Junya Toguchida
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View article: Jawbone-like organoids generated from human pluripotent stem cells
Jawbone-like organoids generated from human pluripotent stem cells Open
View article: Methotrexate, Doxorubicin, and Cisplatin Versus Methotrexate, Doxorubicin, and Cisplatin + Ifosfamide in Poor Responders to Preoperative Chemotherapy for Newly Diagnosed High-Grade Osteosarcoma (JCOG0905): A Multicenter, Open-Label, Randomized Trial
Methotrexate, Doxorubicin, and Cisplatin Versus Methotrexate, Doxorubicin, and Cisplatin + Ifosfamide in Poor Responders to Preoperative Chemotherapy for Newly Diagnosed High-Grade Osteosarcoma (JCOG0905): A Multicenter, Open-Label, Randomized Trial Open
PURPOSE Our previous NECO phase II studies on high-grade osteosarcoma suggested that administering ifosfamide (IF; 16 g/m 2 [4g/m 2 once on day 1, then 2g/m 2 once on days 2-7] × six) to patients showing a poor response (PrRsp) to preopera…
View article: Hydroxycitric acid reconstructs damaged articular cartilages by modifying the metabolic cascade in chondrogenic cells
Hydroxycitric acid reconstructs damaged articular cartilages by modifying the metabolic cascade in chondrogenic cells Open
HCA demonstrates promise as an osteoarthritis therapy by enhancing chondrogenic differentiation. Its ability to modulate crucial metabolic pathways and facilitate cartilage repair suggests potential for clinical translation, addressing a c…
View article: Distinct muscle regenerative capacity of human induced pluripotent stem cell-derived mesenchymal stromal cells in Ullrich congenital muscular dystrophy model mice
Distinct muscle regenerative capacity of human induced pluripotent stem cell-derived mesenchymal stromal cells in Ullrich congenital muscular dystrophy model mice Open
View article: Distinct muscle regenerative capacity of human induced pluripotent stem cell-derived mesenchymal stromal cells in Ullrich congenital muscular dystrophy model mice
Distinct muscle regenerative capacity of human induced pluripotent stem cell-derived mesenchymal stromal cells in Ullrich congenital muscular dystrophy model mice Open
Background Ullrich congenital muscular dystrophy (UCMD) is caused by a deficiency in type 6 collagen (COL6) due to mutations in COL6A1, COL6A2, or COL6A3. COL6 deficiency alters the extracellular matrix structure and biomechanical properti…
View article: Xenograft of bio-3D printed scaffold-free cartilage constructs derived from human iPSCs to regenerate articular cartilage in immunodeficient pigs
Xenograft of bio-3D printed scaffold-free cartilage constructs derived from human iPSCs to regenerate articular cartilage in immunodeficient pigs Open
Arthroplasty is currently the only option for reconstruction of large articular cartilage defects, mainly due to osteoarthritis. However, reconstruction with artificial materials has several issues such as deterioration, foreign body react…
View article: A de novo dominant-negative variant is associated with OTULIN-related autoinflammatory syndrome
A de novo dominant-negative variant is associated with OTULIN-related autoinflammatory syndrome Open
OTULIN-related autoinflammatory syndrome (ORAS), a severe autoinflammatory disease, is caused by biallelic pathogenic variants of OTULIN, a linear ubiquitin-specific deubiquitinating enzyme. Loss of OTULIN attenuates linear ubiquitination …
View article: Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency
Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency Open
View article: Oxidative phosphorylation is a pivotal therapeutic target of fibrodysplasia ossificans progressiva
Oxidative phosphorylation is a pivotal therapeutic target of fibrodysplasia ossificans progressiva Open
Heterotopic ossification (HO) is a non-physiological bone formation where soft tissue progenitor cells differentiate into chondrogenic cells. In fibrodysplasia ossificans progressiva (FOP), a rare genetic disease characterized by progressi…
View article: Automated cell culture system for the production of cell aggregates with growth plate-like structure from induced pluripotent stem cells.
