Explanipedia

P14.18.A SCHWANNOMAS DISPLAY CONSERVED CELLULAR STATES AND PREFERENTIAL MHC CLASS II ANTIGEN PRESENTATION ACROSS DIFFERENT GENETIC BACKGROUNDS AND ANATOMIC LOCATIONS Open

L Gonzalez Castro, Assaf R. Gavish, Lillian Bussema, Cristin A. Mount, Cyril Neftel , et al. · 2025

BACKGROUND Despite being associated with molecular alterations in the NF2 gene, there is limited understanding of the gene expression programs that govern the behavior of schwannomas—both in sporadic cases and in patients with schwannoma p…

A single-cell atlas of Schwannoma across genetic backgrounds and anatomic locations Open

L. Nicolas Gonzalez Castro, Avishai Gavish, Lillian Bussema, Christopher Mount, Cyril Neftel , et al. · 2025

Overall, our atlas describes the spectrum of gene expression across schwannoma entities at the single-cell level and will serve as an important resource for the community.

Enhanced BDNF and ROS in Mucosa of Lower Motor Neuron Lesioned Dog Bladder Following Somatic Motor Nerve Transfer Open

Nagat Frara, Kais Jawawdeh, Dania Giaddui, Istvan P. Tamas, R Garès , et al. · 2025

Neurotrophic factors and reactive oxygen species (ROS) modulate neuronal plasticity. In a model of a lower motor neuron lesioned bladder, somatic nerve transfer was used as a reinnervation strategy. Levels of neurotrophins, ROS, and TNF-α …

Conditioning electrical stimulation enhances functional rewiring in a mouse model of nerve transfer to treat chronic spinal cord injury Open

Juan Sebastián Jara, Marwa H. Soliman, Allan Bernstein, Paola di Grazia, Adam R. Ferguson , et al. · 2025

Nerve transfer surgery is a state-of-the-art surgical approach to restore hand and arm function in individuals living with tetraplegia, significantly impacting daily life. While nearly a third of all individuals with chronic SCI may benefi…

Novel Technologies to Address the Lower Motor Neuron Injury and Augment Reconstruction in Spinal Cord Injury Open

Stanley F. Bazarek, Matthias Krenn, Sameer B. Shah, Ross Mandeville, Justin M. Brown · 2024

Lower motor neuron (LMN) damage results in denervation of the associated muscle targets and is a significant yet under-appreciated component of spinal cord injury (SCI). Denervated muscle undergoes a progressive degeneration and fibro-fatt…

Supinator to Posterior Interosseous Nerve Transfer for Recovery of Hand Opening in the Tetraplegic Patient: A Case Series Open

Stanley Bazarek, Margaret Sten, Jasmine A. Thum, Ross Mandeville, G. Magee , et al. · 2024

BACKGROUND AND OBJECTIVES: Cervical spinal cord injury results in devastating loss of function. Nerve transfers can restore functional use of the hand, the highest priority function in this population to gain independence. Transfer of radi…

Stimulation-Free Concentric-Needle Motor Unit Number Estimate – a potential new biomarker for Nerve Health Open

Merle Göben, Reiner Henson B See, Carl Froilan D. Leochico, Austin Birmingham, Art Eleanore , et al. · 2024

EPCO-03. A COMPREHENSIVE SINGLE-CELL ATLAS OF SCHWANNOMA REVEALS CONSERVED CELLULAR STATES ACROSS DIFFERENT GENETIC BACKGROUNDS AND ANATOMIC LOCATIONS Open

L. Nicolas Gonzalez Castro, Avishai Gavish, Lillian Bussema, Cyril Neftel, Masashi Nomura , et al. · 2023

BACKGROUND Despite being associated with molecular alterations in the NF2 gene, there is limited understanding of the gene expression programs that govern the behavior of schwannomas both in sporadic cases as well as in patients with schwa…

Axillary to Radial Nerve Transfer for Recovery of Elbow Extension After Spinal Cord Injury Open

Stanley Bazarek, Jasmine A. Thum, Margaret Sten, G. Magee, Ross Mandeville , et al. · 2023

BACKGROUND AND OBJECTIVES: Cervical spinal cord injuries (SCI) result in severe loss of function and independence. Nerve transfers have become a powerful method for restoring upper extremity function, the most critical missing function des…

Selective Tibial Neurotomy for Spastic Equinovarus Foot: Operative Technique Open

Jasmine A. Thum, Stanley Bazarek, Margaret Sten, Gabriel Friedman, Ross Mandeville , et al. · 2023

BACKGROUND AND OBJECTIVES: Spastic equinovarus foot (SEF) is a common complication of stroke and other upper motor neuron injuries. It is characterized by a plantigrade and inverted foot, often with toe curling, causing significant disabil…

A scoping review of current and emerging techniques for evaluation of peripheral nerve health, degeneration and regeneration: part 2, non-invasive imaging Open

