using Sin-to-Polymer Waveguide Coupling Open
We present broadband silicon-nitride to polymer waveguide adiabatic coupling interfaces with sub-1 dB loss around 1310 nm, validated using two integration methods: lithography and flip-chip bonding, achieving sub-2 dB chip-to-chip and chip…
View article: Case Report: Acute superior mesenteric artery embolism combined with abdominal aortic aneurysm in an elderly female patient
Case Report: Acute superior mesenteric artery embolism combined with abdominal aortic aneurysm in an elderly female patient Open
Background Both acute superior mesenteric artery embolism (ASMAE) and abdominal aortic aneurysm (AAA) are insidious conditions that can lead to fatal outcomes. The coexistence of ASMAE and AAA in a single patient is rare. Methods and resul…
View article: Low-loss integration of high-density polymer waveguides with silicon photonics for co-packaged optics
Low-loss integration of high-density polymer waveguides with silicon photonics for co-packaged optics Open
Co-packaged optics applications require scalable and high-yield optical interfacing solutions to silicon photonic chiplets, offering low-loss, broadband, and polarization-independent optical coupling while maintaining compatibility with wi…
View article: Dynamic study of streamer interaction with fluidized particles in a plasma fluidized-bed system
Dynamic study of streamer interaction with fluidized particles in a plasma fluidized-bed system Open
Exploration of the interaction dynamics between plasma and fluidized particles in a plasma fluidized-bed holds practical importance for elucidating the mechanism of plasma treatment of powders. In this study, we employed a 2D fluid model t…
View article: Deciphering novel mitochondrial signatures: multi-omics analysis uncovers cross-disease markers and oligodendrocyte pathways in Alzheimer’s disease and glioblastoma
Deciphering novel mitochondrial signatures: multi-omics analysis uncovers cross-disease markers and oligodendrocyte pathways in Alzheimer’s disease and glioblastoma Open
Introduction Alzheimer’s disease (AD) and glioblastoma (GBM) are severe neurological disorders that pose significant global healthcare challenges. Despite extensive research, the molecular mechanisms, particularly those involving mitochond…
View article: A methodical approach to design adiabatic waveguide couplers for heterogeneous integrated photonics
A methodical approach to design adiabatic waveguide couplers for heterogeneous integrated photonics Open
We present an elegant and effective approach for the design of adiabatic waveguide couplers tailored for the heterogeneous integration of photonic building blocks. This method empowers users to incorporate the shortest taper(s) in their de…
View article: Study on trajectory optimization of satellite rapid orbit formation flying for space object
Study on trajectory optimization of satellite rapid orbit formation flying for space object Open
This paper proposes a method of collaborative trajectory planning that utilizes convex optimization and IFPSO to tackle the issue of rapid formation reconstruction by multiple satellites in a low Earth circular orbit. The trajectory optimi…
View article: Experimental and numerical study on atmospheric‐pressure air dielectric barrier discharge via 50 Hz/5000 Hz dual‐frequency excitation
Experimental and numerical study on atmospheric‐pressure air dielectric barrier discharge via 50 Hz/5000 Hz dual‐frequency excitation Open
A dual‐frequency (DF) dielectric barrier discharge, excited by the superposition of a 50 Hz low frequency (LF) and a 5000 Hz intermediate frequency (IF), is proposed to enhance discharge. The effect of the LF voltage component on the break…
View article: Towards Deeply Unified Depth-aware Panoptic Segmentation with Bi-directional Guidance Learning
Towards Deeply Unified Depth-aware Panoptic Segmentation with Bi-directional Guidance Learning Open
Depth-aware panoptic segmentation is an emerging topic in computer vision which combines semantic and geometric understanding for more robust scene interpretation. Recent works pursue unified frameworks to tackle this challenge but mostly …
View article: Luminescent solar concentrators and related methods of manufacturing
Luminescent solar concentrators and related methods of manufacturing Open
Luminescent solar concentrators in accordance with various embodiments of the invention can be designed to minimize photon thermalization losses and incomplete light trapping using various components and techniques. Cadmium selenide core, …
View article: Inverted internal limiting membrane flap technique for retinal detachment due to macular holes in high myopia with axial length ≥ 30 mm
Inverted internal limiting membrane flap technique for retinal detachment due to macular holes in high myopia with axial length ≥ 30 mm Open
To compare the efficacy of internal limiting membrane (ILM) flap covering to that of ILM flap insertion for the treatment of macular hole retinal detachment (MHRD) in highly myopic eyes with axial length (AL) ≥ 30 mm. We retrospectively an…
