Jürgen A. Bohnert
YOU?
Author Swipe
View article: Multi-omics investigation reveals unique markers in Klebsiella pneumoniae compared to closely related species
Multi-omics investigation reveals unique markers in Klebsiella pneumoniae compared to closely related species Open
Introduction The Klebsiella pneumoniae (KP) species complex (KpSC) comprises KP as the predominant species, and six other taxa including two subspecies each of Klebsiella var iicola (KV) and Klebsiella quasipneumoniae (KQ), all capable of …
View article: Potential in-host evolution of <i>Klebsiella pneumoniae</i> ST147: convergence and the role of capsular alterations in morphotype diversity
Potential in-host evolution of <i>Klebsiella pneumoniae</i> ST147: convergence and the role of capsular alterations in morphotype diversity Open
Klebsiella pneumoniae , an important opportunistic pathogen, is traditionally classified into classic and hypervirulent pathotypes. Convergent strains combining antimicrobial resistance (AMR) and hypervirulence have emerged globally, posin…
View article: Multidrug-resistant high-risk clonal Escherichia coli lineages occur along an antibiotic residue gradient in the Baltic Sea
Multidrug-resistant high-risk clonal Escherichia coli lineages occur along an antibiotic residue gradient in the Baltic Sea Open
The global spread of multidrug-resistant Escherichia coli threatens human, animal, and environmental health. Despite the recognition of water bodies as potential reservoirs, research on antimicrobial resistance (AMR) and antibiotic residue…
View article: Multi-omics investigation reveals unique markers underpinning the success of Klebsiella pneumoniae over closely related species
Multi-omics investigation reveals unique markers underpinning the success of Klebsiella pneumoniae over closely related species Open
Background The Klebsiella pneumoniae (KP) species complex comprises KP as the predominant species, and four others including Klebsiella variicola (KV) and Klebsiella quasipneumoniae (KQ), all capable of causing clinical infections and ofte…
View article: Temperatures above 37°C increase virulence of a convergent Klebsiella pneumoniae sequence type 307 strain
Temperatures above 37°C increase virulence of a convergent Klebsiella pneumoniae sequence type 307 strain Open
Background Convergence of Klebsiella pneumoniae (KP) pathotypes has been increasingly reported in recent years. These pathogens combine features of both multidrug-resistant and hypervirulent KP. However, clinically used indicators for hype…
View article: Multidrug-resistant high-risk clonal Escherichia coli lineages occur along an antibiotic residue gradient in the Baltic Sea
Multidrug-resistant high-risk clonal Escherichia coli lineages occur along an antibiotic residue gradient in the Baltic Sea Open
The global spread of multidrug-resistant Escherichia coli threatens human, animal, and environmental health. Despite the recognition of water bodies as potential reservoirs, research on AMR in the Baltic Sea is limited. In this study, we e…
View article: Klebsiella pneumoniae exhibiting a phenotypic hyper-splitting phenomenon including the formation of small colony variants
Klebsiella pneumoniae exhibiting a phenotypic hyper-splitting phenomenon including the formation of small colony variants Open
In this study, we characterized a Klebsiella pneumoniae strain in a patient with shrapnel hip injury, which resulted in multiple phenotypic changes, including the formation of a small colony variant (SCV) phenotype. Although already descri…
View article: Case Report: Hip arthroplasty after fracture-related joint infection caused by extensively drug-resistant Klebsiella pneumoniae
Case Report: Hip arthroplasty after fracture-related joint infection caused by extensively drug-resistant Klebsiella pneumoniae Open
This case-report focuses on a 23-year-old soldier suffering from a fracture-related hip joint infection (FRI) due to extensively drug-resistant Klebsiella pneumoniae and S. epidermidis . The patient underwent multiple septic revision surge…
View article: In-host evolution of classic to convergent<i>Klebsiella pneumoniae</i>sequence type 147 isolates and impact of associated capsular changes on different morphotypes
In-host evolution of classic to convergent<i>Klebsiella pneumoniae</i>sequence type 147 isolates and impact of associated capsular changes on different morphotypes Open
Klebsiella pneumoniae , an important opportunistic pathogen, has long been categorized into two distinct pathotypes: the often multidrug-resistant classic (cKp) and the highly virulent hypervirulent (hvKp). However, a recent global trend h…
View article: Temperatures above 37°C increase virulence of a convergent<i>Klebsiella pneumoniae</i>sequence type 307 strain
Temperatures above 37°C increase virulence of a convergent<i>Klebsiella pneumoniae</i>sequence type 307 strain Open
