Junzhen Wu
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Author Swipe
View article: Effect of itraconazole on pharmacokinetics of ZX-7101A tablets in healthy Chinese subjects
Effect of itraconazole on pharmacokinetics of ZX-7101A tablets in healthy Chinese subjects Open
Aims A single-center, open label trial was conducted to evaluate the effects of itraconazole on the pharmacokinetics of ZX-7101A tablets in healthy Chinese adults. Methods Subjects took a single dose of 40 mg ZX-7101A tablets on Day 1 on D…
View article: Pharmacokinetics, Pharmacodynamics, and Immunogenicity of <scp>CM313</scp> in Healthy Participants: An Open‐Label/Double‐Blind, Randomized, Placebo‐Controlled Phase 1 Trial
Pharmacokinetics, Pharmacodynamics, and Immunogenicity of <span>CM313</span> in Healthy Participants: An Open‐Label/Double‐Blind, Randomized, Placebo‐Controlled Phase 1 Trial Open
CM313, a novel humanized anti‐CD38 monoclonal antibody, has demonstrated therapeutic potential in autoimmune diseases. This Phase 1 trial evaluated safety, tolerability, pharmacokinetics, and pharmacodynamics in healthy participants follow…
View article: A novel approach to ultrasound-guided L3-4 thoracolumbar fascia injection for chronic pain after spine surgery: a prospective pilot study
A novel approach to ultrasound-guided L3-4 thoracolumbar fascia injection for chronic pain after spine surgery: a prospective pilot study Open
The US-guided bilateral L3-4 mid-thoracolumbar fascia injection facilitated a uniform dispersion of the medication, akin to the gentle spread of a goose feather, between the erector spinalis and quadratus lumborum muscles across the affect…
View article: Efficacy of Transcutaneous Electrical Acupoint Stimulation on Modulating Upper Extremity Sympathetic Skin Response in Alleviating Cancer Survivors With Chemotherapy-Induced Peripheral Neuropathy: A Propensity Score-Matched Cohort Study
Efficacy of Transcutaneous Electrical Acupoint Stimulation on Modulating Upper Extremity Sympathetic Skin Response in Alleviating Cancer Survivors With Chemotherapy-Induced Peripheral Neuropathy: A Propensity Score-Matched Cohort Study Open
TEAS significantly decreased the severity of CIPN. TEAS group and baseline SSR amplitude of the upper extremity <1265 µV were the independent predictive factors for the clinical efficacy after treatment.
View article: Dose adjustment not required for contezolid in patients with moderate hepatic impairment based on pharmacokinetic/pharmacodynamic analysis
Dose adjustment not required for contezolid in patients with moderate hepatic impairment based on pharmacokinetic/pharmacodynamic analysis Open
Objective: Contezolid is an oxazolidinone antimicrobial agent newly approved for treatment of Gram-positive bacterial infections. It is primarily metabolized by the liver. This study aimed to assess whether it is required to adjust the dos…
View article: Single-Ascending-Dose, Food-Effect, and Multiple-Dose Study of the Safety, Tolerability, and Pharmacokinetics of the Pangenotypic Anti-Hepatitis C Virus Drug Holybuvir in Healthy Chinese Subjects
Single-Ascending-Dose, Food-Effect, and Multiple-Dose Study of the Safety, Tolerability, and Pharmacokinetics of the Pangenotypic Anti-Hepatitis C Virus Drug Holybuvir in Healthy Chinese Subjects Open
Holybuvir is a novel pangenotypic hepatitis C virus NS5B inhibitor. This first in-human study aimed to evaluate the pharmacokinetics (PK), safety, and tolerability of holybuvir and its metabolites and the effect of food on the PK of holybu…
View article: Musical therapy attenuates neuroma pain by modifying leptin expression
Musical therapy attenuates neuroma pain by modifying leptin expression Open
Background: Accumulating evidence reveals that music therapy appears to help patients with pain. However, there is a limited understanding of the underlying mechanisms. Several studies indicate that leptin level has a crucial relationship …
View article: The Tourniquet Ischemia Test Effectively Predicts the Efficacy of Lumbar Sympathetic Block in Patients with Lower Extremity Complex Regional Pain Syndrome Type 1
The Tourniquet Ischemia Test Effectively Predicts the Efficacy of Lumbar Sympathetic Block in Patients with Lower Extremity Complex Regional Pain Syndrome Type 1 Open
Tourniquet IT is a simple, safe and effective test to distinguish patients with lower extremity CRPS-1. The response to the tourniquet IT is a reliable predictor of LSB effectiveness in lower extremity CRPS-1 patients.
