Justin L. Grodin
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View article: Associations of Electromechanical Activation Time With Cardiac Structure and Function and Clinical Outcomes
Associations of Electromechanical Activation Time With Cardiac Structure and Function and Clinical Outcomes Open
In a community cohort, an increased EMAT was associated with a lower LVEF and adverse prognosis but had poor discriminatory capacity for the former and was not independent of NT-proBNP for the latter.
View article: Association of blood biomarkers with cardiovascular and kidney adverse outcomes in people with heart failure with preserved ejection fraction
Association of blood biomarkers with cardiovascular and kidney adverse outcomes in people with heart failure with preserved ejection fraction Open
Background Greater than 50% of people with chronic kidney disease have left ventricular hypertrophy and are at risk for developing heart failure with preserved ejection fraction (HFpEF). Up to 56% of those with HF suffer from kidney functi…
View article: Transthyretin Amyloid Cardiomyopathy: The Plot Thickens as Novel Therapies Emerge
Transthyretin Amyloid Cardiomyopathy: The Plot Thickens as Novel Therapies Emerge Open
Transthyretin amyloid cardiomyopathy (ATTR-CM) has transitioned from an underdiagnosed condition to a rapidly evolving therapeutic frontier. This review highlights the expanding treatment landscape, beginning with evidence from key clinica…
View article: A Rare Unusually Aggressive Form of Hereditary Transthyretin Amyloidosis
A Rare Unusually Aggressive Form of Hereditary Transthyretin Amyloidosis Open
Understanding the phenotype associated with this ATTRv genotype, along with the patient's family history, guided targeted and timely evaluation and treatment.
View article: Effect of Acoramidis on Recurrent and Cumulative Cardiovascular Outcomes in ATTR-CM
Effect of Acoramidis on Recurrent and Cumulative Cardiovascular Outcomes in ATTR-CM Open
Acoramidis significantly reduced the cumulative burden of CV outcomes in ATTR-CM over 30 months. Numerically fewer events were observed with acoramidis vs placebo by month 1, and the difference increased progressively over time, resulting …
View article: Single Ascending-Dose Study of Selective ErbB4 Agonist JK07 in Heart Failure With Reduced Ejection Fraction
Single Ascending-Dose Study of Selective ErbB4 Agonist JK07 in Heart Failure With Reduced Ejection Fraction Open
This first-in-human, phase 1, double-blind, placebo-controlled study evaluated the safety, tolerability, immunogenicity, pharmacokinetics, and exploratory efficacy of a selective ErbB4 agonist, JK07, in patients with heart failure with red…
View article: Risk for Heart Failure and Atrial Fibrillation Across the Lifespan for Carriers of the Amyloidogenic p.V142I <i>TTR</i> Variant
Risk for Heart Failure and Atrial Fibrillation Across the Lifespan for Carriers of the Amyloidogenic p.V142I <i>TTR</i> Variant Open
BACKGROUND: To better define the importance of the amyloidogenic p.V142I TTR allele across the life span of a carrier, we leveraged data from All of Us to provide a generalizable assessment of the population-level burden of cardiovascular …
View article: Management Patterns and Outcomes of Invasive Mechanical Ventilation in Patients With Cardiogenic Shock
Management Patterns and Outcomes of Invasive Mechanical Ventilation in Patients With Cardiogenic Shock Open
View article: Strengthening the Appreciation of Frailty in Patients With Transthyretin Cardiac Amyloidosis
Strengthening the Appreciation of Frailty in Patients With Transthyretin Cardiac Amyloidosis Open
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View article: Development of Imaging Endpoints for Clinical Trials in AL and ATTR Amyloidosis
Development of Imaging Endpoints for Clinical Trials in AL and ATTR Amyloidosis Open
View article: Adequacy of Loop Diuretic Dosing in Treatment of Acute Heart Failure: Insights from the BAN-ADHF Diuretic Resistance Risk Score
Adequacy of Loop Diuretic Dosing in Treatment of Acute Heart Failure: Insights from the BAN-ADHF Diuretic Resistance Risk Score Open
Diuretic resistance (DR) is common among patients admitted with acute heart failure (AHF) and can be estimated by BAN-ADHF scores. Among 317 consecutive patients hospitalized for AHF, BAN-ADHF scores were compared with metrics of DR and co…
View article: Biomarkers in Subclinical Transthyretin Cardiac Amyloidosis
Biomarkers in Subclinical Transthyretin Cardiac Amyloidosis Open
View article: Phenomapping the Response of Patients With Ischemic Cardiomyopathy With Reduced Ejection Fraction to Surgical Revascularization
Phenomapping the Response of Patients With Ischemic Cardiomyopathy With Reduced Ejection Fraction to Surgical Revascularization Open
Background Coronary artery bypass grafting (CABG) has demonstrated long‐term mortality benefits in patients with HFREF and obstructive coronary artery disease (CAD), but whether phenotypic heterogeneity influences the benefits of CABG is u…
View article: Polymorphic IGLV6-57 AL amyloid fibrils and features of a shared folding pathway
Polymorphic IGLV6-57 AL amyloid fibrils and features of a shared folding pathway Open
Immunoglobulin light chain (AL) amyloidosis is a systemic disorder caused by the misfolding and aggregation of free immunoglobulin light chains (LCs) secreted by abnormal plasma cells. The resulting amyloid fibrils deposit in multiple orga…
View article: Long-Term Efficacy and Safety of Acoramidis in ATTR-CM: Initial Report From the Open-Label Extension of the ATTRibute-CM Trial
Long-Term Efficacy and Safety of Acoramidis in ATTR-CM: Initial Report From the Open-Label Extension of the ATTRibute-CM Trial Open