Hypermucoviscosity in Klebsiella pneumoniae is often related to the overexpression of capsular polysaccharides, regulated by complex biosynthetic mechanisms in response to external cues. However, little is known about the processes involve…
View article: <i>Klebsiella pneumoniae</i>exhibiting a phenotypic hyper-splitting phenomenon including the formation of small colony variants
<i>Klebsiella pneumoniae</i>exhibiting a phenotypic hyper-splitting phenomenon including the formation of small colony variants Open
In this study, we characterized a Klebsiella pneumoniae strain in a patient with shrapnel hip injury, which resulted in multiple phenotypic changes, including the formation of a small colony variant (SCV) phenotype. Although already descri…
View article: Multi-omics investigations uncover unique pathogenic markers in clinical<i>Klebsiella pneumoniae</i>that could be leveraged as novel antimicrobial targets
Multi-omics investigations uncover unique pathogenic markers in clinical<i>Klebsiella pneumoniae</i>that could be leveraged as novel antimicrobial targets Open
Background Klebsiella pneumoniae (KP), often multidrug-resistant (MDR), is a significant public health concern and frequently associated with various diseases including urinary-tract infection. In addition, in recent years, an increasing n…
View article: Convergent <i>Klebsiella pneumoniae</i> strains belonging to a sequence type 307 outbreak clone combine cefiderocol and carbapenem resistance with hypervirulence
Convergent <i>Klebsiella pneumoniae</i> strains belonging to a sequence type 307 outbreak clone combine cefiderocol and carbapenem resistance with hypervirulence Open
View article: Rezension von: Bohnert, Jürgen u.a. (Hrsg.), Die längste Höhle der Schwäbischen Alb
Rezension von: Bohnert, Jürgen u.a. (Hrsg.), Die längste Höhle der Schwäbischen Alb Open
Jürgen Bohnert (u. a.): Die längste Höhle der Schwäbischen Alb. Auf Entdeckungsfahrt in die Wulfbachquellhöhle. DRW-Verlag Leinfelden-Echterdingen 1998. 96 Seiten mit 67 Abbildungen, davon 57 in Farbe, 8 Pläne. Broschiert DM 49,- ISBN 3-87…
View article: Genomic analysis of the international high-risk clonal lineage Klebsiella pneumoniae sequence type 395
Genomic analysis of the international high-risk clonal lineage Klebsiella pneumoniae sequence type 395 Open
View article: Additional file 1 of Genomic analysis of the international high-risk clonal lineage Klebsiella pneumoniae sequence type 395
Additional file 1 of Genomic analysis of the international high-risk clonal lineage Klebsiella pneumoniae sequence type 395 Open
Additional file 1: Table S1. Characteristics of the isolates from the ST395 dataset. Table S2. Comparison of cgMLST profiles of isolates representing ST395 subclades. Table S3. Location of carbapenemase genes.
View article: Splenic rupture and fungal endocarditis in a pediatric patient with invasive fusariosis after allogeneic hematopoietic stem cell transplantation for aplastic anemia: A case report
Splenic rupture and fungal endocarditis in a pediatric patient with invasive fusariosis after allogeneic hematopoietic stem cell transplantation for aplastic anemia: A case report Open
Background Invasive mold infections are a well-known and life-threatening condition after allogeneic hematopoietic stem cell transplantation (HSCT). While Aspergillus species are recognized as predominant pathogens, Fusarium species should…
View article: Geno- and Phenotypic Characteristics of a Klebsiella pneumoniae ST20 Isolate with Unusual Colony Morphology
Geno- and Phenotypic Characteristics of a Klebsiella pneumoniae ST20 Isolate with Unusual Colony Morphology Open
Klebsiella pneumoniae is a common member of the intestinal flora of vertebrates. In addition to opportunistic representatives, hypervirulent (hvKp) and antibiotic-resistant K. pneumoniae (ABR-Kp) occur. While ABR-Kp isolates often cause di…
View article: Extensively Drug-Resistant Klebsiella pneumoniae Counteracts Fitness and Virulence Costs That Accompanied Ceftazidime-Avibactam Resistance Acquisition
Extensively Drug-Resistant Klebsiella pneumoniae Counteracts Fitness and Virulence Costs That Accompanied Ceftazidime-Avibactam Resistance Acquisition Open
Extensively drug-resistant Klebsiella pneumoniae causing major outbreaks and severe infections has become a significant challenge for health care systems worldwide. Rapid resistance development against last-resort therapeutics like ceftazi…
View article: The epidemiological relevance of the COVID-19-vaccinated population is decreasing after booster vaccination, as shown by incidence rate ratios
The epidemiological relevance of the COVID-19-vaccinated population is decreasing after booster vaccination, as shown by incidence rate ratios Open
View article: Heatwave-associated Vibrio infections in Germany, 2018 and 2019
Heatwave-associated Vibrio infections in Germany, 2018 and 2019 Open
