Junying He
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View article: Prenatal diagnosis of a de novo pathogenic HNRNPK variant in a Chinese fetus with abnormal ultrasound soft markers: a case report
Prenatal diagnosis of a de novo pathogenic HNRNPK variant in a Chinese fetus with abnormal ultrasound soft markers: a case report Open
Background Heterozygous pathogenic variants in HNRNPK cause Au-Kline syndrome (AUKS), a neurodevelopmental disorder characterized by congenital anomalies and developmental delay. Prenatal diagnosis of AUKS remains challenging due to nonspe…
View article: Comparison of intracerebrospinal fluid methotrexate by Ommaya reservoir versus lumbar puncture in leptomeningeal carcinomatosis with hydrocephalus: a retrospective cohort study
Comparison of intracerebrospinal fluid methotrexate by Ommaya reservoir versus lumbar puncture in leptomeningeal carcinomatosis with hydrocephalus: a retrospective cohort study Open
Objective The aim of this study was to investigate the clinical efficacy and long-term outcome of different routes of intracerebrospinal fluid (intra-CSF) methotrexate administration in the treatment of leptomeningeal carcinomatosis (LC) w…
View article: Development of a short-term prognostic model for anti-N-methyl-D-aspartate receptor encephalitis in Chinese patients
Development of a short-term prognostic model for anti-N-methyl-D-aspartate receptor encephalitis in Chinese patients Open
Background Recognizing the predictors of poor short-term prognosis after first-line immunotherapy in patients with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is essential for individualized treatment strategy. The objecti…
View article: Adult spinal cord diffuse midline glioma, H3 K27-altered mimics symptoms of central nervous system infection: a case report
Adult spinal cord diffuse midline glioma, H3 K27-altered mimics symptoms of central nervous system infection: a case report Open
Diffuse midline gliomas, H3 K27-altered are infiltrative growth gliomas with histone H3K27M mutations. This glioma is more common in the pediatric population, and the prognosis is usually poor. We report a case of diffuse midline gliomas, …
View article: Prenatal diagnosis of 45,X/46,X,dic(X;18) mosaicism: a case report
Prenatal diagnosis of 45,X/46,X,dic(X;18) mosaicism: a case report Open
Background : A dicentric chromosome is an abnormal chromosome with two centromereson the same chromosome. They are rarely identified in genetic conditions. Robertsonian translocations (ROBs) involving acrocentric chromosomes (13, 14, 15, 2…
View article: Comprehensive proteomic analysis of cerebrospinal fluid exosomes derived from non-small cell lung cancer related leptomeningeal carcinomatosis
Comprehensive proteomic analysis of cerebrospinal fluid exosomes derived from non-small cell lung cancer related leptomeningeal carcinomatosis Open
Background Leptomeningeal carcinomatosis might happen in late non-small cell lung cancer patients and causes a poor median survival period. CSF of leptomeningeal carcinomatosis patients is a special kind of tumor microenvironment. Exosomes…
View article: Human Encephalitis Complicated With Ocular Symptoms Associated With Pseudorabies Virus Infection: A Case Report
Human Encephalitis Complicated With Ocular Symptoms Associated With Pseudorabies Virus Infection: A Case Report Open
Pseudorabies virus (PRV) is an alpha herpesvirus found in many wild and domestic animals, and causes neurological diseases in humans. Several cases of PRV-induced human encephalitis accompanied with severe visual impairment have been repor…
View article: Clinical efficacy and safety of different doses of intrathecal methotrexate in the treatment of leptomeningeal carcinomatosis: a prospective and single-arm study
Clinical efficacy and safety of different doses of intrathecal methotrexate in the treatment of leptomeningeal carcinomatosis: a prospective and single-arm study Open
Objective To investigate the clinical efficacy and safety of different doses of intrathecal methotrexate in the treatment of leptomeningeal carcinomatosis. Methods 53 patients admitted to the Second Hospital of Hebei Medical University wit…
View article: A Deep Reinforcement Learning Approach for Online Parcel Assignment
A Deep Reinforcement Learning Approach for Online Parcel Assignment Open
In this paper, we investigate the online parcel assignment (OPA) problem, in which each stochastically generated parcel needs to be assigned to a candidate route for delivery to minimize the total cost subject to certain business constrain…
View article: [Retracted] A Diagnostic Scoring System for Distinguishing between Tuberculous and Bacterial Meningitis Based on Clinical and Laboratory Findings
[Retracted] A Diagnostic Scoring System for Distinguishing between Tuberculous and Bacterial Meningitis Based on Clinical and Laboratory Findings Open
It is very difficult to diagnose and distinguish tuberculous meningitis, and the current laboratory methods are unsubstantial in developing countries. The study is aimed at creating a scoring system on the basis of basic laboratory and cli…
View article: Validation of the NEOS score in Chinese patients with anti-NMDAR encephalitis
Validation of the NEOS score in Chinese patients with anti-NMDAR encephalitis Open
This study provides Class III evidence that in patients with anti-NMDAR encephalitis, the NEOS score predicts 1-year functional status.