Ross Mandeville, Swati Deshmukh, Ek T. Tan, Viksit Kumar, Benjamin Sanchez , et al. · 2023

Peripheral neuroregenerative research and therapeutic options are expanding exponentially. With this expansion comes an increasing need to reliably evaluate and quantify nerve health. Valid and responsive measures of the nerve status are e…

A scoping review of current and emerging techniques for evaluation of peripheral nerve health, degeneration, and regeneration: part 1, neurophysiology Open

Ross Mandeville, Benjamin Sanchez, Benjamin R. Johnston, Stanley Bazarek, Jasmine A. Thum , et al. · 2023

Peripheral neuroregeneration research and therapeutic options are expanding exponentially. With this expansion comes an increasing need to reliably evaluate and quantify nerve health. Valid and responsive measures that can serve as biomark…

Selective Tibial Neurotomy Outcomes for Spastic Equinovarus Foot: Patient Expectations and Functional Assessment Open

Amber LaMarca, Matthias Krenn, Molly A. Kelso-Trass, Kathryn C. MacDonald, Cristina C. Demeo , et al. · 2023

BACKGROUND: Spastic equinovarus foot (SEF) is a common dysfunctional foot posture after stroke that impairs balance and mobility. Selective tibial neurotomy (STN) is a simple but underutilized surgical option that can effectively address c…

Attenuation of a DNA cruciform by a conserved regulator directs T3SS1 mediated virulence in <i>Vibrio parahaemolyticus</i> Open

Landon J. Getz, Justin M. Brown, Lauren Sobot, Alexandra Chow, Jastina Mahendrarajah , et al. · 2023

Pathogenic Vibrio species account for 3–5 million annual life-threatening human infections. Virulence is driven by bacterial hemolysin and toxin gene expression often positively regulated by the winged helix-turn-helix (wHTH) HlyU transcri…

Restoring bladder function using motor and sensory nerve transfers: a cadaveric feasibility study Open

Benjamin R. Johnston, Stanley Bazarek, Margaret Sten, Brian S. McIntyre, Noam Fine , et al. · 2022

OBJECTIVE Bladder dysfunction after nerve injury has a variable presentation, and extent of injury determines whether the bladder is spastic or atonic. The authors have proposed a series of 3 nerve transfers for functional innervation of t…

Issue Information: Masthead Open

Bret A. Collier, Christopher E. Moorman, D. Richard Cobb, Chris Kreh, Marcus A. Lashley , et al. · 2022

Wildlife Society Bulletin is published in four issues per year.FTE-based pricing, based on the overall demand and on the size and type of the subscribing institution (academic, government, hospital or corporate, applies for this Journal.

Attenuation of a DNA Cruciform by a Conserved Regulator Directs T3SS-1 mediated virulence in <i>Vibrio parahaemolyticus</i> Open

Landon J. Getz, Justin M. Brown, Lauren Sobot, Alexandra Chow, Jastina Mahendrarajah , et al. · 2022

Pathogenic Vibrio species account for 3-5 million annual life-threatening human infections. Virulence is driven by bacterial hemolysin and toxin gene expression often positively regulated by the winged helix-turn-helix (wHTH) HlyU transcri…

MP08-08 NERVE TRANSFER FOR RESTORATION OF LOWER MOTOR NEURON-LESIONED BLADDER FUNCTION. PART 2: ATTENUATION OF PURINERGIC BLADDER SMOOTH MUSCLE CONTRACTIONS Open

Nagat Frara, Dania Giaddui, Alan S. Braverman, Danielle S. Porecca, Justin M. Brown , et al. · 2021

You have accessJournal of UrologyBladder & Urethra: Anatomy, Physiology & Pharmacology (MP08)1 Sep 2021MP08-08 NERVE TRANSFER FOR RESTORATION OF LOWER MOTOR NEURON-LESIONED BLADDER FUNCTION. PART 2: ATTENUATION OF PURINERGIC BLADDER SMOOTH…

MP08-10 LATERALIZATION OF BLADDER FUNCTION IN NORMAL FEMALE CANINES Open

Dania Giaddui, Mary F. Barbe, Ekta Tiwari, Alan S. Braverman, Danielle S. Porreca , et al. · 2021

You have accessJournal of UrologyBladder & Urethra: Anatomy, Physiology & Pharmacology (MP08)1 Sep 2021MP08-10 LATERALIZATION OF BLADDER FUNCTION IN NORMAL FEMALE CANINES Dania Giaddui, Mary F. Barbe, Ekta Tiwari, Alan S. Braverman, Daniel…

MP08-09 NERVE TRANSFER FOR RESTORATION OF LOWER MOTOR NEURON-LESIONED BLADDER FUNCTION. CORRELATION BETWEEN HISTOLOGICAL CHANGES AND NERVE EVOKED CONTRACTIONS Open