Automated cell culture system for the production of cell aggregates with growth plate-like structure from induced pluripotent stem cells. Open
Programmable liquid handling devices for cell culture systems have dramatically enhanced scalability and reproducibility. We previously reported a protocol to produce cell aggregates demonstrating growth plate-like structures containing hy…
View article: The Efficacy of CT Temporal Subtraction Images for Fibrodysplasia Ossificans Progressiva
The Efficacy of CT Temporal Subtraction Images for Fibrodysplasia Ossificans Progressiva Open
Purpose: To evaluate the usefulness of CT temporal subtraction (TS) images for detecting emerging or growing ectopic bone lesions in fibrodysplasia ossificans progressiva (FOP). Materials and Methods: Four patients with FOP were retrospect…
View article: Data from IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress
Data from IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress Open
Osteosarcoma is a malignant bone tumor in children and adolescents characterized by intrinsic therapeutic resistance. The IGF2 is expressed at elevated levels in osteosarcoma after treatment with chemotherapy, prompting an examination of i…
View article: Supplementary Figure S1 from IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress
Supplementary Figure S1 from IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress Open
Supplementary Figure S1: (A) Real-time PCR analysis of Igf1 expression in AXT cell-derived subcutaneous tumors. (B) Serum IGF2 concentration of control and tumor bearing mice with or without chemotherapy. (C) U2OS cells cultured under seru…
View article: Supplementary Information from IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress
Supplementary Information from IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress Open
Supplementary Information. Supplementary Materials and Methods and Supplementary Figure Legends
View article: Supplementary Figure S4 from IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress
Supplementary Figure S4 from IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress Open
Supplementary Figure S4: (A,B) Viable AXT cells after the treatment of chemotherapeutic agents. (C) Representative flow cytometric analysis of γ-H2AX abundance in AXT cells as described in Fig.4E. (D) Immunofluorescence analysis of γ…
View article: Supplementary Table S1 from IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress
Supplementary Table S1 from IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress Open
Supplementary Table S1. Sequences of primers and predicted product sizes for real-time RT-PCR analysis
View article: Supplementary Figure S3 from IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress
Supplementary Figure S3 from IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress Open
Supplementary Figure S3: (A) Immunoblot analysis of p-Akt and Akt expression in AXT cells with the supplement of Akt inhibitor IV or X. Cell viability after the treatment of Akt inhibitors. (B) Phosphorylation status of IGF1R in AXT cells.
View article: Supplementary Table S1 from IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress
Supplementary Table S1 from IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress Open
Supplementary Table S1. Sequences of primers and predicted product sizes for real-time RT-PCR analysis
View article: Supplementary Figure S1 from IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress
Supplementary Figure S1 from IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress Open
Supplementary Figure S1: (A) Real-time PCR analysis of Igf1 expression in AXT cell-derived subcutaneous tumors. (B) Serum IGF2 concentration of control and tumor bearing mice with or without chemotherapy. (C) U2OS cells cultured under seru…
View article: Supplementary Figure S6 from IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress
Supplementary Figure S6 from IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress Open
Supplementary Figure S6: (A) Serum concentrations of Asp, Gln, and Glu in mice. (B) H&E staining of representative AXT cell-derived tumors from mice treated with chemotherapy plus L-asparaginase or bafilomycin A as in Figure 6A. (C) Propos…
View article: Supplementary movie S1 from IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress
Supplementary movie S1 from IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress Open
Supplementary movie S1
View article: Supplementary Figure S5 from IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress
Supplementary Figure S5 from IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress Open
Supplementary Figure S5: (A,B) Viability of AXT cells was assessed after the treatment of aminooxyacetate or bafilomycin A. (C) Cell viability for AXT cells was evaluated after exposure to the indicated agents.
View article: Supplementary movie S1 from IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress
Supplementary movie S1 from IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress Open
Supplementary movie S1
View article: Supplementary Information from IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress
Supplementary Information from IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress Open
Supplementary Information. Supplementary Materials and Methods and Supplementary Figure Legends
View article: Supplementary Figure S2 from IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress
Supplementary Figure S2 from IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress Open
Supplementary Figure S2: (A) Representative flow cytometric analysis of DNA content in AXT cells. (B) Cell cycle distribution for cells treated as in (A). (C) Immunofluorescence analysis of Ki67 expression in AXT cells. (D) Representative …
View article: Data from IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress
Data from IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress Open
Osteosarcoma is a malignant bone tumor in children and adolescents characterized by intrinsic therapeutic resistance. The IGF2 is expressed at elevated levels in osteosarcoma after treatment with chemotherapy, prompting an examination of i…
View article: Supplementary Figure S6 from IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress
Supplementary Figure S6 from IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress Open
Supplementary Figure S6: (A) Serum concentrations of Asp, Gln, and Glu in mice. (B) H&E staining of representative AXT cell-derived tumors from mice treated with chemotherapy plus L-asparaginase or bafilomycin A as in Figure 6A. (C) Propos…
View article: Supplementary Figure S4 from IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress
Supplementary Figure S4 from IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress Open
Supplementary Figure S4: (A,B) Viable AXT cells after the treatment of chemotherapeutic agents. (C) Representative flow cytometric analysis of γ-H2AX abundance in AXT cells as described in Fig.4E. (D) Immunofluorescence analysis of γ…
View article: Supplementary Figure S5 from IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress
Supplementary Figure S5 from IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress Open
Supplementary Figure S5: (A,B) Viability of AXT cells was assessed after the treatment of aminooxyacetate or bafilomycin A. (C) Cell viability for AXT cells was evaluated after exposure to the indicated agents.
View article: Supplementary Figure S3 from IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress
Supplementary Figure S3 from IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress Open
Supplementary Figure S3: (A) Immunoblot analysis of p-Akt and Akt expression in AXT cells with the supplement of Akt inhibitor IV or X. Cell viability after the treatment of Akt inhibitors. (B) Phosphorylation status of IGF1R in AXT cells.