Justin F. Rousseau
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View article: SAT-777 Evaluation of FRAX in a U.S. Cohort of Primary Hyperparathyroidism
SAT-777 Evaluation of FRAX in a U.S. Cohort of Primary Hyperparathyroidism Open
Disclosure: V.R. Sant: None. Y. ElNakieb: None. J.F. Rousseau: None. C.D. Rubin: None. N.M. Maalouf: None. Introduction: Fracture risk prediction in primary hyperparathyroidism (PHPT) remains challenging, particularly in identifying patien…
View article: Advancing delirium detection through the Open Health Natural Language Processing Consortium and the Evolve to Next-Gen Accrual to Clinical Trials Network
Advancing delirium detection through the Open Health Natural Language Processing Consortium and the Evolve to Next-Gen Accrual to Clinical Trials Network Open
Background Delirium is often underdiagnosed in clinical practice and is not routinely coded for billing. While manual chart review can identify delirium, it is labor-intensive and impractical for large-scale studies. Natural language proce…
View article: The structure of posttraumatic stress symptoms in youth with and without obsessive-compulsive disorder: New insights using factor and network analysis
The structure of posttraumatic stress symptoms in youth with and without obsessive-compulsive disorder: New insights using factor and network analysis Open
View article: Latent Classes of Adolescent Trauma Exposure, Posttraumatic Stress Disorder Symptoms, and Substance Use Predict Clinical Diagnoses at 12-Month Follow-Up
Latent Classes of Adolescent Trauma Exposure, Posttraumatic Stress Disorder Symptoms, and Substance Use Predict Clinical Diagnoses at 12-Month Follow-Up Open
Background Trauma exposure, posttraumatic stress disorder (PTSD), and substance use commonly co-occur among youth. Identifying specific subgroups of youth based on unique constellations across these domains may provide a novel way to ident…
View article: Ambient technology in epilepsy clinical practice
Ambient technology in epilepsy clinical practice Open
The utilization of large language model‐based artificial intelligence (AI) in the field of neurology has gained attention as a viable tool to enhance and assist providers with processes ranging from scheduling patients to providing prelimi…
View article: Research on policy mechanisms to address funding bias and conflicts of interest in biomedical research: a scoping review
Research on policy mechanisms to address funding bias and conflicts of interest in biomedical research: a scoping review Open
View article: Leveraging long context in retrieval augmented language models for medical question answering
Leveraging long context in retrieval augmented language models for medical question answering Open
View article: SARS-CoV-2 humoral immune responses in convalescent individuals over 12 months reveal severity-dependent antibody dynamics
SARS-CoV-2 humoral immune responses in convalescent individuals over 12 months reveal severity-dependent antibody dynamics Open
View article: Dissecting clinical features of COVID-19 in a cohort of 21,312 acute care patients
Dissecting clinical features of COVID-19 in a cohort of 21,312 acute care patients Open
View article: Corrigendum to “Clinical characteristics and longitudinal associations with obsessive-compulsive disorder in youth exposed to trauma” [J Mood Anxiety Disord 10C (2025) 100117]
Corrigendum to “Clinical characteristics and longitudinal associations with obsessive-compulsive disorder in youth exposed to trauma” [J Mood Anxiety Disord 10C (2025) 100117] Open
View article: Clinical characteristics and longitudinal associations with obsessive-compulsive disorder in youth exposed to trauma
Clinical characteristics and longitudinal associations with obsessive-compulsive disorder in youth exposed to trauma Open
Childhood trauma exposure is associated with posttraumatic stress symptoms (PTSS) and suicidality, however it is also a risk factor for obsessive-compulsive disorder (OCD) in adults. Research examining the relationship between childhood tr…
View article: Short-Term Safety and Effectiveness for Tenecteplase and Alteplase in Acute Ischemic Stroke
Short-Term Safety and Effectiveness for Tenecteplase and Alteplase in Acute Ischemic Stroke Open
Importance Tenecteplase is an alternative to alteplase for emergency treatment of acute ischemic stroke. However, limited data are available comparing their clinical effectiveness in routine clinical practice. Objective To compare short-te…
View article: Development and Validation of Natural Language Processing Algorithms in the ENACT National Electronic Health Record Research Network
Development and Validation of Natural Language Processing Algorithms in the ENACT National Electronic Health Record Research Network Open
Electronic health record (EHR) data are a rich and invaluable source of real-world clinical information, enabling detailed insights into patient populations, treatment outcomes, and healthcare practices. The availability of large volumes o…
View article: Creating a collaborative culture of learning within a network of community mental health early psychosis programs in Texas
Creating a collaborative culture of learning within a network of community mental health early psychosis programs in Texas Open
View article: Host-microbe multiomic profiling identifies distinct COVID-19 immune dysregulation in solid organ transplant recipients
Host-microbe multiomic profiling identifies distinct COVID-19 immune dysregulation in solid organ transplant recipients Open
View article: Development and validation of natural language processing algorithms in the national ENACT network
Development and validation of natural language processing algorithms in the national ENACT network Open
