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View article: Two-stage cluster sampling to assess SARS-CoV-2 seroprevalence without pre-enumeration: An example from Madagascar
Two-stage cluster sampling to assess SARS-CoV-2 seroprevalence without pre-enumeration: An example from Madagascar Open
Implementing population-based surveys in resource-constrained settings presents logistical challenges when detailed population enumeration is unavailable. We developed a field mapping system integrated into a cluster sampling approach to e…
View article: Evaluation of Midwife‐Led Colposcopy for Female Genital Schistosomiasis Screening at Primary Level of Care in Rural Madagascar: A Cross‐Sectional Study
Evaluation of Midwife‐Led Colposcopy for Female Genital Schistosomiasis Screening at Primary Level of Care in Rural Madagascar: A Cross‐Sectional Study Open
Introduction Female genital schistosomiasis is a condition with a complex diagnosis and severe consequences such as infertility. In the absence of a reliable biomarker, in endemic settings the World Health Organization recommends colposcop…
View article: Assessing rapid response mobile laboratory (RRML) capacities in Europe and Africa to improve One Health disease surveillance activities and pandemic preparedness across two continents
Assessing rapid response mobile laboratory (RRML) capacities in Europe and Africa to improve One Health disease surveillance activities and pandemic preparedness across two continents Open
Background Europe and Africa are increasingly affected by (re-)emerging risk group 3 and 4, zoonotic viral disease epidemics, which not only require diagnostic BSL-3/4 laboratory capacity but also a One Health-based control strategy for ef…
View article: Efficacy of artesunate-amodiaquine for the treatment of uncomplicated Plasmodium falciparum malaria among children aged 2–11 years in the Asante Akim North Municipality, Ghana: a single-arm open trial
Efficacy of artesunate-amodiaquine for the treatment of uncomplicated Plasmodium falciparum malaria among children aged 2–11 years in the Asante Akim North Municipality, Ghana: a single-arm open trial Open
The study confirmed that artesunate (AS) combined with amodiaquine (AQ) remains an effective treatment for uncomplicated Plasmodium falciparum malaria in children aged 2-11 years in Ghana. Additionally, a high prevalence of a haplotype ass…
View article: Home Treatment of Childhood Illnesses Prior to Seeking Formal Care: A Cross‐Sectional Study at Different Health Care Levels in Ghana
Home Treatment of Childhood Illnesses Prior to Seeking Formal Care: A Cross‐Sectional Study at Different Health Care Levels in Ghana Open
Background Many caregivers in Sub‐Saharan Africa attempt to manage childhood illnesses at home, which can delay or complicate later diagnosis and treatment at a health facility. Understanding home treatment practices among children could h…
View article: A capacity strengthening model toward self-reliant and sustainable one-health workforce in six East African Community Partner States
A capacity strengthening model toward self-reliant and sustainable one-health workforce in six East African Community Partner States Open
The burden of infectious diseases and antimicrobial resistance (AMR) in Africa highlights the critical need for strengthened genomic surveillance capacities that are embedded within the national public health framework. In the East African…
View article: Genomic insights into the diversity, antimicrobial resistance and zoonotic potential of Campylobacter fetus across diverse hosts and geographies
Genomic insights into the diversity, antimicrobial resistance and zoonotic potential of Campylobacter fetus across diverse hosts and geographies Open
Introduction. Campylobacter fetus causes reproductive diseases in livestock and can lead to zoonotic infections such as bacteraemia, particularly in immunocompromised individuals. Despite its significance, its genomic characteristics remai…
View article: Genetic association of ACE2 rs2285666 (C>T) and rs2106809 (A>G) and susceptibility to SARS-CoV-2 infection among the Ghanaian population
Genetic association of ACE2 rs2285666 (C>T) and rs2106809 (A>G) and susceptibility to SARS-CoV-2 infection among the Ghanaian population Open
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), enters human cells using the angiotensin-converting enzyme 2 (ACE-2) receptor. ACE2 single nucleotide polymorphisms (SNPs) can influence susceptibility by affecting v…
View article: Non-typhoidal Salmonella transmission reservoirs in sub-Saharan Africa: a genomic assessment from a One Health perspective
Non-typhoidal Salmonella transmission reservoirs in sub-Saharan Africa: a genomic assessment from a One Health perspective Open
Background In sub-Saharan Africa, invasive non-typhoidal Salmonella disease, characterized by bloodstream infections with high mortality rates, poses a significant public health burden. In Africa, Salmonella enterica , which are typically …
View article: Integrated rapid risk assessment for dengue fever in settings with limited diagnostic capacity and uncertain exposure: Development of a methodological framework for Tanzania
Integrated rapid risk assessment for dengue fever in settings with limited diagnostic capacity and uncertain exposure: Development of a methodological framework for Tanzania Open
Background Dengue fever is one of the world’s most important re-emerging but neglected infectious diseases. We aimed to develop and evaluate an integrated risk assessment framework to enhance early detection and risk assessment of potentia…
View article: Detecting Schistosoma infections in endemic countries: a diagnostic accuracy study in rural Madagascar
Detecting Schistosoma infections in endemic countries: a diagnostic accuracy study in rural Madagascar Open
Background Schistosoma haematobium and S. mansoni are endemic in Madagascar, but reliable diagnostic tools are often lacking, contributing to exacerbate transmission and morbidity. This study evaluated the diagnostic accuracy of three test…
View article: Seroprevalence of dengue in the Democratic Republic of Congo, Ghana and Senegal: results of the SERODEN study
Seroprevalence of dengue in the Democratic Republic of Congo, Ghana and Senegal: results of the SERODEN study Open
