Junye Yao
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View article: Brain tissue electrical conductivity as a promising biomarker for dementia assessment using MRI
Brain tissue electrical conductivity as a promising biomarker for dementia assessment using MRI Open
INTRODUCTION Dementia, particularly Alzheimer's disease, involves cognitive decline linked to amyloid beta (Aβ) and tau protein aggregation. Magnetic resonance imaging (MRI)‐based brain tissue conductivity, which increases in dementia, may…
View article: Magnetic resonance imaging of postmortem human brain specimens: methodological considerations and prospects in psychoradiology
Magnetic resonance imaging of postmortem human brain specimens: methodological considerations and prospects in psychoradiology Open
Ex vivo magnetic resonance imaging (MRI) has revolutionized psychoradiological research by enabling detailed structural and pathological assessments of the brain in conditions ranging from psychiatric disorders to neurodegenerative disease…
View article: Distinct regional vulnerability to Aβ and iron accumulation in <i>post mortem</i> AD brains
Distinct regional vulnerability to Aβ and iron accumulation in <i>post mortem</i> AD brains Open
INTRODUCTION The paramagnetic iron, diamagnetic amyloid beta (Aβ) plaques and their interaction are crucial in Alzheimer's disease (AD) pathogenesis, complicating non‐invasive magnetic resonance imaging for prodromal AD detection. METHODS …
View article: Iron accumulation in the ventral tegmental area in Parkinson's disease
Iron accumulation in the ventral tegmental area in Parkinson's disease Open
Introduction The ventral tegmental area (VTA) is less affected compared to substantia nigra pars compacta (SNc) in Parkinson's disease (PD). This study aimed to quantitatively evaluate iron content in the VTA across different stages of PD …
View article: Both noise‐floor and tissue compartment difference in diffusivity contribute to FA dependence on <i>b</i>‐value in diffusion MRI
Both noise‐floor and tissue compartment difference in diffusivity contribute to FA dependence on <i>b</i>‐value in diffusion MRI Open
Noninvasive diffusion magnetic resonance imaging (dMRI) has been widely employed in both clinical and research settings to investigate brain tissue microstructure. Despite the evidence that dMRI‐derived fractional anisotropy (FA) correlate…
View article: Connectivity of corticostriatal circuits in <scp>nonmanifesting LRRK2 G2385R</scp> and <scp>R1628P</scp> carriers
Connectivity of corticostriatal circuits in <span>nonmanifesting LRRK2 G2385R</span> and <span>R1628P</span> carriers Open
Background Neuroimaging studies have shown that the functional connectivity (FC) of corticostriatal circuits in nonmanifesting leucine‐rich repeat kinase 2 (LRRK2) G2019S mutation carriers mirrors neural changes in idiopathic Parkinson's d…
View article: Evaluation of the diffusion MRI white matter tract integrity model using myelin histology and Monte-Carlo simulations
Evaluation of the diffusion MRI white matter tract integrity model using myelin histology and Monte-Carlo simulations Open
Quantitative evaluation of brain myelination has drawn considerable attention. Conventional diffusion-based magnetic resonance imaging models, including diffusion tensor imaging and diffusion kurtosis imaging (DKI),1 have been used to infe…