Ji Xiong
YOU?
Author Swipe
View article: FeaSion decodes the regulatory landscape and functional diversity of RNA polymerase II CTD phosphorylation
FeaSion decodes the regulatory landscape and functional diversity of RNA polymerase II CTD phosphorylation Open
RNA polymerase II’s (RNAPII) C-terminal domain (CTD) contains five phosphorylation sites (pY1, pS2, pT4, pS5, and pS7). However, their regulatome and immediate functions remain elusive. Using the FeaSion (Feature-Screening-Function) strate…
View article: INO80/SWR remodelers regulate Pol II transcription through BRD2 and chromatin landscape
INO80/SWR remodelers regulate Pol II transcription through BRD2 and chromatin landscape Open
INO80/SWR remodelers, including INO80, P400/TIP60, and SRCAP, have been viewed to regulate H2A.Z dynamics, but how they control specific gene expression remains unclear. Here, we reveal distinct phenotypes arising from short- and long-term…
View article: Deep learning-based tumor segmentation and radiogenomic model for predicting EGFR amplification and assessing intratumoural heterogeneity in glioblastoma
Deep learning-based tumor segmentation and radiogenomic model for predicting EGFR amplification and assessing intratumoural heterogeneity in glioblastoma Open
Objectives To predict epidermal growth factor receptor (EGFR) amplification and explore the intratumoural heterogeneity of glioblastoma (GBM) using deep learning segmentation-based radiogenomics. Methods A total of 654 patients were includ…
View article: Deep learning-based radiomics and machine learning for prognostic assessment in IDH-wildtype glioblastoma after maximal safe surgical resection: a multicenter study
Deep learning-based radiomics and machine learning for prognostic assessment in IDH-wildtype glioblastoma after maximal safe surgical resection: a multicenter study Open
Background: Glioblastoma (GBM) is a highly aggressive brain tumor with a poor prognosis. This study aimed to construct and validate a radiomics-based machine learning model for predicting overall survival (OS) in isocitrate dehydrogenase-w…
View article: Alterations of gray matter volume and structural covariance network in unilateral frontal lobe low-grade gliomas
Alterations of gray matter volume and structural covariance network in unilateral frontal lobe low-grade gliomas Open
Not applicable.
View article: Current application of artificial intelligence in emergency medicine
Current application of artificial intelligence in emergency medicine Open
View article: CTDP1 and RPB7 stabilize Pol II and permit reinitiation
CTDP1 and RPB7 stabilize Pol II and permit reinitiation Open
View article: Transcriptional Dichotomy Underpins Zygotic Genome Activation and Totipotency Reacquisition
Transcriptional Dichotomy Underpins Zygotic Genome Activation and Totipotency Reacquisition Open
View article: Brain stem angioleiomyoma mimicking meningioma: a case report
Brain stem angioleiomyoma mimicking meningioma: a case report Open
In summary, primary intracranial angioleiomyoma is rare. Thus, diagnosis and differential diagnosis are important before surgical resection, which was mimicking meningioma in our case. Pathological analysis could reveal spindle shaped cell…
View article: Increased transcriptional elongation and RNA stability of GPCR ligand binding genes unveiled via RNA polymerase II degradation
Increased transcriptional elongation and RNA stability of GPCR ligand binding genes unveiled via RNA polymerase II degradation Open
RNA polymerase II drives mRNA gene expression, yet our understanding of Pol II degradation is limited. Using auxin-inducible degron, we degraded Pol II’s RPB1 subunit, resulting in global repression. Surprisingly, certain genes exhibited i…
View article: Virtual formalin-fixed and paraffin-embedded staining of fresh brain tissue via stimulated Raman CycleGAN model
Virtual formalin-fixed and paraffin-embedded staining of fresh brain tissue via stimulated Raman CycleGAN model Open
Intraoperative histology is essential for surgical guidance and decision-making. However, frozen-sectioned hematoxylin and eosin (H&E) staining suffers from degraded accuracy, whereas the gold-standard formalin-fixed and paraffin-embedded …
View article: Fumarate Hydratase–Deficient Renal Cell Carcinoma With Predominant Tubulocystic Features Mimics Tubulocystic Renal Cell Carcinoma
Fumarate Hydratase–Deficient Renal Cell Carcinoma With Predominant Tubulocystic Features Mimics Tubulocystic Renal Cell Carcinoma Open
Context.— Fumarate hydratase (FH)–deficient renal cell carcinoma (RCC) rarely exhibits a predominant tubulocystic architecture with few other components. RCC with pure tubules and cysts lined by eosinophilic tumor cells with prominent nucl…
View article: Enhanced clinical outcomes with radiotherapy in diagnostically challenging intracranial plasmacytomas: Analysis of 190 cases
Enhanced clinical outcomes with radiotherapy in diagnostically challenging intracranial plasmacytomas: Analysis of 190 cases Open
Background Intracranial plasmacytomas are rare tumors arising from plasma cells with approximately half of the cases progressing to multiple myeloma (MM). However, there is a lack of comprehensive clinical cohort analysis on the clinical a…
View article: Co-Transcriptional Rna Processing Boosts Zygotic Gene Activation
Co-Transcriptional Rna Processing Boosts Zygotic Gene Activation Open
View article: Branch Chain Amino Acid Metabolism Promotes Brain Metastasis of NSCLC through EMT Occurrence by Regulating ALKBH5 activity
Branch Chain Amino Acid Metabolism Promotes Brain Metastasis of NSCLC through EMT Occurrence by Regulating ALKBH5 activity Open
Metabolic reprogramming is one of the essential features of tumors that may dramatically contribute to cancer metastasis. Employing liquid chromatography-tandem mass spectrometry-based metabolomics, we analyzed the metabolic profile from 1…
