Justin S. Smith
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View article: Reactive Chemistry at Unrestricted Coupled Cluster Level: High-throughput Calculations for Training Machine Learning Potentials
Reactive Chemistry at Unrestricted Coupled Cluster Level: High-throughput Calculations for Training Machine Learning Potentials Open
Accurately modeling chemical reactions at the atomistic level requires high-level electronic structure theory due to the presence of unpaired electrons and the need to properly describe bond breaking and making energetics. Commonly used ap…
View article: Analysis, Testing, and Design of a UHF and HF Peer‐to‐Peer Communication System for the Europan Cryosphere
Analysis, Testing, and Design of a UHF and HF Peer‐to‐Peer Communication System for the Europan Cryosphere Open
This study presents a validated design of a dual‐band wireless relay system of “pucks” for through‐ice communication between a cryobot and a surface lander during a future exploration of the Europan cryosphere. The design of a terrestrial …
View article: Identification and Management of Neurologic Complications in Patients Undergoing Adult Spinal Deformity Surgery
Identification and Management of Neurologic Complications in Patients Undergoing Adult Spinal Deformity Surgery Open
Study Design Narrative Literature Review. Objective To provide a comprehensive literature review of neurologic complications in Adult Spinal Deformity (ASD) surgery in the pre-operative, peri-operative and post-operative periods. Methods A…
View article: Blood Management and Conservation During Adult Spine Deformity Surgery
Blood Management and Conservation During Adult Spine Deformity Surgery Open
Study Design Narrative literature review. Objectives To summarize the evidence for perioperative blood conservation for patients undergoing surgery for adult spine deformity. Methods A systematic literature review with narrative analysis w…
View article: Alignment Goals in Adult Spinal Deformity Surgery
Alignment Goals in Adult Spinal Deformity Surgery Open
Study Design Narrative review. Objectives Adult spinal deformity (ASD) surgery has progressively transitioned from mean regional alignment targets to individualized segmental alignment goals, and from health-related quality of life (HRQL) …
View article: Pelvic Fixation in Adult Spinal Deformity: Complications, Controversies, and Future Directions
Pelvic Fixation in Adult Spinal Deformity: Complications, Controversies, and Future Directions Open
Study Design Narrative Review. Objective Pelvic fixation is a crucial technique in modern adult spinal deformity surgery, yet complications and failure rates remain high. Significant controversy exists regarding the type and number of poin…
View article: Unilateral intraoperative neuromonitoring (IONM) MEP alerts in cord level surgeries for severe spinal deformities – etiology and recovery patterns
Unilateral intraoperative neuromonitoring (IONM) MEP alerts in cord level surgeries for severe spinal deformities – etiology and recovery patterns Open
View article: Letter re: Incremental Increase in Hospital Length of Stay Due to Complications of Surgery for Adult Spinal Deformity
Letter re: Incremental Increase in Hospital Length of Stay Due to Complications of Surgery for Adult Spinal Deformity Open
View article: Incremental Increase in Hospital Length of Stay Due to Complications of Surgery for Adult Spinal Deformity
Incremental Increase in Hospital Length of Stay Due to Complications of Surgery for Adult Spinal Deformity Open
Study Design Retrospective Cohort Study. Objectives Length of Stay (LOS) and resource utilization are of primary importance for hospital administration. This study aimed to understand the incremental effect of having a specific complicatio…
View article: Mismatch Between Pelvic Incidence and Lumbar Lordosis After Personalized Interbody Fusion: The Importance of Preoperative Planning and Alignment in Degenerative Spine Diseases
Mismatch Between Pelvic Incidence and Lumbar Lordosis After Personalized Interbody Fusion: The Importance of Preoperative Planning and Alignment in Degenerative Spine Diseases Open
BACKGROUND: Emerging data have highlighted the significance of planning and aligning total and segmental lumbar lordosis with pelvic morphology when performing short-segment fusion with the goal of reducing the risk of adjacent segment dis…
View article: Opioid Use Prior to Adult Spine Deformity Correction Surgery is Associated With Worse Pre- and Postoperative Back Pain and Prolonged Opioid Demands
Opioid Use Prior to Adult Spine Deformity Correction Surgery is Associated With Worse Pre- and Postoperative Back Pain and Prolonged Opioid Demands Open
Study Design Prospective multicenter database post-hoc analysis. Objectives Opioids are frequently prescribed for painful spinal conditions to provide pain relief and to allow for functional improvement, both before and after spine surgery…