View article: Clinical Pharmacology and Utility of Contezolid in Chinese Patients with Complicated Skin and Soft-Tissue Infections
Clinical Pharmacology and Utility of Contezolid in Chinese Patients with Complicated Skin and Soft-Tissue Infections Open
This study aimed to build a population pharmacokinetic (PopPK) model for contezolid tablet (MRX-I) in healthy subjects and adults with complicated skin and soft-tissue infections (cSSTIs) to further evaluate the efficacy and safety of cont…
View article: Real-time ultrasound-guided stellate ganglion block for migraine: an observational study
Real-time ultrasound-guided stellate ganglion block for migraine: an observational study Open
Objective To observe whether ultrasound-guided stellate ganglion block (SGB) can effectively relieve migraine pain and improve the quality of migraine patients’ life. Methods 81 patients with migraines were enrolled in this study. The pati…
View article: Enhanced echo intensity of skeletal muscle is associated with poor physical function in hemodialysis patients：a cross-sectional study
Enhanced echo intensity of skeletal muscle is associated with poor physical function in hemodialysis patients：a cross-sectional study Open
Background: The objective of this study was to evaluate the relationship between ultrasound echo intensity (EI) of skeletal muscle and physical function of patients on maintenance hemodialysis. Methods: Cross-sectional area (CSA) and mean …
View article: Ultrasound-Guided Extraforaminal Thoracic Nerve Root Block Through the Midpoint of the Inferior Articular Process and the Parietal Pleura: A Clinical Application of Thoracic Paravertebral Nerve Block
Ultrasound-Guided Extraforaminal Thoracic Nerve Root Block Through the Midpoint of the Inferior Articular Process and the Parietal Pleura: A Clinical Application of Thoracic Paravertebral Nerve Block Open
Shaofeng Pu,1 Yiyang Wu,1 Qingjian Han,2 Jie Chen,3 Yongming Xu,1 Yingying Lv,1 Chen Li,1 Jing Lu,4 Junzhen Wu,1,* Dongping Du1,* 1Department of Pain Management, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, 2…
View article: Real-Time Ultrasound-Guided Stellate Ganglion Block for Migraine: An Observational Study
Real-Time Ultrasound-Guided Stellate Ganglion Block for Migraine: An Observational Study Open
Objective. To observe whether ultrasound-guided stellate ganglion block (SGB) can effectively relieve migraine pain and improve the quality of migraine patients’ life. Methods. 81 patients with migraines were enrolled in this trial. The pa…
View article: <p>Ultrasonography-Guided Radiofrequency Ablation for Painful Stump Neuromas to Relieve Postamputation Pain: A Pilot Study</p>
Ultrasonography-Guided Radiofrequency Ablation for Painful Stump Neuromas to Relieve Postamputation Pain: A Pilot Study Open
Ultrasonography-guided RFA for painful stump neuromas can effectively relieve stump pain and PLP in amputees with PAP (follow-up time was 12 months). Ultrasonography-guided RFA is easy and safe and does not involve radiation exposure, maki…
View article: Evaluation of the Effect of Contezolid (MRX-I) on the Corrected QT Interval in a Randomized, Double-Blind, Placebo- and Positive-Controlled Crossover Study in Healthy Chinese Volunteers
Evaluation of the Effect of Contezolid (MRX-I) on the Corrected QT Interval in a Randomized, Double-Blind, Placebo- and Positive-Controlled Crossover Study in Healthy Chinese Volunteers Open
Contezolid (MRX-I), a new oxazolidinone, is an antibiotic in development for treating complicated skin and soft tissue infections caused by resistant Gram-positive bacteria. This was a thorough QT study conducted in 52 healthy subjects who…
View article: Epimedium flavonoids mitigate proteotoxicity and extend healthspan via DAF-16 in<i>C. elegans</i>
Epimedium flavonoids mitigate proteotoxicity and extend healthspan via DAF-16 in<i>C. elegans</i> Open
Objective: Epimedium flavonoids (EF), the raw extract of medicinal herb Epimedium, have been shown to have broad beneficial effects in the elderly including those with neurodegeneration. The goal of this study is to investigate whether EF …
View article: The effectiveness of ultrasound-guided cervical transforaminal epidural steroid injections in cervical radiculopathy: a prospective pilot study
The effectiveness of ultrasound-guided cervical transforaminal epidural steroid injections in cervical radiculopathy: a prospective pilot study Open
We suggest that ultrasound-guided CTFESI is an effective, safe, and simple procedure free of radiation or magnetization and provides sustained pain relief in patients with cervical radiculopathy who have failed previous conservation therap…
View article: Role of receptor-interacting protein 1/receptor-interacting protein 3 in inflammation and necrosis following chronic constriction injury of the sciatic nerve
Role of receptor-interacting protein 1/receptor-interacting protein 3 in inflammation and necrosis following chronic constriction injury of the sciatic nerve Open
Nerve damage often leads to nervous system dysfunction and neuropathic pain. The serine-threonine kinases receptor-interacting protein 1 (RIP1) and 3 (RIP3) are associated with inflammation and cell necrosis. This study aimed to explore th…
View article: Effects of ultrasound-guided stellate ganglion block on cervical vascular blood flow: study protocol for a randomized controlled trial
Effects of ultrasound-guided stellate ganglion block on cervical vascular blood flow: study protocol for a randomized controlled trial Open
Chinese Clinical Trial Registry, identifier ChiCTR-IOR-17011536 . Registered on 1 June 2017.
View article: Characteristics of circular RNA expression in lung tissues from mice with hypoxia‑induced pulmonary hypertension
Characteristics of circular RNA expression in lung tissues from mice with hypoxia‑induced pulmonary hypertension Open
Pulmonary hypertension (PH) is a life‑threatening lung disease, characterized by an increase in pulmonary arterial pressure caused by vasoconstriction and vascular remodeling. The pathogenesis of PH is not fully understood, and there is a …
View article: Anti-nociceptive roles of the glia-specific metabolic inhibitor fluorocitrate in paclitaxel-evoked neuropathic pain
Anti-nociceptive roles of the glia-specific metabolic inhibitor fluorocitrate in paclitaxel-evoked neuropathic pain Open
Paclitaxel (Taxol) is a powerful chemotherapy drug used in breast cancers, but it often causes neuropathic pain, leading to the early cessation of therapy and poor treatment outcomes. Approaches for the management of paclitaxel-induced neu…
View article: An Update on Inflamm-Aging: Mechanisms, Prevention, and Treatment
An Update on Inflamm-Aging: Mechanisms, Prevention, and Treatment Open
Inflamm-aging is a challenging and promising new branch of aging-related research fields that includes areas such as immunosenescence. Increasing evidence indicates that inflamm-aging is intensively associated with many aging diseases, suc…