Jure Krasić
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View article: A multi-analyte liquid biopsy approach for nonseminomatous testicular germ cell tumors: combining cfDNA and N-glycan analysis in blood and seminal plasma
A multi-analyte liquid biopsy approach for nonseminomatous testicular germ cell tumors: combining cfDNA and N-glycan analysis in blood and seminal plasma Open
Background Nonseminomatous testicular germ cell tumors (NSE) present significant diagnostic challenges, especially for the early detection of serum tumor marker (STM) negative cases. Current diagnostic tools are limited, highlighting the n…
View article: IMPACT OF TRAUMATIC PARENTAL EXPERIENCES WITH WARS ON OFFSPRING’S MENTAL HEALTH
IMPACT OF TRAUMATIC PARENTAL EXPERIENCES WITH WARS ON OFFSPRING’S MENTAL HEALTH Open
Intergenerational transmission of trauma (ITT) is a process in which the trauma experienced in one generation is transmitted to the second or third generation. Understanding intergenerational transmission of trauma and its complexity promo…
View article: Integrative analysis in head and neck cancer reveals distinct role of miRNome and methylome as tumour epigenetic drivers
Integrative analysis in head and neck cancer reveals distinct role of miRNome and methylome as tumour epigenetic drivers Open
View article: Integrative analysis in head and neck cancer reveals distinct role of miRNome and methylome as tumour epigenetic drivers
Integrative analysis in head and neck cancer reveals distinct role of miRNome and methylome as tumour epigenetic drivers Open
Background Head and neck cancer is the sixth most common malignancy worldwide, with the relatively low 5-year survival rate, mainly because it is diagnosed at a late stage. Infection with HPV is well known etiology, which affects nature of…
View article: Interleukin-2 gene methylation levels and interleukin-2 levels associated with environmental exposure as risk biomarkers for preterm birth
Interleukin-2 gene methylation levels and interleukin-2 levels associated with environmental exposure as risk biomarkers for preterm birth Open
IL-2 levels, hypomethylation of the IL-2 gene site 1, and the mother's rural residence (probably due to pesticide exposure) were predictive biomarkers for preterm birth. For the first time, we present the reference values for the methylati…
View article: Effect of Fetal Bovine Serum or Basic Fibroblast Growth Factor on Cell Survival and the Proliferation of Neural Stem Cells: The Influence of Homocysteine Treatment
Effect of Fetal Bovine Serum or Basic Fibroblast Growth Factor on Cell Survival and the Proliferation of Neural Stem Cells: The Influence of Homocysteine Treatment Open
In vitro cell culture is a routinely used method which is also applied for in vitro modeling of various neurological diseases. On the other hand, media used for cell culture are often not strictly standardized between laboratories, which h…
View article: Testicular Germ Cell Tumor Tissue Biomarker Analysis: A Comparison of Human Protein Atlas and Individual Testicular Germ Cell Tumor Component Immunohistochemistry
Testicular Germ Cell Tumor Tissue Biomarker Analysis: A Comparison of Human Protein Atlas and Individual Testicular Germ Cell Tumor Component Immunohistochemistry Open
The accurate management of testicular germ cell tumors (TGCTs) depends on identifying the individual histological tumor components. Currently available data on protein expression in TGCTs are limited. The human protein atlas (HPA) is a com…
View article: cfDNA Methylation in Liquid Biopsies as Potential Testicular Seminoma Biomarker
cfDNA Methylation in Liquid Biopsies as Potential Testicular Seminoma Biomarker Open
Background: Seminoma is a testicular tumor type, routinely diagnosed after orchidectomy. As cfDNA represents a source of minimally invasive seminoma patient management, this study aimed to investigate whether cfDNA methylation of si…
View article: Valproate Targets Mammalian Gastrulation Impairing Neural Tissue Differentiation and Development of the Placental Source In Vitro
Valproate Targets Mammalian Gastrulation Impairing Neural Tissue Differentiation and Development of the Placental Source In Vitro Open
The teratogenic activity of valproate (VPA), an antiepileptic and an inhibitor of histone deacetylase (HDACi), is dose-dependent in humans. Previous results showed that VPA impairs in vitro development and neural differentiation of the gas…
View article: Extended Prophylactic Effect of N-tert-Butyl-α-phenylnitron against Oxidative/Nitrosative Damage Caused by the DNA-Hypomethylating Drug 5-Azacytidine in the Rat Placenta
Extended Prophylactic Effect of N-tert-Butyl-α-phenylnitron against Oxidative/Nitrosative Damage Caused by the DNA-Hypomethylating Drug 5-Azacytidine in the Rat Placenta Open
Antioxidant N-tert-Butyl-α-phenylnitron (PBN) partly protected embryos from the negative effects of a DNA demethylating drug 5-azacytidine during pregnancy. Our aim was to investigate PBN’s impact on the placenta. Fischer rat dams were tre…
View article: The utility of cfDNA in TGCT patient management: a systematic review
The utility of cfDNA in TGCT patient management: a systematic review Open
Background: Testicular germ cell tumors (TGCTs) are the most common young male malignancy with a steadily rising incidence. Standard clinical practice is radical orchidectomy of suspicious lumps followed by histopathological diagnosis and …
View article: 83 Screening for the Activity of Histone Deacetylation Inhibitors in the Gastrulating Embryo-Derived Teratoma Biological System
83 Screening for the Activity of Histone Deacetylation Inhibitors in the Gastrulating Embryo-Derived Teratoma Biological System Open
In our in vitro natural 3D biological system, rodent embryos explanted at the time of formation of the three germ-layers (gastrulation), develop a teratoma-like structure. We present the results of screening for the activity of Histone De…
View article: Impact of Preanalytical and Analytical Methods on Cell-Free DNA Diagnostics
Impact of Preanalytical and Analytical Methods on Cell-Free DNA Diagnostics Open
Graphical Abstract Depiction of the experimental design.
