Explanipedia

Comparative immunohistochemical expression of TROP2 in brain metastatic and primary tumors Open

You‐Na Sung, Jongmin Sim, Harim Oh, Ji Won Lee, Jwa Hoon Kim , et al. · 2025

Background TROP2 overexpression was reported to predict poor prognosis and increased metastatic potential. This study evaluates TROP2 expression in brain metastases from diverse solid tumors and its consistency with primary tumors, address…

Clinicopathologic Analysis of Five Patients with POLE-Mutated Colorectal Cancer in a Single Korean Institute Open

Harim Oh, In-Ho Jang, Jinha Hwang, Soo Hyun Lee, Jungsuk An , et al. · 2025

Background/Objectives: Mutations in RAS/RAF are common in colorectal cancer (CRC) and play a pivotal role in guiding treatment selection. With the recent advent of immunotherapy, microsatellite (MSI) status, tumor mutation burden (TMB), an…

Optic neuropathy as an early manifestation of granulomatosis with polyangiitis: a case report and literature review Open

Yukang Kim, Tony Woo, Sun‐Uk Lee, Euyhyun Park, Hyun-Jin Shin , et al. · 2025

Introduction Ophthalmic involvement occurs in up to 40% of patients with granulomatosis with polyangiitis (GPA), usually confined to the anterior segment. Herein, we describe patients presenting with optic neuropathy as an early manifestat…

Context-dependent translation inhibition as a novel oncology therapeutic modality Open

Paige D. Diamond, Paul Sauer, Mikael Holm, Canessa J. Swanson-Swett, Lucas Ferguson , et al. · 2025

Inhibitors of protein synthesis, including anisomycin, homoharringtonine, and other natural products bind in the peptidyl-transferase center (PTC) of the eukaryotic ribosome to inhibit translation. Recent work has demonstrated that some PT…

Appendiceal Neuroendocrine Tumor: Clinicopathologic Characteristics of Six Cases and Review of the Literature Open

Yeseul Kim, You‐Na Sung, Anna Therese Datuin, In-Ho Jang, Jongmin Sim · 2024

ANETs are relatively uncommon and mostly benign in terms of prognosis. Because of their malignant potential, meticulous examination of appendectomy specimens is warranted to identify the presence of ANETs.

Role of a Fireboards in Enhancing the Fire Performance of Glued-Laminated Timber Columns Open

Yong Hyun Cho, Kyung‐Suk Cho, Jongmin Sim, In-Hwan Yeo · 2024

High-rise timber buildings have emerged as a sustainable solution to reduce carbon emissions in the construction sector, offering advantages over multistory steel and concrete structures. However, concerns regarding the structural performa…

Network Analysis of the Relationships Between Symptoms, Functioning, and Sleep/Fatigue in Colorectal Cancer Patients Open

Jongmin Sim, Jason C Yu, Yun Yang · 2024

Introduction Among the various patient experiences, cancer-related fatigue and sleep disturbances emerge as pivotal aspects that can substantially impact individuals’ quality of life. There exists a relative scarcity of research focusing o…

A robust model training strategy using hard negative mining in a weakly labeled dataset for lymphatic invasion in gastric cancer Open

Jonghyun Lee, Sangjeong Ahn, Hyun Soo Kim, Jungsuk An, Jongmin Sim · 2023

Gastric cancer is a significant public health concern, emphasizing the need for accurate evaluation of lymphatic invasion (LI) for determining prognosis and treatment options. However, this task is time‐consuming, labor‐intensive, and pron…

Assessment of thyroid cartilage ossification pattern in cancer patients: A suggestion of active ossification by tumor progression Open

You‐Na Sung, Yeseul Kim, Kyung‐Ja Cho, Jongmin Sim · 2023

Background Ossified cartilage is much more susceptible to cancer infiltration, but the reason remains unknown, and the relationship between the ossification pattern and cancer infiltration has not been studied. Methods The presence of thyr…

Eculizumab as rescue therapy in a kidney transplant recipient with atypical hemolytic uremic syndrome: a case report Open

Young Ju Oh, Joohyun Lee, Yeonmi Kim, Heungman Jun, Jongmin Sim , et al. · 2022

A 61-year-old female patient with chronic kidney disease due to diabetes mellitus and hypertension-induced nephropathy received a deceased donor kidney transplant in March 2020. In July 2020, she was transferred from a local hospital due t…

Low expression of DUSP4 expression predicts unfavorable prognosis in gallbladder adenocarcinoma Open

Seungyun Jee, Jongmin Sim, Seongsik Bang, Hosub Park, Jae Kyung Myung , et al. · 2022

