Jun‐Yu Ma
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View article: Curcumin attenuates liver injury by modulating the AGE–RAGE axis and metabolic homeostasis in high-fat diet/streptozotocin-induced type 2 diabetic mice
Curcumin attenuates liver injury by modulating the AGE–RAGE axis and metabolic homeostasis in high-fat diet/streptozotocin-induced type 2 diabetic mice Open
Background Diabetic liver injury is a serious complication of type 2 diabetes mellitus (T2DM). Curcumin (CUR), a natural polyphenol derived from Curcuma longa , exhibits diverse biological activities. This study investigated the hepatoprot…
View article: Sulforaphane attenuates aldose reductase-mediated platelet dysfunction in high glucose-stimulated human platelets via downregulation of the Src/ROS/p53 signaling pathway
Sulforaphane attenuates aldose reductase-mediated platelet dysfunction in high glucose-stimulated human platelets via downregulation of the Src/ROS/p53 signaling pathway Open
Background Platelet abnormalities are well-recognized complications of type 2 diabetes mellitus (T2DM). High glucose (HG) increases platelet mitochondrial dysfunction, apoptosis and hyperreactivity in T2DM, which underlie the occurrence of…
View article: Cognitive Kernel-Pro: A Framework for Deep Research Agents and Agent Foundation Models Training
Cognitive Kernel-Pro: A Framework for Deep Research Agents and Agent Foundation Models Training Open
General AI Agents are increasingly recognized as foundational frameworks for the next generation of artificial intelligence, enabling complex reasoning, web interaction, coding, and autonomous research capabilities. However, current agent …
View article: A study on the influence of normal direction-prioritized anisotropic porous media on the flow characteristics of turbulent flat-plate boundary layers
A study on the influence of normal direction-prioritized anisotropic porous media on the flow characteristics of turbulent flat-plate boundary layers Open
In-flight turbulent friction drag is the main surface resistance for large aircraft. Thus, developing effective turbulent drag control methods is vital in engineering and science. Anisotropic porous materials, as novel materials, offer new…
View article: Sulforaphane attenuates CD36-mediated platelet hyperreactivity through modulating cAMP/PKA/NOX2 signaling in hyperlipidemic conditions
Sulforaphane attenuates CD36-mediated platelet hyperreactivity through modulating cAMP/PKA/NOX2 signaling in hyperlipidemic conditions Open
Hyperlipidemia is a risk factor for clinically significant thrombotic events in cardiovascular diseases. Platelet reactivity in hyperlipidemic conditions is enhanced when platelet scavenger receptor CD36 recognizes oxidized lipids in oxidi…
View article: Dynamic of centromere associated RNAs and the centromere loading of DNA repair proteins in growing oocytes
Dynamic of centromere associated RNAs and the centromere loading of DNA repair proteins in growing oocytes Open
Mammalian centromeres are generally composed of dispersed repeats and the satellites such as α-satellites in human and major/minor satellites in mouse. Transcription of centromeres by RNA polymerase II is evolutionary conserved and critica…
View article: Correction: Chromosomal variants accumulate in genomes of the spontaneous aborted fetuses revealed by chromosomal microarray analysis
Correction: Chromosomal variants accumulate in genomes of the spontaneous aborted fetuses revealed by chromosomal microarray analysis Open
[This corrects the article DOI: 10.1371/journal.pone.0259518.].
View article: Chromosomal variants accumulate in genomes of the spontaneous aborted fetuses revealed by chromosomal microarray analysis
Chromosomal variants accumulate in genomes of the spontaneous aborted fetuses revealed by chromosomal microarray analysis Open
Spontaneous abortion is an impeding factor for the success rates of human assistant reproductive technology (ART). Causes of spontaneous abortion include not only the pregnant mothers’ health conditions and lifestyle habits, but also the f…
View article: Double-strand breaks induce short-scale DNA replication and damage amplification in the fully grown mouse oocytes
Double-strand breaks induce short-scale DNA replication and damage amplification in the fully grown mouse oocytes Open
Break-induced replication (BIR) is essential for the repair of DNA double-strand breaks (DSBs) with single ends. DSBs-induced microhomology-mediated BIR (mmBIR) and template-switching can increase the risk of complex genome rearrangement. …
View article: Cruciform DNA in mouse growing oocytes: Its dynamics and its relationship with DNA transcription
Cruciform DNA in mouse growing oocytes: Its dynamics and its relationship with DNA transcription Open
Cruciform DNA is a causing factor of genome instability and chromosomal translocation, however, most studies about cruciform DNA in mammalian cells were based on palindromic sequences containing plasmids and reports about endogenous crucif…
View article: Double-strand breaks can induce DNA replication and damage amplification in G2 phase-like oocytes of mice
Double-strand breaks can induce DNA replication and damage amplification in G2 phase-like oocytes of mice Open
Break-induced DNA replication (BIR) have been detected not only in the genome of rare disease patients but also in cancer cells, however, the mechanisms of BIR formation haven’t been explained in details. In the late G2 phase-like mouse oo…
View article: Single cell RNA sequencing reveals the landscape of early female germ cell development
Single cell RNA sequencing reveals the landscape of early female germ cell development Open
Female germ cell development consists of complex events including sex determination, meiosis initiation, retardation and resumption. During early oogenesis, the asynchrony of the transition from mitosis to meiosis results in heterogeneity …
View article: DNA Double-Strand Breaks Induce the Nuclear Actin Filaments Formation in Cumulus-Enclosed Oocytes but Not in Denuded Oocytes
DNA Double-Strand Breaks Induce the Nuclear Actin Filaments Formation in Cumulus-Enclosed Oocytes but Not in Denuded Oocytes Open
As a gamete, oocyte needs to maintain its genomic integrity and passes this haploid genome to the next generation. However, fully-grown mouse oocyte cannot respond to DNA double-strand breaks (DSBs) effectively and it is also unable to rep…
View article: Whole-genome scanning for the litter size trait associated genes and SNPs under selection in dairy goat (Capra hircus)
Whole-genome scanning for the litter size trait associated genes and SNPs under selection in dairy goat (Capra hircus) Open
Dairy goats are one of the most utilized domesticated animals in China. Here, we selected extreme populations based on differential fecundity in two Laoshan dairy goat populations. Utilizing deep sequencing we have generated 68.7 and 57.8 …
View article: Removal of mouse ovary fat pad affects sex hormones, folliculogenesis and fertility
Removal of mouse ovary fat pad affects sex hormones, folliculogenesis and fertility Open
As a fat storage organ, adipose tissue is distributed widely all over the body and is important for energy supply, body temperature maintenance, organ protection, immune regulation and so on. In humans, both underweight and overweight wome…