Jürg Kesselring
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View article: Development of a core outcome set for the trials of complementary therapies in people with multiple sclerosis: international survey and consensus meetings
Development of a core outcome set for the trials of complementary therapies in people with multiple sclerosis: international survey and consensus meetings Open
Objectives This study aimed to develop a core outcome set (COS) for trials evaluating the effects of complementary therapies in people with multiple sclerosis (pwMS). We sought to identify the outcomes most relevant to pwMS, their relative…
View article: Vestibular Testing Results in a World-Famous Tightrope Walker
Vestibular Testing Results in a World-Famous Tightrope Walker Open
Purpose: Accurate and precise navigation in space and postural stability rely on the central integration of multisensory input (vestibular, proprioceptive, visual), weighted according to its reliability, to continuously update the internal…
View article: Natural language processing analysis of the theories of people with multiple sclerosis about causes of their disease
Natural language processing analysis of the theories of people with multiple sclerosis about causes of their disease Open
Background While potential risk factors for multiple sclerosis (MS) have been extensively researched, it remains unclear how persons with MS theorize about their MS. Such theories may affect mental health and treatment adherence. Using nat…
View article: A Profound Journey through History
A Profound Journey through History Open
View article: A Profound Journey through History
A Profound Journey through History Open
View article: The Swiss Brain Health Plan 2023–2033
The Swiss Brain Health Plan 2023–2033 Open
The brain and its health are essential for our (physical mental, social, and spiritual) wellbeing, for being able to realize our potential as individuals, and also for a fair, well-functioning, and productive society. However, today the wo…
View article: Summary of Research: Collaboration Between Healthcare Professionals and People with Multiple Sclerosis to Develop Communication Tools to Improve the Standard of Multiple Sclerosis Care
Summary of Research: Collaboration Between Healthcare Professionals and People with Multiple Sclerosis to Develop Communication Tools to Improve the Standard of Multiple Sclerosis Care Open
This is a summary of a previously published paper: Joint Healthcare Professional and Patient Development of Communication Tools to Improve the Standard of MS Care. It describes a collaboration between people with multiple sclerosis (PwMS) …
View article: Summary of Research: Caregiver Involvement in MS: Duty or Disruption?
Summary of Research: Caregiver Involvement in MS: Duty or Disruption? Open
This Summary of Research summarizes a previously published discussion between people with multiple sclerosis (PwMS) and their caregivers and healthcare professionals (HCPs) about how to include caregivers in consultations and decisions abo…
View article: Feelings of loneliness, COVID-19-specific-health anxiety and depressive symptoms during the first COVID-19 wave in Swiss persons with multiple sclerosis
Feelings of loneliness, COVID-19-specific-health anxiety and depressive symptoms during the first COVID-19 wave in Swiss persons with multiple sclerosis Open
The aim of our study was to investigate whether self-reported feeling of loneliness (FoL) and COVID-19-specific health anxiety were associated with the presence of depressive symptoms during the first coronavirus disease 2019 (COVID-19) wa…
View article: The Real-World Experiences of Persons With Multiple Sclerosis During the First COVID-19 Lockdown: Application of Natural Language Processing
The Real-World Experiences of Persons With Multiple Sclerosis During the First COVID-19 Lockdown: Application of Natural Language Processing Open
Background The increasing availability of “real-world” data in the form of written text holds promise for deepening our understanding of societal and health-related challenges. Textual data constitute a rich source of information, allowing…
View article: Fingolimod versus interferon beta 1-a: Benefit–harm assessment approach based on TRANSFORMS individual patient data
Fingolimod versus interferon beta 1-a: Benefit–harm assessment approach based on TRANSFORMS individual patient data Open
Background Fingolimod is a disease-modifying drug approved for multiple sclerosis but its benefit–harm balance has never been assessed compared to other active treatments. Objectives Our aim was to compare the benefits and harms of fingoli…
View article: Real-world disease-modifying therapy usage in persons with relapsing-remitting multiple sclerosis: Cross-sectional data from the Swiss Multiple Sclerosis Registry
Real-world disease-modifying therapy usage in persons with relapsing-remitting multiple sclerosis: Cross-sectional data from the Swiss Multiple Sclerosis Registry Open
This cross-sectional analysis suggested that the majority of individuals with RRMS in Switzerland continuously receive tolerable DMT. However, groups not receiving DMT or struggling with side-effects or continued disease worsening while on…
View article: Promoting urinary continence in people suffering a stroke: Effectiveness of a complex intervention—An intervention study
Promoting urinary continence in people suffering a stroke: Effectiveness of a complex intervention—An intervention study Open
Aim The study aimed to implement and measure effectiveness of a systematic continence management intervention in people suffering a stroke in undertaking rehabilitation. Design An intervention study was conducted. Methods In the first part…
View article: Caregiver Involvement in MS: Duty or Disruption?
