Justin C. Y. Wu
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View article: The conundrum of esophagogastric junction outflow obstruction: Answers to key clinical questions
The conundrum of esophagogastric junction outflow obstruction: Answers to key clinical questions Open
Esophagogastric junction outflow obstruction (EGJOO) is a heterogeneous disorder characterized by abnormal esophagogastric junction residual pressures in the setting of intact esophageal body peristalsis. This manometric finding is most cl…
View article: Exploring the efficacy and safety of Yu-Ping-Feng powder with variation against allergic rhinitis: a randomized, double-blind, placebo-controlled trial
Exploring the efficacy and safety of Yu-Ping-Feng powder with variation against allergic rhinitis: a randomized, double-blind, placebo-controlled trial Open
View article: The Discovery and Development of KH607 as a Treatment for Postpartum Depression(PPD)and Major Depressive Disorder (MDD)
The Discovery and Development of KH607 as a Treatment for Postpartum Depression(PPD)and Major Depressive Disorder (MDD) Open
Introduction Depression is a serious CNS-related disease that may require long-term treatment. Postpartum depression is a critical medical condition that affects the mother, as well as has a short and long-term impact on the growth of the …
View article: Development and Validation of a Multiplex High-Risk Hpv Detection Method Using Lyophilized Microsphere Technology and Multicolor Melting Curve Analysis
Development and Validation of a Multiplex High-Risk Hpv Detection Method Using Lyophilized Microsphere Technology and Multicolor Melting Curve Analysis Open
View article: LOX-1 acts as an N6-methyladenosine-regulated receptor for Helicobacter pylori by binding to the bacterial catalase
LOX-1 acts as an N6-methyladenosine-regulated receptor for Helicobacter pylori by binding to the bacterial catalase Open
View article: The prevalence of gastroesophageal reflux disease and laryngopharyngeal reflux in patients with dysphagia after radiotherapy for nasopharyngeal carcinoma
The prevalence of gastroesophageal reflux disease and laryngopharyngeal reflux in patients with dysphagia after radiotherapy for nasopharyngeal carcinoma Open
Background The prevalence of gastroesophageal reflux disease (GERD) and laryngopharyngeal reflux (LPR) in post‐irradiated patients with nasopharyngeal carcinoma (NPC) is unknown. Materials and methods In a cross‐sectional study, 31 NPC and…
View article: Randomised clinical trial: Faecal microbiota transplantation for irritable bowel syndrome with diarrhoea
Randomised clinical trial: Faecal microbiota transplantation for irritable bowel syndrome with diarrhoea Open
Summary Background Faecal microbiota transplantation (FMT) has been shown to improve symptoms in a proportion of patients with irritable bowel syndrome (IBS). Aim We performed a randomised trial to assess the efficacy of FMT in patients wi…
View article: Comparing diagnostic performance of Cantonese-Chinese version of Rome IV criteria and a short Reference Standard for functional dyspepsia in China
Comparing diagnostic performance of Cantonese-Chinese version of Rome IV criteria and a short Reference Standard for functional dyspepsia in China Open
View article: Kyoto international consensus report on anatomy, pathophysiology and clinical significance of the gastro-oesophageal junction
Kyoto international consensus report on anatomy, pathophysiology and clinical significance of the gastro-oesophageal junction Open
Objective An international meeting was organised to develop consensus on (1) the landmarks to define the gastro-oesophageal junction (GOJ), (2) the occurrence and pathophysiological significance of the cardiac gland, (3) the definition of …
View article: Nurse-led reinforced education by mobile messenger improves the quality of bowel preparation of colonoscopy in a population-based colorectal cancer screening program: A randomized controlled trial
Nurse-led reinforced education by mobile messenger improves the quality of bowel preparation of colonoscopy in a population-based colorectal cancer screening program: A randomized controlled trial Open
View article: Chinese Herbal Medicines Complementary to Mesalazine for Ulcerative Colitis: A Systematic Review with Meta-Analysis
Chinese Herbal Medicines Complementary to Mesalazine for Ulcerative Colitis: A Systematic Review with Meta-Analysis Open
View article: Efficacy and safety of Chinese medicine JCM-16021 for diarrhea-predominant irritable bowel syndrome: study protocol for a multi-center, randomized, double-blind, placebo controlled clinical trial
