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View article: Graft-versus-HIV-reservoir reactivity: Long term HIV remission after allogeneic stem cell transplantation from a donor with active CCR5
Graft-versus-HIV-reservoir reactivity: Long term HIV remission after allogeneic stem cell transplantation from a donor with active CCR5 Open
Background HIV cure is exceptionally rare and is documented in only six cases. All HIV cure cases were individuals receiving allogeneic stem cell transplantations (alloSCT) from donors with rare homozygous CCR5 Δ32 receptor mutation, that …
View article: HLA haplotype frequency analysis reveals large patient benefits from stem cell donor recruitment in Black South African population
HLA haplotype frequency analysis reveals large patient benefits from stem cell donor recruitment in Black South African population Open
View article: Young unrelated donors confer a survival advantage for patients with myeloid malignancies compared to older siblings
Young unrelated donors confer a survival advantage for patients with myeloid malignancies compared to older siblings Open
Donor age is one factor to optimize allogeneic hematopoietic cell transplantation (alloHCT). Therefore, we investigated whether young unrelated donors (UD) provide a benefit for older patients with myeloid malignancies compared to HLA-iden…
View article: Protective effects for HLA-B*40:01 and C*03:04 in NPM1-mutated AML: result of a large HLA association study
Protective effects for HLA-B*40:01 and C*03:04 in NPM1-mutated AML: result of a large HLA association study Open
Introduction Mutations in the nucleophosmin 1 gene (NPM1) are common and recurrent molecular abnormalities in acute myeloid leukemia (AML). NPM1 mutations are considered to be positive prognostic factors. The beneficial effect may be due t…
View article: Extensive Analysis of Genetic Diversity in <scp>HLA</scp> ‐ <scp>DMA</scp> , <scp>HLA</scp> ‐ <scp>DMB</scp> , <scp>HLA</scp> ‐ <scp>DOA</scp> and <scp>HLA</scp> ‐ <scp>DOB</scp> : Characterisation of 236 Novel Alleles
Extensive Analysis of Genetic Diversity in <span>HLA</span> ‐ <span>DMA</span> , <span>HLA</span> ‐ <span>DMB</span> , <span>HLA</span> ‐ <span>DOA</span> and <span>HLA</span> ‐ <span>DOB</span> : Characterisation of 236 Novel Alleles Open
HLA‐DMA , ‐DMB , ‐DOA and ‐DOB are non‐classical HLA Class II genes that play a crucial role in the selection of highly stable HLA Class II/peptide complexes on antigen‐presenting cells. Although the genes were initially thought to have a …
View article: The Registry of Unmet Need: A World Marrow Donor Association Analysis of Patients Without an <scp>HLA</scp> Match
The Registry of Unmet Need: A World Marrow Donor Association Analysis of Patients Without an <span>HLA</span> Match Open
While the World Marrow Donor Association global database currently offers approximately 42.7 million potential donors and cord blood units to patients in need of haematopoietic cell transplant, lack of eight HLA‐matched donors remains a si…
View article: HLA-F expression on CD4 T cells in HIV-1 is linked to the presence of viremia and modulated by KIR3DS1
HLA-F expression on CD4 T cells in HIV-1 is linked to the presence of viremia and modulated by KIR3DS1 Open
KIR3DS1 is an activating natural killer (NK) cell receptor gene– present in 10-40% of humans– and is associated with extended AIDS-free survival. Although its ligand HLA-F has been identified, the underlying protective mechanism in HIV-1 i…
View article: Human leukocyte antigen variation is associated with cytomegalovirus serostatus in healthy individuals
Human leukocyte antigen variation is associated with cytomegalovirus serostatus in healthy individuals Open
Cytomegalovirus (CMV) is a common β-herpes virus worldwide with an estimated seroprevalence among the general population of 83%. Primary infection is usually benign; however, CMV can cause severe morbidity in newborns in whom it is acquire…
View article: HLA allele and haplotype frequencies of eight Indian populations based on 130,518 registered stem cell donors
HLA allele and haplotype frequencies of eight Indian populations based on 130,518 registered stem cell donors Open
Introduction In hematopoietic stem cell transplantation, optimal results are achieved when donors and patients are matched regarding their human leukocyte antigen (HLA) genes. Population-specific HLA allele and haplotype frequency distribu…
View article: Primary infertile couples share more HLA alleles than expected by chance
Primary infertile couples share more HLA alleles than expected by chance Open
These data suggest that HLA similarity between couples relates to primary infertility.