View article: Revision Strategy for Proximal Junctional Failure: Combined Effect of Proximal Extension and Focal Correction
Revision Strategy for Proximal Junctional Failure: Combined Effect of Proximal Extension and Focal Correction Open
Study design Retrospective review of a prospectively-collected multicenter database. Objectives The objective of this study was to determine optimal strategies in terms of focal angular correction and length of proximal extension during re…
View article: Post-operative bracing following adult spine deformity surgery: Results from the AO Spine surveillance of post-operative management of patients with adult spine deformity
Post-operative bracing following adult spine deformity surgery: Results from the AO Spine surveillance of post-operative management of patients with adult spine deformity Open
Study design Cross-sectional international survey with a literature review. Objectives While some surgeons favor spine bracing after surgery for adult spine deformity (ASD) to help prevent mechanical failures, there is a lack of evidence. …
View article: Impact of Self-Reported Loss of Balance and Gait Disturbance on Outcomes following Adult Spinal Deformity Surgery
Impact of Self-Reported Loss of Balance and Gait Disturbance on Outcomes following Adult Spinal Deformity Surgery Open
Background: The objective of this study was to evaluate if imbalance influences complication rates, radiological outcomes, and patient-reported outcomes (PROMs) following adult spinal deformity (ASD) surgery. Methods: ASD patients with bas…
View article: Assessing Surgical Outcomes for Cage Plate System versus Stand-Alone Cage in Anterior Cervical Discectomy and Fusion: A Systematic Review and Meta-Analysis
Assessing Surgical Outcomes for Cage Plate System versus Stand-Alone Cage in Anterior Cervical Discectomy and Fusion: A Systematic Review and Meta-Analysis Open
Most of the included studies had monosegmented fusion, and there wasn't enough data to set recommendations for the multisegmented fusions. Larger studies with longer follow-up are necessary to draw more definitive conclusions to provide ev…
View article: Cost Benefit of Implementation of Risk Stratification Models for Adult Spinal Deformity Surgery
Cost Benefit of Implementation of Risk Stratification Models for Adult Spinal Deformity Surgery Open
Study Design/Setting Retrospective cohort study. Objective Assess the extent to which defined risk factors of adverse events are drivers of cost-utility in spinal deformity (ASD) surgery. Methods ASD patients with 2-year (2Y) data were inc…
View article: Alterations in Magnitude and Shape of Thoracic Kyphosis Following Surgical Correction for Adult Spinal Deformity
Alterations in Magnitude and Shape of Thoracic Kyphosis Following Surgical Correction for Adult Spinal Deformity Open
Study Design Retrospective review of prospective multicenter data. Objectives This study aimed to investigate the shape of TK before and after fusion in ASD patients treated with long fusion. Methods ASD patients undergoing posterior spina…
View article: Analysis of Personalized Interbody Implants in the Surgical Treatment of Adult Spinal Deformity
Analysis of Personalized Interbody Implants in the Surgical Treatment of Adult Spinal Deformity Open
Study Design Multicenter cohort. Objectives A report from the International Spine Study Group (ISSG) noted that surgeons failed to achieve alignment goals in nearly two-thirds of 266 complex adult deformity surgery (CADS) cases. We assess …
View article: Adult Cervical Deformity Patients Have Higher Baseline Frailty, Disability, and Comorbidities Compared With Complex Adult Thoracolumbar Deformity Patients: A Comparative Cohort Study of 616 Patients
Adult Cervical Deformity Patients Have Higher Baseline Frailty, Disability, and Comorbidities Compared With Complex Adult Thoracolumbar Deformity Patients: A Comparative Cohort Study of 616 Patients Open
Study Design Multicenter comparative cohort. Objective Studies have shown markedly higher rates of complications and all-cause mortality following surgery for adult cervical deformity (ACD) compared with adult thoracolumbar deformity (ATLD…
View article: Outcomes of Surgical Treatment for Patients With Mild Scoliosis and Age-Appropriate Sagittal Alignment With Minimum 2-Year Follow-up
Outcomes of Surgical Treatment for Patients With Mild Scoliosis and Age-Appropriate Sagittal Alignment With Minimum 2-Year Follow-up Open
Objective: The goal of this study was to determine if patients with mild scoliosis and age-appropriate sagittal alignment have favorable outcomes following surgical correction.Methods: Retrospective review of a prospective, multicenter adu…
