Justin K. Craig
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View article: Crystal structures of Mycobacterium tuberculosis and Mycobacterium thermoresistibile glycyl-tRNA synthetases in various liganded states
Crystal structures of Mycobacterium tuberculosis and Mycobacterium thermoresistibile glycyl-tRNA synthetases in various liganded states Open
Glycyl tRNA synthetases (GlyRSs) are prospective drug targets for combating Mycobacterium tuberculosis ( Mtb ) and cancer in humans. These synthetases are of the α2-subtype, with the ortholog in humans being dual targeted to the cytosol an…
View article: A functional enzymatic assay as potential readout for a clinical trial of a schistosomiasis vaccine
A functional enzymatic assay as potential readout for a clinical trial of a schistosomiasis vaccine Open
View article: Exquisite selectivity of griselimycin extends to beta subunit of DNA polymerases from Gram-negative bacterial pathogens
Exquisite selectivity of griselimycin extends to beta subunit of DNA polymerases from Gram-negative bacterial pathogens Open
View article: Structures of <i>Trichomonas vaginalis</i> macrophage migratory inhibitory factor
Structures of <i>Trichomonas vaginalis</i> macrophage migratory inhibitory factor Open
The unicellular parasitic protozoan Trichomonas vaginalis causes trichomoniasis, the most prevalent nonviral sexually transmitted disease globally. T. vaginalis evades host immune responses by producing homologs of host proteins, including…
View article: Crystal structure of N-terminally hexahistidine-tagged <i>Onchocerca volvulus</i> macrophage migration inhibitory factor-1
Crystal structure of N-terminally hexahistidine-tagged <i>Onchocerca volvulus</i> macrophage migration inhibitory factor-1 Open
Onchocerca volvulus causes blindness, onchocerciasis, skin infections and devastating neurological diseases such as nodding syndrome. New treatments are needed because the currently used drug, ivermectin, is contraindicated in pregnant wom…
View article: Crystal structures of NAD(P)H nitroreductases from <i>Klebsiella pneumoniae</i>
Crystal structures of NAD(P)H nitroreductases from <i>Klebsiella pneumoniae</i> Open
Klebsiella pneumoniae ( Kp ) is an infectious disease pathogen that poses a significant global health threat due to its potential to cause severe infections and its tendency to exhibit multidrug resistance. Understanding the enzymatic mech…
View article: Characterization of a family I inorganic pyrophosphatase from <i>Legionella pneumophila</i> Philadelphia 1
Characterization of a family I inorganic pyrophosphatase from <i>Legionella pneumophila</i> Philadelphia 1 Open
Inorganic pyrophosphate (PP i ) is generated as an intermediate or byproduct of many fundamental metabolic pathways, including DNA/RNA synthesis. The intracellular concentration of PP i must be regulated as buildup can inhibit many critica…
View article: The transcriptome of Balamuthia mandrillaris trophozoites for structure-guided drug design
The transcriptome of Balamuthia mandrillaris trophozoites for structure-guided drug design Open
View article: High-throughput screening of the ReFRAME, Pandemic Box, and COVID Box drug repurposing libraries against SARS-CoV-2 nsp15 endoribonuclease to identify small-molecule inhibitors of viral activity
High-throughput screening of the ReFRAME, Pandemic Box, and COVID Box drug repurposing libraries against SARS-CoV-2 nsp15 endoribonuclease to identify small-molecule inhibitors of viral activity Open
SARS-CoV-2 has caused a global pandemic, and has taken over 1.7 million lives as of mid-December, 2020. Although great progress has been made in the development of effective countermeasures, with several pharmaceutical companies approved o…
View article: Naegleria fowleri: Protein structures to facilitate drug discovery for the deadly, pathogenic free-living amoeba
Naegleria fowleri: Protein structures to facilitate drug discovery for the deadly, pathogenic free-living amoeba Open
Naegleria fowleri is a pathogenic, thermophilic, free-living amoeba which causes primary amebic meningoencephalitis (PAM). Penetrating the olfactory mucosa, the brain-eating amoeba travels along the olfactory nerves, burrowing through the …