Caregiver Involvement in MS: Duty or Disruption? Open
Multiple sclerosis (MS) is a complex condition with numerous physical, cognitive and emotional symptoms. These may necessitate significant, permanent lifestyle changes for people with multiple sclerosis (PwMS) and their caregivers and fami…
View article: Alastair Compston: 'All manner of ingenuity and industry' A bio-bibliography of Thomas Willis 1621–1675
Alastair Compston: 'All manner of ingenuity and industry' A bio-bibliography of Thomas Willis 1621–1675 Open
View article: Onset Symptom Clusters in Multiple Sclerosis: Characteristics, Comorbidities, and Risk Factors
Onset Symptom Clusters in Multiple Sclerosis: Characteristics, Comorbidities, and Risk Factors Open
Background: Multiple sclerosis (MS) symptoms are expected to aggregate in specific patterns across different stages of the disease. Here, we studied the clustering of onset symptoms and examined their characteristics, comorbidity patterns …
View article: The Effect of Depression on Health-Related Quality of Life Is Mediated by Fatigue in Persons with Multiple Sclerosis
The Effect of Depression on Health-Related Quality of Life Is Mediated by Fatigue in Persons with Multiple Sclerosis Open
The interrelations between fatigue, depression and health-related quality of life (HRQoL) in persons with multiple sclerosis (PwMS) are complex, and the directionality of the effects is unclear. To address this gap, the current study used …
View article: Major depressive disorder subtypes and depression symptoms in multiple sclerosis: What is different compared to the general population?
Major depressive disorder subtypes and depression symptoms in multiple sclerosis: What is different compared to the general population? Open
MDD in PwMS was characterized by a higher risk for specific somatic atypical depression symptoms and the mixed atypical-melancholic MDD subtype. The pure atypical MDD subtype, however, did not differentiate between PwMS and Pw/oMS. Given t…
View article: Disease Progression in Multiple Sclerosis: A Literature Review Exploring Patient Perspectives
Disease Progression in Multiple Sclerosis: A Literature Review Exploring Patient Perspectives Open
Patient perspectives on disease progression in MS and other chronic progressive conditions are under-investigated and under-reported. The limited evidence available highlights the importance of providing adequate information and effective …
View article: Physiotherapy use and access-barriers in persons with multiple sclerosis: A cross-sectional analysis
Physiotherapy use and access-barriers in persons with multiple sclerosis: A cross-sectional analysis Open
View article: Among Persons With Multiple Sclerosis (MS), Objective Sleep, Psychological Functioning, and Higher Physical Activity Scores Remained Stable Over 2 Years—Results From a Small Study Under Naturalistic Conditions
Among Persons With Multiple Sclerosis (MS), Objective Sleep, Psychological Functioning, and Higher Physical Activity Scores Remained Stable Over 2 Years—Results From a Small Study Under Naturalistic Conditions Open
Background: Persons with multiple sclerosis (PwMS) are at increased risk to report poor sleep patterns and lower physical activity indices. To date, data on longitudinal objectively sleep assessment is missing. In the present study, we inv…
View article: Benefit-harm balance of fingolimod in patients with MS: A modelling study based on FREEDOMS
Benefit-harm balance of fingolimod in patients with MS: A modelling study based on FREEDOMS Open
View article: Tolerability and safety of urotainer® polihexanide 0.02% in catheterized patients: a prospective cohort study
Tolerability and safety of urotainer® polihexanide 0.02% in catheterized patients: a prospective cohort study Open
View article: Book Review: Neurology and Religion
Book Review: Neurology and Religion Open
This very readable and erudite book on neurology and religion, edited and co-authored by well-known and very knowledgeable experts in theology and philosophy as well as in neuroscience and medicine. They take on the difficult task to try t…
View article: Factors associated with employment and expected work retention among persons with multiple sclerosis: findings of a cross-sectional citizen science study
Factors associated with employment and expected work retention among persons with multiple sclerosis: findings of a cross-sectional citizen science study Open
View article: Tolerability and Safety of Urotainer® Polihexanide 0.02% in Long-Term Catheterized Patients: A Prospective Cohort Study
Tolerability and Safety of Urotainer® Polihexanide 0.02% in Long-Term Catheterized Patients: A Prospective Cohort Study Open
Background: In patients with long-term indwelling bladder catheters, bacterial colonization is inevitable, leading to urinary tract infections or encrustations with subsequent catheter blockage. Currently, bladder irrigations are the most …
View article: Tolerability And Safety Of Urotainer® Polihexanide 0.02% In Long-Term Catheterized Patients: A Prospective Cohort Study
Tolerability And Safety Of Urotainer® Polihexanide 0.02% In Long-Term Catheterized Patients: A Prospective Cohort Study Open
Background: In patients with long-term indwelling bladder catheters, bacterial colonization is inevitable, leading to urinary tract infections or encrustations with subsequent catheter blockage. Currently, bladder irrigations are the most …
View article: Upper and lower limb performance fatigability in people with multiple sclerosis investigated through surface electromyography: a pilot study
Upper and lower limb performance fatigability in people with multiple sclerosis investigated through surface electromyography: a pilot study Open
Objective : Fatigue experienced by people with multiple sclerosis (pwMS) is multidimensional, consisting of different components, such as perceived, physical and cognitive fatigue and performance fatigability. At present, there is no gold …
View article: Early globalization of neurology—The First International Congress of Neurology 1931 in Bern, Switzerland
Early globalization of neurology—The First International Congress of Neurology 1931 in Bern, Switzerland Open
The First International Neurological Congress took place in 1931 in Berne, Switzerland, convening among >800 participants were many of the best-known neurologists and neuroscientist of that time. It had a great impact on the acknowledgemen…
View article: Joint Healthcare Professional and Patient Development of Communication Tools to Improve the Standard of MS Care
Joint Healthcare Professional and Patient Development of Communication Tools to Improve the Standard of MS Care Open