View article: Editors’ Introduction: Proximal Junctional Kyphosis After Deformity Correction Surgery
Editors’ Introduction: Proximal Junctional Kyphosis After Deformity Correction Surgery Open
The International Journal of Spine Surgery is honored to provide a special issue on the topic of proximal junctional kyphosis (PJK) in deformity surgery. Many spine surgeons are all too familiar with the occurrence of PJK without being fam…
View article: Economic burden of nonoperative treatment of adult spinal deformity
Economic burden of nonoperative treatment of adult spinal deformity Open
OBJECTIVE The purpose of this study was to investigate the cost utility of nonoperative treatment for adult spinal deformity (ASD). METHODS Nonoperatively and operatively treated patients who met database criteria for ASD and in whom compl…
View article: Use of Tethers for Proximal Junctional Kyphosis Prophylaxis in Adult Spinal Deformity Surgery: A Review of Current Clinical Evidence
Use of Tethers for Proximal Junctional Kyphosis Prophylaxis in Adult Spinal Deformity Surgery: A Review of Current Clinical Evidence Open
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View article: Are We Focused on the Wrong Early Postoperative Quality Metrics? Optimal Realignment Outweighs Perioperative Risk in Adult Spinal Deformity Surgery
Are We Focused on the Wrong Early Postoperative Quality Metrics? Optimal Realignment Outweighs Perioperative Risk in Adult Spinal Deformity Surgery Open
Background: While reimbursement is centered on 90-day outcomes, many patients may still achieve optimal, long-term outcomes following adult spinal deformity (ASD) surgery despite transient short-term complications. Objective: Compare long-…
View article: Adherence to the Obeid coronal malalignment classification and a residual malalignment below 20 mm can improve surgical outcomes in adult spine deformity surgery
Adherence to the Obeid coronal malalignment classification and a residual malalignment below 20 mm can improve surgical outcomes in adult spine deformity surgery Open
Purpose Coronal balance is a major factor impacting the surgical outcomes in adult spinal deformity (ASD). The Obeid coronal malalignment (O-CM) classification has been proposed to improve the coronal alignment in ASD surgery. Aim of this …
View article: Independent Prognostic Factors Associated With Improved Patient-Reported Outcomes in the Prospective Evaluation of Elderly Deformity Surgery (PEEDS) Study
Independent Prognostic Factors Associated With Improved Patient-Reported Outcomes in the Prospective Evaluation of Elderly Deformity Surgery (PEEDS) Study Open
Study Design Prospective, multicenter, international, observational study Objective Identify independent prognostic factors associated with achieving the minimal clinically important difference (MCID) in patient reported outcome measures (…
View article: Supplementary Table 3 from Reversing <i>HOXA9</i> Oncogene Activation by PI3K Inhibition: Epigenetic Mechanism and Prognostic Significance in Human Glioblastoma
Supplementary Table 3 from Reversing <i>HOXA9</i> Oncogene Activation by PI3K Inhibition: Epigenetic Mechanism and Prognostic Significance in Human Glioblastoma Open
Supplementary Table 3 from Reversing HOXA9 Oncogene Activation by PI3K Inhibition: Epigenetic Mechanism and Prognostic Significance in Human Glioblastoma
View article: Supplementary Methods from Reversing <i>HOXA9</i> Oncogene Activation by PI3K Inhibition: Epigenetic Mechanism and Prognostic Significance in Human Glioblastoma
Supplementary Methods from Reversing <i>HOXA9</i> Oncogene Activation by PI3K Inhibition: Epigenetic Mechanism and Prognostic Significance in Human Glioblastoma Open
Supplementary Methods from Reversing HOXA9 Oncogene Activation by PI3K Inhibition: Epigenetic Mechanism and Prognostic Significance in Human Glioblastoma
View article: Supplementary Table 2 from Reversing <i>HOXA9</i> Oncogene Activation by PI3K Inhibition: Epigenetic Mechanism and Prognostic Significance in Human Glioblastoma
Supplementary Table 2 from Reversing <i>HOXA9</i> Oncogene Activation by PI3K Inhibition: Epigenetic Mechanism and Prognostic Significance in Human Glioblastoma Open
Supplementary Table 2 from Reversing HOXA9 Oncogene Activation by PI3K Inhibition: Epigenetic Mechanism and Prognostic Significance in Human Glioblastoma
View article: Supplementary Figures 1-7 from Reversing <i>HOXA9</i> Oncogene Activation by PI3K Inhibition: Epigenetic Mechanism and Prognostic Significance in Human Glioblastoma
Supplementary Figures 1-7 from Reversing <i>HOXA9</i> Oncogene Activation by PI3K Inhibition: Epigenetic Mechanism and Prognostic Significance in Human Glioblastoma Open
Supplementary Figures 1-7 from Reversing HOXA9 Oncogene Activation by PI3K Inhibition: Epigenetic Mechanism and Prognostic Significance in Human Glioblastoma