View article: In silico detection of SARS-CoV-2 specific B-cell epitopes and validation in ELISA for serological diagnosis of COVID-19
In silico detection of SARS-CoV-2 specific B-cell epitopes and validation in ELISA for serological diagnosis of COVID-19 Open
View article: High-throughput screening of the ReFRAME, Pandemic Box, and COVID Box drug repurposing libraries against SARS-CoV2 nsp15 endoribonuclease to identify small-molecule inhibitors of viral activity
High-throughput screening of the ReFRAME, Pandemic Box, and COVID Box drug repurposing libraries against SARS-CoV2 nsp15 endoribonuclease to identify small-molecule inhibitors of viral activity Open
SARS-CoV-2 has caused a global pandemic, and has taken over 1.7 million lives as of mid-December, 2020. Although great progress has been made in the development of effective countermeasures, with several pharmaceutical companies approved o…
View article: Backbone chemical shift assignments for the SARS-CoV-2 non-structural protein Nsp9: intermediate (ms – μs) dynamics in the C-terminal helix at the dimer interface
Backbone chemical shift assignments for the SARS-CoV-2 non-structural protein Nsp9: intermediate (ms – μs) dynamics in the C-terminal helix at the dimer interface Open
View article: <i>Naegleria fowleri:</i>protein structures to facilitate drug discovery for the deadly, pathogenic free-living amoeba
<i>Naegleria fowleri:</i>protein structures to facilitate drug discovery for the deadly, pathogenic free-living amoeba Open
Naegleria fowleri is a pathogenic, thermophilic, free-living amoeba which causes primary amebic meningoencephalitis (PAM). Penetrating the olfactory mucosa, the brain-eating amoeba travels along the olfactory nerves, burrowing through the …
View article: The transcriptome of<i>Balamuthia mandrillaris</i>trophozoites for structure-based drug design
The transcriptome of<i>Balamuthia mandrillaris</i>trophozoites for structure-based drug design Open
Balamuthia mandrillaris , a pathogenic free-living amoeba (FLA), causes cutaneous skin lesions as well as the brain-eating disease: Balamuthia granulomatous amoebic encephalitis (GAE). These diseases, and diseases caused by other pathogeni…
View article: In silico detection of SARS-CoV-2 specific B-cell epitopes and validation in ELISA for serological diagnosis of COVID-19
In silico detection of SARS-CoV-2 specific B-cell epitopes and validation in ELISA for serological diagnosis of COVID-19 Open
Rapid generation of diagnostics is paramount to understand epidemiology and to control the spread of emerging infectious diseases such as COVID-19. Computational methods to predict serodiagnostic epitopes that are specific for the pathogen…
View article: Toward a structome of <scp><i>Acinetobacter baumannii</i></scp> drug targets
Toward a structome of <span><i>Acinetobacter baumannii</i></span> drug targets Open
Acinetobacter baumannii is well known for causing hospital‐associated infections due in part to its intrinsic antibiotic resistance as well as its ability to remain viable on surfaces and resist cleaning agents. In a previous publication, …
View article: Structures of glyceraldehyde 3‐phosphate dehydrogenase in <scp><i>Neisseria gonorrhoeae</i></scp> and <i>Chlamydia trachomatis</i>
Structures of glyceraldehyde 3‐phosphate dehydrogenase in <span><i>Neisseria gonorrhoeae</i></span> and <i>Chlamydia trachomatis</i> Open
Neisseria gonorrhoeae ( Ng ) and Chlamydia trachomatis ( Ct ) are the most commonly reported sexually transmitted bacteria worldwide and usually present as co‐infections. Increasing resistance of Ng to currently recommended dual therapy of…
View article: Mycobacterium Cytidylate Kinase Appears to Be an Undruggable Target
Mycobacterium Cytidylate Kinase Appears to Be an Undruggable Target Open
New and improved drugs against tuberculosis are urgently needed as multi-drug-resistant forms of the disease become more prevalent. Mycobacterium tuberculosis cytidylate kinase is an attractive target for screening due to its essentiality …