View article: High-dimensional, outcome-dependent missing data problems: Models for the human KIR loci
High-dimensional, outcome-dependent missing data problems: Models for the human KIR loci Open
Missing data problems are common in biological, high-dimensional data, where data can be partially or completely missing. Algorithms have been developed to reconstruct the missing values by means of imputation or expectation-maximization a…
View article: Author Correction: Simulation shows that HLA-matched stem cell donors can remain unidentified in donor searches
Author Correction: Simulation shows that HLA-matched stem cell donors can remain unidentified in donor searches Open
View article: Optimisation of global stem cell donor recruitment based on analysis of unsuccessful donor searches
Optimisation of global stem cell donor recruitment based on analysis of unsuccessful donor searches Open
Despite over 41 million registered potential volunteer stem cell donors worldwide, many patients in need of a transplant do not find an HLA‐matched unrelated donor or cord blood units, with the respective odds differing significantly betwe…
View article: The 18th International <scp>HLA</scp> & Immunogenetics workshop project report: Creating fully representative <scp>MHC</scp> reference haplotypes
The 18th International <span>HLA</span> & Immunogenetics workshop project report: Creating fully representative <span>MHC</span> reference haplotypes Open
A fundamental endeavor of the International Histocompatibility and Immunogenetics Workshop (IHIW) was assembling a collection of DNA samples homozygous through the MHC genomic region. This collection proved invaluable for assay development…
View article: Donor KIR genotype based outcome prediction after allogeneic stem cell transplantation: no land in sight
Donor KIR genotype based outcome prediction after allogeneic stem cell transplantation: no land in sight Open
Optimizing natural killer (NK) cell alloreactivity could further improve outcome after allogeneic hematopoietic cell transplantation (alloHCT). The donor’s Killer-cell Immunoglobulin-like Receptor (KIR) genotype may provide important infor…
View article: Body odours as putative chemosignals in the father-child relationship: New insights on paternal olfactory kin recognition and preference from infancy to adolescence
Body odours as putative chemosignals in the father-child relationship: New insights on paternal olfactory kin recognition and preference from infancy to adolescence Open
Children's body odours are effective chemical cues in the parent-child relationship. Mothers can recognize the odour of their child and prefer this odour over that of unfamiliar children. This effect is mediated by genetic similarity and d…
View article: Providing hematopoietic stem cell products from unrelated donors to the world: DKMS donor centers and DKMS Registry
Providing hematopoietic stem cell products from unrelated donors to the world: DKMS donor centers and DKMS Registry Open
Allogeneic hematopoietic stem cell (HSC) transplantation is a curative therapy for many severe blood diseases. As many patients have no suitable family donor, large unrelated donor registries and donor centers have been established in many…
View article: High population frequencies of MICA copy number variations originate from independent recombination events
High population frequencies of MICA copy number variations originate from independent recombination events Open
MICA is a stress-induced ligand of the NKG2D receptor that stimulates NK and T cell responses and was identified as a key determinant of anti-tumor immunity. The MICA gene is located inside the MHC complex and is in strong linkage disequil…
View article: Haplotype reconstruction for genetically complex regions with ambiguous genotype calls: Illustration by the <i>KIR</i> gene region
Haplotype reconstruction for genetically complex regions with ambiguous genotype calls: Illustration by the <i>KIR</i> gene region Open
Advances in DNA sequencing technologies have enabled genotyping of complex genetic regions exhibiting copy number variation and high allelic diversity, yet it is impossible to derive exact genotypes in all cases, often resulting in ambiguo…
View article: High population frequencies of MICA copy number variations originate from independent recombination events
High population frequencies of MICA copy number variations originate from independent recombination events Open