Efficacy and safety of Chinese medicine JCM-16021 for diarrhea-predominant irritable bowel syndrome: study protocol for a multi-center, randomized, double-blind, placebo controlled clinical trial Open
View article: Cricopharyngeal peroral endoscopic myotomy improves oropharyngeal dysphagia in patients with Parkinson’s disease
Cricopharyngeal peroral endoscopic myotomy improves oropharyngeal dysphagia in patients with Parkinson’s disease Open
Background and study aims Oropharyngeal dysphagia (OPD) is prevalent in patients with Parkinson’s disease (PD). Upper esophageal sphincter (UES) dysfunction is an important pathophysiological factor for OPD in PD. The cricopharyngeus (CP) …
View article: IDDF2021-ABS-0053 Chinese herbal medicine for functional dyspepsia: network meta-analysis of prokinetic-controlled randomised trials
IDDF2021-ABS-0053 Chinese herbal medicine for functional dyspepsia: network meta-analysis of prokinetic-controlled randomised trials Open
Background Functional dyspepsia (FD) is a common functional gastrointestinal disorder, with a prevalence of 5–30% among Asian countries. Prokinetic is the first-line conventional treatment in Asia, despite potential adverse events ranging …
View article: IDDF2021-ABS-0052 Chinese herbal medicine for functional dyspepsia: network meta-analysis of placebo-controlled randomised trials
IDDF2021-ABS-0052 Chinese herbal medicine for functional dyspepsia: network meta-analysis of placebo-controlled randomised trials Open
Background Functional dyspepsia (FD) is a common functional gastrointestinal disorder, having a prevalence of 10–40% in Western countries and 5–30% in Asia. Conventional treatments for FD are limited and associated with bothersome adverse …
View article: Elderly acceptance of telemedicine use in Hong Kong during and after the COVID-19 pandemic: a cross-sectional cohort survey
Elderly acceptance of telemedicine use in Hong Kong during and after the COVID-19 pandemic: a cross-sectional cohort survey Open
Background Telemedicine services worldwide have experienced an unprecedented boom since the beginning of the COVID-19 pandemic. Multiple studies have noted telemedicine as an effective alternative to traditional face-to-face management of …
View article: Prioritizing Chinese medicine clinical research questions in cancer palliative care from patient and caregiver perspectives
Prioritizing Chinese medicine clinical research questions in cancer palliative care from patient and caregiver perspectives Open
Background Chinese medicine (CM) modalities, including acupuncture and Chinese herbal medicine (CHM), are popular palliative interventions among patients with cancer, but further clinical research is required to assess their effectiveness …
View article: Effects of a Rice Bran Dietary Intervention on the Composition of the Intestinal Microbiota of Adults with a High Risk of Colorectal Cancer: A Pilot Randomised-Controlled Trial
Effects of a Rice Bran Dietary Intervention on the Composition of the Intestinal Microbiota of Adults with a High Risk of Colorectal Cancer: A Pilot Randomised-Controlled Trial Open
Rice bran exhibits chemopreventive properties that may help to prevent colorectal cancer (CRC), and a short-term rice bran dietary intervention may promote intestinal health via modification of the intestinal microbiota. We conducted a pil…
View article: Esophageal motility disorders on high‐resolution manometry: Chicago classification version 4.0<sup>©</sup>
Esophageal motility disorders on high‐resolution manometry: Chicago classification version 4.0<sup>©</sup> Open
Chicago Classification v4.0 (CCv4.0) is the updated classification scheme for esophageal motility disorders using metrics from high‐resolution manometry (HRM). Fifty‐two diverse international experts separated into seven working subgroups …
View article: Evaluating traditional Chinese medicine diagnostic instruments for functional dyspepsia: A systematic review on measurement properties
Evaluating traditional Chinese medicine diagnostic instruments for functional dyspepsia: A systematic review on measurement properties Open
The quality of TCM diagnostic instruments for FD warrants urgent improvements. None of them was considered reliable or valid for guiding TCM pattern diagnosis. To support the evidence base of the standardization of TCM patterns in ICD-11, …
View article: Unaltered Brain GABA Concentrations and Resting fMRI Activity in Functional Dyspepsia With and Without Comorbid Depression
Unaltered Brain GABA Concentrations and Resting fMRI Activity in Functional Dyspepsia With and Without Comorbid Depression Open
We did not find altered GABA concentrations or brain resting activity in FD-PDS or its MDD comorbidity. The neurochemical link between MDD and FD remains elusive.
