Justin Sibert
YOU?
Author Swipe
View article: Genome rearrangements induce biofilm formation in Escherichia coli C – an old model organism with a new application in biofilm research
Genome rearrangements induce biofilm formation in Escherichia coli C – an old model organism with a new application in biofilm research Open
View article: Genome maps across 26 human populations reveal population-specific patterns of structural variation
Genome maps across 26 human populations reveal population-specific patterns of structural variation Open
View article: MOESM11 of Genome rearrangements induce biofilm formation in Escherichia coli C â an old model organism with a new application in biofilm research
MOESM11 of Genome rearrangements induce biofilm formation in Escherichia coli C â an old model organism with a new application in biofilm research Open
Additional file 11: Table S1. Gene content comparison between five E. coli strains.
View article: OMSV enables accurate and comprehensive identification of large structural variations from nanochannel-based single-molecule optical maps
OMSV enables accurate and comprehensive identification of large structural variations from nanochannel-based single-molecule optical maps Open
We present a new method, OMSV, for accurately and comprehensively identifying structural variations (SVs) from optical maps. OMSV detects both homozygous and heterozygous SVs, SVs of various types and sizes, and SVs with or without creatin…
View article: High-throughput single-molecule telomere characterization
High-throughput single-molecule telomere characterization Open
We have developed a novel method that enables global subtelomere and haplotype-resolved analysis of telomere lengths at the single-molecule level. An in vitro CRISPR/Cas9 RNA-directed nickase system directs the specific labeling of human (…
View article: OMSV enables accurate and comprehensive identification of large structural variations from nanochannel-based single-molecule optical maps
OMSV enables accurate and comprehensive identification of large structural variations from nanochannel-based single-molecule optical maps Open
Human genomes contain structural variations (SVs) that are associated with various phenotypic variations and diseases. SV detection by sequencing is incomplete due to limited read length. Nanochannel-based optical mapping (OM) allows direc…
View article: High-throughput single-molecule mapping links subtelomeric variants and long-range haplotypes with specific telomeres
High-throughput single-molecule mapping links subtelomeric variants and long-range haplotypes with specific telomeres Open
Accurate maps and DNA sequences for human subtelomere regions, along with detailed knowledge of subtelomere variation and long-range telomere-terminal haplotypes in individuals, are critical for understanding telomere function and its role…
View article: Additional file 7 of OMSV enables accurate and comprehensive identification of large structural variations from nanochannel-based single-molecule optical maps
Additional file 7 of OMSV enables accurate and comprehensive identification of large structural variations from nanochannel-based single-molecule optical maps Open
Gaps in hg38. This file provides the locations of unspecified nucleotides (Nâ s) in the human reference genome hg38. (BED 18 kb)
View article: Additional file 4 of OMSV enables accurate and comprehensive identification of large structural variations from nanochannel-based single-molecule optical maps
Additional file 4 of OMSV enables accurate and comprehensive identification of large structural variations from nanochannel-based single-molecule optical maps Open
Overlapping of C666-1 indels with segmental duplications. This file provides the overlap of C666-1 indels identified by OMSV with human segmental duplications. The first three columns show the genomic location of the SVs. The fourth column…
View article: Additional file 3 of OMSV enables accurate and comprehensive identification of large structural variations from nanochannel-based single-molecule optical maps
Additional file 3 of OMSV enables accurate and comprehensive identification of large structural variations from nanochannel-based single-molecule optical maps Open
SV list from the C666-1 cell line. This file provides the SVs identified by OMSV from the C666-1 cell line. The first sheet lists the indels identified. The second sheet lists all the sites with multiple indels called at the same site (two…
View article: Additional file 2 of OMSV enables accurate and comprehensive identification of large structural variations from nanochannel-based single-molecule optical maps
Additional file 2 of OMSV enables accurate and comprehensive identification of large structural variations from nanochannel-based single-molecule optical maps Open
SV lists from the CEU (Northern Europeans from Utah) trio. This file provides the SVs identified by OMSV from the CEU trio. The first three sheets list the indels identified from NA12878, NA12891, and NA12892, respectively. The fourth shee…
View article: Additional file 8 of OMSV enables accurate and comprehensive identification of large structural variations from nanochannel-based single-molecule optical maps
Additional file 8 of OMSV enables accurate and comprehensive identification of large structural variations from nanochannel-based single-molecule optical maps Open
Pseudo-autosomal regions in hg38. This file provides the locations of pseudo-autosomal regions in the human reference genome hg38. (BED 0.078 kb)
View article: Additional file 6 of OMSV enables accurate and comprehensive identification of large structural variations from nanochannel-based single-molecule optical maps
Additional file 6 of OMSV enables accurate and comprehensive identification of large structural variations from nanochannel-based single-molecule optical maps Open
Fragile sites in the in silico map based on hg38. This file provides the locations of fragile sites in the human reference genome hg38. (BED 90 kb)
View article: Genome-Wide Structural Variation Detection by Genome Mapping on Nanochannel Arrays
Genome-Wide Structural Variation Detection by Genome Mapping on Nanochannel Arrays Open
Comprehensive whole-genome structural variation detection is challenging with current approaches. With diploid cells as DNA source and the presence of numerous repetitive elements, short-read DNA sequencing cannot be used to detect structu…
View article: CRISPR-CAS9 D10A nickase target-specific fluorescent labeling of double strand DNA for whole genome mapping and structural variation analysis
CRISPR-CAS9 D10A nickase target-specific fluorescent labeling of double strand DNA for whole genome mapping and structural variation analysis Open
We have developed a new, sequence-specific DNA labeling strategy that will dramatically improve DNA mapping in complex and structurally variant genomic regions, as well as facilitate high-throughput automated whole-genome mapping. The meth…