Justin A. Bishop
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View article: High-Risk HPV Testing in Head and Neck Carcinoma: Key Updates from the 2025 College of American Pathologists Guideline
High-Risk HPV Testing in Head and Neck Carcinoma: Key Updates from the 2025 College of American Pathologists Guideline Open
View article: Characterization of Malignant Adnexal Tumors of the Head and Neck by Targeted Analysis of Cancer Genes and Human Papillomavirus 42
Characterization of Malignant Adnexal Tumors of the Head and Neck by Targeted Analysis of Cancer Genes and Human Papillomavirus 42 Open
View article: Wnt/β-catenin activation by mutually exclusive FBXW11 and CTNNB1 hotspot mutations drives salivary basal cell adenoma
Wnt/β-catenin activation by mutually exclusive FBXW11 and CTNNB1 hotspot mutations drives salivary basal cell adenoma Open
View article: A pilot study of PSMA-targeted F-18-DCFPyL PET imaging of patients with adenoid cystic carcinoma
A pilot study of PSMA-targeted F-18-DCFPyL PET imaging of patients with adenoid cystic carcinoma Open
Adenoid cystic carcinoma (ACC) is a rare malignancy of the salivary glands with poor long-term outcomes and with a need for improved imaging and therapeutic options. Prostate-specific membrane antigen (PSMA) expression has been observed in…
View article: Human Papillomavirus Testing in Head and Neck Carcinomas: Guideline Update
Human Papillomavirus Testing in Head and Neck Carcinomas: Guideline Update Open
Context.— In 2018, an evidence-based guideline was published by the College of American Pathologists to develop recommendations for the testing, application, interpretation, and reporting of high-risk human papillomavirus and surrogate mar…
View article: Novel RUNX1/2 Fusions in Unclassified Cystic Squamous Salivary Gland Tumors: Possible Expansion of the Keratocystoma Family
Novel RUNX1/2 Fusions in Unclassified Cystic Squamous Salivary Gland Tumors: Possible Expansion of the Keratocystoma Family Open
View article: Nodal Yield From Neck Dissection Predicts the Anti‐Tumor Immune Response in Head and Neck Cancers
Nodal Yield From Neck Dissection Predicts the Anti‐Tumor Immune Response in Head and Neck Cancers Open
Background Lymph node count (LNC) from neck dissection has been associated with undernutrition and survival in head and neck squamous cell carcinoma (HNSCC). As local components of the immune system, cervical lymph nodes may reflect anti‐t…
View article: Activation of Wnt/β-catenin signalling by mutually exclusive<i>FBXW11</i>and<i>CTNNB1</i>hotspot mutations drives salivary gland basal cell adenoma
Activation of Wnt/β-catenin signalling by mutually exclusive<i>FBXW11</i>and<i>CTNNB1</i>hotspot mutations drives salivary gland basal cell adenoma Open
Wnt signalling must be ‘just right’ to promote tumour growth. Basal cell adenoma (BCA) and basal cell adenocarcinoma (BCAC) of the salivary gland are rare tumours that can be difficult to distinguish from each other and other salivary glan…
View article: Extra-abdominal and intra-abdominal FET::CREM fusion mesenchymal neoplasms: comparative clinicopathological study of 9 new cases further supporting a distinct potentially aggressive sarcoma and report of novel sites
Extra-abdominal and intra-abdominal FET::CREM fusion mesenchymal neoplasms: comparative clinicopathological study of 9 new cases further supporting a distinct potentially aggressive sarcoma and report of novel sites Open
With the wide use of RNA sequencing technologies, the family of FET::CREB fusion mesenchymal neoplasms has expanded rapidly to include potentially aggressive neoplasms, not fitting any well established WHO entity. Recently, a group of intr…
View article: The genomic and evolutionary landscapes of anaplastic thyroid carcinoma
The genomic and evolutionary landscapes of anaplastic thyroid carcinoma Open
Anaplastic thyroid carcinoma is arguably the most lethal human malignancy. It often co-occurs with differentiated thyroid cancers, yet the molecular origins of its aggressivity are unknown. We sequenced tumor DNA from 329 regions of thyroi…
View article: Figure S2 from Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma
Figure S2 from Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma Open
Axonal guidance signaling pathway alterations in adenoid cystic carcinoma.
View article: Figure S1 from Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma
Figure S1 from Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma Open
Circos plots for chromosomal rearrangements in adenoid cystic carcinoma.
View article: Table S2 from Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma
Table S2 from Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma Open
Somatic mutations in adenoid cystic carcinoma (N=25 tumors).
View article: Table S4 from Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma
Table S4 from Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma Open
Somatic chromosomal rearrangements in adenoid cystic carcinoma (N=25).
View article: Figure S1 from Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma
Figure S1 from Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma Open
Circos plots for chromosomal rearrangements in adenoid cystic carcinoma.
View article: Table S5 from Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma
Table S5 from Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma Open
NFIB fusion genes.
View article: Data from Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma
Data from Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma Open
Adenoid cystic carcinomas (ACC) of the salivary glands are challenging to understand, treat, and cure. To better understand the genetic alterations underlying the pathogenesis of these tumors, we performed comprehensive genome analyses of …
View article: Data from Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma
Data from Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma Open
Adenoid cystic carcinomas (ACC) of the salivary glands are challenging to understand, treat, and cure. To better understand the genetic alterations underlying the pathogenesis of these tumors, we performed comprehensive genome analyses of …
View article: Table S5 from Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma
Table S5 from Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma Open
NFIB fusion genes.