BACKGROUND: In the phase 3 randomized controlled study ATTRibute-CM (Efficacy and Safety of AG10 in Subjects With Transthyretin Amyloid Cardiomyopathy), acoramidis, a transthyretin stabilizer, demonstrated significant efficacy on the prima…
View article: Structure-Based Probe Reveals the Presence of Large Transthyretin Aggregates in Plasma of ATTR Amyloidosis Patients
Structure-Based Probe Reveals the Presence of Large Transthyretin Aggregates in Plasma of ATTR Amyloidosis Patients Open
View article: Exercise cardiac magnetic resonance imaging across the lifespan
Exercise cardiac magnetic resonance imaging across the lifespan Open
Introduction Exercise cardiac magnetic resonance imaging (cMRI) offers several advantages over contemporary stress imaging approaches, including improved spatial resolution, free of ionizing radiation. With exercise cMRI becoming increasin…
View article: Glucagon-like peptide-1 agonist use for obesity treatment in patients with left ventricular assist devices
Glucagon-like peptide-1 agonist use for obesity treatment in patients with left ventricular assist devices Open
View article: Detection of Circulating Transthyretin Amyloid Aggregates in Plasma: A Novel Biomarker for Transthyretin Amyloidosis
Detection of Circulating Transthyretin Amyloid Aggregates in Plasma: A Novel Biomarker for Transthyretin Amyloidosis Open
View article: Detection of ATTR aggregates in plasma of polyneuropathic ATTR-V30M amyloidosis patients
Detection of ATTR aggregates in plasma of polyneuropathic ATTR-V30M amyloidosis patients Open
ATTR amyloidosis is caused by the deposition of transthyretin amyloid fibrils in tissues often leading to organ failure and death. The clinical spectrum of this disease is highly diverse and dependent on many factors including the presence…
View article: Structure-based probe reveals the presence of large transthyretin aggregates in plasma of ATTR amyloidosis patients
Structure-based probe reveals the presence of large transthyretin aggregates in plasma of ATTR amyloidosis patients Open
ATTR amyloidosis is a relentlessly progressive disease caused by the misfolding and systemic accumulation of amyloidogenic transthyretin into amyloid fibrils. These fibrils cause diverse clinical phenotypes, mainly cardiomyopathy and/or po…
View article: Circulating transthyretin and retinol binding protein 4 levels among middle-age V122I <i>TTR</i> carriers in the general population
Circulating transthyretin and retinol binding protein 4 levels among middle-age V122I <i>TTR</i> carriers in the general population Open
V122I TTR carrier status is independently associated with lower TTR and RBP4 in comparison with non-carriers. These findings support the hypothesis that TTR and RBP4 may correlate with evidence of subclinical ATTRv-CA.
View article: Abstract 1015 Structure-specific peptide probes detect aggregated transthyretin in plasma of transthyretin amyloidosis patients
Abstract 1015 Structure-specific peptide probes detect aggregated transthyretin in plasma of transthyretin amyloidosis patients Open
The aggregation of the circulatory protein transthyretin leads to transthyretin amyloidosis (ATTR amyloidosis), an incurable condition that can lead to neuropathy and heart failure. We understand very little regarding the aggregation of tr…
View article: Association of Ratio of eGFR by Cystatin C and Creatinine with Mortality in Heart Failure
Association of Ratio of eGFR by Cystatin C and Creatinine with Mortality in Heart Failure Open
Roehm, Bethany; McAdams, Meredith; Gordon, Jonathan; Grodin, Justin L.; Hedayati, S. Susan Author Information
View article: Giants Hiding in Small Places: A Case of New Onset Heart Failure, Atrioventricular Block, and Ventricular Arrhythmias
Giants Hiding in Small Places: A Case of New Onset Heart Failure, Atrioventricular Block, and Ventricular Arrhythmias Open
Woman with new-onset heart failure, atrioventricular block, and ventricular tachycardia found to have giant cell myocarditis.
View article: Effective medications can work only in patients who take them: Implications for post‐acute heart failure care
Effective medications can work only in patients who take them: Implications for post‐acute heart failure care Open
Acute heart failure (AHF) remains a predominant cause of hospitalization, especially among individuals aged 65 years or older, contributing to millions of hospitalizations per year globally.1, 2 Despite advances in therapeutic approach, AH…
View article: Temporal Trends in Left Ventricular Mechanical Unloading With Venoarterial Extracorporeal Membrane Oxygenation
Temporal Trends in Left Ventricular Mechanical Unloading With Venoarterial Extracorporeal Membrane Oxygenation Open
View article: Outcomes of Transcatheter Aortic Valve Replacement in Patients With Coexisiting Amyloidosis
Outcomes of Transcatheter Aortic Valve Replacement in Patients With Coexisiting Amyloidosis Open
View article: A Review of Current and Evolving Imaging Techniques in Cardiac Amyloidosis
A Review of Current and Evolving Imaging Techniques in Cardiac Amyloidosis Open
Purpose of review Establishing an early, efficient diagnosis for cardiac amyloid (CA) is critical to avoiding adverse outcomes. We review current imaging tools that can aid early diagnosis, offer prognostic information, and possibly track …
View article: Disentangling the Pulmonary Capillary Wedge Pressure From the Pulmonary Artery Pressure as the Hemodynamic Underpinning of Bendopnea
Disentangling the Pulmonary Capillary Wedge Pressure From the Pulmonary Artery Pressure as the Hemodynamic Underpinning of Bendopnea Open