Justin H. Nguyen
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View article: Comparison of Subcutaneous Versus Intravenous Filgrastim in Autologous Hematopoietic Stem Cell Transplantation: A Retrospective Study
Comparison of Subcutaneous Versus Intravenous Filgrastim in Autologous Hematopoietic Stem Cell Transplantation: A Retrospective Study Open
Purpose Filgrastim is administered to shorten the duration of chemotherapy‐induced neutropenia. Filgrastim can be administered intravenously or subcutaneously, but different routes of administration may result in different pharmacokinetic …
View article: Spatial multiomics of human hepatic lymph nodes reveals early APC bifurcation in liver transplant rejection
Spatial multiomics of human hepatic lymph nodes reveals early APC bifurcation in liver transplant rejection Open
The highest risk for liver allograft rejection is within the first weeks to months after a liver transplant; however, while later-stage mechanisms are well described, the initial window at the moment of alloantigen influx (e.g., ~ 1 h post…
View article: Bipartite chromatin recognition by Hop1 from two diverged Holozoa
Bipartite chromatin recognition by Hop1 from two diverged Holozoa Open
In meiosis, ploidy reduction is driven by a complex series of DNA breakage and recombination events between homologous chromosomes, orchestrated by meiotic HORMA domain proteins (HORMADs). Meiotic HORMADs possess a central chromatin bindin…
View article: Bipartite chromatin recognition by Hop1 from two diverged holozoa
Bipartite chromatin recognition by Hop1 from two diverged holozoa Open
In meiosis, ploidy reduction is driven by a complex series of DNA breakage and recombination events between homologous chromosomes, orchestrated by meiotic HORMA domain proteins (HORMADs). Meiotic HORMADs possess a central chromatin bindin…
View article: Clinical Management of Vision Degrading Myodesopsia from Vitreous Floaters
Clinical Management of Vision Degrading Myodesopsia from Vitreous Floaters Open
View article: Cutaneous Implications of Liver Cirrhosis: A Case of Acrodermatitis Enteropathica
Cutaneous Implications of Liver Cirrhosis: A Case of Acrodermatitis Enteropathica Open
View article: Potential impact of hormone replacement therapy on the risk of hepatocellular carcinoma in women of the PLCO cohort
Potential impact of hormone replacement therapy on the risk of hepatocellular carcinoma in women of the PLCO cohort Open
Objectives Studies on the impact of hormone replacement therapy (HRT) on hepatocellular carcinoma (HCC) have been investigated in the past. This study aims to further address this topic using a large population dataset of the Prostate, Lun…
View article: P-2095. Ultrasensitive <i>Clostridioides difficile</i> Toxin A/B Assay (in Development) for Higher Diagnostic Accuracy
P-2095. Ultrasensitive <i>Clostridioides difficile</i> Toxin A/B Assay (in Development) for Higher Diagnostic Accuracy Open
Background Diagnostic tests for Clostridioides difficile infection (CDI) have either poor sensitivity or specificity, which has led to guideline recommendations for complex multistep testing algorithms. Ultrasensitive C. difficile toxin A/…
View article: Alterations of PINK1-PRKN signaling in mice during normal aging
Alterations of PINK1-PRKN signaling in mice during normal aging Open
The ubiquitin kinase-ligase pair PINK1-PRKN identifies and selectively marks damaged mitochondria for elimination via the autophagy-lysosome system (mitophagy). While this cytoprotective pathway has been extensively studied in vitro…
View article: The Influence of Vitamin D Levels on Dental Caries: A Retrospective Study of the United States Population
The Influence of Vitamin D Levels on Dental Caries: A Retrospective Study of the United States Population Open
(1) Background: This study examines vitamin D’s impact on dental caries to inform prevention strategies, given its critical role in bone and calcium regulation, vital for dental health. (2) Methods: Data from 18,683 participants of the Nat…
View article: Light Scattering by Vitreous of Humans With Vision Degrading Myodesopsia From Floaters
Light Scattering by Vitreous of Humans With Vision Degrading Myodesopsia From Floaters Open
Increased vitreous echodensity in vivo is associated with more straylight scattering in vitro, validating ultrasonography as a clinical surrogate for light scattering. Contrast sensitivity in vivo is more degraded in the presence of dark-f…
View article: Alterations of PINK1-PRKN signaling in mice during normal aging
Alterations of PINK1-PRKN signaling in mice during normal aging Open
The ubiquitin kinase-ligase pair PINK1-PRKN identifies and selectively marks damaged mitochondria for elimination via the autophagy-lysosome system (mitophagy). While this cytoprotective pathway has been extensively studied in vitro upon a…
View article: A Device to Prevent Night-time Sudden Unexpected Death in Epilepsy
A Device to Prevent Night-time Sudden Unexpected Death in Epilepsy Open
Background Sudden Unexpected Death in Epilepsy (SUDEP) is the leading cause of death in epilepsy children and otherwise healthy adult epilepsy patients. About 70% of SUDEP occurs during sleep, and nearly 90% are found in the prone (face-do…
View article: Association of Atrial Fibrillation with Insomnia in the Elderly Population
Association of Atrial Fibrillation with Insomnia in the Elderly Population Open
Introduction/Objectives: Insomnia is a common sleep disorders that affects most individuals in the United States, and worldwide. Insomnia is linked with an increased risk of atrial fibrillation (AF) in adults, although the strengths of ass…
View article: Association of Risk Factors and Comorbidities With Chronic Pain in the Elderly Population
Association of Risk Factors and Comorbidities With Chronic Pain in the Elderly Population Open
Introduction/Objective: Chronic pain disorders affect about 20% of adults in the United States, and it disproportionately affects individuals living in the neighborhoods of extreme socioeconomic disadvantage. In many instances, chronic pai…
View article: Machine Independence of Ultrasound-Based Quantification of Vitreous Echodensities
Machine Independence of Ultrasound-Based Quantification of Vitreous Echodensities Open
QUS may be applied across clinical ophthalmic ultrasound scanners and imaging frequencies to effectively evaluate VDM.