MICA is a stress-induced ligand of the NKG2D receptor that stimulates NK and T cell responses and was identified as a key determinant of anti-tumor immunity. The MICA gene is located inside the MHC complex and is in strong linkage disequil…
View article: HLA-DP on Epithelial Cells Enables Tissue Damage by NKp44+ Natural Killer Cells in Ulcerative Colitis
HLA-DP on Epithelial Cells Enables Tissue Damage by NKp44+ Natural Killer Cells in Ulcerative Colitis Open
View article: The genotype list string code syntax for exchanging <scp>nomenclature‐level</scp> genotyping results in clinical and research data management and analysis systems
The genotype list string code syntax for exchanging <span>nomenclature‐level</span> genotyping results in clinical and research data management and analysis systems Open
The nomenclatures used to describe HLA and killer‐cell immunoglobulin‐like receptor (KIR) alleles distinguish unique nucleotide and peptide sequences, and patterns of expression, but are insufficient for describing genotyping results, as d…
View article: Genotype List String 1.1: Extending the Genotype List String grammar for describing <scp>HLA</scp> and Killer‐cell Immunoglobulin‐like Receptor genotypes
Genotype List String 1.1: Extending the Genotype List String grammar for describing <span>HLA</span> and Killer‐cell Immunoglobulin‐like Receptor genotypes Open
The Genotype List (GL) String grammar for reporting HLA and Killer‐cell Immunoglobulin‐like Receptor (KIR) genotypes in a text string was described in 2013. Since this initial description, GL Strings have been used to describe HLA and KIR …
View article: HLA allele and haplotype frequencies of registered stem cell donors in Chile
HLA allele and haplotype frequencies of registered stem cell donors in Chile Open
Patients in need of hematopoietic stem cell transplantation often rely on unrelated stem cell donors matched in certain human leukocyte antigen (HLA) genes. Donor search is complicated by the extensive allelic variability of the HLA system…
View article: World Marrow Donor Association guidelines for the reporting of novel <scp>HLA</scp> alleles
World Marrow Donor Association guidelines for the reporting of novel <span>HLA</span> alleles Open
The guidelines for the implementation and reporting of HLA nomenclature for the World Marrow Donor Association have served as a reliable standard for communication of HLA data in the hematopoietic cell transplantation process. Wider use of…
View article: Large case-control study indicates no association of <i>KIR</i> genotype and risk of developing acute myeloid leukemia
Large case-control study indicates no association of <i>KIR</i> genotype and risk of developing acute myeloid leukemia Open
Immunogenetic association studies may give rise to new hypotheses on the immune surveillance of cancer. We hypothesized that certain combinations of killer immunoglobulin-like receptor (KIR) and HLA genotypes may enhance natural killer (NK…
View article: Body Odours as Chemosignals in the Father-Child Relationship: New Insights on Paternal Olfactory Kin Recognition and Preference from Infancy to Adolescence
Body Odours as Chemosignals in the Father-Child Relationship: New Insights on Paternal Olfactory Kin Recognition and Preference from Infancy to Adolescence Open
View article: Post‐COVID‐19 condition in the German working population: A cross‐sectional study of 200,000 registered stem cell donors
Post‐COVID‐19 condition in the German working population: A cross‐sectional study of 200,000 registered stem cell donors Open
Background The SARS‐CoV‐2 pandemic has strained health systems worldwide, and infection numbers continue to rise. While previous data have already shown that many patients suffer from symptoms for months after an acute infection, data on r…
View article: Host KIR/HLA-C Genotypes Determine HIV-Mediated Changes of the NK Cell Repertoire and Are Associated With Vpu Sequence Variations Impacting Downmodulation of HLA-C
Host KIR/HLA-C Genotypes Determine HIV-Mediated Changes of the NK Cell Repertoire and Are Associated With Vpu Sequence Variations Impacting Downmodulation of HLA-C Open
NK cells play a pivotal role in viral immunity, utilizing a large array of activating and inhibitory receptors to identify and eliminate virus-infected cells. Killer-cell immunoglobulin-like receptors (KIRs) represent a highly polymorphic …
View article: Engagement of TRAIL triggers degranulation and IFNγ production in human natural killer cells
Engagement of TRAIL triggers degranulation and IFNγ production in human natural killer cells Open