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View article: RAS-mutant leukaemia stem cells drive clinical resistance to venetoclax
RAS-mutant leukaemia stem cells drive clinical resistance to venetoclax Open
View article: Supplementary Figure S5 from CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify <i>KDM3B</i> as a Genotype-specific Vulnerability in <i>IDH2</i>- and <i>TET2</i>-mutant Cells
Supplementary Figure S5 from CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify <i>KDM3B</i> as a Genotype-specific Vulnerability in <i>IDH2</i>- and <i>TET2</i>-mutant Cells Open
In vivo validation of Jmjd1c dependency
View article: Supplementary Table S5 from CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify <i>KDM3B</i> as a Genotype-specific Vulnerability in <i>IDH2</i>- and <i>TET2</i>-mutant Cells
Supplementary Table S5 from CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify <i>KDM3B</i> as a Genotype-specific Vulnerability in <i>IDH2</i>- and <i>TET2</i>-mutant Cells Open
ATAC-seq results
View article: Supplementary Figure S1 from CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify <i>KDM3B</i> as a Genotype-specific Vulnerability in <i>IDH2</i>- and <i>TET2</i>-mutant Cells
Supplementary Figure S1 from CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify <i>KDM3B</i> as a Genotype-specific Vulnerability in <i>IDH2</i>- and <i>TET2</i>-mutant Cells Open
Ex vivo characterization of BMEC/HSPC co-cultures
View article: Supplementary Figure S9 from CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify <i>KDM3B</i> as a Genotype-specific Vulnerability in <i>IDH2</i>- and <i>TET2</i>-mutant Cells
Supplementary Figure S9 from CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify <i>KDM3B</i> as a Genotype-specific Vulnerability in <i>IDH2</i>- and <i>TET2</i>-mutant Cells Open
Effects on TPO, GM-CSF, and ruxolitinib on Idh2R140Q HSPCs
View article: Supplementary Figure S7 from CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify <i>KDM3B</i> as a Genotype-specific Vulnerability in <i>IDH2</i>- and <i>TET2</i>-mutant Cells
Supplementary Figure S7 from CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify <i>KDM3B</i> as a Genotype-specific Vulnerability in <i>IDH2</i>- and <i>TET2</i>-mutant Cells Open
Role of 2-HG and KDM3B catalytic activity in KDM3B dependency
View article: Supplementary Figure S3 from CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify <i>KDM3B</i> as a Genotype-specific Vulnerability in <i>IDH2</i>- and <i>TET2</i>-mutant Cells
Supplementary Figure S3 from CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify <i>KDM3B</i> as a Genotype-specific Vulnerability in <i>IDH2</i>- and <i>TET2</i>-mutant Cells Open
CRISPR screens in Dnmt3a- and Asxl1-mutant HSPCs and Jmjd1c dependency in Idh2- and Tet2-mutant HSPCs
View article: Supplementary Figure S4 from CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify <i>KDM3B</i> as a Genotype-specific Vulnerability in <i>IDH2</i>- and <i>TET2</i>-mutant Cells
Supplementary Figure S4 from CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify <i>KDM3B</i> as a Genotype-specific Vulnerability in <i>IDH2</i>- and <i>TET2</i>-mutant Cells Open
In vivo validation of Kdm3b dependency
View article: Supplementary Figure S2 from CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify <i>KDM3B</i> as a Genotype-specific Vulnerability in <i>IDH2</i>- and <i>TET2</i>-mutant Cells
Supplementary Figure S2 from CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify <i>KDM3B</i> as a Genotype-specific Vulnerability in <i>IDH2</i>- and <i>TET2</i>-mutant Cells Open
Development of CRISPR screens with BMEC/HSPC co-cultures
View article: Supplementary Table S4 from CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify <i>KDM3B</i> as a Genotype-specific Vulnerability in <i>IDH2</i>- and <i>TET2</i>-mutant Cells
Supplementary Table S4 from CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify <i>KDM3B</i> as a Genotype-specific Vulnerability in <i>IDH2</i>- and <i>TET2</i>-mutant Cells Open
HSPC RNA-seq results
View article: Supplementary Table S2 from CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify <i>KDM3B</i> as a Genotype-specific Vulnerability in <i>IDH2</i>- and <i>TET2</i>-mutant Cells
Supplementary Table S2 from CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify <i>KDM3B</i> as a Genotype-specific Vulnerability in <i>IDH2</i>- and <i>TET2</i>-mutant Cells Open
CRISPR screens results
View article: Supplementary Table S3 from CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify <i>KDM3B</i> as a Genotype-specific Vulnerability in <i>IDH2</i>- and <i>TET2</i>-mutant Cells
Supplementary Table S3 from CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify <i>KDM3B</i> as a Genotype-specific Vulnerability in <i>IDH2</i>- and <i>TET2</i>-mutant Cells Open
TF-1 RNA-seq results
View article: Supplementary Figure S8 from CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify <i>KDM3B</i> as a Genotype-specific Vulnerability in <i>IDH2</i>- and <i>TET2</i>-mutant Cells
Supplementary Figure S8 from CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify <i>KDM3B</i> as a Genotype-specific Vulnerability in <i>IDH2</i>- and <i>TET2</i>-mutant Cells Open
Chromatin and transcriptional changes mediated by KDM3B
View article: Supplementary Table S1 from CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify <i>KDM3B</i> as a Genotype-specific Vulnerability in <i>IDH2</i>- and <i>TET2</i>-mutant Cells
Supplementary Table S1 from CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify <i>KDM3B</i> as a Genotype-specific Vulnerability in <i>IDH2</i>- and <i>TET2</i>-mutant Cells Open
sgRNA and shRNA sequences
View article: Data from CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify <i>KDM3B</i> as a Genotype-specific Vulnerability in <i>IDH2</i>- and <i>TET2</i>-mutant Cells
Data from CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify <i>KDM3B</i> as a Genotype-specific Vulnerability in <i>IDH2</i>- and <i>TET2</i>-mutant Cells Open
Clonal hematopoiesis (CH) is a common premalignant state in the blood and confers an increased risk of blood cancers and all-cause mortality. Identification of therapeutic targets in CH has been hindered by the lack of an ex vivo pl…
View article: Supplementary Figure S6 from CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify <i>KDM3B</i> as a Genotype-specific Vulnerability in <i>IDH2</i>- and <i>TET2</i>-mutant Cells
Supplementary Figure S6 from CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify <i>KDM3B</i> as a Genotype-specific Vulnerability in <i>IDH2</i>- and <i>TET2</i>-mutant Cells Open
Validation of KDM3B and JMJD1C dependencies in human HSPCs and Tet2-/-Npm1cAFlt3ITD leukemia model
View article: CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify <i>KDM3B</i> as a Genotype-specific Vulnerability in <i>IDH2</i> - and <i>TET2</i> -mutant Cells
CRISPR Dependency Screens in Primary Hematopoietic Stem Cells Identify <i>KDM3B</i> as a Genotype-specific Vulnerability in <i>IDH2</i> - and <i>TET2</i> -mutant Cells Open
Clonal hematopoiesis (CH) is a common premalignant state in the blood and confers an increased risk of blood cancers and all-cause mortality. Identification of therapeutic targets in CH has been hindered by the lack of an ex vivo platform …