Explanipedia

EOR-1/PLZF promotes WAH-1/AIF-dependent compartment-specific corpse clearance Open

Aladin Elkhalil, Melvin Williams, Rashna Sharmin, Geoffrey Clark · 2025

Programmed cell death (PCD) is a crucial, evolutionarily conserved process required for development and homeostasis. We previously described a genetically non-canonical apoptotic, highly ordered cell death program called Compartmentalized …

Stratigraphic Narratives from the Eastern Torres Strait: A Multi-proxy Geoarchaeological Study at Ormi, Dauar Island Open

Elisa Scorsini, Geoffrey Clark, Tim Denham, Yannick Devos, Jillian Huntley , et al. · 2025

Genomic and morphometric evidence for Austronesian-mediated pig translocation in the Pacific Open

David W. G. Stanton, Aurélie Manin, Allowen Evin, Kristina Tabbada, Anna Linderholm , et al. · 2025

Human mediated translocation of non-native pig species (genus Sus ) to the islands of Wallacea and Oceania has significantly altered local ecosystems. To investigate the timing and trajectory of these introductions, we conducted both genom…

CDH-3/Cadherin, YAP-1/YAP and EGL-44/TEAD promote SYX-2/Syntaxin and EFF-1 fusogen-mediated phagosome closure Open

Piya Ghose, Allison M. Whited, Aladin Elkhlail, Geoffrey Clark · 2025

Physical interactions between cells, such as cell-cell junctions, can profoundly impact cell fate. A vital cell fate for normal development and homeostasis is programmed cell death. Cells fated to die must be efficiently cleared away via p…

EOR-1/PLZF-regulated WAH-1/AIF sequentially promotes early and late stages of non-apoptotic corpse removal Open

Nathan Rather, Melvin Williams, Aladin Elkhalil, Karen Juanez, Rashna Sharmin , et al. · 2024

Programmed cell death (PCD) is a crucial, genetically-encoded, and evolutionarily-conserved process required for development and homeostasis. We previously identified a genetically non-apoptotic, highly ordered, and stereotyped killing pro…

Exploring the potential of dental calculus to shed light on past human migrations in Oceania Open

Irina M. Velsko, Zandra Fagernäs, Monica Tromp, Stuart Bedford, Hallie R. Buckley , et al. · 2024

A Behavior Architecture for Fast Humanoid Robot Door Traversals Open

Duncan Calvert, Luigi Penco, D. D. Anderson, Tomasz Bialek, A. Chatterjee , et al. · 2024

Towards the role of humanoid robots as squad mates in urban operations and other domains, we identified doors as a major area lacking capability development. In this paper, we focus on the ability of humanoid robots to navigate and deal wi…

NORE1A loss promotes MASLD/MASH Open

Howard Donninger, Katherine Hobbing, Gavin E. Arteel, Geoffrey Clark · 2024

Exotic ceramics from the Murray Islands, Eastern Torres Strait Open

Emily Nutman, Geoffrey Clark, Mathieu Leclerc, Michael Anenburg, Joshua Willsher , et al. · 2024

Low-Density Urbanisation: Prestate Settlement Growth in a Pacific Society Open

Phillip Parton, Geoffrey Clark · 2024

The recognition of low-density urbanisation has been important in documenting how diverse human settlements generated enduring social and economic change. In tropical regions, the key challenges to studying low-density urbanisation have be…

Early architecture in Tonga: implications for the development of Polynesian chiefdoms Open

Geoffrey Clark, Phillip Parton, Christian Reepmeyer · 2024

Durable architecture is a hallmark of Polynesian chiefdoms, associated with centralised control of residential and agricultural land. Previous work in West Polynesia has indicated a relatively late date for the onset of such construction a…

A Behavior Architecture for Fast Humanoid Robot Door Traversals Open

Duncan Calvert, Luigi Penco, D. D. Anderson, Tomasz Bialek, A. Chatterjee , et al. · 2024

The NORE1A/RASSF5 Tumor Suppressor Forms a Complex with GSK-3β to Regulate β-Catenin Open

Marianne Schmidt, Howard Donninger, Geoffrey Clark · 2024

NORE1A (RASSF5) is a tumor suppressor of the RASSF family that is often down-regulated in human tumors. NORE1A has multiple roles in controlling cellular homeostasis, one of them being regulating levels of β-catenin by binding and modulati…

K-RAS Is…Complicated Open

Geoffrey Clark · 2023

There is little argument that the K-RAS onco-protein is the most important single oncoprotein in human cancer [...]

Low-Density Urbanisation: Prestate Settlement Growth in a Pacific Society Open

Phillip Parton, Geoffrey Clark · 2023

The recognition of low-density urbanisation has been important in documenting how diverse human settlements generated enduring social and economic change. In tropical regions, the key challenges to studying low-density urbanisation have be…

Exploring archaeogenetic studies of dental calculus to shed light on past human migrations in Oceania Open

Irina M. Velsko, Zandra Fagernäs, Monica Tromp, Stuart Bedford, Hallie R. Buckley , et al. · 2023

The Pacific islands have experienced multiple waves of human migrations, providing a case study for exploring the potential of using the microbiome to study human migration. We performed a metagenomic study of archaeological dental calculu…

BRCA1 and NORE1A Form a Her2/Ras Regulated Tumor Suppressor Complex Modulating Senescence Open

Nicholas Nelson, Raphael Jigo, Geoffrey Clark · 2023

BRCA1 is a tumor suppressor with a complex mode of action. Hereditary mutations in BRCA1 predispose carriers to breast cancer, and spontaneous breast cancers often exhibit defects in BRCA1 expression. However, haploinsufficiency or suppres…

Supplementary Figure 2 from NORE1A Tumor Suppressor Candidate Modulates p21CIP1 via p53 Open