Background: Dual specificity phosphatase 4 (DUSP4), which regulates the mitogen activated protein kinases, has emerged as a tumor suppressor gene in several human malignancies. Aims and Objectives: In this study, we investigated the clinic…

CD47 Expression Predicts Unfavorable Prognosis in Clear Cell Renal Cell Carcinoma after Curative Resection Open

Hosub Park, Seungyun Jee, Seongsik Bang, Hwangkyu Son, Hyebin Cha , et al. · 2022

The role of CD47 expression as a ‘do not eat me’ signal that inhibits phagocytosis of tumor cells by macrophages is well established. Immune checkpoint therapy that targets CD47 has been successful in preclinical trials and is currently un…

Recoverability of Diabetic Nephropathy of Donor Kidney After Kidney Transplantation Open

Kyo Won Lee, Jongmin Sim, Sean S. W. Park, Junseok Jeon, Gyuri Kim , et al. · 2022

Some kidney donors have diabetes, and little of their natural course of diabetic nephropathy (DN) is known. The aim of this study was to analyze the changes in pathologic lesions in the diabetic donor kidney after KT by performing protocol…

Clinicopathological Implications of ASAP1 Expression in Hepatocellular Carcinoma Open

Seongsik Bang, Seungyun Jee, Hwangkyu Son, Hyebin Cha, Jongmin Sim , et al. · 2022

Background: The expression of ArfGAP with SH3 domain ankyrin repeat and PH domain 1 (ASAP1) is increased in various types of cancer, showing potential as a prognostic marker. The clinicopathological implications of ASAP1 expression in pati…

Decreased Expression of Cell Adhesion Molecule 4 in Gastric Adenocarcinoma and Its Prognostic Implications Open

Seongsik Bang, Seungyun Jee, Hwangkyu Son, Hyebin Cha, Jongmin Sim , et al. · 2022

Cell adhesion molecule 4 (CADM4) is a novel tumor suppressor candidate. The prognostic implications of CADM4 in gastric cancer have not been conclusively elucidated. Therefore, we evaluated the clinicopathological significance and prognost…

Omission of chemotherapy for hormone receptor-positive and human epidermal growth factor receptor 2-negative breast cancer: patterns of treatment and outcomes from the Korean Breast Cancer Society Registry Open

Hannah Lois Kangleon-Tan, Jongmin Sim, Ji Young You, Eun-Shin Lee, Haemin Lee , et al. · 2022

Over the years, there has been a shift from CTx + HT to HT alone without a significant difference in OS. Therefore, HT alone could be a safe treatment option in selected patients, even those with T2N1 disease.

Low-Level Expression of MTUS1 Is Associated with Poor Survival in Patients with Lung Adenocarcinoma Open

Seungyun Jee, Hyunsung Kim, Seongsik Bang, Yeseul Kim, Ha Young Park , et al. · 2021

Microtubule-associated tumor suppressor 1 (MTUS1) is thought to be downregulated in arious human cancers, which suggests its role as a tumor suppressor. This study investigated the clinicopathological significance of MTUS1 expression in lu…

Correlation of CD47 Expression with Adverse Clinicopathologic Features and an Unfavorable Prognosis in Colorectal Adenocarcinoma Open

Hyunsung Kim, Seungyun Jee, Yeseul Kim, Jongmin Sim, Seongsik Bang , et al. · 2021

CD47, a transmembrane protein, is widely overexpressed on the tumor cell surface. However, the prognostic significance of CD47 expression in colorectal adenocarcinoma (CRA) has not yet been clarified. Here, we investigated the clinicopatho…

Clinicopathological Significance of MTUS1 Expression in Patients With Renal Cell Carcinoma Open

Jongmin Sim, Young Chan Wi, Ha Young Park, Sung Yul Park, Young Eun Yoon , et al. · 2020

Loss of MTUS1 expression in RCC might be a potential biomarker for predicting clinical outcome.

Low Expression of Single-stranded DNA Binding Protein 2 (SSBP2) Predicts Unfavourable Postoperative Outcomes in Patients With Clear Cell Renal Cell Carcinoma Open

Hyunsung Kim, Yeseul Kim, Seongsik Bang, Seongeon Park, Seungyun Jee , et al. · 2019

ccRCC with low SSBP2 expression was associated with adverse clinicopathological characteristics and poor patient outcomes.