Introduction: There are limited data on dengue transmission across most of African countries, including Senegal, Ghana, and the Democratic Republic of the Congo (DRC). We aimed to assess the age-stratified dengue seroprevalence and estimat…
View article: Genomic Insights into the Diversity, Antimicrobial Resistance, and Zoonotic Potential of <i>Campylobacter fetus</i> Across Diverse Hosts and Geographies
Genomic Insights into the Diversity, Antimicrobial Resistance, and Zoonotic Potential of <i>Campylobacter fetus</i> Across Diverse Hosts and Geographies Open
Background Campylobacter fetus causes reproductive diseases in livestock and zoonotic infections in humans, especially in immunocompromised individuals. Despite its significance, its genomic characteristics are poorly understood. This stud…
View article: Knowledge of local snakes, first‐aid and prevention of snakebites among community health workers and community members in rural Malawi: A cross‐sectional study
Knowledge of local snakes, first‐aid and prevention of snakebites among community health workers and community members in rural Malawi: A cross‐sectional study Open
Objective Snakebite envenoming remains a public health threat in many tropical countries. While community knowledge of local snakes and snakebite first‐aid and prevention are needed to reduce snakebite incidence and improve the outcomes fo…
View article: Socioeconomic disparities in Plasmodium falciparum infection risk in Southern Malawi: mediation analyses
Socioeconomic disparities in Plasmodium falciparum infection risk in Southern Malawi: mediation analyses Open
This study investigated the mediators of the association between socioeconomic position (SEP) and Plasmodium falciparum (Pf) infection in Southern region of Malawi. We utilized data from the 2014 International Center of Excellence for Mala…
View article: Methodological framework for early detection of dengue outbreaks in Tanzania
Methodological framework for early detection of dengue outbreaks in Tanzania Open
Background Dengue fever is a major public health problem because it is a widespread and rapidly transmitted mosquito-borne viral disease. We developed a framework for early detection of dengue outbreaks in Tanzania, starting with detection…
View article: Awareness and knowledge about Female Genital Schistosomiasis among European healthcare workers
Awareness and knowledge about Female Genital Schistosomiasis among European healthcare workers Open
Background Female Genital Schistosomiasis (FGS) is a gynaecological manifestation of persistent infection with Schistosoma haematobium, which can lead to severe consequences, such as miscarriage and infertility. It is estimated to affect 5…
View article: Wastewater-based surveillance for Hepatitis A virus, Enterovirus, Poliovirus, and SARS-CoV-2 in São Tomé and Príncipe: A pilot study
Wastewater-based surveillance for Hepatitis A virus, Enterovirus, Poliovirus, and SARS-CoV-2 in São Tomé and Príncipe: A pilot study Open
Our findings provide evidence of high transmission of HAV and EV in communities in São Tomé and continuous circulation of SARS-CoV-2, even in weeks without COVID-19 case notifications. This study demonstrates that monitoring of viral patho…
View article: Drivers of COVID-19 vaccine uptake among rural populations in Madagascar: a cross-sectional study
Drivers of COVID-19 vaccine uptake among rural populations in Madagascar: a cross-sectional study Open
Background The WHO set the global immunisation threshold for COVID-19 at 70% to achieve worldwide protection against the disease. To date, global COVID-19 vaccine coverage is still below this threshold, in particular in several sub-Saharan…
View article: Rapid regional mobile laboratory response and genomic monkeypox virus (MPXV) surveillance in seven East African Community partner states, August 2024: preparedness activities for the ongoing outbreak
Rapid regional mobile laboratory response and genomic monkeypox virus (MPXV) surveillance in seven East African Community partner states, August 2024: preparedness activities for the ongoing outbreak Open
The East African Community (EAC) is experiencing an unprecedented, emerging mpox outbreak since July 2024 in five of eight partner states. We highlight rapid regional response measures, initiated August 2024 coordinated by EAC: field deplo…
View article: Prevalence of Strongyloides stercoralis and other helminths in four districts of Madagascar
Prevalence of Strongyloides stercoralis and other helminths in four districts of Madagascar Open
Background Estimation of prevalence of Strongyloides stercoralis infection is required in endemic areas, in order to identify areas in need of control programmes. Data on prevalence of strongyloidiasis in Madagascar are scant. Aim of this …
View article: Understanding pre‐hospital disease management of fever and diarrhoea in children—Care pathways in rural Tanzania
Understanding pre‐hospital disease management of fever and diarrhoea in children—Care pathways in rural Tanzania Open
Objective Many children in sub‐Saharan Africa die from infectious diseases like malaria, pneumonia, and diarrhoea that can be prevented by early diagnosis, effective and targeted treatment. This study aimed to gain insights into case manag…
View article: Epidemiology and multiple colonization of gastrointestinal pathogens in rural Tanzanian children with and without diarrhea: A case-control study
Epidemiology and multiple colonization of gastrointestinal pathogens in rural Tanzanian children with and without diarrhea: A case-control study Open
Diarrheal diseases are important causes of morbidity and mortality, worldwide. The occurrence of multiple pathogens in stool samples of symptomatic and asymptomatic individuals in resource-limited countries have been repeatedly described. …
View article: Impact of different mutations on Kelch13 protein levels, ART resistance, and fitness cost in <i>Plasmodium falciparum</i> parasites
Impact of different mutations on Kelch13 protein levels, ART resistance, and fitness cost in <i>Plasmodium falciparum</i> parasites Open
Reduced susceptibility to ART, the first-line treatment against malaria, is common in South East Asia (SEA). It is associated with point mutations, mostly in kelch13 ( k13 ) but also in other genes, like ubp1 . K13 and its compartment neig…