View article: Case Retrieval Strategy of Turning Process Based on Grey Relational Analysis
Case Retrieval Strategy of Turning Process Based on Grey Relational Analysis Open
To solve the problem of long response time when users obtain suitable cutting parameters through the Internet based platform, a case-based reasoning framework is proposed. Specifically, a Hamming distance and Euclidean distance combined me…
View article: Subcellular localization shapes the fate of RNA polymerase III
Subcellular localization shapes the fate of RNA polymerase III Open
RNA polymerase III (Pol III) plays a vital role in transcription and as a viral-DNA sensor, but how it is assembled and distributed within cells remains poorly understood. Here, we show that Pol III is assembled with chaperones in the cyto…
View article: A CT-based radiomics integrated model for discriminating pulmonary cryptococcosis granuloma from lung adenocarcinoma—a diagnostic test
A CT-based radiomics integrated model for discriminating pulmonary cryptococcosis granuloma from lung adenocarcinoma—a diagnostic test Open
An integrated model with radiomics and demoradiological features improves discrimination of cryptococcosis granulomas from solid adenocarcinomas on noncontrast CT. This model may be an effective strategy for machine complementation to disc…
View article: Protocol for quantitative analysis of RNA 3′-end processing induced by disassociated subunits using chromatin-associated RNA-seq data
Protocol for quantitative analysis of RNA 3′-end processing induced by disassociated subunits using chromatin-associated RNA-seq data Open
View article: Multiomic analysis of cohesin reveals that ZBTB transcription factors contribute to chromatin interactions
Multiomic analysis of cohesin reveals that ZBTB transcription factors contribute to chromatin interactions Open
One bottleneck in understanding the principles of 3D chromatin structures is caused by the paucity of known regulators. Cohesin is essential for 3D chromatin organization, and its interacting partners are candidate regulators. Here, we per…
View article: Nuclear Translocation of LDHA Promotes the Catabolism of BCAAs to Sustain GBM Cell Proliferation through the TxN Antioxidant Pathway
Nuclear Translocation of LDHA Promotes the Catabolism of BCAAs to Sustain GBM Cell Proliferation through the TxN Antioxidant Pathway Open
Glutamate is excitotoxic to neurons. The entry of glutamine or glutamate from the blood into the brain is limited. To overcome this, branched-chain amino acids (BCAAs) catabolism replenishes the glutamate in brain cells. Branched-chain ami…
View article: Meet the authors: The Ji lab
Meet the authors: The Ji lab Open
View article: Droplet formation assay for investigating phase-separation mechanisms of RNA Pol II transcription and CTCF functioning
Droplet formation assay for investigating phase-separation mechanisms of RNA Pol II transcription and CTCF functioning Open
Clustering of RNA polymerase II carboxy-terminal domain (CTD) and CTCF DNA-binding domains (DBDs) have been viewed as emerging mechanisms of transcription regulation and three-dimensional chromatin organization. In this protocol, we addres…
View article: Never a dull enzyme, RNA polymerase II
Never a dull enzyme, RNA polymerase II Open
RNA polymerase II (Pol II) is composed of 12 subunits that collaborate to synthesize mRNA within the nucleus. Pol II is widely recognized as a passive holoenzyme, with the molecular functions of its subunits largely ignored. Recent studies…
View article: Corrigendum: H3K27M mutation doesn’t mean worse prognosis in old patients
Corrigendum: H3K27M mutation doesn’t mean worse prognosis in old patients Open
[This corrects the article DOI: 10.3389/fonc.2022.912166.].
View article: Cross-regulome profiling of RNA polymerases highlights the regulatory role of polymerase III on mRNA transcription by maintaining local chromatin architecture
Cross-regulome profiling of RNA polymerases highlights the regulatory role of polymerase III on mRNA transcription by maintaining local chromatin architecture Open
View article: The transcriptional coactivator RUVBL2 regulates Pol II clustering with diverse transcription factors
The transcriptional coactivator RUVBL2 regulates Pol II clustering with diverse transcription factors Open
View article: Noninvasive Delineation of Glioma Infiltration with Combined 7T Chemical Exchange Saturation Transfer Imaging and MR Spectroscopy: A Diagnostic Accuracy Study
Noninvasive Delineation of Glioma Infiltration with Combined 7T Chemical Exchange Saturation Transfer Imaging and MR Spectroscopy: A Diagnostic Accuracy Study Open
For precise delineation of glioma extent, amino acid PET is superior to conventional MR imaging. Since metabolic MR sequences such as chemical exchange saturation transfer (CEST) imaging and MR spectroscopy (MRS) were developed, we aimed t…
View article: CTCF DNA-binding domain undergoes dynamic and selective protein–protein interactions
CTCF DNA-binding domain undergoes dynamic and selective protein–protein interactions Open
CTCF is a predominant insulator protein required for three-dimensional chromatin organization. However, the roles of its insulation of enhancers in a 3D nuclear organization have not been fully explained. Here, we found that the CTCF DNA-b…
View article: A Pituitary Carcinoma Patient With Cerebrospinal Fluid Dissemination Showing a Good Response to Temozolomide Combined With Whole-Brain and Spinal Cord Radiotherapy: A Case Report and Literature Review
A Pituitary Carcinoma Patient With Cerebrospinal Fluid Dissemination Showing a Good Response to Temozolomide Combined With Whole-Brain and Spinal Cord Radiotherapy: A Case Report and Literature Review Open
Pituitary carcinoma (PC) is extremely rare, with its incidence only accounting for 0.1%-0.2% of pituitary tumor (PT). Existing histological features, including invasiveness, cellular pleomorphism, nuclear atypia, mitosis, necrosis, etc., c…