Mary F. Barbe, Courtney L. Testa, Geneva E. Cruz, Nagat Frara, Ekta Tiwari , et al. · 2021

You have accessJournal of UrologyBladder & Urethra: Anatomy, Physiology & Pharmacology (MP08)1 Sep 2021MP08-09 NERVE TRANSFER FOR RESTORATION OF LOWER MOTOR NEURON-LESIONED BLADDER FUNCTION. CORRELATION BETWEEN HISTOLOGICAL CHANGES AND NER…

PD36-03 RESTORATION OF BLADDER, URETHRAL AND ANAL SPHINCTER FUNCTION AFTER SURGICAL REINNERVATION IN LOWER MOTOR NEURON LESIONED CANINES Open

Ekta Tiwari, Lucas J. Hobson, Danielle S. Porreca, Alan S. Braverman, Carolina T. Caban Rivera , et al. · 2021

You have accessJournal of UrologyUrodynamics/Lower Urinary Tract Dysfunction/Female Pelvic Medicine: Neurogenic Voiding Dysfunction (PD36)1 Sep 2021PD36-03 RESTORATION OF BLADDER, URETHRAL AND ANAL SPHINCTER FUNCTION AFTER SURGICAL REINNER…

Neurophysiology of epidurally evoked spinal cord reflexes in clinically motor-complete posttraumatic spinal cord injury Open

José Luis Vargas Luna, Justin M. Brown, Matthias Krenn, Barry McKay, Winfried Mayr , et al. · 2021

Safety and efficacy of bexarotene in patients with relapsing-remitting multiple sclerosis (CCMR One): a randomised, double-blind, placebo-controlled, parallel-group, phase 2a study. Open

Justin M. Brown, Nick Cunniffe, Ferrán Prados, Baris Kanber, Joanna E. Jones , et al. · 2021

LncRNA-miRNA axes in breast cancer: Novel points of interaction for strategic attack Open

Jaganathan Venkatesh, Marie‐Claire D. Wasson, Justin M. Brown, Wasundara Fernando, Paola Marcato · 2021

Therapeutic effectiveness in breast cancer can be limited by the underlying mechanisms of pathogenesis, including epithelial-mesenchymal transition (EMT), cancer stem cells (CSCs) and drug resistance. Long non-coding RNAs (lncRNAs) and mic…

Nerve transfer for restoration of lower motor neuron–lesioned bladder and urethra function: establishment of a canine model and interim pilot study results Open

Ekta Tiwari, Danielle M. Salvadeo, Alan S. Braverman, Nagat Frara, Lucas J. Hobson , et al. · 2019

OBJECTIVE Previous patient surveys have shown that patients with spinal cord or cauda equina injuries prioritize recovery of bladder function. The authors sought to determine if nerve transfer after long-term decentralization restores blad…

The Flick of a Switch: Conferring Survival Advantage to Breast Cancer Stem Cells Through Metabolic Plasticity Open

H. Walsh, Brianne M. Cruickshank, Justin M. Brown, Paola Marcato · 2019

Within heterogeneous tumors, cancer stem cell (CSC) populations exhibit the greatest tumor initiation potential, promote metastasis, and contribute to therapy resistance. For breast cancer specifically, CSCs are identified by CD44^high…

Nerve transfer versus muscle transfer to restore elbow flexion after pan–brachial plexus injury: a cost-effectiveness analysis Open

Arvin R. Wali, David R. Santiago-Dieppa, Justin M. Brown, Ross Mandeville · 2017

OBJECTIVE Pan–brachial plexus injury (PBPI), involving C5–T1, disproportionately affects young males, causing lifelong disability and decreased quality of life. The restoration of elbow flexion remains a surgical priority for these patient…

Contralateral C-7 transfer: is direct repair really superior to grafting? Open

Anil Bhatia, Piyush Doshi, Ashok Raj Koul, Vitrag Shah, Justin M. Brown , et al. · 2017

It is not uncommon for a severe traumatic brachial plexus injury to involve all 5 roots, resulting in a flail upper limb. In such cases, surgical reconstruction is often palliative, providing only rudimentary function. Nerve transfers are …

A neurophysiological approach to nerve transfer to restore upper limb function in cervical spinal cord injury Open

Ross Mandeville, Justin M. Brown, Geoffrey Sheean · 2017

A successful nerve transfer surgery can provide a wealth of benefits to a patient with cervical spinal cord injury. The process of surgical decision making ideally uses all pertinent information to produce the best functional outcome. Reli…

Establishing reconstructive neurosurgery as a subspecialty Open

Justin M. Brown, Mark A. Mahan, Ross Mandeville, Bob S. Carter · 2017

Neurosurgery is experiencing the emergence of a new subspecialty focused on function restoration. New, evolving, and reappraised surgical procedures have provided an opportunity to restore function to many patients with previously undertre…

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