Justin M. Wolter
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View article: Multi-targeting zinc finger nuclease vector unsilences paternal UBE3A in a mouse model of Angelman syndrome
Multi-targeting zinc finger nuclease vector unsilences paternal UBE3A in a mouse model of Angelman syndrome Open
Angelman syndrome (AS) is a severe neurodevelopmental disorder most often caused by deletion of the maternally inherited UBE3A allele (matUBE3A). In neurons, a long non-coding antisense RNA (Ube3a-ATS) silences the paternally-inherited UBE…
View article: Assessing molecular gene by treatment interactions using a population of neural progenitors exposed to valproic acid and lithium
Assessing molecular gene by treatment interactions using a population of neural progenitors exposed to valproic acid and lithium Open
Gene by treatment (GxT) interactions likely contribute to variability in clinical response, but are difficult to identify in population studies. Here, we applied psychiatric and neurological disorder treatments to a genotyped population of…
View article: AAV-dCas9 vector unsilences paternal Ube3a in neurons by impeding Ube3a-ATS transcription
AAV-dCas9 vector unsilences paternal Ube3a in neurons by impeding Ube3a-ATS transcription Open
Angelman syndrome (AS) is a debilitating neurodevelopmental disorder caused by loss of maternally-inherited UBE3A. In neurons, paternally-inherited UBE3A is silenced in cis by a long non-coding RNA called Ube3a-ATS. Here, we found that Nei…
View article: Stimulating Wnt signaling reveals context-dependent genetic effects on gene regulation in primary human neural progenitors
Stimulating Wnt signaling reveals context-dependent genetic effects on gene regulation in primary human neural progenitors Open
View article: Autism-linked UBE3A gain-of-function mutation causes interneuron and behavioral phenotypes when inherited maternally or paternally in mice
Autism-linked UBE3A gain-of-function mutation causes interneuron and behavioral phenotypes when inherited maternally or paternally in mice Open
View article: Wnt activity reveals context-specific genetic effects on gene regulation in neural progenitors
Wnt activity reveals context-specific genetic effects on gene regulation in neural progenitors Open
Gene regulatory effects in bulk-post mortem brain tissues are undetected at many non-coding brain trait-associated loci. We hypothesized that context-specific genetic variant function during stimulation of a developmental signaling pathway…
View article: MicroRNA-eQTLs in the developing human neocortex link miR-4707-3p expression to brain size
MicroRNA-eQTLs in the developing human neocortex link miR-4707-3p expression to brain size Open
Expression quantitative trait loci (eQTL) data have proven important for linking non-coding loci to protein-coding genes. But eQTL studies rarely measure microRNAs (miRNAs), small non-coding RNAs known to play a role in human brain develop…
View article: MicroRNA-eQTLs in the developing human neocortex link miR-4707-3p expression to brain size
MicroRNA-eQTLs in the developing human neocortex link miR-4707-3p expression to brain size Open
Expression quantitative trait loci (eQTL) data have proven important for linking non-coding loci to protein-coding genes. But eQTL studies rarely measure microRNAs (miRNAs), small non-coding RNAs known to play a role in human brain develop…
View article: Author response: MicroRNA-eQTLs in the developing human neocortex link miR-4707-3p expression to brain size
Author response: MicroRNA-eQTLs in the developing human neocortex link miR-4707-3p expression to brain size Open
View article: Multi-omic profiling reveals the ataxia protein sacsin is required for integrin trafficking and synaptic organization
Multi-omic profiling reveals the ataxia protein sacsin is required for integrin trafficking and synaptic organization Open
View article: Cellular Genome-wide Association Study Identifies Common Genetic Variation Influencing Lithium-Induced Neural Progenitor Proliferation
Cellular Genome-wide Association Study Identifies Common Genetic Variation Influencing Lithium-Induced Neural Progenitor Proliferation Open
View article: MicroRNA-eQTLs in the developing human neocortex link miR-4707-3p expression to brain size
MicroRNA-eQTLs in the developing human neocortex link miR-4707-3p expression to brain size Open
Expression quantitative trait loci (eQTL) data have proven important for linking non-coding loci to protein-coding genes. But eQTL studies rarely measure microRNAs (miRNAs), small non-coding RNAs known to play a role in human brain develop…
View article: <scp>ToxCast</scp> chemical library Wnt screen identifies diethanolamine as an activator of neural progenitor proliferation
<span>ToxCast</span> chemical library Wnt screen identifies diethanolamine as an activator of neural progenitor proliferation Open
Numerous autism spectrum disorder (ASD) risk genes are associated with Wnt signaling, suggesting that brain development may be especially sensitive to genetic perturbation of this pathway. Additionally, valproic acid, which modulates Wnt s…
View article: Cellular genome wide association study identifies common genetic variation influencing lithium induced neural progenitor proliferation
Cellular genome wide association study identifies common genetic variation influencing lithium induced neural progenitor proliferation Open
Lithium is used in the treatment of bipolar disorder (BD) and is known to increase neural progenitor cell (NPC) proliferation. Though the mechanism of lithium’s therapeutic effect is not understood, evidence suggests that genetic variation…
View article: The ataxia protein sacsin is required for integrin trafficking and synaptic organization
The ataxia protein sacsin is required for integrin trafficking and synaptic organization Open
Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is caused by mutations in SACS , which manifest as a childhood-onset cerebellar ataxia. Cellular ARSACS phenotypes include mitochondrial dysfunction, intermediate filament …
View article: Cell-type-specific effects of genetic variation on chromatin accessibility during human neuronal differentiation
Cell-type-specific effects of genetic variation on chromatin accessibility during human neuronal differentiation Open
View article: ToxCast chemical library screen identifies diethanolamine as an activator of Wnt signaling
ToxCast chemical library screen identifies diethanolamine as an activator of Wnt signaling Open
Numerous autism spectrum disorder (ASD) risk genes are associated with Wnt signaling, suggesting that brain development may be especially sensitive to genetic perturbation of this pathway. Additionally, valproic acid, which modulates Wnt s…
View article: Cas9 gene therapy for Angelman syndrome traps Ube3a-ATS long non-coding RNA
Cas9 gene therapy for Angelman syndrome traps Ube3a-ATS long non-coding RNA Open
View article: High-throughput screening and classification of chemicals and their effects on neuronal gene expression using RASL-seq
High-throughput screening and classification of chemicals and their effects on neuronal gene expression using RASL-seq Open
View article: The autism-linked UBE3A T485A mutant E3 ubiquitin ligase activates the Wnt/β-catenin pathway by inhibiting the proteasome
The autism-linked UBE3A T485A mutant E3 ubiquitin ligase activates the Wnt/β-catenin pathway by inhibiting the proteasome Open
UBE3A is a HECT domain E3 ubiquitin ligase whose dysfunction is linked to autism, Angelman syndrome, and cancer. Recently, we characterized a de novo autism-linked UBE3A mutant (UBE3AT485A) that disrupts phosphorylation c…
View article: Evolutionary patterns of metazoan microRNAs reveal targeting principles in the let-7 and miR-10 families
Evolutionary patterns of metazoan microRNAs reveal targeting principles in the let-7 and miR-10 families Open
MicroRNAs (miRNAs) regulate gene output by targeting degenerate elements in mRNAs and have undergone drastic expansions in higher metazoan genomes. The evolutionary advantage of maintaining copies of highly similar miRNAs is not well under…
View article: Differential expression of conserved and novel microRNAs during tail regeneration in the lizard Anolis carolinensis
Differential expression of conserved and novel microRNAs during tail regeneration in the lizard Anolis carolinensis Open
Differentially expressed microRNAs were identified in the regenerating lizard tail, including known regulators of stem cell proliferation. The identification of 3 putative novel microRNAs suggests that regulatory networks, either conserved…
View article: Additional file 4: Table S4. of Differential expression of conserved and novel microRNAs during tail regeneration in the lizard Anolis carolinensis
Additional file 4: Table S4. of Differential expression of conserved and novel microRNAs during tail regeneration in the lizard Anolis carolinensis Open
List of microRNA targets predicted by both RNAhybrid and miRanda. (XLSX 2990Â kb)
View article: Additional file 2: Table S2. of Differential expression of conserved and novel microRNAs during tail regeneration in the lizard Anolis carolinensis
Additional file 2: Table S2. of Differential expression of conserved and novel microRNAs during tail regeneration in the lizard Anolis carolinensis Open
MicroRNA expression in green anole tail regeneration: counts from miRDeep2 and normalized DESeq values. (XLSX 120Â kb)
View article: Additional file 5: Table S5. of Differential expression of conserved and novel microRNAs during tail regeneration in the lizard Anolis carolinensis
Additional file 5: Table S5. of Differential expression of conserved and novel microRNAs during tail regeneration in the lizard Anolis carolinensis Open
Expression summary of down- or upregulated microRNAs and their mRNA targets. (XLSX 218Â kb)
View article: Additional file 1: Table S1. of Differential expression of conserved and novel microRNAs during tail regeneration in the lizard Anolis carolinensis
Additional file 1: Table S1. of Differential expression of conserved and novel microRNAs during tail regeneration in the lizard Anolis carolinensis Open
Putative novel and known microRNA precursors in the green anole lizard, Anolis carolinensis, predicted by miRDeep2. (XLSX 127Â kb)
View article: Additional file 7: Table S7. of Differential expression of conserved and novel microRNAs during tail regeneration in the lizard Anolis carolinensis
Additional file 7: Table S7. of Differential expression of conserved and novel microRNAs during tail regeneration in the lizard Anolis carolinensis Open
Primers used for quantitative RT-PCR validation of microRNA differentially expressed in the regenerating lizard tail. (XLSX 43Â kb)
View article: Additional file 6: Table S6. of Differential expression of conserved and novel microRNAs during tail regeneration in the lizard Anolis carolinensis
Additional file 6: Table S6. of Differential expression of conserved and novel microRNAs during tail regeneration in the lizard Anolis carolinensis Open
DAVID Gene Ontology Biological Processes analysis results for downregulated microRNA/upregulated mRNA target pairs. (XLSX 53Â kb)
View article: Additional file 3: Table S3. of Differential expression of conserved and novel microRNAs during tail regeneration in the lizard Anolis carolinensis
Additional file 3: Table S3. of Differential expression of conserved and novel microRNAs during tail regeneration in the lizard Anolis carolinensis Open
DESeq differential expression testing of microRNA between the regenerating green anole tail tip and base. (XLSX 85Â kb)
View article: A human 3′UTR clone collection to study post-transcriptional gene regulation
A human 3′UTR clone collection to study post-transcriptional gene regulation Open