View article: The Practice of Gastrointestinal Motility Laboratory During COVID-19 Pandemic: Position Statements of the Asian Neurogastroenterology and Motility Association (ANMA-GML-COVID-19 Position Statements)
The Practice of Gastrointestinal Motility Laboratory During COVID-19 Pandemic: Position Statements of the Asian Neurogastroenterology and Motility Association (ANMA-GML-COVID-19 Position Statements) Open
During the Coronavirus Disease 2019 (COVID-19) pandemic, practices of gastrointestinal procedures within the digestive tract require special precautions due to the risk of contraction of severe acute respiratoy syndrome coronavirus-2 (SARS…
View article: Diagnosing functional dyspepsia in Traditional Medicine: a systematic review of diagnostic instruments and their measurement properties
Diagnosing functional dyspepsia in Traditional Medicine: a systematic review of diagnostic instruments and their measurement properties Open
View article: Acupuncture and related therapies for treating irritable bowel syndrome: overview of systematic reviews and network meta-analysis
Acupuncture and related therapies for treating irritable bowel syndrome: overview of systematic reviews and network meta-analysis Open
View article: Phase 4 Study in Patients From Asia With Gastroesophageal Reflux Disease Treated With Dexlansoprazole
Phase 4 Study in Patients From Asia With Gastroesophageal Reflux Disease Treated With Dexlansoprazole Open
In Asian patients with GERD, treatment with dexlansoprazole modified-release indicates a favorable efficacy and safety profile in relieving heartburn and acid regurgitation symptoms.
View article: A double-blinded, randomized placebo-controlled trial on the effect of traditional Chinese medicine formula Wuzi Yanzong pill on improving semen qualities in men with suboptimal parameters
A double-blinded, randomized placebo-controlled trial on the effect of traditional Chinese medicine formula Wuzi Yanzong pill on improving semen qualities in men with suboptimal parameters Open
Chinese Clinical Trial Registry (ChiCTR), ChiCTR-INR-17010790 . Registered on 27 February 2017. Centre for Clinical Research and Biostatistics - Clinical Trials Registry, CUHK_CCRB00548 . Registered on 27 February 2017.
View article: Prioritizing Chinese Medicine Clinical Research Questions in Cancer Palliative Care: International Delphi Survey
Prioritizing Chinese Medicine Clinical Research Questions in Cancer Palliative Care: International Delphi Survey Open
View article: Effect of Peroral Endoscopic Myotomy vs Pneumatic Dilation on Symptom Severity and Treatment Outcomes Among Treatment-Naive Patients With Achalasia
Effect of Peroral Endoscopic Myotomy vs Pneumatic Dilation on Symptom Severity and Treatment Outcomes Among Treatment-Naive Patients With Achalasia Open
Netherlands Trial Register number: NTR3593.
View article: Second Asian Consensus on Irritable Bowel Syndrome
Second Asian Consensus on Irritable Bowel Syndrome Open
Our consensus is that all patients with functional gastrointestinal disorders should be evaluated comprehensively with a view to holistic management. Physicians should be encouraged to take a positive attitude to the treatment outcomes for…
View article: IDDF2019-ABS-0118 Electroacupuncture plus on-demand gastrocaine for refractory functional dyspepsia: pragmatic randomized trial
IDDF2019-ABS-0118 Electroacupuncture plus on-demand gastrocaine for refractory functional dyspepsia: pragmatic randomized trial Open
Background Treatment options for functional dyspepsia (FD) refractory to pharmacological treatments are limited, but the effectiveness of electroacupuncture (EA) is uncertain. Our aim was to assess the effectiveness of EA combined with on-…