View article: Supplementary Table 2 from Cleaved NOTCH1 Expression Pattern in Head and Neck Squamous Cell Carcinoma Is Associated with NOTCH1 Mutation, HPV Status, and High-Risk Features
Supplementary Table 2 from Cleaved NOTCH1 Expression Pattern in Head and Neck Squamous Cell Carcinoma Is Associated with NOTCH1 Mutation, HPV Status, and High-Risk Features Open
Supplementary Table 2. Clinicopathological characteristics associated with NICD1 IHC staining pattern for NOTCH1-wild type only.
View article: Table S3 from Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma
Table S3 from Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma Open
Copy number variations in adenoid cystic carcinoma (N=25).
View article: Table S1 from Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma
Table S1 from Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma Open
Summary of sequence analysis of adenoid cystic carcinoma.
View article: Supplementary Tables 4 - 6 from Clusterin Is a Gene-Specific Target of microRNA-21 in Head and Neck Squamous Cell Carcinoma
Supplementary Tables 4 - 6 from Clusterin Is a Gene-Specific Target of microRNA-21 in Head and Neck Squamous Cell Carcinoma Open
XLSX file - 841K, Supplementary Table 4. miRNA array analysis of discovery cohort. Supplementary Table 5. miRNA array significant call signals. Supplementary Table 6. RT-qPCR validation of miRNA array.
View article: Supplementary Tables 1 - 3 from Clusterin Is a Gene-Specific Target of microRNA-21 in Head and Neck Squamous Cell Carcinoma
Supplementary Tables 1 - 3 from Clusterin Is a Gene-Specific Target of microRNA-21 in Head and Neck Squamous Cell Carcinoma Open
XLSX file - 15K, Supplementary Table 1. Clinical characteristics of discovery cohort. Supplementary Table 2. Clinical characteristics of mRNA expression array cohort. Supplementary Table 3. Clinical characteristics of validation cohort.
View article: Supplementary Table S4 from Whole-Exome Sequencing of Salivary Gland Mucoepidermoid Carcinoma
Supplementary Table S4 from Whole-Exome Sequencing of Salivary Gland Mucoepidermoid Carcinoma Open
Supplementary Table S4 provides information on the spectra of mutations seen in MEC tumors of varying histologic grades.
View article: Supplementary Table S2 from Whole-Exome Sequencing of Salivary Gland Mucoepidermoid Carcinoma
Supplementary Table S2 from Whole-Exome Sequencing of Salivary Gland Mucoepidermoid Carcinoma Open
Supplementary Table S2 provides a comprehensive list of somatic mutations identified via whole-exome sequencing in 18 MEC tumor samples.
View article: Data from A Phase I Trial of the VEGF Receptor Tyrosine Kinase Inhibitor Pazopanib in Combination with the MEK Inhibitor Trametinib in Advanced Solid Tumors and Differentiated Thyroid Cancers
Data from A Phase I Trial of the VEGF Receptor Tyrosine Kinase Inhibitor Pazopanib in Combination with the MEK Inhibitor Trametinib in Advanced Solid Tumors and Differentiated Thyroid Cancers Open
Purpose:Differentiated thyroid cancer (DTC) responds to VEGF receptor inhibitors. VEGF signals through RAS/RAF/MEK signaling. We evaluated the safety and efficacy of the VEGF receptor inhibitor pazopanib and MEK inhibitor trametinib in adv…
View article: Supplementary Figure Legend from Clusterin Is a Gene-Specific Target of microRNA-21 in Head and Neck Squamous Cell Carcinoma
Supplementary Figure Legend from Clusterin Is a Gene-Specific Target of microRNA-21 in Head and Neck Squamous Cell Carcinoma Open
PDF file - 67K
View article: Supplemental Tables S1-S11 from Integrated Analysis of Whole-Genome ChIP-Seq and RNA-Seq Data of Primary Head and Neck Tumor Samples Associates HPV Integration Sites with Open Chromatin Marks
Supplemental Tables S1-S11 from Integrated Analysis of Whole-Genome ChIP-Seq and RNA-Seq Data of Primary Head and Neck Tumor Samples Associates HPV Integration Sites with Open Chromatin Marks Open
Table S1. Clinical data for patient-derived PDX1, PDX2, UPPP1, and UPPP2 samples used for ChIP-based analysis. Table S2. ChIP-DNA qRT-PCR primers-probe sequence Table S3. Sample-specific enrichment of H3K4me3 histone mark at 5''UTR of indi…
View article: Data from A Phase I Trial of the VEGF Receptor Tyrosine Kinase Inhibitor Pazopanib in Combination with the MEK Inhibitor Trametinib in Advanced Solid Tumors and Differentiated Thyroid Cancers
Data from A Phase I Trial of the VEGF Receptor Tyrosine Kinase Inhibitor Pazopanib in Combination with the MEK Inhibitor Trametinib in Advanced Solid Tumors and Differentiated Thyroid Cancers Open
Purpose:Differentiated thyroid cancer (DTC) responds to VEGF receptor inhibitors. VEGF signals through RAS/RAF/MEK signaling. We evaluated the safety and efficacy of the VEGF receptor inhibitor pazopanib and MEK inhibitor trametinib in adv…