Junzheng Wang
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View article: A simulation study of the impact of population-wide lifestyle modifications on life expectancy in the Chinese population
A simulation study of the impact of population-wide lifestyle modifications on life expectancy in the Chinese population Open
View article: Salting-Out Effect Behavior of Protein/λ-Carrageenan Composite Gels Enhanced by Enzymatic Pretreatment: Focusing on Microstructure, Interactions and the Potential for Dysphagia Food
Salting-Out Effect Behavior of Protein/λ-Carrageenan Composite Gels Enhanced by Enzymatic Pretreatment: Focusing on Microstructure, Interactions and the Potential for Dysphagia Food Open
This study aimed to investigate the effects of synergistic K+ immersion-induced salting-out on the rheological properties, microstructure, molecular interactions, and swallowing adaptability of soy protein isolate (SPI)/λ-carrageenan compo…
View article: Effect of the Number of Gallate Groups of Polyphenols on the Structure, Gel Properties, and Biological Activity of Soy Protein Fibrils
Effect of the Number of Gallate Groups of Polyphenols on the Structure, Gel Properties, and Biological Activity of Soy Protein Fibrils Open
Amyloid fibril hydrogels prepared via protein acid heating currently exhibit inadequate gel properties and biological activity. These limitations can be addressed by modifying the amyloid fibrils with polyphenols. In this study, two types …
View article: Predictive value of 8-year blood pressure measures in intracerebral haemorrhage risk over 5 years
Predictive value of 8-year blood pressure measures in intracerebral haemorrhage risk over 5 years Open
Aims The relationships between long-term blood pressure (BP) measures and intracerebral haemorrhage (ICH), as well as their predictive ability on ICH, are unclear. In this study, we aim to investigate the independent associations of multip…
View article: Causal association between snoring and stroke: a Mendelian randomization study in a Chinese population
Causal association between snoring and stroke: a Mendelian randomization study in a Chinese population Open
National Natural Science Foundation of China, Kadoorie Charitable Foundation Hong Kong, UK Wellcome Trust, National Key R&D Program of China, Chinese Ministry of Science and Technology.
View article: Long-Term Exposure to Fine Particulate Matter and Incidence of Esophageal Cancer: A Prospective Study of 0.5 Million Chinese Adults
Long-Term Exposure to Fine Particulate Matter and Incidence of Esophageal Cancer: A Prospective Study of 0.5 Million Chinese Adults Open
View article: Estimated minimum prices and lowest available national prices for antiobesity medications: Improving affordability and access to treatment
Estimated minimum prices and lowest available national prices for antiobesity medications: Improving affordability and access to treatment Open
Objective Novel antiobesity treatments are highly effective in recent clinical trials. Access to these medications is needed to supplement lifestyle and surgical interventions for millions living with obesity worldwide, but high prices are…
View article: Maintaining healthy sleep patterns and frailty transitions: a prospective Chinese study
Maintaining healthy sleep patterns and frailty transitions: a prospective Chinese study Open
View article: Risks of Stroke and Heart Disease Following Hysterectomy and Oophorectomy in Chinese Premenopausal Women
Risks of Stroke and Heart Disease Following Hysterectomy and Oophorectomy in Chinese Premenopausal Women Open
Background: Little is known about the long-term risks of stroke and ischemic heart disease (IHD) in women who had a hysterectomy alone (HA) or with bilateral oophorectomy (HBO) for benign diseases, particularly in China where the burden of…
View article: Estimated global cost of treating COVID-19, HIV, Hepatitis B and Hepatitis C with approved effective oral medications
Estimated global cost of treating COVID-19, HIV, Hepatitis B and Hepatitis C with approved effective oral medications Open
Background High drug prices can limit treatment access. Patented drugs can be sold for prices far higher than the costs of production. This analysis aimed to determine prices currently feasible to treat COVID-19, HIV, and Hepatitis B or C,…
View article: Current prices versus minimum costs of production for CFTR modulators
Current prices versus minimum costs of production for CFTR modulators Open
View article: Barriers to Worldwide Access for Paxlovid, a New Treatment for COVID-19
Barriers to Worldwide Access for Paxlovid, a New Treatment for COVID-19 Open
Pfizer and the Medicines Patent Pool (MPP) have reached a voluntary licensing agreement for Paxlovid (nirmatrelvir+ritonavir), a novel antiviral for coronavirus disease 2019 (COVID-19) taken orally in the first 5 days from symptom onset. T…
View article: Retraction to: Meta-analysis of Randomized Trials of Ivermectin to Treat SARS-CoV-2 Infection
Retraction to: Meta-analysis of Randomized Trials of Ivermectin to Treat SARS-CoV-2 Infection Open
[This retracts the article DOI: 10.1093/ofid/ofab358.]