Loss of MTUS1 Expression Is Associated With Poor Prognosis in Patients With Gallbladder Carcinoma Open

Jongmin Sim, Yeseul Kim, Hyungsung Kim, Seongsik Bang, Seungyun Jee , et al. · 2019

MTUS1 may act as tumor suppressor and might be a potential biomarker for predicting prognosis in GBC.

Changing trends in lymphoid neoplasm distribution in South Korea: analysis of 8615 cases from a single institute, 1997–2016 Open

Jongmin Sim, Takuya Takayama, Junhun Cho, Seok Jin Kim, Won Seog Kim , et al. · 2019

The purpose of this study was to evaluate changes in the proportion of lymphoid neoplasm subtypes in South Korea. A total of 8615 cases of lymphoid neoplasms diagnosed in 1997–2016 at Samsung Medical Center in South Korea were classified a…

MicroRNA-374a Expression as a Prognostic Biomarker in Lung Adenocarcinoma Open

Yeseul Kim, Jongmin Sim, Hyunsung Kim, Seongsik Bang, Seungyun Jee , et al. · 2019

miR-374a expression may serve as a potential prognostic biomarker for predicting recurrence in early stage lung adenocarcinoma after curative surgery.

The clinicopathologic significance of extranodal tumor extension in locally advanced (pT3) colorectal adenocarcinoma and its association with the loss of E-cadherin expression. Open

Hyunsung Kim, Su‐Jin Shin, Yeseul Kim, Seongsik Bang, Seongeon Park , et al. · 2019

We investigated the clinicopathologic significance of extranodal tumor extension (ENTE) in locally advanced and prognostically inhomogeneous pT3 (pathologic T3) colorectal adenocarcinomas with regional lymph node metastasis. ENTE is define…

Single-stranded DNA binding protein 2 expression is associated with patient survival in hepatocellular carcinoma Open

Hyunsung Kim, Yeseul Kim, Yumin Chung, Abdul Rehman, Jongmin Sim , et al. · 2018

The minority of hepatocellular carcinomas expressed SSBP2 by immunohistochemistry, whereas normal hepatocytes were negative. SSBP2-positive hepatocellular carcinomas were significantly associated with aggressive phenotypes and poor clinica…

Pulmonary Nodular Lymphoid Hyperplasia with Mass-Formation: Clinicopathologic Characteristics of Nine Cases and Review of the Literature Open

Jongmin Sim, Hyun Hee Koh, Sangjoon Choi, Jinah Chu, Tae Sung Kim , et al. · 2018

PNLH is an uncommon but distinct entity with a benign nature, and understanding the radiological and clinicopathological characteristics of PNLH is important.

Identification of recurrence-associated microRNAs in stage I lung adenocarcinoma Open

Jongmin Sim, Ye-Seul Kim, Hyunsung Kim, Su‐Jin Shin, Dong‐Hoon Kim , et al. · 2018

Lung cancer is the most common cause of cancer-associated death worldwide. Postoperative relapse and subsequent metastasis result in a high mortality rate, even in early stage lung cancer. MicroRNAs (miRNAs) are small non-coding RNAs that …

Loss of Wnt7a expression correlates with tumor progression and poor prognosis in colorectal carcinoma. Open

Se Min Jang, Young Chan Wi, Yeseul Kim, Seongsik Bang, Jongmin Sim , et al. · 2018

Wnt7a is a known tumor suppressor gene in non-small cell lung cancer that regulates normal cellular proliferation and differentiation. The purpose of this study was to investigate the clinicopathologic significance of Wnt7a expression in c…

Anaplastic lymphoma kinase (ALK)-expressing Lung Adenocarcinoma with Combined Neuroendocrine Component or Neuroendocrine Transformation: Implications for Neuroendocrine Transformation and Response to ALK-tyrosine Kinase Inhibitors Open

Jongmin Sim, Hyunjin Kim, Jiyeon Hyeon, Yoon‐La Choi, Joungho Han · 2018

We suggest that ALK-rearranged adenocarcinoma with combined neuroendocrine component is responsive to ALK-TKIs. Moreover, even after neuroendocrine transformation as a result of resistance to ALK-TKIs, the tumor may have partial response t…

Overexpression of Forkhead Box O3a and Its Association With Aggressive Phenotypes and Poor Prognosis in Human Hepatocellular Carcinoma Open

Hyein Ahn, Hyunsung Kim, Abdul Rehman, Yesul Kim, Jongmin Sim , et al. · 2017

Recent research has demonstrated that forkhead box O3a (FoxO3a) may function as an oncogenic transcription factor. We sought to validate the clinicopathologic significance of FoxO3a expression in hepatocellular carcinoma (HCC). Western blo…

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