Junxia Qi
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View article: Unraveling the Mechanism of Immunity and Inflammation Related to Molecular Signatures Crosstalk Among Obesity, T2D, and AD: Insights From Bioinformatics Approaches
Unraveling the Mechanism of Immunity and Inflammation Related to Molecular Signatures Crosstalk Among Obesity, T2D, and AD: Insights From Bioinformatics Approaches Open
Individuals with type 2 diabetes (T2D) and obesity have a higher risk of developing Alzheimer disease (AD), and increasing evidence indicates a link between impaired immune signaling pathways and the development of AD. However, the shared …
View article: EphA3 deficiency in the hypothalamus promotes high-fat diet-induced obesity in mice
EphA3 deficiency in the hypothalamus promotes high-fat diet-induced obesity in mice Open
Erythropoietin-producing hepatocellular carcinoma A3 (EphA3) is a member of the largest subfamily of tyrosine kinase receptors-Eph receptors. Previous studies have shown that EphA3 is associated with tissue development. Recently, we have f…
View article: NGPF2 triggers synaptic scaling up through ALK-LIMK-cofilin-mediated mechanisms
NGPF2 triggers synaptic scaling up through ALK-LIMK-cofilin-mediated mechanisms Open
Synaptic scaling is an extensively studied form of homeostatic plasticity critically involved in various brain functions. Although it is accepted that synaptic scaling is expressed through the postsynaptic accumulation of AMPA receptors (A…
View article: Cdk7 Is Required for Activity-Dependent Neuronal Gene Expression, Long-Lasting Synaptic Plasticity and Long-Term Memory
Cdk7 Is Required for Activity-Dependent Neuronal Gene Expression, Long-Lasting Synaptic Plasticity and Long-Term Memory Open
In the brain, de novo gene expression driven by learning-associated neuronal activities is critical for the formation of long-term memories. However, the signaling machinery mediating neuronal activity-induced gene expression, especially t…
View article: Mutations of <i>PQBP1</i> in Renpenning syndrome promote ubiquitin-mediated degradation of FMRP and cause synaptic dysfunction
Mutations of <i>PQBP1</i> in Renpenning syndrome promote ubiquitin-mediated degradation of FMRP and cause synaptic dysfunction Open
Renpenning syndrome is a group of X-linked intellectual disability syndromes caused by mutations in human polyglutamine-binding protein 1 (PQBP1) gene. Little is known about the molecular pathogenesis of the various mutations that cause th…
View article: p21-activated kinase 1 restricts tonic endocannabinoid signaling in the hippocampus
p21-activated kinase 1 restricts tonic endocannabinoid signaling in the hippocampus Open
PAK1 inhibitors are known to markedly improve social and cognitive function in several animal models of brain disorders, including autism, but the underlying mechanisms remain elusive. We show here that disruption of PAK1 in mice suppresse…
View article: Author response: p21-activated kinase 1 restricts tonic endocannabinoid signaling in the hippocampus
Author response: p21-activated kinase 1 restricts tonic endocannabinoid signaling in the hippocampus Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract PAK1 inhibitors are known to markedly improve s…
View article: Neuroligin 1 regulates spines and synaptic plasticity via LIMK1/cofilin-mediated actin reorganization
Neuroligin 1 regulates spines and synaptic plasticity via LIMK1/cofilin-mediated actin reorganization Open
Neuroligin (NLG) 1 is important for synapse development and function, but the underlying mechanisms remain unclear. It is known that at least some aspects of NLG1 function are independent of the presynaptic neurexin, suggesting that the C-…
View article: Application Research of Library Management System of Network and Information Technology
Application Research of Library Management System of Network and Information Technology Open
The school library is one of organic component in the school organization system, which is an important place for the teachers and the students to learn in, improve the quality of education and train talents.With the deepening of the curri…