View article: <p>Knockdown of IKKβ Inhibits Tumor Development in a Leptomeningeal Metastasis Mouse Model and Proliferation of Lung Cancer Cells</p>
Knockdown of IKKβ Inhibits Tumor Development in a Leptomeningeal Metastasis Mouse Model and Proliferation of Lung Cancer Cells Open
Blocking the NF-κB signaling pathway by IKKβ knockdown in LLC cells inhibited tumor growth in the LM mouse model. IKKβ supports leptomeningeal tumor progression by promoting cancer cell proliferation and migration and inhibiting cancer cel…
View article: Detection of genes mutations in cerebrospinal fluid circulating tumor DNA from neoplastic meningitis patients using next generation sequencing
Detection of genes mutations in cerebrospinal fluid circulating tumor DNA from neoplastic meningitis patients using next generation sequencing Open
Background: This study profiled the somatic gene mutations and the copy number variations (CNVs) in cerebrospinal fluid (CSF)-circulating tumor DNA (ctDNA) from patients with neoplastic meningitis (NM). Methods: A total of 62 CSF ctDNA sam…
View article: Angiostrongyliasis detected by next-generation sequencing in a ELISA-negative eosinophilic meningitis: A case report
Angiostrongyliasis detected by next-generation sequencing in a ELISA-negative eosinophilic meningitis: A case report Open
Next-generation sequencing (NGS) is an emerging method with the potential of pan-pathogen screening. This study described a case of eosinophilic meningitis (EoM) with enzyme-linked immunosorbent assay (ELISA)-negative results for Angiostro…
View article: Detection of genes mutations in cerebrospinal fluid circulating tumor DNA from neoplastic meningitis patients using next generation sequencing
Detection of genes mutations in cerebrospinal fluid circulating tumor DNA from neoplastic meningitis patients using next generation sequencing Open
Background: This study profiled the somatic gene mutations and the copy number variations (CNVs) in cerebrospinal fluid (CSF)-circulating tumor DNA (ctDNA) from patients with neoplastic meningitis (NM). Methods: A total of 62 CSF ctDNA sam…
View article: Evaluating the cerebrospinal fluid ctDNA detection by next-generation sequencing in the diagnosis of meningeal Carcinomatosis
Evaluating the cerebrospinal fluid ctDNA detection by next-generation sequencing in the diagnosis of meningeal Carcinomatosis Open
Background Meningeal carcinomatosis (MC) is the most severe form of brain metastasis and causes significant morbidity and mortality. Currently, the diagnosis of MC is routinely confirmed on the basis of clinical manifestation, positive cer…
View article: Study on Business Data Analysis Course Based on Business Scenario Requirement
Study on Business Data Analysis Course Based on Business Scenario Requirement Open
With the advent of the big data era, e-commerce enterprises pay more and more attention on various kinds of data, and so the demand for data analysis talents has been increasing.At present, students of higher vocational colleges lack pract…
View article: A Study on Effective Study Path for Open Education Students Based on Complex Network
A Study on Effective Study Path for Open Education Students Based on Complex Network Open
This paper is based on the constructivism learning theory.The knowledge nodes in study were taken as network nodes to build complex knowledge nodes relation network model by applying the method to build a complex network, to find the basic…
View article: Staining with two observational methods for the diagnosis of tuberculous meningitis
Staining with two observational methods for the diagnosis of tuberculous meningitis Open
Ziehl-Neelsen (Z-N) staining of cerebrospinal fluid (CSF) for acid-fast bacilli (AFB) is the cornerstone of the laboratory diagnosis of tuberculous meningitis (TBM). However, the sensitivity of conventional Z-N staining for the detection o…
View article: Study on the value of detecting early secretory antigenic target-6 in cerebrospinal fluid monocytes by laser scanning confocal microscopy techniques in the early diagnosis of tuberculous meningitis
Study on the value of detecting early secretory antigenic target-6 in cerebrospinal fluid monocytes by laser scanning confocal microscopy techniques in the early diagnosis of tuberculous meningitis Open
Objective To explore the value of detecting early secretory antigenic target-6 (ESAT-6) in cerebrospinal fluid (CSF) monocytes by laser scanning confocal microscopy (LSCM) techniques in early diagnosis of tuberculous meningitis (TBM), and …