Justin V. Le
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View article: Design of parallel 𝛽‐sheet nanofibrils using Monte Carlo search, coarse‐grained simulations, and experimental testing
Design of parallel 𝛽‐sheet nanofibrils using Monte Carlo search, coarse‐grained simulations, and experimental testing Open
Peptide self‐assembly into amyloid fibrils provides numerous applications in drug delivery and biomedical engineering applications. We augment our previously‐established computational screening technique along with experimental biophysical…
View article: Structural Consequences of Introducing Bioactive Domains to Designer β-Sheet Peptide Self-Assemblies
Structural Consequences of Introducing Bioactive Domains to Designer β-Sheet Peptide Self-Assemblies Open
We applied solid- and solution-state nuclear magnetic resonance spectroscopy to examine the structure of multidomain peptides composed of self-assembling β-sheet domains linked to bioactive domains. Bioactive domains can be selected to sti…
View article: Design of parallel<i>β</i>-sheet nanofibrils using Monte-Carlo search, coarse-grained simulations, and experimental testing
Design of parallel<i>β</i>-sheet nanofibrils using Monte-Carlo search, coarse-grained simulations, and experimental testing Open
Peptide self-assembly into amyloid fibrils provides numerous applications in drug delivery and biomedical engineering applications. We augment our previously-established computational screening technique along with experimental biophysical…
View article: Sequence patterns and signatures: Computational and experimental discovery of amyloid-forming peptides
Sequence patterns and signatures: Computational and experimental discovery of amyloid-forming peptides Open
Screening amino acid sequence space via experiments to discover peptides that self-assemble into amyloid fibrils is challenging. We have developed a computational peptide assembly design (PepAD) algorithm that enables the discovery of amyl…