View article: Teratoma Growth Retardation by HDACi Treatment of the Tumor Embryonal Source
Teratoma Growth Retardation by HDACi Treatment of the Tumor Embryonal Source Open
Among testicular germ cell tumors, teratomas may often be very aggressive and therapy-resistant. Our aim was to investigate the impact of histone deacetylase inhibitors (HDACi) on the in vitro growth of experimental mouse teratoma by treat…
View article: In Search of TGCT Biomarkers: A Comprehensive In Silico and Histopathological Analysis
In Search of TGCT Biomarkers: A Comprehensive In Silico and Histopathological Analysis Open
Testicular germ cell tumors (TGCTs) are ever more affecting the young male population. Germ cell neoplasia in situ (GCNIS) is the origin of TGCTs, namely, seminomas (SE) and a heterogeneous group of nonseminomas (NS) comprising embryonal c…
View article: The Impact of Mother’s Living Environment Exposure on Genome Damage, Immunological Status, and Sex Hormone Levels in Newborns
The Impact of Mother’s Living Environment Exposure on Genome Damage, Immunological Status, and Sex Hormone Levels in Newborns Open
Background: The aim of this study was to compare for the first time IL-6 (Interleukin 6), testosterone (T) and estradiol (E) levels, their ratio (E/T), micronucleus (MN), and nuclear bridge (NB) frequency between newborns with regard to th…
View article: Embryo‐derived teratoma <i>in vitro</i> biological system reveals antitumor and embryotoxic activity of valproate
Embryo‐derived teratoma <i>in vitro</i> biological system reveals antitumor and embryotoxic activity of valproate Open
Antiepileptic/teratogen valproate ( VPA ) is a histone deacetylase inhibitor/epigenetic drug proposed for the antitumor therapy where it is generally crucial to target poorly or undifferentiated cells to prevent a recurrence. Transplanted …
View article: A Free Radical Scavenger Ameliorates Teratogenic Activity of a DNA Hypomethylating Hematological Therapeutic
A Free Radical Scavenger Ameliorates Teratogenic Activity of a DNA Hypomethylating Hematological Therapeutic Open
The spin-trap free radical scavenger N-tert-butyl-α-phenylnitron (PBN) ameliorated effects of several teratogens involving reactive oxygen species (ROS). We investigated for the first time whether PBN could ameliorate teratogenesis …
View article: LIQUID BIOPSY FOR PATIENTS WITH CANCER: DIFFERENT APPROACHES AND CLINICAL APPLICATIONS
LIQUID BIOPSY FOR PATIENTS WITH CANCER: DIFFERENT APPROACHES AND CLINICAL APPLICATIONS Open
Treatment of cancer patients is now based on extensive analysis of cancer cells obtained by tissue biopsy. In addition to being invasive, tissue biopsy relies on analysis of single cancer sample in one time point, which may not be represen…
View article: PO-362 Influence of epigenetic agents on mouse teratoma development in vitro
PO-362 Influence of epigenetic agents on mouse teratoma development in vitro Open
Introduction Testicular Germ Cell Tumours (TGCT) are the most frequent malignancies in young male population and believed to be initiated by epimutations, i.e. aberrant epigenetics. Among various, teratoma is the most differentiated TGCT …