View article: Complications of dsngle-port robotic radical prostatectomy: A multi-institutional report from the Single-Port Advanced Research Consortium (SPARC)
Complications of dsngle-port robotic radical prostatectomy: A multi-institutional report from the Single-Port Advanced Research Consortium (SPARC) Open
View article: RECURRENT FLOATERS AFTER LIMITED VITRECTOMY FOR VISION DEGRADING MYODESOPSIA
RECURRENT FLOATERS AFTER LIMITED VITRECTOMY FOR VISION DEGRADING MYODESOPSIA Open
Purpose: Limited vitrectomy improves vision degrading myodesopsia, but the incidence of recurrent floaters postoperatively is not known. We studied patients with recurrent central floaters using ultrasonography and contrast sensitivity (CS…
View article: Comorbidities and Risk Factors Associated With Insomnia in the Elderly Population
Comorbidities and Risk Factors Associated With Insomnia in the Elderly Population Open
Introduction/Objectives: Sleep disorders affect around 50 to 70 million Americans, with chronic insomnia being the most common, especially in the elderly population. With an 11-fold increase in the US office visits due to insomnia, from 0.…
View article: Combined laryngeal cleft injection laryngoplasty and salivary botulinum toxin for saliva aspiration
Combined laryngeal cleft injection laryngoplasty and salivary botulinum toxin for saliva aspiration Open
Objectives Children with type I laryngeal clefts and sialorrhea can have posterior drooling, aspiration of oral secretions, and respiratory complications. Laryngeal cleft injection laryngoplasty (LCIL) and salivary botulinum injections (Sa…
View article: Table of Contents (4 pgs)
Table of Contents (4 pgs) Open
View article: Surgical and logistical concerns for ex vivo–based perfusion strategies for “donation after circulatory death” multiorgan recovery
Surgical and logistical concerns for ex vivo–based perfusion strategies for “donation after circulatory death” multiorgan recovery Open
View article: Intranodal Sirolimus Induces Regulatory T Cells in Human Hepatic Lymph Nodes via Interleukin 10 Signaling
Intranodal Sirolimus Induces Regulatory T Cells in Human Hepatic Lymph Nodes via Interleukin 10 Signaling Open
Many transplant recipients die with functional transplant grafts. Immune-related morbidity and mortality attributed to conventional systemic immunosuppression continue to be the major barriers against the long-term success of solid organ t…
View article: Percutaneous direct pancreatic duct intervention in management of pancreatic fistulas: a primary treatment or temporizing therapy to prepare for elective surgery
Percutaneous direct pancreatic duct intervention in management of pancreatic fistulas: a primary treatment or temporizing therapy to prepare for elective surgery Open
View article: Attenuation of Acute Rejection in a Rat Liver Transplantation Model by a Liver-Targeted Dextran Prodrug of Methylprednisolone
Attenuation of Acute Rejection in a Rat Liver Transplantation Model by a Liver-Targeted Dextran Prodrug of Methylprednisolone Open
The use of methylprednisolone (MP) and other corticosteroids for the treatment of acute liver allograft rejection is associated with severe toxicities in non-target tissues. Therefore, selective delivery of MP to the liver may improve its …
View article: Adipose-derived stem cells in wound healing of full-thickness skin defects: a review of the literature
Adipose-derived stem cells in wound healing of full-thickness skin defects: a review of the literature Open
The complex process of wound healing can be delayed in circumstances when the natural niche is extremely altered. Adipose-derived stem cells (ADSC) seem to be a promising therapy for these type of wounds. We aim to describe the studies tha…
View article: Issue Information
Issue Information Open
Underlying mechanisms contributing to sarcopenia (reduced skeletal muscle mass and reduced muscle function) in adults and children with end-stage liver disease (ESLD) is multifactorial encompassing changes in degradative and synthetic path…
View article: Sexual dimorphism in the incidence of human cancers
Sexual dimorphism in the incidence of human cancers Open
View article: Evolving Role of Liver Transplantation in Elderly Recipients
Evolving Role of Liver Transplantation in Elderly Recipients Open
The need for liver transplantation (LT) among older patients is increasing, but the role of LT in the elderly (≥70 years) is not well defined. We retrospectively reviewed all primary LTs from 1998 through 2016 at our center. Survival and a…
View article: Assessment of Vitreous Structure and Visual Function after Neodymium:Yttrium–Aluminum–Garnet Laser Vitreolysis
Assessment of Vitreous Structure and Visual Function after Neodymium:Yttrium–Aluminum–Garnet Laser Vitreolysis Open