Objective: Electronic Health Record (EHR) data are critical for advancing translational research and AI technologies. The ENACT network offers access to structured EHR data across 57 CTSA hubs. However, substantial information is contained…
View article: A MapReduce Approach to Effectively Utilize Long Context Information in Retrieval Augmented Language Models
A MapReduce Approach to Effectively Utilize Long Context Information in Retrieval Augmented Language Models Open
While holding great promise for improving and facilitating healthcare, large language models (LLMs) struggle to produce up-to-date responses on evolving topics due to outdated knowledge or hallucination. Retrieval-augmented generation (RAG…
View article: Conflicts of Interest Publication Disclosures: Descriptive Study
Conflicts of Interest Publication Disclosures: Descriptive Study Open
Background Multiple lines of previous research have documented that author conflicts of interest (COI) can compromise the integrity of the biomedical research enterprise. However, continuing research that would investigate why, how, and in…
View article: Hidden flaws behind expert-level accuracy of multimodal GPT-4 vision in medicine
Hidden flaws behind expert-level accuracy of multimodal GPT-4 vision in medicine Open
View article: Sample Size Considerations for Fine-Tuning Large Language Models for Named Entity Recognition Tasks: Methodological Study
Sample Size Considerations for Fine-Tuning Large Language Models for Named Entity Recognition Tasks: Methodological Study Open
Background Large language models (LLMs) have the potential to support promising new applications in health informatics. However, practical data on sample size considerations for fine-tuning LLMs to perform specific tasks in biomedical and …
View article: Patient Characteristics, Management, and Outcomes in a Novel Cohort of Primary Hyperparathyroidism
Patient Characteristics, Management, and Outcomes in a Novel Cohort of Primary Hyperparathyroidism Open
Context Primary hyperparathyroidism (PHPT) increases the risk of bone loss, debilitating fractures, kidney stones, impaired renal function, and neurocognitive symptoms. Studies describing the natural history of PHPT have been limited to sm…
View article: Comparative effectiveness of dexamethasone in treatment of hospitalized COVID-19 patients in the United States during the first year of the pandemic: Findings from the National COVID Cohort Collaborative (N3C) data repository
Comparative effectiveness of dexamethasone in treatment of hospitalized COVID-19 patients in the United States during the first year of the pandemic: Findings from the National COVID Cohort Collaborative (N3C) data repository Open
Background Dexamethasone was approved for use in hospitalized COVID-19 patients early in the pandemic based on the RECOVERY trial, but evidence is still needed to support its real-world effectiveness in heterogeneous populations of patient…
View article: The risk and burden of thromboembolic and hemorrhagic events in patients with malignant gliomas receiving bevacizumab
The risk and burden of thromboembolic and hemorrhagic events in patients with malignant gliomas receiving bevacizumab Open
View article: Hidden flaws behind expert-level accuracy of multimodal GPT-4 vision in medicine
Hidden flaws behind expert-level accuracy of multimodal GPT-4 vision in medicine Open
Recent studies indicate that Generative Pre-trained Transformer 4 with Vision (GPT-4V) outperforms human physicians in medical challenge tasks. However, these evaluations primarily focused on the accuracy of multi-choice questions alone. O…
View article: IgM N-glycosylation correlates with COVID-19 severity and rate of complement deposition
IgM N-glycosylation correlates with COVID-19 severity and rate of complement deposition Open
The glycosylation of IgG plays a critical role during human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, activating immune cells and inducing cytokine production. However, the role of IgM N-glycosylation has not …
View article: Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study
Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study Open
View article: SARS-CoV-2 Humoral Immune Responses in Convalescent Individuals Over 12 Months Reveal Severity-Dependent Antibody Dynamics
SARS-CoV-2 Humoral Immune Responses in Convalescent Individuals Over 12 Months Reveal Severity-Dependent Antibody Dynamics Open
Background Understanding the kinetics and longevity of antibody responses to SARS-CoV-2 is critical to informing strategies toward reducing Coronavirus disease 2019 (COVID-19) reinfections, and improving vaccination and therapy approaches.…
View article: Dissecting Clinical Features of COVID-19 in a Cohort of 21,312 Acute Care Patients
Dissecting Clinical Features of COVID-19 in a Cohort of 21,312 Acute Care Patients Open
COVID-19 has resulted in over 645 million hospitalization and 7 million deaths globally. However, many questions still remain about clinical complications in COVID-19 and if these complications changed with different circulating SARS-CoV-2…
View article: EPID-08. CLINICAL AND MOLECULAR DETERMINANTS OF BLEEDING-RELATED ADVERSE OUTCOMES IN HIGH-GRADE GLIOMA
EPID-08. CLINICAL AND MOLECULAR DETERMINANTS OF BLEEDING-RELATED ADVERSE OUTCOMES IN HIGH-GRADE GLIOMA Open
Cancer is an independent risk factor for the development of venous thromboembolism (VTE) however patients with high-grade glioma (HGG) including glioblastoma (GBM) are at a particularly high risk of VTE with an incidence up to 20- 30% per …
View article: Evaluating large language models on medical evidence summarization
Evaluating large language models on medical evidence summarization Open
Recent advances in large language models (LLMs) have demonstrated remarkable successes in zero- and few-shot performance on various downstream tasks, paving the way for applications in high-stakes domains. In this study, we systematically …