View article: Luminescent Cavity Design for High Ambient Contrast Ratio, High Efficiency Displays
Luminescent Cavity Design for High Ambient Contrast Ratio, High Efficiency Displays Open
A key display characteristic is its efficiency (emitted light power divided by input power). While display efficiencies are being improved through emissive (e.g., quantum dot and organic light emitting display (OLED) designs1,2, which remo…
View article: Solution processes for ultrabroadband and omnidirectional graded-index glass lenses with near-zero reflectivity in high concentration photovoltaics
Solution processes for ultrabroadband and omnidirectional graded-index glass lenses with near-zero reflectivity in high concentration photovoltaics Open
Concentrator photovoltaic (CPV) systems, where incident direct solar radiation is tightly concentrated onto high-efficiency multi-junction solar cells by geometric optical elements, exhibit the highest efficiencies in converting the sun’s …
View article: Design Criteria for Micro-Optical Tandem Luminescent Solar Concentrators
Design Criteria for Micro-Optical Tandem Luminescent Solar Concentrators Open
© 2018 IEEE. Luminescent solar concentrators (LSCs) harness light generated by luminophores embedded in a light-trapping waveguide to concentrate onto smaller cells. LSCs can absorb both direct and diffuse sunlight, and thus can operate as…
View article: Assembly and light management of solar microcells for concentration photovoltaics
Assembly and light management of solar microcells for concentration photovoltaics Open
Advances in printing-based assembly technology enable high volume integration of microscale solar cells and afford novel module architectures with attributes not present in conventional concentration photovoltaic (CPV) systems. The work co…
View article: Optimization of Photon and Electron Collection Efficiencies in Silicon Solar Microcells for Use in Concentration‐Based Photovoltaic Systems
Optimization of Photon and Electron Collection Efficiencies in Silicon Solar Microcells for Use in Concentration‐Based Photovoltaic Systems Open
Ultrathin silicon solar microcells (μ‐cells) afford a means to reduce semiconductor material consumption and can be integrated with concentration optics to improve their power density. A μ‐cell design is described that optimizes electron a…
View article: Micro-optical Tandem Luminescent Solar Concentrators
Micro-optical Tandem Luminescent Solar Concentrators Open
Traditional concentrating photovoltaic (CPV) systems utilize multijunction cells to minimize thermalization losses, but cannot efficiently capture diffuse sunlight, which contributes to a high levelized cost of energy (LCOE) and limits the…
View article: Porous Nanomaterials: Porous Nanomaterials for Ultrabroadband Omnidirectional Anti‐Reflection Surfaces with Applications in High Concentration Photovoltaics (Adv. Energy Mater. 7/2017)
Porous Nanomaterials: Porous Nanomaterials for Ultrabroadband Omnidirectional Anti‐Reflection Surfaces with Applications in High Concentration Photovoltaics (Adv. Energy Mater. 7/2017) Open
In article number 1601992, Ralph G. Nuzzo, John A. Rogers, and co-workers demonstrate broadband anti-reflection coatings that rely on porous nanomaterials formed by self-assembly. The image shows the use of such coatings (orange) on an arr…
View article: Porous Nanomaterials for Ultrabroadband Omnidirectional Anti‐Reflection Surfaces with Applications in High Concentration Photovoltaics
Porous Nanomaterials for Ultrabroadband Omnidirectional Anti‐Reflection Surfaces with Applications in High Concentration Photovoltaics Open
Materials for nanoporous coatings that exploit optimized chemistries and self‐assembly processes offer capabilities to reach ≈98% transmission efficiency and negligible scattering losses over the broad wavelength range of the solar spectru…
View article: Concentrator photovoltaic module architectures with capabilities for capture and conversion of full global solar radiation
Concentrator photovoltaic module architectures with capabilities for capture and conversion of full global solar radiation Open
Significance Concentrator photovoltaic (CPV) systems, wherein light focuses onto multijunction solar cells, offer the highest efficiencies in converting sunlight to electricity. The performance is intrinsically limited, however, by an inab…
View article: Inorganic Materials and Assembly Techniques for Flexible and Stretchable Electronics
Inorganic Materials and Assembly Techniques for Flexible and Stretchable Electronics Open
In recent years, important progress has been made in developing design strategies, materials, and associated assembly techniques that provide empowering approaches to electronics with unconventional formats, ones that allow useful but prev…
View article: Ocular biometry in the adult population in rural central China: a population-based, cross-sectional study.
Ocular biometry in the adult population in rural central China: a population-based, cross-sectional study. Open
Our findings can serve as an important normative reference for multiple purposes and may help to improve the quality of rural eye care.