Background Vibrio spp. are aquatic bacteria that prefer warm seawater with moderate salinity. In humans, they can cause gastroenteritis, wound infections, and ear infections. During the summers of 2018 and 2019, unprecedented high sea surf…
View article: Chemical composition, antibacterial activity and effect of Rhus albida Schousb essential oil on the inhibition of NorA efflux pump in Staphylococcus aureus
Chemical composition, antibacterial activity and effect of Rhus albida Schousb essential oil on the inhibition of NorA efflux pump in Staphylococcus aureus Open
Human infectious diseases once treatable with antibiotics are now becoming a serious life-threatening problem due to the emergence of multidrug resistant (MDR) micro-organisms. For this, essential oils (EOs) could constitute a viable sourc…
View article: Antibiotic-Resistant Enterobacteriaceae in Wastewater of Abattoirs
Antibiotic-Resistant Enterobacteriaceae in Wastewater of Abattoirs Open
Antibiotic-resistant Enterobacteriaceae are regularly detected in livestock. As pathogens, they cause difficult-to-treat infections and, as commensals, they may serve as a source of resistance genes for other bacteria. Slaughterhouses prod…
View article: A Klebsiella pneumoniae ST307 outbreak clone from Germany demonstrates features of extensive drug resistance, hypermucoviscosity, and enhanced iron acquisition
A Klebsiella pneumoniae ST307 outbreak clone from Germany demonstrates features of extensive drug resistance, hypermucoviscosity, and enhanced iron acquisition Open
View article: Automated and rapid identification of multidrug resistant Escherichia coli against the lead drugs of acylureidopenicillins, cephalosporins, and fluoroquinolones using specific Raman marker bands
Automated and rapid identification of multidrug resistant Escherichia coli against the lead drugs of acylureidopenicillins, cephalosporins, and fluoroquinolones using specific Raman marker bands Open
A Raman‐based, strain‐independent, semi‐automated method is presented that allows the rapid (<3 hours) determination of antibiotic susceptibility of bacterial pathogens isolated from clinical samples. Applying a priori knowledge about the …
View article: Genome Sequence of Escherichia coli KI683, Isolated from a Urosepsis Patient
Genome Sequence of Escherichia coli KI683, Isolated from a Urosepsis Patient Open
Escherichia coli KI683 was isolated from blood of a patient who developed septicemia as a complication of a urinary tract infection. Genome sequencing resulted in three contigs with a total genome size of 5,243,173 bp encoding 5,143 genes.
View article: Flies from a tertiary hospital in Rwanda carry multidrug-resistant Gram-negative pathogens including extended-spectrum beta-lactamase-producing E. coli sequence type 131
Flies from a tertiary hospital in Rwanda carry multidrug-resistant Gram-negative pathogens including extended-spectrum beta-lactamase-producing E. coli sequence type 131 Open
Multidrug-resistant gram-negative (MRGN) bacteria are a serious threat to global health. We used genomics to study MRGN obtained from houseflies in a tertiary Rwandan hospital. Our analysis revealed a high abundance of different MRGN inclu…
View article: Additional file 1 of Flies from a tertiary hospital in Rwanda carry multidrug-resistant Gram-negative pathogens including extended-spectrum beta-lactamase-producing E. coli sequence type 131
Additional file 1 of Flies from a tertiary hospital in Rwanda carry multidrug-resistant Gram-negative pathogens including extended-spectrum beta-lactamase-producing E. coli sequence type 131 Open
Additional file 1: Table S1. Results based on whole genome sequence analysis. Abbreviations: BLA: beta-lactams (incl. ampicillin, piperacillin, cefuroxime, cefpodoxime, cefotaxime, ceftazidime); GEN: gentamicin; CIP: ciprofloxacin/moxiflox…
View article: Additional file 2 of A Klebsiella pneumoniae ST307 outbreak clone from Germany demonstrates features of extensive drug resistance, hypermucoviscosity, and enhanced iron acquisition
Additional file 2 of A Klebsiella pneumoniae ST307 outbreak clone from Germany demonstrates features of extensive drug resistance, hypermucoviscosity, and enhanced iron acquisition Open
Additional file 2: Table S1. Overview of strains investigated in this study. Table S2. Overview of publicly available Klebsiella pneumoniae ST307 genomes obtained from online sources. Table S3. Overview of accumulated variants in transferr…
View article: Extensively drug-resistant Klebsiella pneumoniae ST307 outbreak, north-eastern Germany, June to October 2019
Extensively drug-resistant Klebsiella pneumoniae ST307 outbreak, north-eastern Germany, June to October 2019 Open
From June to October 2019, 17 patients (six infected, 11 colonised) with an extensively drug-resistant (XDR) Klebsiella pneumoniae strain were notified from four Western Pomerania medical facilities. The XDR K. pneumoniae produced carbapen…