View article: Current prices versus minimum costs of production for CFTR modulators
Current prices versus minimum costs of production for CFTR modulators Open
Background While the clinical benefits of CFTR modulators are clear, their high prices render them inaccessible outside of a select few countries. Despite this, there is currently limited evidence regarding access to these transformative t…
View article: Estimated Costs of Production Compared with National Prices, for Drugs to Treat Clinical Obesity
Estimated Costs of Production Compared with National Prices, for Drugs to Treat Clinical Obesity Open
View article: Minimum Manufacturing Costs, National Prices, and Estimated Global Availability of New Repurposed Therapies for Coronavirus Disease 2019
Minimum Manufacturing Costs, National Prices, and Estimated Global Availability of New Repurposed Therapies for Coronavirus Disease 2019 Open
Background Currently, only dexamethasone, tocilizumab, and sarilumab have conclusively been shown to reduce mortality of coronavirus disease 2019 (COVID-19). Safe and effective treatments will need to be both affordable and widely availabl…
View article: Prices versus costs of production for molnupiravir as a COVID-19 treatment
Prices versus costs of production for molnupiravir as a COVID-19 treatment Open
Background Molnupiravir has been recently approved in the United Kingdom for the treatment of COVID-19 for showing promising survival benefits in clinical trials. This analysis will estimate and compare potential generic minimum costs of m…
View article: Importance of healthy lifestyle factors and ideal cardiovascular health metrics for risk of heart failure in Chinese adults
Importance of healthy lifestyle factors and ideal cardiovascular health metrics for risk of heart failure in Chinese adults Open
Background The relative importance of healthy lifestyle factors and cardiovascular health metrics for the risk of heart failure is uncertain in Chinese populations. We aimed to compare the strength of associations between healthy lifestyle…
View article: 529. Systematic Review and Meta-Analysis of Ivermectin Safety Profile in COVID-19 Trials
529. Systematic Review and Meta-Analysis of Ivermectin Safety Profile in COVID-19 Trials Open
Background There is a continued and pressing need for safe and effective treatment of COVID-19. Significant survival benefits have been shown by dexamethasone, tocilizumab and sarilumab, however they are only recommended in hospitalised CO…
View article: 407. Minimum Manufacturing Costs, National Prices and Estimated Global Availability of New Repurposed Therapies for COVID-19
407. Minimum Manufacturing Costs, National Prices and Estimated Global Availability of New Repurposed Therapies for COVID-19 Open
Background Currently, only dexamethasone, tocilizumab and sarilumab have conclusively been shown to reduce mortality of COVID-19. No drug for prevention or treatment in earlier stages of COVID-19 are yet found, with previously promising dr…
View article: 891. Minimum Manufacturing Costs and National Prices for Weight Loss Treatments, as Potential Mitigation for Anti-Retroviral Related Weight Gain in HIV
891. Minimum Manufacturing Costs and National Prices for Weight Loss Treatments, as Potential Mitigation for Anti-Retroviral Related Weight Gain in HIV Open
Background Weight gain is being observed for a wide range of antiretroviral treatments. Weight gains are higher for people taking first-line integrase inhibitor based treatments, especially those including TAF/FTC. Weight gains are higher …
View article: Modification effect of ideal cardiovascular health metrics on genetic association with incident heart failure in the China Kadoorie Biobank and the UK Biobank
Modification effect of ideal cardiovascular health metrics on genetic association with incident heart failure in the China Kadoorie Biobank and the UK Biobank Open
View article: Publisher Correction: Utility of single versus sequential measurements of risk factors for prediction of stroke in Chinese adults
Publisher Correction: Utility of single versus sequential measurements of risk factors for prediction of stroke in Chinese adults Open
View article: Utility of single versus sequential measurements of risk factors for prediction of stroke in Chinese adults
Utility of single versus sequential measurements of risk factors for prediction of stroke in Chinese adults Open
View article: RETRACTED: Expression of Concern: “Meta-analysis of Randomized Trials of Ivermectin to Treat SARS-CoV-2 Infection”
RETRACTED: Expression of Concern: “Meta-analysis of Randomized Trials of Ivermectin to Treat SARS-CoV-2 Infection” Open
View article: Retracted: Meta-analysis of Randomized Trials of Ivermectin to Treat SARS-CoV-2 Infection
Retracted: Meta-analysis of Randomized Trials of Ivermectin to Treat SARS-CoV-2 Infection Open
Ivermectin is an antiparasitic drug being investigated for repurposing against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Ivermectin showed in vitro activity against SARS-COV-2, but only at high concentrations. This meta…
View article: Minimum manufacturing costs, national prices and estimated global availability of new repurposed therapies for COVID-19
Minimum manufacturing costs, national prices and estimated global availability of new repurposed therapies for COVID-19 Open
Background Currently, only dexamethasone, tocilizumab and sarilumab have conclusively been shown to reduce mortality of COVID-19. Safe and effective treatments will need to be both affordable and widely available globally to be used alongs…
View article: Development and external validation of a breast cancer absolute risk prediction model in Chinese population
Development and external validation of a breast cancer absolute risk prediction model in Chinese population Open
View article: Value of [68Ga]Ga-FAPI-04 Imaging in the Diagnosis of Renal Fibrosis
Value of [68Ga]Ga-FAPI-04 Imaging in the Diagnosis of Renal Fibrosis Open
PurposeRenal fibrosis is a pathological state in the progression of chronic kidney disease. Early detection and treatment are vital to prolong the survival of patients. Renal puncture examination represents the gold standard examination me…
View article: Meta-analysis of randomized trials of ivermectin to treat SARS-CoV-2 infection
Meta-analysis of randomized trials of ivermectin to treat SARS-CoV-2 infection Open
Ivermectin is an antiparasitic drug being investigated for repurposing to SARS-CoV-2. In-vitro, ivermectin showed limited antiviral activity and a COVID-19 animal model demonstrated pathological benefits but no effect on viral RNA. This me…