Takahiro Nishimura
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View article: Iridium‐Catalyzed <i>α</i>‐C–H Alkenylation of Alkylamines with Alkynes Followed by Alkene Isomerization Into Enamines
Iridium‐Catalyzed <i>α</i>‐C–H Alkenylation of Alkylamines with Alkynes Followed by Alkene Isomerization Into Enamines Open
The iridium‐catalyzed intermolecular α ‐C–H alkenylation of N ‐methyl‐2‐aminopyridine derivatives proceeds via alkene isomerization to give the corresponding enamines. The reaction is efficiently catalyzed by a cationic iridium catalyst un…
View article: Iridium-catalysed direct C–H functionalisation as a platform for stereoselective C–C bond formation
Iridium-catalysed direct C–H functionalisation as a platform for stereoselective C–C bond formation Open
This feature article discusses recent advances in indium-catalysed C–H bond addition reactions to unsaturated bonds, focusing on the achievement of regioselective and enantioselective C–C bond formation.
View article: Iridium/chiral phosphoramidite–olefin complex-catalysed enantioselective [3+2] annulation of <i>ortho</i>-ketoarylboron compounds with conjugated dienes
Iridium/chiral phosphoramidite–olefin complex-catalysed enantioselective [3+2] annulation of <i>ortho</i>-ketoarylboron compounds with conjugated dienes Open
Iridium-catalysed asymmetric [3+2] annulation proceeded to give indanol derivatives with high enantioselectivity by using a phosphoramidite–olefin ligand.
View article: CCDC 2248102: Experimental Crystal Structure Determination
CCDC 2248102: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Introducing Ritonavir-Boosted Nirmatrelvir (Paxlovid) at the National Center for Global Health and Medicine: Surveys Following its Introduction
Introducing Ritonavir-Boosted Nirmatrelvir (Paxlovid) at the National Center for Global Health and Medicine: Surveys Following its Introduction Open
【背景】経口COVID-19治療薬であるパキロビッドパック（以下パキロビッド：ニルマトレルビル/リトナビル）は，各種薬物代謝酵素への影響の大きいリトナビル配合の薬剤であることから，併用薬との薬物相互作用が懸念されている．しかし実臨床での使用経験に関する報告は乏しい．
View article: Ruthenium-catalysed <i>N</i>-alkylation of anilines with primary carbohydrate alcohols <i>via</i> borrowing hydrogen strategy
Ruthenium-catalysed <i>N</i>-alkylation of anilines with primary carbohydrate alcohols <i>via</i> borrowing hydrogen strategy Open
Ruthenium-catalysed N -alkylation of anilines with primary carbohydrate alcohols efficiently proceeded via borrowing hydrogen strategy.
View article: Iridium-catalyzed asymmetric addition of imides to alkenes
Iridium-catalyzed asymmetric addition of imides to alkenes Open
Iridium-catalyzed asymmetric N–H addition of imides to alkenes proceeded to give the chiral N -alkylamides with high enantioselectivity.
View article: Iridium-catalyzed Annulation of α,β-Unsaturated Amides with Electron-deficient Conjugated Dienes
Iridium-catalyzed Annulation of α,β-Unsaturated Amides with Electron-deficient Conjugated Dienes Open
Annulation of α,β-unsaturated amides with electron-deficient 1,3-dienes gave 5,6-dihydropyridin-2(1H)-ones in the presence of a hydroxoiridium catalyst. The reaction proceeded via direct C–H alkyla...
View article: Cover Picture: Iridium‐Catalyzed Asymmetric Hydroarylation of Chromene Derivatives with Aromatic Ketones: Enantioselective Synthesis of 2‐Arylchromanes (Adv. Synth. Catal. 9/2019)
Cover Picture: Iridium‐Catalyzed Asymmetric Hydroarylation of Chromene Derivatives with Aromatic Ketones: Enantioselective Synthesis of 2‐Arylchromanes (Adv. Synth. Catal. 9/2019) Open
The inside cover picture, provided by Kana Sakamoto and Takahiro Nishimura, illustrates enantioselective synthesis of 2-arylchromane derivatives by the Ir-catalyzed hydroarylation of 2H-chromenes with aromatic ketones. The reaction involve…
View article: Automatic ISP image quality tuning using non-linear optimization
Automatic ISP image quality tuning using non-linear optimization Open
Image Signal Processor (ISP) comprises of various blocks to reconstruct image sensor raw data to final image consumed by human visual system or computer vision applications. Each block typically has many tuning parameters due to the comple…
View article: Helix-Sense-Selective Polymerization of Phenylacetylenes Having a Porphyrin and a Zinc-Porphyrin Group: One-Handed Helical Arrangement of Porphyrin Pendants
Helix-Sense-Selective Polymerization of Phenylacetylenes Having a Porphyrin and a Zinc-Porphyrin Group: One-Handed Helical Arrangement of Porphyrin Pendants Open
Newly synthesized two kinds of achiral phenylacetylenes having a free-base- or a zinc-porphyrin (1 and Zn1, respectively) were polymerized by using a chiral rhodium catalyst system, Rh+(nbd)[(η6-C6H5)B–(C6H5)3] catalyst and (R)-(+)- or (S)…
View article: CCDC 1574178: Experimental Crystal Structure Determination
CCDC 1574178: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Iridium-catalyzed sp<sup>3</sup> C–H Alkylation of 3-Carbonyl-2-(alkylamino)pyridines with Alkenes
Iridium-catalyzed sp<sup>3</sup> C–H Alkylation of 3-Carbonyl-2-(alkylamino)pyridines with Alkenes Open
Iridium-catalyzed C–H alkylation of 3-carbonyl-2-(alkylamino)pyridines via secondary sp3 C–H activation adjacent to the nitrogen atom, with terminal alkenes proceeded to give the corresponding α-secondary amines in high yields. The reactio…
View article: CCDC 1508667: Experimental Crystal Structure Determination
CCDC 1508667: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Iridium-Catalyzed Asymmetric Reactions Realizing High Atom Efficiency
Iridium-Catalyzed Asymmetric Reactions Realizing High Atom Efficiency Open
This article summarizes our recent studies on iridium-catalyzed asymmetric reactions realizing the high atom efficiency. Iridium complexes efficiently catalyzed asymmetric functionalization of aromatic compounds via directed C-H activation…
View article: CCDC 1521370: Experimental Crystal Structure Determination
CCDC 1521370: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1570785: Experimental Crystal Structure Determination
CCDC 1570785: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1444245: Experimental Crystal Structure Determination
CCDC 1444245: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Iridium-catalyzed asymmetric [3+2] annulation of aromatic ketimines with alkynes via C–H activation: unexpected inversion of the enantioselectivity induced by protic acids
Iridium-catalyzed asymmetric [3+2] annulation of aromatic ketimines with alkynes via C–H activation: unexpected inversion of the enantioselectivity induced by protic acids Open
The enantiodivergent synthesis of annulation products was achieved in the Ir-catalyzed asymmetric [3+2] annulation of cyclicN-acyl ketimines with internal alkynesviaC–H activation.
View article: CCDC 1444246: Experimental Crystal Structure Determination
CCDC 1444246: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1449863: Experimental Crystal Structure Determination
CCDC 1449863: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …